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曲桐

 

 

 

 

 

 

Scott C. Schuyler

AppointmentsAssistant professor

LabYeast biochemistry& genetics lab

EducationPh.D.

School/NationHarvard University/USA

Tel: (03)211-8800 ext:3596

E-mail: schuyler@mail.cgu.edu.tw

Research website: https://sites.google.com/site/cguscschuyler/

研究室現有: 博士後研究員 

博士班研究生   

碩士班研究生 

專任研究助理  4

大學部專題生   

 

Research outline(1-3 pages)

The mitotic spindle checkpoint prevents chromosome loss.  I want to understand how this checkpoint regulates chromosome segregation during eukaryotic cell division, primarily by studying how the spindle checkpoint inhibits the cell cycle regulator the Anaphase-Promoting Complex (APC).  Yeast genetics, cell biology, and biochemistry in combination are powerful tools for exploring the molecular roles of protein complexes.  In the lab, I use my training in these fields to develop biochemical, cell biological and genetic approaches to ask how the mitotic spindle checkpoint functions to inhibit APC.

  

Publications:

Shiao-Yii Wu*, Vivian Jen-Wei Kuan*, Yao-Wei Tseng*, Scott C. Schuyler#, and Yue-Li Juang#. (2016) The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase. Fungal Genet Biol. Jun; 91:6-19. (SCI IF: 2.933) *equal contribution. #co-corresponding authors.

 

Wu CC, Wu HJ, Wang CH, Lin CH, Hsu SC, Chen YR, Hsiao M, Schuyler SC, Lu FL, Ma N, Lu J. (2015) Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells. Cell Cycle. 14(8):1207-17. (SCI IF: 3.952)

 

Gopinath RK*, You ST*, Chien KY*, Swamy KBS, Yu JS, Schuyler SC# and Leu JY#. (2014) The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity. Genome Biol. Evol. Oct 13;6(10):2851-65. (SCI IF: 4.098) *equal contribution, #co-corresponding authors

 

Liu YC, Kao YT, Huang WK, Lin KY, Wu SC, Hsu SC, Schuyler SC, Li LY, Leigh Lu F, Lu J. (2014) CCL5/RANTES is important for inducing osteogenesis of human mesenchymal stem cells and is regulated by dexamethasone. Biosci Trends. Jun; 8(3):138-43. (SCI IF: 1.533)

 

Hsuan L, Ma C-P, Chen Y-T, Schuyler SC, Chang K-P and Tan BC. (2014) Functional Impact of RNA Editing and ADARs on Regulation of Gene Expression: Perspectives from Deep Sequencing Studies. Cell & Biosci. Aug 19; 4:44. (SCI IF: 2.883)

 

Huang H-N, Chen S-Y, Hwang S-M, Su M-W, Mai W, Wang H-W, Cheng W-C, Schuyler SC, Ma N, Lu FL, Lu J. (2013) miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation. Stem Cell Res. Dec 3;12(2): 338-353 (SCI IF: 3.892)

 

Wang C-H, Ma N, Lin Y-T, Wu C-C, Wu H-J, Yu C-C, Hsiao M, Lu FL, Schuyler SC, and Lu J. (2013) Array-Based High Through-put Screen in Mouse Embryonic Stem Cells with shRNAs. Curr. Protoc. Stem Cell Biol. Sept; 26:5C.3.1–5C.3.19

 

Lu FL, Yu C-C, Chiu H-H, Liu HE, Chen S-Y, Lin S, Goh T-Y, Hsu H-C, Chien C-H, Wu H-C, Chen M-S, Schuyler SC, Hsieh W-S, Wu M-H, Lu J. (2013) Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells in the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons. Invest. New Drug. Aug 31(4):823-32 (SCI IF: 3.281)

 

Schuyler SC#, Wu Y-F*, Kuan VJ-W*. (2012) The Mad1-Mad2 balancing act - a damaged spindle checkpoint in chromosome instability and cancer. J Cell Sci. Sep 15;125(Pt 18):4197-4206 *equal contribution (SCI IF: 4.706) #corresponding author, *equal contribution

 

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