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林光輝

 

 

 

林光輝 (Kwang-Huei Lin)

Appointment:Professor/Associate Dean College of Medicine

LabGene Regulation Laboratory

EducationPh.D.

University/NationAlabama, USA

Tel: (03)2118800 ext.5975

E-mailkhlin@mail.cgu.edu.tw

Research website http://lncrna103.wixsite.com/cgu-lkh

Research interests:

A. The role of thyroid hormone during liver carcinogenesis.

B. The mechanism of genes including miRNAs, long non-coding

     (Lnc)RNAs  regulated by thyroid hormone during cell

     proliferation, differentiation and /or tumorigenesis.

     The genomic or proteomic approaches will be applied.

C. The identification of cancer biomarkers including miRNAs, LncRNAs in liver,gastric, cervical, skin cancer and glioma by genomic or proteomic approaches.

D. The mechanism of autophagy regulated by thyroid hormone.

E. The role and regulation of LncRNAs in tumor.

    

 

 

2011-2016 publication(Jan. 10, 2017 updated)

2011

 

1. Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chia-Siu Wang, Ming-Ming Tsai, Chung-Yuan Hsu, Min-Hung Tsai, Chyong-Huey Lai, and K-H Lin (corresponding author) Overexpression of gelsolin in human cervical carcinoma and its clinicopathological significance Gynecology oncology 120:135-144. 2011 (SCI; IF, 3.760, 4/75= 5.33%)

 

2. S-M Wu, Y-H Huang, Ch-T Yeh, M-M Tsai, C-H Liao, W-L Cheng ,W-J Chen , K-H Lin (corresponding author) Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells. Oncogene 30:2057-2069, 2011 (SCI; IF, 7.414, 15/184=8.1%)

 

3. W-J Chen, Y-H Chen, K-H Lin, C-H Ting, Yung-Hsin Yeh  Cilostazol Promotes Vascular Smooth Muscles Cell Differentiation Through the cAMP Response Element-Binding Protein-Dependent Pathway Arterioscl Throm Vas 31(9):2106-13. 2011 (SCI; IF, 7.215, 3/66=4.5%)

 

4. W-J Chen, Y-H Yeh, K-H Lin, G-J Chang, C-T Kuo Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res Cardiol. 106 (2):163-174, 2011 (SCI; IF:6.128, 8/114=7%).

 

5. W-L Cheng, C-S Wang, Y-H Huang, M-M Tsai, Y Liang, and K-H Lin (corresponding author) Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer Annals oncology 22: 2267-2276, 2011. (SCI; IF, 6.452 20/184=10.9%)

 

6. Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chia-Siu Wang, Ming-Ming Tsai, Chyong-Huey Lai, Ying Liang, and K-H Lin (corresponding author) Glucose-regulated protein 58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer. Cancer Science 102:2255-2263, 2011 (SCI; IF, 3.846, 53/184=28.8%)

 

2012

7. Cheng-Yi Chen, Lang-Ming Chi, Hsiang-Cheng Chi, Ming-Ming Tsai, Chung-Ying Tsai, Yi-Hsin Tseng, Yang-Hsiang Lin, Wei-Jan Chen, K-H Lin (corresponding author) Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-based quantitative proteomics study of a thyroid hormone-regulated secretome in human hepatoma cells. Mol. Cell. Proteomics 11(4): 10.1074/mcp.M111.011270, 1-19, 2012 (SCI; IF:7.398, 5/72=6.9%).

 

8. Chen-Hsin Liao, Chau-Ting Yeh,Ya-Hui Huang, Sheng-Ming Wu, Hsiang-Cheng Chi, Ming-Ming Tsai, Chung-Ying Tsai, Chia-Jung Liao, Yi-Hsin Tseng,Yang-Hsiang Lin, Cheng-Yi Chen, I-Hsiao Chung, Wan-Li Cheng, Wei-Jan Chen, K-H Lin (corresponding author) Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells. Hepatology 55(3):910-20, 2012 (SCI; IF:12.003, 2/74=2.7% ,GASTROENTEROLOGY & HEPATOLOGY)

 

9. Ming-Ming Tsai, Paul Y. Lin, Wan-Li Cheng, Chung-Ying Tsai, Hsiang-Cheng Chi, Cheng-Yi Chen, Yi-Hsin Tseng, Yi-Fen Cheng, Chi-De Chen, Ying Liang, Chia-Jung Liao, Sheng-Ming Wu, Yang-Hsiang Lin, I-Hsiao Chung, Chia-Siu Wang, and K-H Lin. (corresponding author) Overexpression of ADP-Ribosylation factor 1 in Human Gastric Carcinoma and its Clinicopathological Significance Cancer Science doi: 10.1111/j.1349-7006.2012.02243.x, 2012 (SCI; IF, 3.325, 68/196=34.7%)

