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趙清貴

趙清貴 (Chuck C.-K. Chao)

Appointment:Division Director / Professor

Lab:Tumor Biology Laboratory

Education:Ph.D.

University/Nation:Univ. Texas Southwestern Med. Ctr, USA

Tel:5157

E-mailcckchao@mail.cgu.edu.tw

Research websitehttp://cckchao1.wix.com/chao-lab

 

Publications (among 114 peer-reviewed papers)

1. Wu, Z.-Z., Lu, H.-P. and Chao, C.C.-K. Identification and functional analysis of genes which potentially confer resistance to cisplatin in tumor cells. Biochem. Pharmacol. 80: 262-276, 2010 SCI IF=5.009

2. Sun, N.-K.*, Sun, C.-L.*, Lin, C.-H., Pai, L.-M. and Chao, C.C.-K. Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila. J. Biomed. Sci., 2010 (*equal contribution) IF=2.763

3. Wu, Z.-Z. and Chao, C.C.-K. Knockdown of NAPA using short-hairpin RNA sensitizes cancer cells to cisplatin: implications to overcome chemoresistance. Biochem. Pharmacol. 80: 827-837, 2010 IF=5.009

4. Kuo, T.-C. and Chao, C.C.-K. Hepatitis B virus X protein prevents apoptosis of hepatocellular carcinoma cells by upregulating SATB1 and HURP expression. Biochem. Pharmacol. 80: 1093-1102, 2010 IF=5.009

5. Hung, F.-C. and Chao, C.C.-K. Knockdown of growth-arrest-specific 7b gene (gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: implications to prevent apoptosis of neurons. J. Neurosci. Res. 88: 3578-3587, 2010  IF=2.594

6. Wu, Z.-Z., Sun, N.-K. and Chao, C.C.-K. Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis. J. Cell. Physiol.226: 2415-2428, 2011 IF=3.839

7. Chao, C.C.-K. A Search for the genes involved in resistance to cisplatin chemotherapy: Review of the experimental evidence. Curr. Top. Pharmacol. 14: 47-54, 2011 January [invited review article]

8. Chao, C.C.-K. The role of DDB2 in regulating cell survival and apoptosis following DNA damage - a mini-review. In DNA Repair (ed., Kruman, I.), InTech: 2011 July (ISBN 978-953-307-697-3) [invited review]

9. Hung, F.-C., Chang, Y.-H., Lin-Chao, S. and Chao, C.C.-K. Gas7 mediates the differentiation of human bone marrow-derived mesenchymal stem cells into functional osteoblasts by enhancing Runx2-dependent gene expression. J. Orthopaedic Res. 29: 1528-1535, 2011 IF=2.986

10. Kuo, T.-C.*, Lu, H.-P.* and Chao, C.C.-K. The tyrosine kinase inhibitor sorafenib sensitizes hepatocellular carcinoma cells to taxol by suppressing the HURP protein. Biochem. Pharmacol. 82: 184-194, 2011 (*equal contribution) IF=5.009

11. Wu, Z.-Z., Sun, N.-K., Chien, K.-Y. and Chao, C.C.-K. Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem Pharmacol. 82: 1630-1640, 2011 IF=5.009

12. Wu, Z.-Z.*, Chow, K.-P.N.*, Kuo, T.-C., Chang, Y.-S., Chao, C.C.-K. Latent membrane protein 1 of Epstein–Barr virus sensitizes cancer cells to cisplatin by enhancing NF-B p50 homodimer formation and downregulating NAPA expression. Biochem. Pharmacol. 82: 1860-1872, 2011 (*equal contribution) IF=5.009

13. Kuo, T.-C., Chang, P.-Y., Huang, S.-F., Chou, C.-K. and Chao, C.C.-K. Knockdown of HURP inhibits the proliferation of hepatocellular carcinoma cells via downregulation of gankyrin and accumulation of p53. Biochem Pharmacol. 83: 758- 768, 2012 IF=5.009

14. Chao, C.C.-K. Adapting new ways to escape attacks by anti-cancer drugs: Epigenetic changes and alternative splicing. Adaptive Medicine 4: 64-68, 2012 [invited review]

15. Sun, N.-K., Huang, S.-L., Chien, K.-Y. and Chao, C.C.-K. Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28/MDM2/p53 complexes and by preventing the ubiquitination and degradation of p53. Biochem. J. 444: 303-314, 2012 IF=4.396

16. Huang, B.-T., Chang, P.-Y., Su, C.-H., Chao, C.C.-K. and Lin-Chao, S. Deficiency of Gas7 in mice reveals motor coordination defects due to abnormal motor neuron function and muscle fiber composition during aging. PLoS ONE 7(5): e37702. DOI:10.1371/journal.pone.0037702, 2012 IF=3.234

17. Lu, H.-P. and Chao, C.C.-K. Cancer cells acquire resistance to anticancer drugs: An update. Biomed. J. 35: 479-491, 2012 [invited review]

