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柯博元

Po-Yuan Ke, Ph.D. (柯博元 博士)

Appointment:Assistant Professor

Lab:Stress Response & Molecular Mechanism Laboratory

Education:Ph.D.


Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taiwan, Republic of China

University/Nation:National Taiwan University, Taiwan

Tel:+886-3-2118800 ext 5115

E-mail:pyke0324@mail.cgu.edu.tw

Research website

Research interests

Publication

Journal articles:

    1. Autophagy in hepatitis C virus-host interactions: Potential roles and therapeutic targets for      liver-associated diseases.
    Ke, P.Y. and Chen, S,S.L. World Journal of Gastroenterology 20: 5773-5793, 2014

    2. Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction.
    Wu, M.J., Ke, P.Y., Hsu, J.T., Yeh, C.T., and Horng, J.T. Cellular Microbiology 2014 Jun 4. doi: 10.1111/cmi.12318. [Epub ahead of print]

    3. Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism.
    Tseng, Y.H., Ke, P.Y., Liao, C.J., Wu, S.M., Chi, H.C., Tsai, C.Y., Chen, C.Y., Lin, Y. H., and Lin, K.H.Autophagy 10: 20-31, 2014.

    4. Active RNA replication of hepatitis C virus downregulates CD81 expression.
    Ke, P.Y. and Chen, S.S.L.   PLoS ONE 8: e54866, 2013.

    5. An occult hepatitis B-derived hepatoma cell line carrying persistent nuclear viral DNA and permissive for exogenous hepatitis B virus infection.
    Lin, C.L., Chien, R.N., Lin, S.M., Ke, P.Y., Lin, C.C., and Yeh, C.T.PLoS ONE 8: e65456, 2013.

    6. Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases.
    Ke, P.Y. and Chen, S.S.L. Viruses 4: 2251-2290, 2012.

    7.  Guidelines for the use and interpretation of assays for monitoring autophagy.
    Daniel J. Klionsky et al., and Ke, P.Y., and 1269 authors. Autophagy 8; 4:1-100, 2012.

    8.  Autophagy: a new guardian of HCV against innate immune response.
    Ke, P.Y. and Chen, S.S.L. Autophagy 7: 533-535, 2011.

    9. Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro.
    Ke, P.Y. and Chen, S.S.L. Journal of Clinical Investigation 121: 37-56, 2011.

    • SciBX editorial board recommended
    • Journal of Hepatology editorial board recommended

    10. Identification of the LWYIK motif located in the human immunodeficiency virus type 1 transmembrane go41 protein as a distinct determinant for viral infection.  
    Chen, S.S-L., Yang, P., Ke, P.Y., Li, H.F., Chan, W.E., Chang, DK., Chuang C.K., Tsai, Y., and Huang, S.C.   Journal of Virology 83: 870-883, 2009.

    11. Hiding human thymidine kinase 1 from APC/C-mediated destruction by thymidine binding.
    Ke, P.Y., Hu, C.M., Chang, Y.C., and Chang, Z.F. FASEB Journal 21: 1276-1284, 2007.

    12. Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability.
    Ke, P.Y., Kuo, Y.Y., Hu, C.M., and Chang, Z.F.    Genes & Development 19: 1920-1933, 2005.

    • Faculty of 1000 in Biology recommended with a score of 10.

    13. Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site.
    Li, C.L., Lu, C.Y., Ke, P.Y., and Chang, Z.F.Biochem. Biophys. Res. Commun. 313: 587-593, 2004.

    14. Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.
    Ke, P.Y. and Chang, Z.F.   Molecular and Cellular Biology 24: 514-526, 2004.

    15. Degradation of human thymidine kinase is dependent on serine-13 phosphorylation: involvement of the SCF-mediated pathway.
    Ke, P.Y., Yang, C.C., Tsai, I.C., and Chang, Z.F. Biochemical Journal 370: 265-273, 2003.

Books:

1. Suppression of innate antiviral immunity after hepatitis C virus infection: role of the unfolded protein response and autophagy. Chen, S.S. and Ke, P.Y.  Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 2 - Role in General Diseases Chapter 9. (ISBN: 9780124058774). Amsterdam, Netherlands: ELSEVIER. Dec, 2013.

