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余兆松 (Jau-Song Yu)


LabSignal Transduction Biology Laboratory


University/NationNational Tsing-Hua University, Taiwan

Tel: (03)2118800 ext.5171

Research website

Research interests:


Publications: *corresponding author

1.      Ni M-H, Wu C-C, Chan W-H, Chien K-Y and Yu J-S*. (2008) GSK-3 mediates the okadai acid-induced modification of CRMP-2 in human SK-N-SH neuroblastoma cells. J. Cell. Biochem103(6):1833-1848. [PubMed]

2.      Wu C-C, Chen H-C, Chen S-J, Liu H-P, Hsieh Y-Y, Yu C-J, Tang R, Liang Y, Hsieh L-L*Yu J-S* and Chang Y-S. (2008) Identification of collapsin response mediator protein-2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomesProteomics 8, 316-332. [PubMed]

3.      Wu CC, Peng PH, Chang YT, Huang YS, Chang KP, Hao SP, Tsang NM, Yeh CT, Chang YS, Yu JS*. (2008) Identification of potential serum markers for nasopharyngeal carcinoma from a xenografted mouse model using Cy dye labeling combined with three-dimensional fractionation. Proteomics 8(17), 3605-3620. [PubMed]

4.      Chang K-P, Hao S-P, Chang JH, Wu C-C, Tsang N-M, Lee Y-S, Hsu CL, Ueng S-H, Liang Y, Liu SC, Liu YL, Wei PC, Chang Y-S and Yu J-S*. (2008) Macrophage inflammatory protein-3a is a novel serum marker for nasopharyngeal carcinoma detection and prediction of treatment outcomes. Clin. Cancer Res. 14(21):6979-87. [PubMed]

5.      Weng L-P, Wu C-C, Hsu B-L, Chi L-M, Liang Y, Tseng C-P, Hsieh L-L*, and Yu J-S*. (2008) Secretome-based identification of Mac-2 binding protein as a potential oral cancer marker involved in cell growth and motility. J. Proteome Res.  7(9):3765-75. [PubMed]

6.      Wu C-C, Huang Y-S, Lee L-Y, Liang Y, Tang R-P, Chang Y-S, Hsieh L-L*, and Yu J-S*. (2008) Overexpression and elevated plasma level of tumor-associated antigen 90K/Mac-2 binding protein in colorectal carcinoma. Proteomics-Clin. Appl. 2(12), 1586 - 1595  [PubMed]

7.      Chen L-C, Hsueh C*, Tsang N-M, Liang Y, Chang K-P, Hao S-P, Yu J-S, Chang Y-S* (2008) Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma. Clin. Cancer Res. 14, 3807-3813[PubMed]

8.      Lin C-S, Liu N-T, Liao D-C, Yu J-S, Tsao C-H, Lin C-H, Sun C-W, Jane W-N, Tsay H-S, Chen JJ-W, Lai E-M, Lin N-S, Chang W-C, Lin C-C*. (2008) Differential protein expression of two photosystem II subunits, PsbO and PsbP, in an albino mutant of Bambusa edulis with chloroplast DNA aberration. J. Am. Soc. Hortic. Sci. 133, 270-277.

9.      Chang K-P, Hsu C-L, Chang Y-L, Tsang N-M, Lee T-J, Tsao K-C, Huang C-K, Chang Y-S, Yu J-S, Hao S-P*. (2008) The complementary serum test of Epstein-Barr virus nuclear antigen -1 and early antigen might be a good alternative tool for primary screening of nasopharyngeal carcinomas in Taiwan. Oral Oncol. 44, 784-792. [PubMed]

10.  Lee LY, Wu CM, Wang CC, Yu JS, Liang Y, Huang KH, Lo CH, Hwang TL*. (2008) Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression. Histol. Histopathol. 23, 515-521. [PubMed]

11.  Chi L-M, Lee C-W, Chang K-P, Hao S-P, Lee H-M, Liang Y, Hsueh C, Yu C-J, Lee I-N, Chang Y-J, Lee S-Y, Yeh Y-M, Chang Y-S, Chien K-Y* and Yu J-S*. (2009) Enhanced interferon signaling pathway in oral cancer revealed by quantitative proteome analysis of microdissected specimens using 16O/18O labeling and integrated 2DLC-ESI-MALDI tandem MS. Mol. Cell. Proteomics 8:1453-1474. [PubMed]

12.  Chen L-C, Liu H-P, Li H-P, Hsueh C, Yu J-S, Liang C-L, Chang Y-S.* (2009) Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells. Oncogene 28(17):1904-15.[PubMed]

13.  Dong Y, Leu Y-L, Chien K-Y and Yu J-S*. (2009) Separation and determination of low abundant flavonoids in Scutellaria baicalensis Georgi by micellar electrokinetic capillary electrophoresis. Anal. Lett. 42(10):1444 -57. [linkout]

