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Graduate Institute of Biomedical Sciences



郭敏玲(Ming-Ling Kuo)

Appointment: Professor

LabMolecular Immunology Laboratory


University/NationState University of New Jersey, USA

Tel: (03)2118800 ext.3319/3320


Research websitehttps://sites.google.com/site/mlkmolecularimmunology/

Research interests:

 著作(近年發表   2010~迄今)

※   Pubication

*: Correspondence author  : Co-correspondence author  #: equal contribution


l   Lee M-H, Chang T-C, Liao C-T, Chen Y-S, Kuo M-L, Shen C-R. 2017 (). Interleukin 17 and Peripheral IL-17-Expressing T cells are Negatively Correlated with the Overall Survival of Head and Neck Cancer Patients. Oncotarget. Accepted: Nov 04, 2017.

l   Chen L-C, Tseng H-M, Kuo M-L, Chiu C-Y, Liao S-L, Su K-W, Tsai M-H, Hua M-C, Lai S-H, Yao T-C, Yeh K-W, Wu A-H, Huang J-L and Huang S-K. 2017 (Nov 27). A composite of exhaled LTB4, LXA4, FeNO and FEV1 as an “asthma classification ratio” characterizes childhood asthma. Allergy. Accepted: Sep 25. Version online: November 27, 2017. (DOI: 10.1111/all.13318)

l   Kuo C-Y, Huang W-C, Liou C-J, Chen L-C, Shen J-J* and Kuo M-L*. 2017 (Nov 21). Tomatidine attenuates airway hyperresponsiveness and inflammation by suppressing Th2 cytokines in a mouse model of asthma. Mediat. Inflamm.
Accepted: Sep 28. Published November 21, 2017. (DOI 10.1155/2017/5261803)

l   Lin S-J, Kuo M-L, Hsiao H-S, Lee P-T, Chen J-Y, Huang J-L. 2017 (Oct 12). Activating and inhibitory receptors on natural killer cells in patients with systemic lupus erythematosis-regulation with interleukin-15. PLoS One. 12(10):e0186223.
Accepted: Sep 27. Published: October 12, 2017. (DOI 10.1371/journal.pone.0186223)

Hua M-C, Su H-M, Yao T-C, Kuo M-L, Lai M-W, Tsai M-H, Huang J-L. 2017 (July 31). Alternation of Plasma Fatty Acids Composition and Desaturase Activities in Children with Liver Steatosis. PLoS One. 12(7):e0182277.
Accepted: July 14. Published: July 31, 2017. (DOI 10.1371/journal.pone.0182277)


l   Lu C-H, Wu C-J, Chan C-C, Duc T. Nguyen, Lin K-R, Lin S-J, Chen L-C, Yen J-Y and Kuo M-L*. 2016 (Nov). DNA Methyltransferase Inhibitor Promotes Human CD4+CD25hFOXP3+ Regulatory T Lymphocyte Induction under Suboptimal TCR Stimulation. Front. Immunol. (7): 488-499. (Online Published: November 8 2016)
(DOI 10.3389/fimmu.2016.00488)

l   Lin S-J, Kuo M-L, Hsiao H-S, Lee P-T. 2016 (Nov). Azithromycin modulates immune response of monocyte-derived dendritic cells and CD4+ T cells. Int. Immunopharmacol. 40:318-326. (Online Published: November 2016)(DOI 10.1016/j.intimp.2016.09.012)

l   Lin S-J, Chen J-Y, Kuo M-L, Hsiao H-S, Lee P-T and Huang J-L. 2016 (Oct). Effect of interleukin-15 on CD11b, CD54, and CD62l expression on natural killer cell and Natural Killer T-like Cells in Systemic Lupus Erythematosis. Mediat. Inflamm. Article ID 9675861, 8 pages. (Online: 2016 Oct 26 2016) (DOI: 10.1155/2016/9675861)

l   Chan C-K, Lin T-C, Huang Y-A, Chen Y-S, Wu C-L, Lo H-Y, Kuo M-L, Wu K-H, Huang J-L. 2016 (Oct). The modulation of Th2 immune pathway in the immunosuppressive effect of human umbilical cord mesenchymal stem cells in a murine asthmatic model. Inflamm. Res. 65(10):795-801. (Online: July 6, 2016.)(DOI 10.1007/s00011-016-0961-y)

