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賴志河

 

 

賴志河 (Chih-Ho Lai)   

職稱:教授

研究室名稱感染免疫研究室

最高學歷Ph.D.

學校/國家:清華大學/台灣

分機號碼(lab) 3895/ (office) 5116

電子郵件帳號chlai@mail.cgu.edu.tw

個人網頁網址:https://sites.google.com/a/gap.cgu.edu.tw/infection-and-immunity/

研究室現有: 博士後研究員  

博士班研究生  1 

碩士班研究生 5

專任研究助理  2 

大學部專題生   6

 

研究方向研究室特色

我們實驗室主要的研究方向是探討微生物致病機轉與宿主免疫反應,並開發有效之治療藥物。研究之微生物主題包含:幽門螺旋桿菌(Helicobacter pylori)、空腸彎曲桿菌(Campylobacter jejuni)、鏈球菌(Streptococcus pyogenes)及嗜血桿菌(Haemophilus influenzae)等人類常見致病菌與免疫細胞之相互作用。此外,我們也嘗試開發細菌毒素應用於治療癌幹細胞(cancer stem cells)、探討癌症生物學及轉譯醫學等臨床議題,希望能將研究成果應用於癌症之臨床治療。我們非常歡迎對感染免疫學領域有興趣的大學部專題生、碩、博班研究生一起參與實驗室的研究。

 

最近五年所發表論文:

  1. Liao WC, Huang MZ, Wang ML, Lin CJ, Lu TL, Lo HR, Pan YJ, Sun YC, Kao MC, Lin HJ, Lai CH*. Statin decreases Helicobacter pylori burden in macrophages by promoting autophagy. Front Cell Infect Microbiol. 2017;6(203):1-11.
  2. Lin LC, Gao AC, Lai CH*, Hsieh JT*, Lin H*. Induction of neuroendocrine differentiation in castration resistant prostate cancer cells by adipocyte differentiation-related protein (ADRP) delivered by exosomes. Cancer Lett. 2017;391:74-82.
  3. Chen YA, Lien HM, Kao MC, Lo UG, Lin LC, Lin CJ, Chang SJ, Hsieh JT, Lin H, Tang CH, Lai CH*. Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems. PLoS One. 2017;12(1):1-16.
  4. Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH*. Cytolethal distending toxin enhances radiosensitivity in prostate cancer cells by regulating autophagy. Front Cell Infect Microbiol. 2017;7(223):1-8.
  5. Peng YH, Chen CK, Su CH, Liao WC, Muo CH, Hsia TC, Sung FC, Lai CH*, Kao CH*. Increased risk of chronic obstructive pulmonary disease among patients with Helicobacter pylori infection: a population-based cohort study. Clin Respir J. 2017;11(5):558-565.
  6. Tsou YA, Tung YT, Wu TF, Chang GR, Chen HC, Lin CD, Lai CH, Chen HL, Chen CM. Lactoferrin interacts with SPLUNC1 to attenuate lipopolysaccharide-induced inflammation of human nasal epithelial cells via down-regulated MEK1/2-MAPK signaling. Biochem Cell Biol. 2017;95(3):394-399.
  7. Lin CJ, Liao WC, Chen YA, Lin HJ, Feng CL, Lin CL, Lin YJ, Kao MC, Huang MZ, Lai CH*, Kao CH*. Statin therapy is associated with reduced risk of peptic ulcer disease in the Taiwanese population. Front Pharmacol. 2017; 8(210):1-8.
  8. Lin HJ, Hsu FY, Chen WW, Lee CH, Lin YJ, Chen YY, Chen CJ, Huang MZ, Kao MC, Lai HC, Lai CH*. Helicobacter pylori activates HMGB1 expression and recruits RAGE into lipid rafts to promote inflammation in gastric epithelial cells. Front Immunol. 2016;7:1-11.
  9. Lin CJ, Lien HM, Lin HJ, Huang CL, Kao MC, Chen YA, Wang CK, Chang HY, Chang YK, Lai CH*. Modulation of T cell response by Phellinus linteus. J Biosci Bioeng. 2016;121:84-88.
  10. Lin CJ, Liao WC, Lin HJ, Hsu YM, Lin CL, Chen YA, Feng CL, Chen CJ, Kao MC, Lai CH*, Kao CH*. Statins attenuate Helicobacter pylori CagA translocation and reduce incidence of gastric cancer. PLoS One. 2016;11(1):1-16.
  11. Lai CK, Chen YA, Lin CJ, Lin HJ, Kao MC, Huang MZ, Lin YH, Chiang-Ni C, Chen CJ, Lo UG, Lin LC, Lin H, Hsieh JT, Lai CH*. Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin. Front Cell Infect Microbiol. 2016;6:1-8.
  12. Lai CH*, Huang CJ, Chiang-Ni C, Li JP, Wu LT, Wu HS, Sun YC, Lin ML, Lee JF, Lin HJ. Mixed infections of Helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan. Gastroenterol Res Pract. 2016;2016:1-5.
  13. Huang PH, Chen MC, Peng YT, Kao WH, Chang CH, Wang YC, Lai CH, Hsieh JT, Wang JH, Lee YT, Lin E, Yue CH, Wang HY, You SC, Lin H. Cdk5 Directly Targets Nuclear p21CIP1 and Promotes Cancer Cell Growth. Cancer Res. 2016;76(23):6888-6900.
  14. Tsou YA, Lin CD, Chen HC, Hsu HY, Wu LT, Chiang-Ni C, Chen CJ, Wu TF, Kao MC, Chen YA, Peng MT, Tsai MH, Chen CM, Lai CH*. Interleukin-13 inhibits lipopolysaccharide-induced BPIFA1 expression in nasal epithelial cells. PLoS One 2015;10(12):1-16.
  15. Tsou YA, Lin CD, Hsu HY, Peng MT, Kuo YY, Tien N, Li JP, Wang CK, Wu HS, Tsai MH, Chen CM, Lai CH*. Association of β-lactam-sensitive Haemophilus influenzae type b with adenoid biofilm formation in patients with adenoidectomy surgery. Surg Infect. 2015;16:709-715.
  16. Lai CK, Su JC, Lin YH, Chang CS, Feng CL, Lin HJ, Tseng GC, Hsieh JT, Su HL, Lai CH*. Involvement of cholesterol in Campylobacter jejuni cytolethal distending toxin-induced pathogenesis. Future Microbiol. 2015;10:489-501.
  17. Hung CL, Cheng HH, Hsieh WC, Tsai ZT, Tsai HK, Chu CH, Hsieh WP, Chen YF, Tsou Y, Lai CH*, Wang WC*. The CrdRS two-component system in Helicobacter pylori responds to nitrosative stress. Mol Microbiol. 2015;97:1128-41.
  18. Lin YH, Chen ZR, Lai CH, Hsieh CH, Feng CL. Active targeted nanoparticles for oral administration of gastric cancer therapy. Biomacromolecules. 2015;16:3021-32.
  19. Gandee L, Hsieh JT, Sperandio V, Moreira CG, Lai CH, Zimmern PE. The efficacy of immediate versus delayed antibiotic administration on bacterial growth and biofilm production of selected strains of uropathogenic Escherichia coli and Pseudomonas aeruginosa. Int Braz J Urol. 2015;41(1):67-77.