14.  Wang C-L, Wang C-I, Liao P-C, Liang Y, Chen C-D, Liang Y, Chuang W-Y, Tsai Y-H, Chen H-C, Chang Y-S, Yu J-S, Wu C-C*, and Yu C-J*. (2009) Discovery of retinoblastoma-associated binding protein 46 as a novel prognostic marker for distant metastasis in non-small cell lung cancer by combined analysis of cancer cell secretome and pleural effusion proteome. J. Proteome Res. 8(10):4428-4440. [PubMed]

15.  Wu H-Y, Tseng VSM, Chen L-C, Ping P, Chang Y-C, Tsay Y-G, Yu J-S and Liao P-C*. (2009) Combining alkaline phosphatase treatment and LTQ/Orbitrap high mass accuracy LC-MS data for the efficient and confident identification of protein phosphorylation. Anal. Chem. 81(18):7778-7787. [PubMed]

16.  Fang K-H, Kao H-K, Cheng M-H, Chang Y-L, Tseng N-M, Huang Y-C, Lee L-Y, Yu J-S, Hao S-P, Chang K-P*. (2009) Histological differentiation of primary oral squamous cell carcinomas in betel quid prevalent area. Otolaryngology-Head and Neck Surgery. 2009 Dec;141(6):743-749. [PubMed]

17.  Chang Y-H, Wu C-C, Chang K-P, Yu J-S, Liao P-C*. (2009) Cell secretome analysis using hollow fiber culture system leads to the discovery of CLIC1 protein as a novel plasma marker for nasopharyngeal carcinoma. J. Proteome Res. 8(12):5465-74. [PubMed]

18.  Hsu R-M, Tsai M-H, Hsieh Y-J, Lyu P-C and Yu J-S*. (2010) Identification of MYO18A as a novel interacting partner of PAK2/bPIX/GIT1 complex and its potential function in modulating epithelial cell migration. Mol. Biol. Cell 21(2):287-301. [PubMed]

19.  Wu C-C, Hsu C-W, Chen C-D, Yu C-J, Chang K-P, Dai D-I, Liu H-P, Su W-H, Chang Y-S, and Yu J-S*. (2010) Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. Mol. Cell. Proteomics 9(6):1100-17. [PubMed]

20.  Kao S-H, Hsu T-C, Yu J-S, Chen J-T, Li S-L, Lai W-X, Tzang B-S*. (2010) Proteomic analysis for the anti-apoptotic effects of cystamine on apoptosis-prone macrophage. J. Cell. Biochem110(3):660-70[PubMed]

21.  Chen J-S*, Chen K-T, Fan W-C, Yu J-S, Chang Y-S and Chan E-C*. (2010) Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer. Clin. Chem. Lab. Med. 48(5):719-25[PubMed]

22.  Zhai H-L*, Chang Y-T, Wu C-C and Yu J-S*. (2010) An approach to the elimination of inter-individual variability in tumor detection Analyst 135(5):875-9. [PubMed].

23.  Chang K-P, Wu C-C, Chen H-C, Chen S-J, Peng P-H, Tsang N-M, Lee L-Y, Liu S-C, Liang Y, Lee, Y-S, Hao S-P, Chang Y-S and Yu J-S*. (2010) Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: Potential usage of cystatin A for predicting nodal stage and poor prognosis. Proteomics 10, 2644-2660. [PubMed].

24.  Kao H-K, Guo L-F, Cheng M-H, Chen I-H, Liao C-T, Fang K-H, Yu J-S, Chang K-P*. (2011) Predicting postoperative morbidity and mortality by model for endstage live disease score for patients with head and neck cancer and liver cirrhosis. Head & Neck 33(4):529-34. [PubMed].

25.  Lin C-J, Ho H-Y, Cheng M-L, Yu J-S* and Chiu DT-Y.* (2010) Impaired dephosphorylation process renders G6PD-knockdown HepG2 cells more susceptible to H2O2-induced apoptosisFree Radic. Biol. Med. 49(3), 361–373. [PubMed]

26.  Chen, J-S, Chen, K-T, Fan C-W, Han C-L, Chen Y-J, Yu J-S, Chang Y-S, Chien C-W, Wu C-P, Hung R-P, Chan E-C*. (2010) Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry. FEBS J. 277(14), 3028-3038. [PubMed].

27.  Chang K-P, Chang Y-T, Wu C-C, Liu Y-L, Chen M-C, Tsang N-M, Hsu C-L, Chang Y-S, and Yu J-S*. (2011) Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival. Head & Neck 33(6):886-97. Epub 2010 Nov 29. [PubMed].

28.  Hsieh Y-J, Yu J-S* and Lyu P-C*. (2010) Characterization of the photodynamic therapy-elicited responses of A431 cells with intracellular organelle-localized PhotofrinJ. Cell. Biochem. 111(4):821-33. [PubMed].

