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吳宗圃

吳宗圃(Chung-Pu Wu)

AppointmentAssociate Professor

Lab:Cancer Biology Laboratory

Education:Ph.D.

University/Nation:University of Cambridge, UK

Tel:3754

E-mail: wuchung@mail.cgu.edu.tw

Research websitehttp://paulwea.wix.com/2014-06-13

Research interests

Publications

  1. Overexpression of human ABCB1 in cancer cells leads to reduced activity of GSK461364, a specific inhibitor of polo-like kinase 1. Molecular Pharmaceutics. (2014) Sep, in press

  2. The overexpression of ABCG2 reduces the efficacy of volasertib (BI 6727) and GSK461364 in human S1-M1-80 colon carcinoma cells. Journal of Cancer Research Updates (2014) 3(2): 108-116.

  3. The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy. Acta Pharmaceutica Sinica B (2014) 4(2): 105-111.

  4. Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of polo-like kinase 1. Biochemical Pharmacology (2013) Oct, 86(7): 904-913.

  5. HIV protease inhibitors interact with ABCC4/MRP4: a basis for unanticipated enhanced cytotoxicity. Molecular Pharmacology (2013) Sep, 84(3): 361-71.

  6. Overexpression of ATP-Binding Cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells. Biochemical Pharmacology (2013) Feb, 85: 325-334 (IF = 4.705; Journal Rank in PHARMACOLOGY & PHARMACY = 28/261)

  7. Differentiation of oral precancerous stages with optical coherence tomography based on the evaluation of optical scattering property. Laser Physics (2013) April, 23: 045602 (IF = 3.605; Journal Rank in OPTICS = 4/77)

  8. Noninvasive imaging of heart chamber in Drosophila with dual-beam optical coherence tomography. Journal of Biophotonics (2012) Nov, DOI: 10.1002/jbio.201200164 (IF = 4.343; Journal Rank in BIOPHYSICS = 15/74)

  9. Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1. Neuro-Oncology (2012) Oct, 14(10): 1227-38 (IF = 5.723; Journal Rank in CLINICAL NEUROLOGY = 15/192)

  10. OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochemical Pharmacology (2012) Sep, 84(6): 766-774 (IF = 4.705; Journal Rank in PHARMACOLOGY & PHARMACY = 28/261)

  11. NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in Glioblastoma multiforme. Free Radical Biology & Medicine. (2012) Aug, 53(4): 649-658. (IF = 5.423; Journal Rank in ENDOCRINOLOGY & METABOLISM = 18/122)

  12. Resistance analysis and characterization of a Thiazole analogue, BP008, as a potent Hepatitis C Virus NS5A inhibitor. Antimicrobial Agents and Chemotherapy. (2012) Jan, 56(1): 44-53 (IF = 4.841; Journal Rank in PHARMACOLOGY & PHARMACY = 24/261)

  13. The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy. Molecular Pharmaceutics. (2011) Dec, 8(6): 1996-2011 (IF = 4.782; Journal Rank in PHARMACOLOGY & PHARMACY = 27/261)

  14. In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs. Biochemical Pharmacology (2011) Aug, 82(11): 1562-1571. (IF = 4.705; Journal Rank in PHARMACOLOGY & PHARMACY = 28/261)

  15. Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (Nilotinib): Evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. Molecular Pharmaceutics. (2011) Aug, 8(4): 1292-1302 (IF = 4.782; Journal Rank in PHARMACOLOGY & PHARMACY = 27/261)

  16. Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's Sarcoma cells. British Journal of Cancer. (2011) Aug, 105(4): 513-522 (IF = 5.042; Journal Rank in ONCOLOGY = 33/196)

  17. Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy. Current Pharmaceutical Biotechnology. (2011) Apr, 12(4): 609-620 (IF = 2.805; Journal Rank in PHARMACOLOGY & PHARMACY = 93/261)

  18. Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a High-Throughput Screening assay. Antimicrobial Agents and Chemotherapy. (2011) Jan, 55(1): 229-238 (IF = 4.841; Journal Rank in PHARMACOLOGY & PHARMACY = 24/261)

  19. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochemical Pharmacology (2010) Nov, 80(10): 1497-506. (IF = 4.705; Journal Rank in PHARMACOLOGY & PHARMACY = 28/261)

  20. Prolonged drug selection of breast cancer cells and enrichment of cancer stem-cell characteristics. Journal of the National Cancer Institute (2010) Nov, 102(21): 1637-52. (IF = 13.757; Journal Rank in ONCOLOGY = 6/196)

  21. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Research (2010) Oct, 70(20): 7981-91. (IF = 7.856; Journal Rank in ONCOLOGY = 12/196)

  22. Dependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductance. Molecular Pharmacology (2010) Feb, 77(2):270-9. (IF = 4.883; Journal Rank in PHARMACOLOGY & PHARMACY = 22/261)

  23. Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function. Biochemical Pharmacology (2009) Aug, 78(4): 355-64. (IF = 4.705; Journal Rank in PHARMACOLOGY & PHARMACY = 28/261)

  24. Evaluation of current methods used to analyze the expression profiles of ABC transporters yields an improved drug-discovery database. Molecular Cancer Therapeutics (2009) Jul, 8(7): 2057-2066. (IF = 5.226; Journal Rank in ONCOLOGY = 29/196)

  25. Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Research (2008) Oct, 68: 7905-7914. (IF = 7.856; Journal Rank in ONCOLOGY = 12/196)

  26. Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: Evaluation of current strategies. Current Molecular Pharmacology (2008) Jun, 1:93-105.

  27. Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes. British Journal of Cancer (2008) May, 98: 1515-1524. (IF = 5.042; Journal Rank in ONCOLOGY = 33/196)

  28. Development of inhibitors of ATP-binding cassette drug transporters-present status and challenges. Expert Opinion on Drug Metabolism & Toxicology (2008) Feb, 4: 1-19. (IF = 3.119; Journal Rank in PHARMACOLOGY & PHARMACY = 73/261)

 

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