 

10.Wan-Li Cheng, Ming-Ming Tsai, Chung-Ying Tsai, Ya-Hui Huang, Cheng-Yi Chen, Hsiang-Cheng Chi, Yi-Hsin Tseng, Im-Wai Chao, Wei-Chi Lin, Sheng-Ming Wu, Ying Liang4, Chia-Jung Liao1, Yang-Hsiang Lin1, I-Hsiao Chung, Wei-Jan Chen, Paul Y. Lin, and Chia-Siu Wang, K-H Lin. (corresponding author) Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression. PLoS ONE 7(3): e34352. doi:10.1371/journal.pone.0034352 (SCI; IF, 4.092, 12/85=14.1%, Biology)

 

11. Hsiang-Cheng Chi, Shen-Liang Chen, Chen-Hsin Liao,Ya-Hui Huang,Ming-Ming Tsai,Chau-Ting Yeh, Sheng-Ming Wu, Chia-Jung Liao, Yi-Hsin Tseng, Yang-Hsiang Lin,Cheng-Yi Chen, Chung-Ying Tsai, I-Hsiao Chung,Wan-Li Cheng,Wei-Jan Chen, K-H Lin (corresponding author) Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL. Cell Death and Differentiation, 19 (10): 1802-1814 2012. doi:10.1038/cdd.2012.58 (SCI; IF:8.371, 23/290=7.9%).

 

12. Wan-Li Cheng, Chia-Siu Wang, Ming-Ming Tsai1, and K-H Lin (corresponding author) Biomarkers and Oncogenic Pathways in Gastric Cancer Adaptive Medicine 4(3):125-131, 2012.

 

13. Huang YH, Lin KH, Liao CH, Lai MW, Tseng YH, Yeh CT Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma PLoS ONE 2012;7(7): e40738. doi: 10.1371/journal.pone. 0040738. (SCI; IF, 4.092, 12/85=14.1%, Biology)

 

14. Huang YH, Lin KH, Chen HC, Chang ML, Hsu CW, Lai MW, Chen TC, Lee WC, Tseng YH, Yeh CT Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma PLoS ONE 2012;7(5):e37188. doi: 10.1371/journal.pone. 0037188. (SCI; IF, 4.092, 12/85=14.1%, Biology)

 

2013

 

15. Ya-Hui Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Chen-Hsin Liao, Chia-Jung Liao, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, Sheng-Yen Lin, Yu-Ting Hung2, Chih-Jen Wang3, Crystal D. Lin4, and K-H Lin (corresponding author) Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma Cancer Research 73(8) April, pp.2505-17, 2013 (SCI; IF:8.65, 11/196=5.61%, ONCOLOGY)

 

16. Sheng-Ming Wu, Wan-Li Cheng, Crystal D. Lin, and K-H Lin (corresponding author) Thyroid Hormone Actions in Liver Cancer Cellular and Molecular Life Sciences 70 (11) June, pp.1915-1936, 2013 (SCI; IF: 5.615, 45/290=15.51%, BIOCHEMISTRY & MOLECULAR BIOLOGY)

 

17. Yang-Hsiang Lin, Ya-Hui Huang, Meng-Han Wu, Sheng-Ming Wu, Hsiang-Cheng Chi, Chia-Jung Liao, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, Ming-Ming Tsai and K-H Lin (corresponding author) Thyroid Hormone Suppresses Cell Proliferation through Endoglin-Mediated Promotion of p21 Stability Oncogene 32 (August), 3904-3914, 2013. (SCI; IF:7.357, 31/290=10.69%, BIOCHEMISTRY & MOLECULAR BIOLOGY)

 

18. Cheng-Yi Chen, Ming-Ming Tsai, Hsiang-Cheng Chi, and K-H Lin (corresponding author) Biological Significance of a Thyroid Hormone-Regulated Secretome Biochimica et Biophysica ACTA- Proteins and Proteomics (invited article) 1834(11), 2271-2284, 2013 (SCI; IF:3.733 , 93/290=32.07%, BIOCHEMISTRY & MOLECULAR BIOLOGY)

 

19.Yang-Hsiang Lin, Chia-Jung Liao, Ya-Hui Huang, Meng-Han Wu, Hsiang-Cheng Chi, Sheng-Ming Wu, Crystal D. Lin, and K-H Lin (corresponding author) Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells

Oncogene 32 (38), 4509-4518, 2013 (SCI; IF:7.357, 19/196=9.96%, Oncology)

 