29.  Liu H-P, Wu C-C, Kao H-Y, Huang Y-C, Liang Y, Chen C-C, Yu J-S, Chang Y-S*. (2010) Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration. Mol. Cell. Proteomics 2011 Mar;10(3):M900641MCP200. Epub 2010 Jun 30. [PubMed]

30.  Wang C-I, Wang C-L, Wang C-W, Chen C-D, Wu C-C, Tsai Y-H, Chang Y-S, Yu J-S, and Yu C-J*. (2010) Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of cancer cell secretome and tissue transcriptomeInt. J. Cancer 128(10):2364-72. [PudMed]

31.  Chen J-S, Chou Y-P, Chen K-T, Hung R-P, Yu J-S, Chang Y-S, Chan E-C*. (2011) Detection of annexin A autoantibodies in sera from colorectal cancer patients. J. Clin. Gastroenterol. 45(2), 125-32. [PudMed]

32.  Chen Y-T*, Chen C-L, Chen H-W, Chung T, Wu C-C, Chen C-D, Hsu C-W, Chen M-C, Tsui K-H, Chang P-L, Chang Y-S, Yu J-S*. (2010) Discovery of novel bladder cancer biomarkers by comparative urine proteomics using iTRAQ technology. J. Proteome Res. 9(11):5803-15. [PubMed]

33.  Mapes J, Chen J-T, Yu J-S and Xue D*. (2010) Somatic sex determination in C. elegans is modulated by SUP-26 repression of tra-2 translation. Proc. Natl. Acad. Sci. USA 107(42):18022-7. [PubMed]

34.  Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, Lin YC, Bravo DT, Jablons DM*, You L*. (2011) Cul4A is an oncogene in malignant pleural mesothelioma. J. Cell. Mol. Med. 15(2), 350-358. Epub 2009 Nov 19. [PubMed]

35.  Kuo YB, Fan CW, Chan CC, Hung RP, Hung YS, Chen KT, Chang CA, Yu JS, Chang YS, Chan EC*. (2011) Identification of phospholipid scramblase 1 as a biomarker and it's prognostic value for colorectal cancer. Mol. Med. 17(1-2):41-7. [PubMed]

36.  Chang K-P, Kao H-K; Yen T-C, Chang Y-L, Liang Y, Liu S-C, Lee L-Y, Chang Y-L, Kang C-J, I-How Chen, Liao C-T*, Yu J-S*. (2011) Overexpression of macrophage inflammatory protein-3a in oral cavity squamous cell carcinoma associated with tumor metastasis. Oral Oncol.  47, 108–113. [PubMed]

37.  Hsueh C, Lin J-D*, Wu I-C, Chao T-C, Yu J-S, Liou M-J, Yeh C-J. (2011) Angiogenesis in papillary thyroid carcinoma: Expression of vascular endothelial growth factor, angiopoietin-1 angiogoitin-2 and Tie-2 correlated with tumor progression and prognosis J. Sur. Oncol. 103(5):395-9. [PubMed]

38.  Han C-L, Chen J-S, Chan E-C, Wu C-P, Yu K-H, Chen K-T, Tsou C-C, Tsai C-F, Chien C-W, Kuo Y-B, Lin P-Y, Yu J-S, Hsueh C, Chen M-C, Chan C-C, Chang Y-S, Chen Y-J*. (2011) An informatics-assisted label-free approach for personalized tissue membrane proteomics: Case study on colorectal cancer. Mol. Cell. Proteomics 10(4):M110.003087. [PubMed]

39.  Fan C-W, Chan C-C, Chen K-T, Twu J, Huang Y-S, Han C-L, Chen Y-J, Yu J-S, Chang Y-S, Kuo Y-B, Chan E-C*. (2011) Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer. Clin. Chim. Acta 412(11-12):887-93. [PubMed]

40.  Chang K-P, Chang Y-T , Liao C-T, Yen T-C, Chen I-H, Chang Y-L, Liu Y-L, Chang Y-S, Yu J-S* and Wu C-C*. (2011) Prognostic cytokine markers in peripheral blood for oral cavity squamous cell carcinoma identified by multiplexed immunobead-based profiling. Clin. Chim. Acta 412(11-12):980-7. [PubMed]

41.  Peng P-H, Wu C-C*, Liu S-C, Chang K-P, Chen C-D, Chang Y-T, Hsu C-W, Chang Y-S, and Yu J-S* (2011) Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma. J. Proteomics 74(5):744-57. [PubMed]

42.  Chang Y-T, Wu C-C*, Shyr Y-M, Chen T-C, Hwang T-L, Yeh T-S, Chang K-P, Liu H-P, Liu-Y-L, Tsai, M-H, Chang Y-S, and Yu J-S*. (2011) Identification of ULBP2 as a novel serum marker for pancreatic cancer detection. PLoS One6(5):e20029. [PubMed]

