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江倪全

江倪全 ( Chuan Chiang-Ni ) 

職稱:助理教授

研究室名稱:細菌遺傳學實驗室 

最高學歷:Ph.D.

學校/國家:成功大學/台灣 

分機號碼:3712 

電子郵件帳號: entchuan@mail.cgu.edu.tw

個人網頁網址:https://sites.google.com/a/gap.cgu.edu.tw/bac_pathog/

研究室現有: 博士後研究員 0

博士班研究生  0

碩士班研究生 3 人

專任研究助理  2

大學部專題生  2

 

研究方向研究室特色

Streptococcus pyogenes (group A Streptococcus, GAS) is the major human pathogen causes various diseases including pharyngitis, cellulitis, scarlet fever, necrotizing fasciitis, and toxic shock syndrome.  Although this pathogen is sensitive to antibiotics treatment, it still causes more than 500,000 deaths per year in the global scale.  In addition, no vaccine is available for preventing GAS infections.  My research focuses on studying the mechanism of GAS virulence genes regulation under stress conditions, and the biological significance of GAS phenotypic heterogeneity and instability.

最近五年所發表論文:

 

Hsieh CL, Huang HM, Hsieh SY, Zheng PX, Lin YS, Chiang-Ni C, Tsai PJ, Wang SY, Liu CC, Wu JJ*. 2018. NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells. Front in Microbiol 9:1733. https://doi.org/10.3389/fmicb.2018.01733

Chiang-Ni C*, Tseng HC, Hung CH, Chiu CH. 2017. Acidic stress enhances CovR/S-dependent gene repression through activation of the covR/S promoter in emm1-type group A Streptococcus. Int J Med Microbiol 307:329-339. https://doi.org/10.1016/j.ijmm.2017.06.002

Zheng PX, Chan YC, Chiou CS, Hsieh CL, Chiang-Ni C, Wu JJ*. 2017. Highly prevalent emmSTG840.0 and emmSTC839.0 types of erythromycin non-susceptible group G Streptococcus isolated from bacteremia in southern Taiwan. J Microbiol Immunol Infect 50:831-838. https://doi.org/10.1016/j.jmii.2016.12.010

Hou JN, Chen TH, Chiang YH, Peng JY, Yang TH, Cheng CC, Sofiyatun E, Chiu CH, Chiang-Ni C*, Chen WJ*. 2017. PERK signal-modulated protein translation promotes the survivability of Dengue 2 virus-infected mosquito cells and extends viral replication. Viruses 9. https://doi.org/10.3390/v9090262

Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH*. 2017. Cytolethal distending toxin enhances radiosensitivity in prostate cancer cells by regulating autophagy. Front Cell Infect Microbiol 7:223. https://doi.org/10.3389/fcimb.2017.00223

Chiang-Ni C*, Chu TP, Wu JJ, Chiu CH. 2016. Repression of Rgg but not upregulation of LacD.1 in emm1-type covS mutant mediates the SpeB repression in group A Streptococcus. Front Microbiol 7:1935. https://doi.org/10.3389/fmicb.2016.01935

Chiang-Ni C, Zheng PX, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2016. Epidemiology analysis of Streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system. J Clin Microbiol 54:157-162. https://doi.org/10.1128/JCM.02089-15

Chiang-Ni C*, Nian SY, Wu JJ, Chen CJ. 2016. Oxygen-dependent phenotypic variation in group A Streptococcus. J Microbiol Immunol Infect 49:837-842. https://doi.org/10.1016/j.jmii.2014.11.010

Lai CH*, Huang JC, Chiang-Ni C, Li JP, Wu LT, Wu HS, Sun YC, Lin ML, Lee JF, Lin HJ. 2016. Mixed infections of Helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan. Gastroenterol Res Pract 2016:7521913. https://doi.org/10.1155/2016/7521913

Lai CK, Chen YA, Lin CJ, Lin HJ, Kao MC, Huang MZ, Lin YH, Chiang-Ni C, Chen CJ, Lo UG, Lin LC, Lin H, Hsieh JT, Lai CH*. 2016. Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin. Front Cell Infect Microbiol 6:9. https://doi.org/10.3389/fcimb.2016.00009

Zheng PX, Chan YC, Chiou CS, Chiang-Ni C, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2015. Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci. PLoS One 10:e0145223. https://doi.org/10.1371/journal.pone.0145223

Tsou YA, Lin CD, Chen HC, Hsu HY, Wu LT, Chiang-Ni C, Chen CJ, Wu TF, Kao MC, Chen YA, Peng MT, Tsai MH, Chen CM, Lai CH*. 2015. Interleukin-13 inhibits lipopolysaccharide-induced BPIFA1 expression in nasal epithelial cells. PLoS One 10:e0143484. https://doi.org/10.1371/journal.pone.0143484