  20. Chen CM, Liu JJ, Chou CW, Lai CH*, Wu LT*. RpA, an extracellular protease similar to the metalloprotease of serralysin family, is required for pathogenicity of Ralstonia pickettii. J App Microbiol. 2015;119:1101-1111.
  21. Kao MC, Yerra KR, Hsieh YW, Weng SH, Lu TL, Tzeng David-TW, Liu JJ, Lin CJ, Lai CH*, Tzeng YW*. A cyclohexadepsipeptide from entomogenous fungi Metarhizium anisopliae inhibits the Helicobacter pylori induced pathogenesis through attenuation of vacuolating cytotoxin-A activity. Process Biochem 2015;50:134–139.
  22. Lin CD, Kou YY, Liao CY, Li CH, Huang SP, Cheng YM, Liao WC, Wu PL, Kang JJ, Lee CC, Lai CH*. Zinc oxide nanoparticles impair bacterial clearance by macrophages. Nanomedicine 2014;9:1327–1339.
  23. Lai CH*, Chang CS, Liu HH, Tsai YS, Yu YL, Lai CK, Gandee L, Pong RC, Hsu HW, Yu L, Saha D, and Hsieh JT. Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin. Oncotarget 2014;5:5523-5534.
  24. Lin CJ, Lien HM, Chang HY, Huang CL, Liu JJ, Chang YC, Chen CC, Lai CH*. Biological evaluation of Phellinus linteus-fermented broths as anti-inflammatory agents. J Biosci Bioeng 2014;118:88-93.
  25. Lai CK, Lu YL, Hsieh JT, Tsai SC, Feng CL, Tsai YS, Tsai PC, Su HL, Lin YH, Lai CH*. Development of chitosan/heparin nanoparticle-encapsulated cytolethal distending toxin for gastric cancer therapy. Nanomedicine 2014;9:803-817.
  26. Tsai YS, Lai CL, Lai CH, Chang KH, Wu K, Tseng SF, Fazli L, Gleave M, Xiao G, Gandee L, Sharifi N, Moro L, Tzai TS, Hsieh JT*. The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth. Oncotarget. 2014;5:6425-36.
  27. Lai CK, Yerra KR, Chang KR, Lin CW, Su HL, Chang CS, Lai CH*, Tzeng YM*. 3,3′,4′,5′-tetramethoxychalcone inhibits human oral cancer cell proliferation and migration via p53-mediated mitochondrial-dependent apoptosis. Anticancer Res 2014;34:1811-1819.
  28. Lai CH*, Lai CK, Lin YJ, Hung CL, Chu CH, Feng CL, Chang CH, Su HL. Characterization of putative cholesterol recognition/interaction amino acid consensus-like motif of Campylobacter jejuni cytolethal distending toxin C. PLoS One 2013;8(6):e66202.
  29. Lin YH, Tsai SC, Lai CH, Lee CH, He ZS, Tseng GC. Genipin-cross-linked fucoseechitosan/heparin nanoparticles for the eradication of Helicobacter pylori. Biomaterials 2013;34:4466-4479.
  30. Ho CM, Ho MW, Chi CY, Lin CD, Lin CW, Chang HL, Chang YF, Lu JJ, Lai CH*. Repeated colonization of multidrug–resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex and changes in antimicrobial susceptibilities in surgical intensive care units. Surg Infect 2013;14:43-48.
  31. Lai CH, Perng CL, Lan KH, Lin HJ*. Association of IS605 and cag-PAI of Helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan. Gastroenterol Res Pract 2013;356217:1-5.
  32. Lai CH*, Hsu YM, Wang HJ, Wang WC. Manipulation of host cholesterol by Helicobacter pylori for their beneficial ecological niche. BioMedicine 2013, 3: 27-33 (review article).
  33. Lien HM, Wang CY, Chang HY, Huang CL, Peng MT, Sing YT, Chen CC, Lai CH*. Bioevaluation of Anisomeles indica extracts and their inhibitory effects on Helicobacter pylori-mediated inflammation. J Ethnopharmacol 2013;145:397-401.
  34. Lu DY, Chen HC, Yang MS, Hsu YM, Lin HJ, Tang CH, Lee CH, Lai CK, Lin CJ, Lai CH*. Ceramide and TLR4 are mobilized into membrane rafts in response to Helicobacter pylori infection in gastric epithelial cells. Infect Immun 2012;80:1823-33.
  35. Wang HJ, Cheng WC, Cheng HH, Lai CH, Wang WC*. H. pylori cholesteryl glucosides interfere host membrane phase and affect type IV secretion system function during infection in AGS cells. Mol Microbiol 2012;83:67-84.
  36. Chang CS, Liu JF, Lin HJ, Lin CD, Tang CH, Lu DY, Chen LY, Kuo SC, Lai CH*. Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. Eur J Med Chem. 2012;48:244-54.
  37. Koteswara Y, Lien HM, Lin YH, Hsu YM, Lai CH*, Tzeng YM*. Antibacterial activities of Anisomeles indica constituents and their inhibition effect on Helicobacter pylori-induced inflammation in human gastric epithelial cells. Food Chem 2012;132:780-787.
  38. Chiu YF, Sugden B, Chang PJ, Chen LW, Lin YJ, Lan YC, Lai CH, Liou JY, Liu ST, Hung CH*. Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation. J Virol 2012;86:9647-55.
  39. Lu DY, Tang CH, Chang CH, Maa MC, Fang SH, Hsu YM, Lee CH, Lai CH*. Helicobacter pylori attenuates lipopolysaccharide-induced nitric oxide production by murine macrophages. Innate Immun 2012;18:406-417.

 

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