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王錫五

王錫五

職稱:副教授

研究室名稱:內分泌實驗室

最高學歷:Ph.D.

學校/國家:美國北卡羅來納州立大學

分機號碼:× 5253

電子郵件帳號swwang@mail.cgu.edu.tw

個人網頁網址:http://163.25.114.16/shyi-wu/index.htm

研究室現有: 博士後研究員 0

博士班研究生

碩士班研究生 5

專任研究助理  1 

大學部專題生  3  

 

研究方向研究室特色
內分泌實驗室位於醫學大樓八樓醫學生物共同研究室的一角,共同研究室係由六位不同研究領域的老師組成,包括藥理、生化、解剖及生理方面。本實驗室除在開放的空間擁有三個實驗檯外,尚有細胞培養室、放射線操作室及共用之儀器室,並與解剖科莊宏亨老師實驗室互動,進行分生方面的研究。本實驗室主要的研究主題為:
食物中的營養成分對於人體內分泌及免疫細胞功能之作用機制
此類營養成分有來自蕃茄的茄紅素,茶葉的兒茶素,辣椒中的蕃椒辣素等小分子,觀察這些營養物對:
(1) 人血中免疫細胞(如:淋巴球、單核球)分泌細胞素(Cytokines)的影響。
(2) 內分泌系統(大鼠卵巢、睪丸、腎上腺)荷爾蒙分泌之影響。
(3) 腎癌細胞RCC分泌細胞素及生長之影響。

中藥及藥物對免疫或內分泌之作用
以市面上常見之中藥,如「甘草素」、「黃蓮」、「雷公藤」、或救心的成分「毛地黃」為主,觀察其對內分泌腺體分泌荷爾蒙、腎癌細胞RCC、及免疫細胞分泌細胞素之影響。

 

最近五年所發表論文:

  1. Lo HI, Tsi D, Tan ACL, Wang SW, and Hsu MC*. Effects of postexercise supplementation of chicken essence on the elimination of exercise-induced plasma lactate and ammonia. Chinese J. Physiol. 2005, 48:187-192.
  2. Pu HF, Wang, SW, Tseng CI, Huang HL, Lin CW, Hsu JM, Chen MJ, Chow YC, and Wang, PS*. Mechanisms of digoxin and digitoxin on the production of corticosterone in zona fasciculata-reticularis cells of ovariectomized rats. J. Cell. Biochem. 2006, 97:303-313.
  3. Lee CW, Lin CC, Lin WN, Liang KC, Luo SF, Wu CB, Wang SW, and Yang CM*. TNF-α induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-{kappa}B/p300 binding in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol,2007, 292: L799 - L812.
  4. Hwang GS, Wang, SW*, Tseng, WM; Yu, CH, and Wang, PS*. Effect of Hypoxia on the Release of Vascular Endothelial Growth Factor and Testosterone in Mouse TM3 Leydig cells. Am J Physiol Endocrinol Metabol. 2007, 292:E1763-E1769.
  5. Tung WH, Sun CC, Hsich HL, Wang SW, Horng HT, and Yang CM*. EV71 induces VCAM-1 expression via PDGF receptor, PI3-K/Akt, p38 MAPK, JNK and NF-κB in vascular smooth muscle cells. Cell Signal 2007, 19:2127-2137.
  6. Wang SW*, Hwang GS, Chen TJ, and Wang PS. Effects of arecoline on testosterone release in rats. Am J Physiol Endocrinol Metabol. 2008, 295:E497-E504
  7. Lee IT, Wang SW, Lee CW, Chang CC, Lin CC, Luo SF, and Yang CM*. Lipoteichoic acid induces HO-1 expression via the TLR-2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells. J. Immunol. 2008, 181:5098-5110.
  8. Kau MM, Kan SF, Wang JR, Wang PS, Lau YT, and Wang SW*. Acute effects of digoxin on plasma aldosterone and cortisol in monkeys. Metabolism-Clin & Exp. 2009, 58:55-61.
  9. Hsia SM, Tseng YW, Wang SW, Kuo YH, Huang DW, Wang PS, and Chiang W. Effect of Adlay (Coix lachryma-jobi L. var.ma-yuen Stapf.) Hull extracts on testosterone release from rat Leydig cells.Phytother. Res. 2009, 23:687– 695.
  10. Yu PL, Chao HL, Wang SW, and Wang PS.  Effects of evodiamine and rutaecarpine on the secretion of corticosterone by Zona fasciculata-reticularis cells in male rats. J Cell Biochem, 2009; 108: 469-475.

 

最近五年所發表論文:

  1. Hwang GS, Chen ST, Chen TJ, and Wang SW*. Effects of hypoxia on testosterone release in rat Leydig cells. Am J Physiol Endocrinol Metab, 2009; 297: E1039 - E1045.
  2. Yu PL, Wu CI, LeeTS, Pan WHT, Wang PS, and Wang SW*. Attenuation of estradiol on the reduction of striatal dopamine by amphetamine in ovariectomized rats. J Cell Biochem, 2009; 108:1318-1324.
  3. Lee IT, Lee CW, Tung WH, Wang, SW, Lin CC, Shu JC, and Yang CM*. Cooperation of TLR2 with MyD88, PI3K, and Rac1 in Lipoteichoic Acid–Induced cPLA2/COX-2–Dependent Airway Inflammatory Responses. Am J Pathol 2010, 176:1671–1684.
  4. Yu PL, Pu HF, Chen SY, Wang SW*, and Wang PS*. Effects of Catechin, Epicatechin and Epigallocatechin Gallate on Testosterone Production in Rat Leydig Cells. J. Cell. Biochem. , 2010, 110: 333–342.
  5. Wu JJ, Wang KL, Wang SW, Hwang GS, Mao IF, Chen ML, and Wang PS. Differential effects of nonylphenol on testosterone secretion in rat Leydig cells. Toxicology, 2010; 268: 1-7.
  6. Chang CP, Wang SW, Huang ZL, Wang OY, Muang MI, Lu LM, Tarng DC, Chien CH, and Chien EJ.  Non-genomic rapid inhibition of Na+/H+-exchange 1 and apoptotic immunosuppression in human T cells by glucocorticoids. J Cell Physiol, 2010; 223: 679-686.     
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