Chiang-Ni C, Zheng PX, Wang S, Tsai PJ, Kuo CF, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2014. Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments. Pathog Dis 70:194-201. https://doi.org/10.1111/2049-632X.12114

Zheng PX, Chiang-Ni C, Wang SY, Tsai PJ, Kuo CF, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2014. Arrangement and number of clustered regularly interspaced short palindromic repeat spacers are associated with erythromycin susceptibility in emm12, emm75 and emm92 of group A Streptococcus. Clin Microbiol Infect 20:516-523. https://doi.org/10.1111/1469-0691.12379

Wen YT, Wang JS, Tsai SH, Chiang-Ni C, Wu JJ, Liao PC*. 2014. Label-free proteomic analysis of environmental acidification-influenced Streptococcus pyogenes secretome reveals a novel acid-induced protein histidine triad protein A (HtpA) involved in necrotizing fasciitis. J Proteomics 109:90-103. https://doi.org/10.1016/j.jprot.2014.06.026

Zheng PX, Chung KT, Chiang-Ni C, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2013. Complete genome sequence of emm1 Streptococcus pyogenes A20, a strain with an intact two-component system, CovRS, isolated from a patient with necrotizing fasciitis. Genome Announc 1. https://doi.org/10.1128/genomeA.00149-12

Wang CH#, Chiang-Ni C#, Kuo HT, Zheng PX, Tsou CC, Wang S, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ. 2013. Peroxide responsive regulator PerR of group A Streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress. PLoS One 8:e81882. https://doi.org/10.1371/journal.pone.0081882 (#: Equal contribution)

Chiang-Ni C#, Zheng PX#, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2012. Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci. J Med Microbiol 61:16-22. https://doi.org/10.1099/jmm.0.036012-0 (#: Equal contribution)

Hung CH, Tsao N, Zeng YF, Lu SL, Chiang-Ni C, Lin YS, Wu JJ, Kuo CF*. 2012. Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection. Med Microbiol Immunol 201:357-369. https://doi.org/10.1007/s00430-012-0241-6

Chiang-Ni C, Wu AB, Liu CC, Chen KT, Lin YS, Chuang WJ, Fang HY, Wu JJ*. 2011. Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan. J Microbiol Immunol Infect 44:424-429. https://doi.org/10.1016/j.jmii.2011.04.005

Su YF, Chuang WJ, Wang SM, Chen WY, Chiang-Ni C, Lin YS, Wu JJ, Liu CC*. 2011. The deficient cleavage of M protein-bound IgG by IdeS: insight into the escape of Streptococcus pyogenes from antibody-mediated immunity. Mol Immunol 49:134-142. https://doi.org/10.1016/j.molimm.2011.08.002

Wu AB, Wang MC, Tseng CC, Lin WH, Teng CH, Huang AH, Hung KH, Chiang-Ni C, Wu JJ*. 2011. Clinical and microbiological characteristics of community-acquired Staphylococcus lugdunensis infections in Southern Taiwan. J Clin Microbiol 49:3015-3018. https://doi.org/10.1128/JCM.01138-11

Tsou CC, Chiang-Ni C, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ*. 2010. Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes. Int J Med Microbiol 300:259-264. https://doi.org/10.1016/j.ijmm.2009.09.002

Chiang-Ni C, Zheng PX, Ho YR, Wu HM, Chuang WJ, Lin YS, Lin MT, Liu CC, Wu JJ*. 2009. emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier SpeB secretion. J Clin Microbiol 47:3161-3169. https://doi.org/10.1128/JCM.00202-09

Chiang-Ni C, Tsou CC, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ*. 2008. The transcriptional terminator sequences downstream of the covR gene terminate covR/S operon transcription to generate covR monocistronic transcripts in Streptococcus pyogenes. Gene 427:99-103. https://doi.org/10.1016/j.gene.2008.08.025

Tsou CC, Chiang-Ni C, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ*. 2008. An iron-binding protein, Dpr, decreases hydrogen peroxide stress and protects Streptococcus pyogenes against multiple stresses. Infect Immun 76:4038-4045. https://doi.org/10.1128/IAI.00477-08

Chiang-Ni C, Wu JJ*. 2008. Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes. J Formos Med Assoc 107:677-685. https://doi.org/10.1016/S0929-6646(08)60112-6

Chiang-Ni C, Wang CH, Tsai PJ, Chuang WJ, Lin YS, Lin MT, Liu CC, Wu JJ*. 2006. Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A Streptococcus. Med Microbiol Immunol 195:55-63. https://doi.org/10.1007/s00430-005-0001-y

 

 

CONFERENCE PAPER

 

 

Chiang-Ni, C. and Shi, Y.A., (2018) Intracellular group A Streptococcus in the pathogenesis of invasive infections. 2018 Microbial Pathogenesis Symposium. Taoyuan, Taiwan.