l   Chen J-C, Chan C-C, Wu C-J, Ou L-S, Yu H-Y, Chang H-L, Tseng L-Y, Kuo M-L*. 2016 (Oct). Fetal phagocytes take up allergens to initiate Th2 immunity and facilitate allergic airway responses. Am. J. Respir. Crit. Care Med. 194(8):934-947. (Online: 11 Apr 2016)(DOI: 10.1164/rccm.201508-1703OC)

l   Chan C-C, Lai C-W, Wu C-J, Chen L-C, Tao M-H , Kuo M-L. 2016 (Aug). Liver-specific allergen gene transfer by adeno-associated virus suppresses allergic airway inflammation in mice. Hu. Gene Ther. 27(8):631-642. (Online: 13 May 2016)
DOI: 10.1089/hum.2015.161)

l   Chiang N-Y, Chang G-W, Huang Y-S g), Peng Y-M  , Hsiao C-C, Kuo M-L, Lin H-H *. 2016 (June 1). Heparin interacts with adhesion-GPCR GPR56/ADGRG1, reduces receptor shedding, and promotes cell adhesion and motility. J. Cell Sci. 129 (11): 2156-2169. (Online: 11 April 2016.) (DOI:10.1242/jcs.174458)

l   Wu C-J, Lu C-H, Chen L-C, Nguyen DT, Huang Y-S, Lin H-H, Lin C-Y, Kuo M-L*. 2016 (May 13).CD4 down regulation and raft dissociation by the non-depleting YTS177 antibody hinder murine T helper cell activities. Biochem. Biophy. Res. Co. 473 (4): 973-979.(DOI: 10.1016/j.bbrc.2016.04.001 )


l   Lin T-C , Wu J-Y, Kuo M-L, Ou L-S, Yeh K-W, and Huang J-L *. 2016 (Jan 12). Correlation between Disease Activity of Pediatric-onset Systemic Lupus Erythematosus and Level of Vitamin D in Taiwan: A Case-Cohort Study. J. Microbiol. Immunol. Infect. pii: S1684-1182(16)00006-2. IRB: 103-2832B (DOI:10.1016/j.jmii.2015.12.005)

l   Cho S, Wu C-J, Yasuda T, Cruz L, Khan A, Lin L-L, Nguyen D, Miller M, Lee H-M, Kuo M-L, Broide DH, Rajewsky K, Rudensky A, and Lu L-F*. 2016 (Feb 8). MiR-23~27~24 clusters control effector T cell differentiation and function. J. Exp. Med. 213 (2): 235-249. (DOI: 10.1084/jem.20150990).


l   Lin S-J, Huang Y-C, Cheng P-J, Lee P-T, Hsiao H-S, Kuo M-L*. 2015 (Dec). Interleukin-15 enhances the expansion and function of natural killer T cells from adult peripheral and umbilical cord blood. Cytokine. 76 (2): 348-355.

l   Shen C-R, Juang H-H, Chen H-S, Yang C-J, Wu C-J, Lee M-H, Hwang Y-S, Kuo M-L, Chen Y-S, Chen J-K, Liu C-L. 2015 (Nov). The correlation between chitin and acidic mammalian chitinase in animal models of allergic asthma. Int. J. Mol. Sci. 16 (11): 27371-27377. (DOI:10.3390/ijms161126033).

l   Chen J-C, Ou L-S, Yu H-Y, Kuo M-L, Chang P-Y, Chang H-L. 2015 (May). Postnatal donor lymphocytes enhance prenatally-created chimerism at the risk of graft-versus-host disease. Am. J. Transl. Res. 17 (5): 941-949. (DOI: 10.1155/2014/531092).

l   Yang T-Y, Chiang N-Y, Tseng W-Y, Pan H-L, Peng Y-M, Shen J-J, Wu K-A, Kuo M-L, Chang G-W, Lin H-H. 2015 (May). Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA. Protein Expr. Purif. 109: 85-92. (DOI: 10.1016/j.pep.2014.11.0, pii: S1046-5928(14)00274-513).