20. Hsiang-Cheng Chi, Chen-Hsin Liao, Ya-Hui Huang, Sheng-Ming Wu, Chung-Ying Tsai, Chia-Jung Liao, Yi-Hsin Tseng,Yang-Hsiang Lin, Cheng-Yi Chen , I-Hsiao Chung, Tzu-I Wu, Wei-Jan Chen, K-H Lin (corresponding author) Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4 Biochem. Bioph Res. Co.439 (1), 60-65, 2013(SCI; IF, 2.406, 39/72=54.2%; Biophysics)

 

21. Hsiang Cheng Chi, Cheng-Yi Chen, Ming-Ming Tsai, Chung-Ying Tsai, and K-H Lin (corresponding author) Molecular Functions of Thyroid Hormones and Their Clinical Significance in Liver-Related Diseases Journal of Biomedicine and Biotechnology (invited article). 2013, 1-6, 2013 (SCI; IF:2.88, 50/159=31.45%; BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

 

2014

 

22. Yi-Hsin Tseng, Po-Yuan Ke, Chia-Jung Liao, Sheng-Ming Wu, Hsiang-Cheng Chi, Chung-Ying Tsai, Cheng-Yi Chen, Yang-Hsiang Lin, and K-H Lin (corresponding author) Chromosome 19 Open Reading Frame 80 Is Upregulated by the Thyroid Hormone and Modulates Autophagy and Lipid Metabolism Autophagy 10(1),20-31, 2014 (SCI; IF, 11.423 , 15/185=8.1%; Cell Biol.)

 

23. Chung-Ying Tsai, Chia-Siu Wang, Ming-Ming Tsai, Hsiang-Cheng Chi, Wan-Li Cheng, Yi-Hsin Tseng, Cheng-Yi Chen, Crystal D. Lin, Jun-I Wu, Lu-Hai Wang, and K-H Lin (corresponding author) Interleukin 32 Increases Human Gastric Cancer cell invasion Associated with Tumor Progression and Metastasis Clinical Cancer Re. May, 20(9), 2276-88, 2014.  (SCI; IF:8.193, 12/202=5.9%, Oncology)

 

24. Cheng-Yi Chen, I-Hsiao Chung, Ming-Ming Tsai, Yi-Hsin Tseng, Hsiang-Cheng Chi, Chung-Ying Tsai, Yang-Hsiang Lin, You-Ching Wang, Tzu-I Wu, Chau-Ting Yeh, Dar-In Tai4 and K-H Lin (corresponding author) Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling Mol. Cancer 13(7):162, 2014 (SCI; IF:5.397, 29/202=14.3%, Oncology)

 

25. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Cheng-Yi Chen, Hsiang-Cheng Chi, Yi-Hsin Tseng, Pei-Jung Chung , Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen and K-H Lin (corresponding author) microRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer Cancer lett. 351(9):222-231, 2014 (SCI; IF:5.016, 33/202=16.3%, Oncology)

 

26. Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chyong-Huey Lai, Shih-Ming Jung, Chuen Hsueh and K-H Lin (corresponding author) Glucose-regulated protein 58 modulates β-catenin protein stability in a cervical adenocarcinoma cell line BMC Cancer 14:555, 2014 (SCI; IF:3.319, 74/202=36.6%, Oncology)

 

27. Tsai MM, Wang CS, Tsai CY, Chi HC, Tseng YH, K-H Lin (corresponding author) Potential prognostic, diagnostic and therapeutic markers for human gastric cancer. World J Gastroenterol. 20(38): 13791-13803, 2014. (review; SCI; IF: 2.433, 36/74=48.6%, Gastroenterology & hepatology)

 

28. Y-H Tseng, Y-H Yeh, W-J Chen, and K-H Lin (corresponding author) Emerging Regulation and Function of Betatrophin Int. J. Mol. Sci. 15(12), 23640-23657, 2014 (review; SCI; IF: 2.339, 52/148=35.1%, Chemistry, multidisciplinary)

 

2015

29. Sheng-Ming Wu, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Yi-Hsin Tseng, Chung-Ying Tsai, Ching-Ying Chen, Syuan-ling Lin, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Ying F. Huang, Ming-Huang Chen, Yi-Chen Yeh and K-H Lin (corresponding author) Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth Inter. J. Cancer 137:37-49, 2015 (SCI; IF:5.007, 34/202=16.8%, Oncology)

 

 

30. Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, Ya-Hui Huang, Hsiang-Cheng Chi, Sheng-Ming Wu, Cheng-Yi Chen, Yi-Hsin Tseng, Chung-Ying Tsai, I-Hsiao Chung, Ming-Ming Tsai, Ching-Ying Chen, Tina P. Lin, Yung-Hsin Yeh, Wei-Jan Chen and K-H Lin (corresponding author) Repression of microRNA-130b by thyroid hormone enhances cell motility J Hepatology 62:1328-1340,2015 (SCI; IF: 10.401, 5/74=6.7% gastroenterology & hepatology)