Chiang-Ni, C., Chu, T. P, Wu, J. J., and Chiu, C. H. (2016) Role of the Rgg-LacD.1 system in speB repression in invasive group A Streptococcus. 21th Conference on Bacteriology. Taipei, Taiwan.

Chiang-Ni, C., Hsiesh, C. M., Wu, J. J., and Chu, T. P. (2015) Role of CovS on regulation of CovR expression and phosphorylation in M1 type group A Streptococcus. The Annual Meeting of Taiwan Society of Microbiology. Taipei, Taiwan.

Lu, C.H., Lin, M.C., Chiang-Ni, C., and Kuo, M.L. (2015) TNFɑ plays a pivotal role in the induction of CD4+CD25+FOXP3+ regulatory T cell with the stimulation of streptococcal pyrogenic exotoxin A. Federation of Clinical Immunology Societies. San Diego, CA.

Kang, N. and Chiang-Ni, C. (2015) Role of CovR/S in cell invasion and intracellular fitness of Streptococcus pyogenes. The 20th Conference of Bacteriology. Tainan, Taiwan.

Tseng, W. H. and Chiang-Ni, C. (2015) Role of environmental pH changes in Streptococcus pyogenes and phagocytic cells interaction. The 20th Conference of Bacteriology. Tainan, Taiwan.

Chiang-Ni, C., Hsiesh, C. M., Wu, J. J., and Chu, T. P. (2015) Role of CovS on regulation of CovR expression and phosphorylation in M1 type group A Streptococcus. The Annual Meeting of Taiwan Society of Microbiology. Taipei, Taiwan.

Hsieh, C. M. and Chiang-Ni, C. (2014) Study of the CovR protein phosphorylation status in Group A streptococcus under different environmental stress conditions.  19th Conference on Bacteriology. Kaohsiung, Taiwan.

Huang, C. H. and Chiang-Ni, C. (2013) Analysis of the roles of CovR/S regulation in response to acidic stimuli in Streptococcus pyogenes. 18th Conference on Bacteriology. Taichung, Taiwan.

Chiang-Ni, C., C. C. Tsou, P. J. Tsai, W. J. Chuang, S. Y. Wang, Y. S. Lin, C. C. Liu, J. J. Wu. (2012) Stress signals and group A Streptococcus pathogenesis. 13th Asia-Pacific Congress of Clinical Microbiology and Infection.  Beijing, China.

Chiang-Ni, C., P. J. Tsai, W. J. Chuang, Y. S. Lin, C. C. Liu, and J. J. Wu. (2011) Regulation of the speB expression under acidic culture condition of emm1 group A Streptococcus., 台灣微生物學會第二十屆第二次會員大會暨學術研討會., Tainan, Taiwan.

Lo, C. C., C. Chiang-Ni, P. X. Zheng, C. C. Tsou, Y. S. Lin, W. J. Chuang, C. C. Liu, M.-T. Lin, and J. J. Wu. (2010) Streptococcal regulator of virulence (Srv) interacts with mga to positively regulate the mga operon expression in Streptococcus pyogenes., American Society for Microbiology 110th General meeting., San Diego, CA.

Chiang-Ni, C., C. C. Liu, Y. S. Lin, W. J. Chuang, H. Y. Fang, and J. J. Wu. (2010) Distribution of mef(A)-containing genetic elements among emm types of erythromycin-resistant group A streptococci., 台灣微生物學會第二十屆第 一次會員大會及學術研討會., Taipei, Taiwan.

Chiang-Ni, C., A. B. Wu, H. Y. Fang, K. T. Chen, W. J. Chuang, Y. S. Lin, M.-T. Lin, C. C. Liu, and J. J. Wu. (2009) Emergence of emm11, emm81, and emm102 type group A streptococci after 2004 in Southern Taiwan., 台灣微生物學會 第十九屆第三次會員大會及學術研討會., Taipei, Taiwan.

 

BOOK CHAPTER

 

 

2009

Chiang-Ni, C., and Wu, J. J., 醫學分子檢驗: 細菌分子檢驗分型法., 五南出版社., 18:381-406., 2009,11.

 

 

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