Yang T-Y, Chiang N-Y, Tseng W-Y, Pan H-L, Peng Y-M, Shen J-J, Wu K-A, Kuo M-L, Chang G-W, Lin H-H. 2015 (May). Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA. Protein Expr. Purif. 109: 85-92.
(DOI: 10.1016/j.pep.2014.11.0, pii: S1046-5928(14) 00274-513).

Liou C-J, Cheng P-Y; Huang W-C, Chan C-C, Chen M-C, Kuo M-L, Shen J-J. 2014 (Nov). Oral lovastatin attenuates airway inflammation and mucus secretion in ovalbumin-induced asthmatic mice. Allergy Asthma Immunol. Res. 6 (6): 548-557.
(DOI: 10.4168/aair.2014.6.6.548, Epub 2014 Aug 19).

Lin S-J, Lu C-H, Yan D-C, Lee P-T, Hsiao H-S, Kuo M-L*. 2014 (Oct). Expansion of regulatory T cells from umbilical cord blood and adult peripheral blood CD4+CD25+ T cells. Immunol. Res. 60 (1): 105-111. (DOI: 10.1006/s12026-014-8488-1. 2014 Feb 11).

Chen J-C, Ou L-S, Yu H-Y, Kuo M-L, Chang P-Y, Chang H-L. 2014 (Jul). Recipients with in utero induction of tolerance up-regulated MHC class I in the engrafted donor skin. Dis. Markers. (Article ID 531092, DOI:10.1155/2014/531092).

Huang W-C, Chan C-C, Wu S-J, Chen L-C, Shen J-J, Kuo M-L, Chen M-C, Liou C-J. 2014 (Jan). Matrine attenuates allergic airway inflammation and eosinophil infiltration by suppressing eotaxin and Th2 cytokines production in asthmatic mice. J. Ethnopharmacol. 151 (1): 470-477. (DOI:10.1016/j.jep.2013.10.065. 2013 Nov 11. pii: S0378-8741(13)00791-5).


Hsieh C-H, Chen H-C, Chang Y-H, Pang S-T, Kuo M-L, Chuang C-K, Liao S-K. 2013 (Nov). Co-existence of epithelioid and fibroblastoid subsets in a sarcomatoid renal carcinoma cell line revealed by clonal studies. Anticancer Res. 33 (11): 4875-4889.

Chan C-C, Liou C-J, Xu P-Y, Shen J-J, Kuo M-L, Len W-B, Chang L-E, Huang W-C. 2013 (Nov). Effect of dehydroepiandrosterone on atopic dermatitis-like skin lesions induced by 1-chloro-2,4-dinitrobenzene in mouse. J. Dermatol. Sci. 72(2):149-157.
(DOI: 10.1016/j.jdermsci.2013.06.015, 2013 Jul 9)

Chang S-H, Tang P, Lai C-H, Kuo M-L, Wang L-C. 2013 (Sep). Identification and characterization of microRNAs in young adults of Angiostrongylus cantonensis by a deep-sequencing approach. Mem. Inst. Oswaldo. Cruz. (Memórias do Instituto Oswaldo Cruz.). 108 (6): 699-706. (DOI: 10.1590/0074-0276108062013005).


Chen J-C, Ou L-S, Yu H-Y, Chang H-L, Chang P-Y, Kuo M-L. 2013 (Jul). Allogeneic lymphocytes exerted graft-versus-host rather than tolerogenic effects on preimmune fetuses. J. Surg. Res. 183 (1): 405-411. (DOI: 10.1016/j.jss.2012.12.015).

Lee W-I, Chen, S-H, Huang J-L, Jaing T-H, Chung H-T, Yeh K-W, Chen L-C, Yao T-C, Hsieh M-Y, Lin S-J, Kuo M-L. 2013 (May). Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia. Immunobiol. 218 (5): 828-8. (DOI: 10.1016/j.imbio.2012.09.001.)

Wu C-J, Chou H-W, Liou C-J, Shen J-J, Wang L-C, Kuo M-L*. 2013 (May). Prophylactic vaccination with adjuvant monophosphoryl lipid A prevents Th2-mediated murine asthmatic responses. J. Asthma. 50 (4): 327-333.
(DOI: Jan 31, 2013, 10.3109/02770903.2013.769268).

