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Graduate Institute of Biomedical Sciences



謝森永 (Sen-Yung Hsieh)

AppointmentProfessor of Medicine

Lab:Liver Research Unit

Education: MD, PhD

University/Nation:U Penn/USA

Tel: 03 3281200 ext 8128

E-mail: siming@adm.cgmh.org.tw

Research website

Laboratory personnel:

Postdoctoral fellows:2; Ph.D. students:2 ; Master students:2 ; Res. Assistants:2 ; undergraduate:0


Research interests:

The long-term goals of our research are to elucidate the molecular basis for hepatocellular carcinogenesis and identify the genes and pathways that hepatoma cells are addicted so as to contribute to future improvement of survival of patients with hepatoma.

We are interested in developing novel approaches to conduct a genomewide and subgenomewide approaches for a systematic screen to identify genes, proteins and pathways that are implicated in the development and progression of human hepatoma. We have developed a novel high efficiency method for isolation of differentially expressed genes between tumor and non-tumor liver tissues. We also have utilized loss-of-function assays for a genomewide identification of genes implicated in carcinogenesis of hepatoma. Meanwhile we utilized cellular hermetic responses to identify proteins and pathways that are involved in apoptosis evasion in hepatoma cells.


  1. Lee CH, Chang CJ, Lin YJ, Yeh CN, Chen MF, Hsieh SY*. Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma. Br J Cancer. 2009 Jun 2;100(11):1765-70. Epub 2009 May 12. (Hsieh SY, the corresponding author)
  2. Hsieh SY*, Hsu CY, He JR, Liu CL, Lo SJ, Chen YC, Huang HY. Identifying Apoptosis-Evasion Proteins/Pathways in Human Hepatoma Cells via Induction of Cellular Hormesis by UV Irradiation. J Proteome Res. 2009 Aug;8(8):3977-86.
  3. Hsieh SY*, Huang SF, Yu MC, Yeh TS, Chen TC, Lin YJ, Chang CJ, Sung CM, Lee YL, Hsu CY. Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinogenesis, 2010, 49(5):476-87.
  4. Hsieh SY, He JR, Hsu CY, Chen WJ, Bera R, Lin KY, Shih TC, Yu MC, Lin YJ, Chang CJ, Weng WH, Huang HF. Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma. Hepatology. 2011 Feb;53(2):504-16.
  5. Hsieh SY*, He JR, Yu MC, Lee WC, Chen TC, Lo SJ, Bera R, Sung CM, Chiu CT.  Secreted ERBB3 Isoforms are Serum Markers for Early Hepatoma in Patients with Chronic Hepatitis and Cirrhosis. J Proteome Res. 2011 Aug 31. 10:4715-24.
  6. Shih TC, Tien YJ, Chih-Jen Wen, Ta-Sen Yeh, Ming-Chin Yu, Chia-Hao Huang, Yun-Shien Lee, Tzu-Chen Yen, and Hsieh SY*. MicroRNA-214 downregulation contributes to tumor angiogenesis via inducing secretion of hepatoma-derived growth factor in human hepatoma. J Hepatology, 2012 Sept 57(3):584-91.
  7. Lo SL, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang HF, Chang CJ, Lin YJ, Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-Associated X protein regulating death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013May;57(5):1893-905.
  8. Rabindranath Bera,* Chih-Yung Chiou,* Ming-Chin Yu, Jei-Ming Peng, Chung-Ru He, Chih-Yun Hsu, Hsiao-Ling Huang, Uda Y. Ho, Shi-Ming Lin, Yu-Jr Lin,and Sen-Yung Hsieh**  Functional Genomics Identified a Novel Protein Tyrosine Phosphatase Receptor Type F-Mediated Growth Inhibition in Hepatocarcinogenesis. HEPATOLOGY. 2014Jun;59(6):2238-2250.


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