43.  Yu C-J, Chang K-P, Chang Y-J, Hsu C-W, Liang Y, Yu J-S, Chi L-M, Chang Y-S, and Wu CC*. (2011) Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis. J. Proteome Res. 10(8):3778-88. [PubMed]

44.  Martel J, Young D, Young A, Wu C-Y, Chen C-D, Yu J-S, Young JD*. (2011) Comprehensive proteomic analysis of mineral nanoparticles derived from human body fluids and analyzed by liquid chromatography-tandem mass spectrometry. Anal. Biochem. 418(1):111-25. [PubMed]

45.  Yu C-J*, Wang C-L, Wang C-I, Chen C-D, Dan Y-M, Wu C-C, Wu Y-C, Lee I-N, Tsai Y-H, Chang J-S and Yu J-S.  (2011) Comprehensive proteome analysis of malignant pleural effusion for lung cancer biomarker discovery by using multidimensional protein identification technology. J. Proteome Res. 10(10):4671-82. [PubMed]

46.  Chang K-P, Yu J-S, Chien K-Y, Lee C-W, Liang Y, Liao C-T, Yen T-C, Lee L-Y, Huang L-L, Liu S-C, Chang Y-S, Chi L-M*. (2011) Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology. J. Proteome Res. 10(11):4935-47. [PubMed]

47.  Tsai M-H, Wu C-C, Peng P-H , Liang Y, Shiao Y-C, Chien K-Y, Chen J-T, Lin S-J, Tang R-P, Hsieh L-L*, Yu J-S* (2012) Identification of secretory gelsolin as a plasma biomarker associated with distant organ metastasis of colorectal cancer. J. Mol. Med. (Berl) 90(2), 187-200. [PubMed]

48.  Chen Y-T, Chen H-W, Smith DS, Liang K-H, Wu C-C, Chen C-L, Chung T, Chen M-C, Chang Y-S, Borchers CH*, Yu J-S* (2012) Multiplexed quantification of 63 proteins by multiple reaction monitoring-based mass spectrometry in human urine for discovery of potential bladder cancer biomarkers. J. Proteomics 75(12):3529-45. [PubMed]

49.  Pan T-L*, Wang P-W, Huang C-C, Yeh C-T, Hu T-H, Yu J-S. (2012) Network analysis and proteomic identification of vimentin as a key regulator associated with the invasiveness and metastasis of human hepatocellular carcinoma cells. J. Proteomics 75(15):4676-92. [PubMed]

50.  Wang I-S, Lu T-F, Lue C-E, Huang C-H, Yang P, Lin Y-T, Pijanswska DG, Yang C-M, Wang J-C, Yu J-S, Chang Y-S, and Lai C-S* (2012). Immobilization of enzyme and antibody on ALD-HfO2 EIS structure by NH3 plasma treatment. Nanoscale Res. Lett. 7(1):179. [PubMed]

51.  Hsieh Y-J, Chien K-Y, Lin S-Y, Sabu S, Hsu R-M, Chi L-M, Lyu P-C, and Yu J-S*. (2012) Photofrin binds to procaspase-3 and mediates photodynamic treatment–triggered methionine oxidation and inactivation of procaspase-3. Cell Death Dis3: e347; doi:10.1038/cddis.2012.85. [PubMed]

52.  Wang C-I, Chien K-Y, Wang C-L, Liu H-P, Cheng C-C, Chang Y-S, Yu J-S, and Yu C-J*. (2012) Quantitative proteomics reveals regulation of KPNA2 and its potential novel cargo proteins in non-small cell lung cancer. Mol. Cell. Proteomics 2012 Jul 25. [Epub ahead of print] [PubMed]

53.  Hsueh C, Lin J-D, Chang Y-S, Hsueh S, Chao T-C, Yu J-S, Jung S-M, Tseng N-M, Sun J-H, Kuo S-Y. (2012) Prognostic significance of expression of pituitary tumor-transforming gene-binding factor in papillary thyroid carcinoma. Clin. Endocrinol. 2012 Aug 13. doi: 10.1111/cen.12007. [Epub ahead of print] [PubMed]

54.  Chang Y-F#Yu J-S#, Chang Y-T, Su L-C, Li Y-C, Wu C-C, Chang Y-S, Lai C-S, Chou C* (2012). The utility of a high-throughput scanning biosensor in the detection of pancreatic cancer marker ULBP2. Biosens. Bioelectron. 2012 Aug 23. [Epub ahead of print] [PubMed] #Equal contributions to this research.


1. Yu JS, Chang KP. (2012) Method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker. United States Patent, US8,148,059B2, Apr. 3, 2012. [link to Google patents]




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