Wu S-A, Yeh K-W, Lee W-I, Yao T-C, Kuo M-L, Huang B, Huang J-L. 2013 (Mar) Impaired Phagocytosis and Susceptibility to Infection in Pediatric-Onset Systemic Lupus Erythematosus. Lupus. 22 (3): 279-288.
(DOI:10.1177/0961203312474704, Jan 31, 2013).

Wu C-J, Yang C-Y, Chen Y-H, Chen C-M, Chen L-C, Kuo M-L*. 2013 (Mar). The DNA methylation inhibitor, 5-azacytidine, increases regulatory T cells and alleviates airway inflammation in OVA-sensitized mice. Int. Arch. Allergy Immunol. 160 (4): 356-364.
(DOI: 10.1159/000343030).

Wu C-J, Chen L-C, Huang W-C, Chuang C-L, Kuo M-L*. 2013 (Jan). Alleviation of lung inflammatory responses by adeno-associated virus 2/9 carrying CC10 in OVA-sensitized mice. Hu. Gene Ther. 24 (1): 48-57.


Wu C-J, Huang W-C, Chen L-C, Shen C-R, Kuo M-L*. 2012 (Nov). Pseudotyped adeno-associated virus 2/9-delivered CCL11 shRNA alleviates lung inflammation in an allergen-sensitized mouse model. Hu. Gene Ther. 23 (11): 1156-1165. (DOI:10.1089/hum.2012.012).

Chen L-C, Tseng H-M, Wu C-J, Kuo M-L, Wu C-J, Gao P-S, Yeh K-W, Yao T-C, Lee W-I, Ou L-S, Huang J-L, Huang S-K. 2012 (Sep). Evaluation of a common variant of the gene encoding Clara cell 10 kd protein (CC10) as a candidate determinant for asthma severity and steroid responsiveness among Chinese children. J. Asthma. 49 (7): 665-672.
(DOI: 10.3109/02770903.2012.697954. Jul 13, 2012).

Chan C-K, Wu K-H, Lee Y-S, Hwang S-M, Lee M-S, Liao S-K, Cheng E-H, See L-C, Tsai C-N, Kuo M-L, Huang J-L. 2012 (Jul). The comparison of interleukin-6 associated immunosuppressive effects of human ESCs, fetal-type MSCs, and adult-type MSCs. Transplant. 94 (2): 132-138. (DOI: 10.1097/TP.0b013e31825940a4).

Lin S-J, Yan D-C, Lee W-I, Kuo M-L, Hsiao H-S, Lee P-Y(T). 2012 (May). Effect of azithromycin on natural killer cell function. Int. Immunopharmacol. 13 (1): 8-14.

Chen Y-H #, Kuo M-L #, Cheng P-J, Hsiao H-S, Lee P-T, Lin S-J. 2012 (Apr). Regulation of CD28 expression on umbilical cord blood and adult peripheral blood CD8+ T cells by interleukin (IL)-15/IL-21. Cytokine. 58 (1): 40-46. (DOI:10.1016/j.cyto.2011.12.013). (

Lin S-J, Cheng P-J, Lin T-Y, Lee P-T, Hsiao H-S, Kuo M-L*. 2012 (Mar). Effect of influenza A infection on umbilical cord blood natural killer function-regulation with interleukin-15. J. Infect. Dis. 205 (5): 745-756. (DOI: 10.1093/infdis/jir843).


Lee W-I, Huang J-L, Jaing T-H, Shyur S-D, Yang K-D, Chien Y-H, Chiang B-L, Soong W-J, Chiou S-S, Shieh C-C, Lin S-J, Yeh K-W, Chen L-C, Ou L-S, Yao T-C, Lin T-Y, Chiu C-H, Huang Y-C, Wu K-H, Lin C-Y, Yu H-H, Yang Y-H, Yu H-R, Yen H-J, Hsieh M-Y, Kuo M-L, Hwu W-L, Tsai Y-C, Kuo H-C, Lin Y-L, Shih Y-F, Chang K-W. 2011 (Dec). Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985-2010. Immunobiol. 216 (12): 1286-1294. (DOI:10.1016/j.imbio.2011.06.002).

