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楊佳郁

楊佳郁 (Chia-Yu Yang)

職稱助理教授

研究室名稱:臨床免疫體學實驗室

最高學歷Ph.D.

學校/國家:國防醫學院/台灣

分機號碼3527/3469

電子郵件帳號chiayu-yang@mail.cgu.edu.tw

個人網頁網址:

研究室現有: 博士後研究員  

博士班研究生   

碩士班研究生 1

專任研究助理  1 

大學部專題生  3  

 

研究方向研究室特色

: 感染性肺炎的免疫調節因子鑑定與功能性探討

    肺炎(pneumonia)是指肺部實質出現發炎的現象,其致病原以感染細菌或病毒為主,偶有其他微生物的感染而引起。肺炎常見的症狀有咳嗽、胸痛、發熱與呼吸困難,約有百分之四十的肺炎病人會合併出現肋膜腔積液,肋膜腔積液的產生會大幅增加肺炎病人的死亡率,抗生素治療或搭配胸管引流是目前臨床上治療的選擇。我們利用蛋白質體學技術(Proteomics),系統性的建立肺炎病人肋膜腔積液的蛋白質體資料庫,並從其中鑑定出多個參與免疫調節機制的新穎蛋白標誌(immune-related biomarker),我們評估這些新穎的蛋白標誌在臨床應用於肺炎病人分期、治療與預後的成效,更進一步探討這些免疫調節因子在肺炎中扮演的生物學角色與機轉。我們也利用代謝體學技術(Metabolomics),分析肺炎病人肋膜腔積液的代謝分子組成並探討其生物功能。同時,肺炎病人肋膜腔積液中也存在著大量的免疫細胞,其中以嗜中性球為主,我們以基因體學技術(Genomics/Next-generation sequencing),分析免疫細胞的轉錄體變化,以了解免疫細胞在於疾病進展的機轉與角色。我們以感染性肺炎為模式,串連高通量實驗的數據與基礎分生實驗,建立免疫體學的應用。

二: 口腔癌的功能性探討

     口腔癌是指發生在口腔各個部位的惡性腫瘤,其中大約有九成都是屬於鱗狀細胞癌,好發於45歲以上的男性,但近年來口腔癌好發年紀有下降趨勢。嚼食檳榔、吸菸、喝酒、蛀牙與不良的口腔衛生習慣等等,都是可能的危險因子。治療方式是以外科手術和放射線治療為主,有些病人會搭配抗癌藥物的化學治療。口腔癌早期個案治療後,有七成以上的人其五年存活率很好,所以早期發現與治療會有相當好的成效。我們實驗室關注於口腔癌的癌化機轉研究,我們建立口腔癌的癌症動物模式以及人類腫瘤細胞異體移植動物模式,以研究口腔癌病患的病理及基因多樣性,並分析腫瘤細胞對藥物的敏感性以及免疫相關訊號路徑的調控。此外,我們也分析病原菌和口腔癌的相關性,利用次世代定序平台,建立口腔癌病人的口水與癌組織的菌相圖譜,探究病原菌在口腔癌之癌化機轉的角色。

 

 

最近五年所發表論文:

1.    Yang CY, Lin NH, Lee JM, Huang CY, Min HJ, Yen JJ, Liao NS, Yang-Yen HF. (2009) Promoter Knock-In Mutations Reveal a Role of Mcl-1 in Thymocyte-Positive Selection and Tissue or Cell Lineage-Specific Regulation of Mcl-1 Expression. Journal of Immunology 182:2959 -2968. (IF=5.646, 18/128 in IMMUNOLOGY)

2.  Wu PS, Yang CY, Yen JJ, Chou CH, Chen SH, Wang CK, Lai YG, Liao NS, Yang-Yen HF. (2009) Critical Roles of Translationally Controlled Tumor Protein in the Homeostasis and TCR-Mediated Proliferation of Peripheral T Cells. Journal of Immunology 183: 2373 -2381. (IF=5.646, 18/128 in IMMUNOLOGY)

3.  Weng SY, Yang CY, Li CC, Sun TP, Tung SY, Yen JJ, Tsai TF, Chen CM, Chen SH, Hsiao M, Huang PH, and Yang-Yen HF. (2011) Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. Journal of Hepatology 54: 685-694. (IF=9.264, 4/74 in GASTROENTEROLOGY & HEPATOLOGY)

4. Chuang HC, Lan JL*, Chen DY*, Yang CY*, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH. (2011) The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nature Immunology 12:1113-1118. (*These authors contributed equally to this study) (IF=26.008, 3/144 in IMMUNOLOGY)

5.  Wang X, Li JP, Kuo HK, Chiu LL, Dement GA, Lan JL, Chen DY, Yang CY, Hu H, Tan TH. (2012) Downregulation of B-cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of the activated BLNK. Journal of Biological Chemistry 287:11037-11048. (IF=4.651, 62/290 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

6.  Chen KR, Chang CH, Huang CY, Lin CY, Lin WY, Lo YC, Yang CY, Hsing EW, Chen LF, Shih SR, Shiau AL, Lei HY, Tan TH, Ling P. (2012) TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. Journal of Biological Chemistry 287:32216-32221. (IF=4.651, 62/290 in BIOCHEMISTRY & MOLECULAR BIOLOGY)

7.  Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan TH. (2014) Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates T-cell receptor signaling by inhibiting TAB1 activation. Journal of Immunology 192:1547-1557. (IF=4.922, 26/148 in Immunology) (This paper was highlighted in Journal of Immunology “In This Issue” section.)

8.  Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen A, Belmont J, Tan TH. (2014) JKAP inhibits TCR signaling and autoimmunity by inactivating Lck. Nature Communications 5, 3618. DOI: 10.1038/ncomms4618 (IF=11.470, 3/55 in MULTIDISCIPLINARY SCIENCES)

9.  Chuang HC, Sheu W, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider M, Tan TH. (2014) HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nature Communications 5, 4602. DOI: 10.1038/ncomms5602 (IF=11.470, 3/55 in MULTIDISCIPLINARY SCIENCES)

10. Yang CY, Chiu LL, Tan TH. (2016) TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cellular Signalling, 28, 145-151. (IF=4.191, 65/184 in CELL BIOLOGY)

11. Wu KA, Wu CC, Chen CD, Chu CM, Shih LJ, Liu YC, Wang CL, Lin HH, Yang CY. (2017) Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions. Scientific Reports 7(4026):1-10. (IF=4.259, 10/64 in MULTIDISCIPLINARY SCIENCES)

12.   Chen TW, Lee CC, Liu H, Wu CS, Pickering CR, Huang PJ, Wang J, Chang YF, Yeh YM, Chen CD, Li HP, Luo JD, Tan BC, Chan EH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW, See LC, Tang P, Yu JS, Liao WC, Chiang KW, Rodriguez H, Myers JN, Chang KP, Chang YS. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. (2017) Nature Communications 8(1):465. (IF=12.124, 3/64 in MULTIDISCIPLINARY SCIENCES)

13.   Wu SM, Liu H, Huang PJ, Chang IY, Lee CC, Yang CY, Tsai WS, Tan BC. (2018) circlncRNAnet: an integrated web-based resource for mapping functional networks of long or circular forms of noncoding RNAs. GigaScience. 7(1):1-10. (IF=6.871, 6/64 in MULTIDISCIPLINARY SCIENCES)

 

 

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