18. Hung, F.-C., Cheng, Y.-C., Sun, N.-K. and Chao, C.C.-K. Identification and characterization of zebrafish gas7 gene in early development. J, Neurosci. Res. 91:51-61, 2013  IF=2.594

19. Chao, C.C.-K., Hung, F.C. and Chao, J.J. Gas7 is required for mesenchymal stem cell-derived bone development. Stem Cells Int. vol. 2013, Article ID 137010, 6 pages, 2013. DOI:10.1155/2013/137010 [invited review] IF=2.813

20. Sun, N.-K., Huang, S.-L., Chang, T.-C. and Chao, C.C.-K. Sorafenib induces apoptosis in endometrial carcinoma cells by inhibiting Elk-1-dependent Mcl-1 gene expression and by inducing Akt/GSK3β-dependent Mcl-1 protein degradation. J. Cell. Biochem. 114: 1819-1831, 2013 IF=3.263

21. Chang, P.-Y.*, Wu, Z.-Z.*, Sun, N.-K. and Chao, C.C.-K. EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression. J. Cell. Physiol. 229: 309-322, 2014 (*equal contribution) IF=3.839

22. Sun, N.-K.*, Huang, S.-L.*, Chang, P.-Y., Lu, H.-P. and Chao, C.C.-K. Transcriptomic profiling of taxol-resistant ovarian cancer cells identifies FKBP5 and the androgen receptor as critical markers of chemotherapeutic response. Oncotarget 5: 11939-11956, 2014 (*equal contribution) IF=6.359

23. Chao, C.C.-K. Mechanisms of p53 degradation. Clinica Chimica Acta 438: 139-147, 2015 (online: Aug. 13, 2014, doi: 10.1016/j.cca.2014.08.015) [invited review] IF=2.824

24. Huang, S.-L. and Chao, C.C.-K. Linking immunophilin FKBP5 to taxol resistance in ovarian cancer. Cancer Cell & Microenviron. 2015; 2: e692. doi: 10.14800/ccm.692 [invited research highlight]

25. Lin, Y.-T., Lu, H.-P. and Chao, C.C.-K. Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis. Biochem. Pharmacol. 93: 110-124, 2015 (first online: 3 Nov. 2014, DOI:10.1016/j.bcp.2014.10.012) IF=5.009

26. Lin, Y.-T. and Chao, C.C.-K. Sorafenib induces apoptosis in hepatocellular carcinoma Cells by inhibiting c-Myc and prothymosin-alpha. Cancer Cell & Microenviron. 2015; 2: e788. doi: 10.14800/ccm.788 [invited research highlight]

27. Huang, S.-L. and Chao, C.C.-K. Silencing of taxol-sensitizer genes in cancer cells: Lack of sensitization effects. Cancers 7: 1052-1071, 2015; doi:10.3390/cancers7020824 (special issue - Cancer Cell Proliferation) [invited article].

28. Ho, C.H., Hsu, J.L., Liu, S.P., Hsu, L.C., Chang, W.L., Chao, C.C.-K., Guh, J.H. Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway. Prostate 75 (13):1454-1466, 2015 IF=3.565

29. Sun, N.-K.*, Huang, S.-L.*, Lu, H.-P., Chang, T.-C. and Chao, C.C.-K. Integrative transcriptomics-based identification of cryptic drivers of taxol-resistance genes in ovarian carcinoma cells: analysis of the androgen receptor. Oncotarget 6: 27065-27082, 2015 (*equal contribution) IF=6.359

30. Liu, Y.-C., Chang, P.-Y. and Chao, C.C.-K. CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene. Nucleic Acids Res. 43: 10760-10781, 2015 IF=9.112

31. Lin, Y.-T. and Chao, C.C.-K. Identification of the  β-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells. Oncotarget 6: 38999-39017, 2015 IF=6.359

32. Hung, F.-C.*, Shih, H.-Y.*, Cheng, Y.-C. and Chao, C.C.-K. Growth-arrest-specific 7 gene regulates neural crest formation and craniofacial development in zebrafish. Stem Cells Dev. 24: 2943-2951, 2015 (*equal contribution) IF=3.727

33. Chang, PY#, Huang, Y #, Hung, TY, Chong, KY, Chang, YS, Chao, CC-K* and Chow, KPN* Spontaneous metastases in immunocompetent mice harboring a primary tumor driven by oncogene latent membrane protein 1 from Epstein-Barr virus. Biomed J 39: 261-271, 2016 (#equal contribution, *co-correspondence)

34. Chao, C.C.-K. Inhibition of apoptosis by oncogenic hepatitis B virus X protein: Implications for the treatment of hepatocellular carcinoma. World J. Hepatol. 8(25): 1061-1066, 2016 [invited review/highlight]

35.Lin, Y.-T., Liu, Y.-C. and Chao, C.C.-K. Inhibition of JNK and prothymosin-alpha sensitizes hepatocellular carcinoma cells to cisplatin. Biochem. Pharmacol. 122: 80-89, 2016. IF=5.091

 

 

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