Tsai Y-C, Yeh K-W, Yao T-C, Huang Y-L, Kuo M-L, Huang J-L. 2011 (Jul). Mannose binding lectin expression genotype in paediatric-onset systemic lupus erythematosus: Associations with susceptibility to nephritis and protection against infections. J. Rheumatol. 38 (7): 1429-1435. (DOI:10.3899/jrheum.100961).


Shen J-J, Chiang M-S, Kuo M-L, Hwang T-L, Liou C-J, Huang W-C. 2011 (Jun). Partially purified extract and viscolin, isolated from Viscum coloratum, attenuate airway inflammation and eosinophil infiltration in ovalbumin- sensitized mice. J. Ethnopharmacol. 135: 646-653. (DOI: 10.1016/j.jep.2011.03.065).

Lin S-J, Lee W-J, Yan D-C, Cheng P-J, Kuo M-L*. 2011 (May). Azithromycin inhibits IL-5 production of T helper type 2 cells from asthmatic children. Int. Arch. Allergy Immunol. 156 (5): 179-186. (DOI:10.1159/000322872).

Hua M-C, Lai M-W, Kuo M-L, Yao T-C, Huang J-L, Chen S-M. 2011 (Apr). Decreased interleukin-10 secretion in peripheral blood mononuclear cells of children with irritable bowel syndrome. J. Pediatr. Gastr. Nutr. 52 (4): 376-381.
(DOI: 10.1097/MPG.0b013e3181fd9816).


Chen J-C, Kuo M-L, Ou L-S, Chang M-L, Chang P-Y, Muench MO, Shen C-R, Chang H-L, Yu H-Y, Fu R-H. 2010 (Dec). Characterization of tolerance induction through prenatal marrow transplantation: the requirement for a threshold level of chimerism to establish rather than maintain postnatal skin tolerance. Cell Transpl. 19 (12): 1609-1622.
(DOI: 10.3727/096368910X516583).

Liou C-J, Huang W-C, Kuo M-L, Yang R-C, Shen J-J. 2010 (Oct). Long-term oral administration of Gynostemma pentaphyllum extract attenuates airway inflammation and Th2 cell activities in ovalbumin- sensitized mice. Food Chem. Toxicol. 48 (8): 2592-2598. (DOI:10.1016/j.fct.2010.06.020).

※   Review articles:

Lin S-J, Yan D-C, Lee Y-C, Hsiao H-S, Lee P-T, and Kuo M-L*. 2012 (Feb). Umbilical cord blood immunology - revelance to stem cell transplantation. Clin. Rev. Allergy Immunol. 42 (1): 45-57.
(DOI: 10.1007/s12016-011-8289-4
, Dec 2011)

Lin S-J and Kuo M-L. 2011 (Nov). Cytotoxic function of umbilical cord blood natural killer cells: relevance to adoptive immunotherapy. Pediatr. Hematol. Oncol. 28 (8): 640-646.
(DOIi:10.3109/08880018.2011.613092, Oct 4, 2011)

Lin S-J, Yan D-C, Lee Y-C, and Kuo M-L*. 2008 (Nov). Role of interleukin-15 in umbilical cord blood transplantation. Int. Rev. Immunol. 27 (6): 518-531.
(DOI: 10.1080/08830180802317940).

※   Book chapters:

Lin S-J, Lee P-T, Kuo M-L. Cytokine activation of natural killer cells. Ch19. pp  in Cancer Vaccines: Methods and Protocols, Methods in Molecular Biology, Vol 1139. Springer Science+Business Media, New York, NY, USA. DOI:10.1007/978-1-4939-0345-0_19.

Lin S-J, Lee Y-C, Yan D-C, Kuo M-L. Natural killer cells in allergy. Ch38, pp 511-517, in Lotze M and Thomson A, eds. Natural Killer Cells, Basic Science and Clinical Application, Elsevier, San Diego, CA, USA. 2009.

※   Perspectives or comments:

Lin H-H, Kuo M-L. 2012 (Mar). The 2011 Nobel Prize in Physiology or Medicine. Chang Gung Med. J. 35 (2): 93-95.

Kuo M-L*. 2009. Attempts to bridge the gap between scientific mechanism-based medicine and Chinese herbal extract treatment for asthma. in press, Pediatr. Neonatol. 49 (4): 101-102. (editorial comments, not SCI)








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