Your browser does not support JavaScript!
:::
:::
謝森永

謝森永 (Sen-Yung Hsieh)

職稱:教授

研究室名稱:肝癌研究室及臨床蛋白質體學中心

最高學歷:MD & Ph.D.

學校/國家:U Pennsylvania/USA

分機號碼:03 3281200 ext 8128

電子郵件帳號: siming@adm.cgmh.org.tw

個人網頁網址:

研究室現有: 博士後研究員 2

博士班研究生 2

碩士班研究生2

專任研究助理  2

大學部專題生  0

 

研究方向研究室特色
我們的興趣在於探討肝癌細胞與一般的肝細胞究竟在分子及細胞的層次上有什麼不同,那些不同是造成細胞癌化的關鍵,那些癌細胞內外環境的特點會趨使癌細胞逐步地惡化及擴散。期待藉由上述的研究及了解,能確定細胞癌化的關鍵機制,對未來更佳的肝癌的治療提供指針。

    本實驗結合了基礎與臨床,使研究目標與內涵能緊扣疾病之實情與生物學之意義。結合了基因體學、表基因體學及蛋白體學,並運用“功能性”基因體學及蛋白體學進行高效能之基因及功能篩選。再以先進之生化、分生、細胞、分子影像及動物模式,進行理論之驗證。所有的理論再回歸到肝癌病患之臨床表現及病程分析,以臨床實例驗證實驗之結果。本研究題材十分適合做為博士論文之題材,也適合博士後研究員之研究主題。

最近五年所發表論文:

  1. Lee CH, Chang CJ, Lin YJ, Yeh CN, Chen MF, Hsieh SY*. Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma. Br J Cancer. 2009 Jun 2;100(11):1765-70. Epub 2009 May 12. (Hsieh SY, the corresponding author)
  2. Hsieh SY*, Hsu CY, He JR, Liu CL, Lo SJ, Chen YC, Huang HY. Identifying Apoptosis-Evasion Proteins/Pathways in Human Hepatoma Cells via Induction of Cellular Hormesis by UV Irradiation. J Proteome Res. 2009 Aug;8(8):3977-86.
  3. Hsieh SY*, Huang SF, Yu MC, Yeh TS, Chen TC, Lin YJ, Chang CJ, Sung CM, Lee YL, Hsu CY. Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinogenesis, 2010, 49(5):476-87.
  4. Hsieh SY, He JR, Hsu CY, Chen WJ, Bera R, Lin KY, Shih TC, Yu MC, Lin YJ, Chang CJ, Weng WH, Huang HF. Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma. Hepatology. 2011 Feb;53(2):504-16.
  5. Hsieh SY*, He JR, Yu MC, Lee WC, Chen TC, Lo SJ, Bera R, Sung CM, Chiu CT.  Secreted ERBB3 Isoforms are Serum Markers for Early Hepatoma in Patients with Chronic Hepatitis and Cirrhosis. J Proteome Res. 2011 Aug 31. 10:4715-24.
  6. Shih TC, Tien YJ, Chih-Jen Wen, Ta-Sen Yeh, Ming-Chin Yu, Chia-Hao Huang, Yun-Shien Lee, Tzu-Chen Yen, and Hsieh SY*. MicroRNA-214 downregulation contributes to tumor angiogenesis via inducing secretion of hepatoma-derived growth factor in human hepatoma. J Hepatology, 2012 Sept 57(3):584-91.
  7. Lo SL, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang HF, Chang CJ, Lin YJ, Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-Associated X protein regulating death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013May;57(5):1893-905.
  8. Rabindranath Bera,* Chih-Yung Chiou,* Ming-Chin Yu, Jei-Ming Peng, Chung-Ru He, Chih-Yun Hsu, Hsiao-Ling Huang, Uda Y. Ho, Shi-Ming Lin, Yu-Jr Lin,and Sen-Yung Hsieh**  Functional Genomics Identified a Novel Protein Tyrosine Phosphatase Receptor Type F-Mediated Growth Inhibition in Hepatocarcinogenesis. HEPATOLOGY. 2014Jun;59(6):2238-2250.
瀏覽數  
  • 友善列印
  • 新增到收藏夾
  • 分享
將此文章推薦給親友
請輸入此驗證碼
Voice Play
更換驗證碼