 

31. Cheng-Yi Chen, Chie-Pein Chen, and K-H Lin (corresponding author) Biological Functions of Thyroid Hormone in Placenta Int. J. Mol. Sci. 16(2): 4161-4179, 2015 (review; SCI; IF: 2.339, 52/148=35.1%, Chemistry, multidisciplinary)

 

32. Chia-Jung Liao, Hsiang-Cheng Chi, Chung-Ying Tsai, Chi-De Chen, Sheng-Ming Wu, Yi-Hsin Tseng, Yang-Hsiang Lin, I-Hsiao Chung, Ching-Ying Chen, Syuan-Ling Lin, Ya-Hui Huang, and K-H Lin (corresponding author)A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis Oncotarget 6(11)9341-54,2015 (SCI; IF:6.627, 17/202=8.4%, Oncology)

 

33. I-Hsiao Chung, Cheng-Yi Chen, Yang-Hsiang Lin, Hsiang-Cheng Chi, Ya-Hui Huang, Pei-Ju Tai, Chia-Jung Liao, Chung-Ying Tsai, Syuan-Ling Lin, Meng-Han Wu, Ching-Ying Chen and K-H Lin (corresponding author)  Thyroid hormone-Mediated Regulation of Lipocalin 2 through the Met/FAK Pathway in Liver Cancer Oncotarget 6(17) 15050-64, 2015 (SCI; IF:6.627, 17/202=8.4%, Oncology)

 

 2016

 

34. I-Hsiao Chung, Tzu-I Wu, Chia-Jung Liao, Jin-Yo Hu, Yang-Hsiang Lin, Pei-ju Tai, Chyong-Huey Lai and K-H Lin Overexpression of lipocalin 2 in human cervical cancer enhances tumor invasion Oncotarget 7(10):11113-26, 2016 (SCI; IF:5.008, 36/213=16.9%, Oncology)

 

35 I-Hsiao Chung, Hsuan Liu, Yang-Hsiang Lin, Hsiang-Cheng Chi, Ya-Hui Huang , Chang-Ching Yang, Bertrand Chin-Ming Tan and K-H Lin (corresponding author)  ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance Oncotarget 19;7(16):22448-59. 2016 (SCI; IF:5.008, 36/213=16.9%, Oncology)

 

36 Ming-Ming Tsai, Hsiang-Wei Huang, Chia-Siu Wang, Kam-Fai Lee, Chung-Ying Tsai, Pei-Hsuan Lu, Hsiang-Cheng Chi, Yang-Hsiang Lin, Liang-Mou Kuo, and K-H Lin (corresponding author) MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer Oncotarget 28;7(26):39511-39526, 2016. (SCI; IF:5.008, 36/213=16.9%, Oncology)

 

37. Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author) Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer Int. J. Mol. Sci., 17(6), 945, 2016 (review; SCI; IF: 3.251, 51/163=31.2%, Chemistry, multidisciplinary)

 

38 Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi , Yang-Hsiang Lin, Pei-Hsuan Lu and K-H Lin (corresponding author)  Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer Eur. J Cancer 64:137-48. 2016. (SCI; IF: 6.163, 22/213=10.3%, Oncology)

 

39. Hsiang-Cheng Chi, Shen-Liang Chen, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Sheng-Ming Wu, Cheng-Pu Sun, Chau-Ting Yeh and K-H Lin (corresponding author) Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1 dependent selective Autophagy 12(12): 2271-2285, 2016. (SCI; IF: 9.108, 19/187=10.1%; Cell Biol.).

 

40. Hsiang-Cheng Chi, Shen-Liang Chen, Yi-Hung Cheng, Tzu-Kang Lin, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Ya-Hui Huang and K-H Lin (corresponding author)  Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway Cell Death & Disease 4;7(8):2016. (SCI; IF:5.378, 38/187=20% Cell Biol.).

 

41 Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, and K-H Lin (corresponding author)  Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression Int. J. Cancer 2016 Dec 7. doi: 10.1002/ijc.30559. [Epub ahead of print] (SCI; IF:5.531, 29/213=13.6%, Oncology)

 

42 Tseng YH, Huang YH, Lin TK, Wu SM, Chi HC, Tsai CY, Tsai MM, Lin YH, Chang WC, Chang YT, Chen WJ, and K-H Lin (corresponding author) Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci Rep. 9; 6:38756. 2016. (SCI; IF:5.228, 7/63=11.1%, multidisciplinary sciences)

 

 

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