2. Multifaceted Roles of Autophagy in the Life Cycle of Flaviviridae. Ke, P.Y. and Chen, S.S. Recent Research Developments in Virology, Vol. 8. (ISBN: 978-81-7895-563-6). Kerala, India: Transworld Research Network. Apr, 2012.

Presentations

1. Cell Cycle-Regulated Degradation of Human Thymidine Kinase is Dependent on the APC/CCDH1- Mediated Proteolytic Pathway in Mammalian Cells.
Ke, P.Y. and Chang, Z.F. Poster presentation: The 43th annual meeting of American Society of Cell Biology, San Francisco, USA (Dec. 2003)

2. Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.
 Ke, P.Y. and Chang, Z.F. Oral presentation: The 12th symposium on recent advances in cellular and molecular biology, Taiwan, R.O.C. (Feb. 2004)

3. Stabilization of human thymidine kinase 1 and thymidylate kinase by substrate binding.
Ke, P.Y. and Chang, Z.F.   Poster presentation: The 4th symposium on signal transduction, National Health research Institute, Taiwan, R.O.C. (Mar. 2005)

4. Proteomic and Functional analysis of Hepatitis C virus NS5A protein.
Poster presentation: The 8th conference on biomedical sciences, National Defense Medical Center, Taiwan, R.O.C. (Jun 2008)
Ke, P.Y., Shih, C., and Chen, S.S.-L.

5.Stable growth of hepatitis C virus: a new cell model for study of host-virus interaction.
Ke, P.Y. and Chen, S.S.L.Poster presentation: The 48th annual meeting of American Society of Cell Biology, San Francisco, USA (Dec. 2008)

6. Stable growth of hepatitis C virus in cell culture: a novel model for study of host-virus interactions and screening of anti-viral agents.
Ke, P.Y., Shih, C., and Chen, S.S.L.
Poster presentation: The 17th symposium on recent advances in cellular and molecular biology, Taiwan, R.O.C. (Feb. 2009)

7. Autophagy controls hepatitis C virus RNA replication through suppression antiviral innate immunity.
Ke, P. Y. and Chen, S.S.L.
Poster presentation: The 18th symposium on recent advances in cellular and molecular biology, Taiwan, R.O.C. (Feb. 2010)

8. Autophagic control of hepatitis C virus RNA replication through repression of the innate immune response.
Ke, P. Y. and Chen, S.S.L.
Oral presentation: The 17th International Meeting on Hepatitis C virus and Related Viruses, Yokohama, Japan (Sep. 2010)

9. A role of autophagy in emergence of a host cellular restriction mechanism on propagation of hepatitis C virus.
Ke, P. Y. and Chen, S.S.L.
Poster presentation: The 19th symposium on recent advances in cellular and molecular biology, Taiwan, R.O.C. (Feb. 2011)

10. Emergence of a host cellular restriction mechanism on propagation of hepatitis C virus.
Ke, P. Y. and Chen, S.S.L.
Poster presentation: The 18th International Meeting on Hepatitis C Virus and Related Viruses, Seattle, USA (Sep. 2011)

Awards & Honors

  • 2003  Excellent Publication Award for Graduate Student, National Taiwan University, College of Medicine
  • 2003  International Conference Travel Award, The Chinese Society of Cell and Molecular Biology
  • 2004  Dr. Chien-Tien Hsu Award in 12th Symposium on Recent Advances in Cellular and Molecular Biology
  • 2004  Outstanding Student Award in Academy, National Taiwan University
  • 2005  Post-doctoral Fellowship Award, National Health Research Institute
  • 2005  The President Award in Medicine and Technology, Tien-Te Lee Biomedical Foundation, Yung Shin PHARM. IND. CO., LTD
  • 2009  Poster Award, 17th Symposium on Recent Advances in Cellular and Molecular Biology
  • 2010  Poster Award, 18th Symposium on Recent Advances in Cellular and Molecular Biology
  • 2010  Research Article Competition Award for Post-Doctoral Research Fellow, Institution of Biomedical Sciences, Academia Sinica
  • 2010  International Travel Fellowship and Invited Oral Presentation Award, 17th International Meeting on Hepatitis C Virus and Related Viruses
  • 2011  Outstanding Paper Award on hepatitis C virus research of Liver Disease Prevention & Treatment Research Foundation, Taiwan, R.O.C.
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