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Graduate Institute of Biomedical Sciences



Yunn-Hwa Ma (馬蘊華)


Lab:Pharmacology Laboratory


University/Nation:University of Minnesota, Minneapolis, USA

Tel+886-3-2118800 ext 5266


Research website : https://www.linkedin.com/in/yunn-hwa-ma-16179b11/

Research interests:

- Magnetic nanoparticles as drug carriers for target therapeutics

- Vascular biology and signal transduction


List of Publications (2010-present):

   Siow WX, Chang YT, Babič M, Lu YC, Horák D, and Ma YH*: Interaction of poly(L-lysine) coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells. International Journal of Nanomedicine. 13:1693-1706, 2018

   Ma YH*, Huang CW, Wen CJ, Lu YC, Wey SP, Wun TC: Passivating Injured Endothelium with Kinexins in Thrombolytic Therapy. Thrombosis and Haemostasis. 118(1):90-102, 2018

    Lu YC, Chang FY, Tu SJ, Chen JP, Ma YH*: Cellular uptake of magnetite nanoparticles enhanced by NdFeB magnets in staggered arrangement. Journal of Magnetism and Magnetic Materials. 427: 71-80, 2017

    Chen JP, Liu JS, Hsu HL, Wu T, Lu YJ and Ma YH*: Magnetically controlled release of recombinant tissue plasminogen activator from chitosan nanocomposites for targeted thrombolysis. Journal of Materials Chemistry B. 4(15): 2578-2590, 2016

Lu YC, Luo PC, Huang CW, Leu YL, Wang TH, Wei KC, Wang HE, Ma YH*: Augmented cellular uptake of nanoparticles by tea catechins: an effect of surface modification on nanoparticle-cell interaction. Nanoscale. 6:10297-10306, 2014

Tu SJ, Wu SY, Wang FS, and Ma YH: Retention assessment of magnetic nanoparticles in rat arteries with micro computed tomography. Physics in Medicine & Biology. 59: 1271-1281, 2014

Yang HW, Hua MY, Lin KJ, Wey SP, Tsai RY, Wu SY, Lu YC, Liu HL, Wu T, Ma YH*: Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis. International Journal of Nanomedicine. 7: 5159–5173, 2012

Chen JP, Yang PC, and Ma YH,Tu SJ and Lu YJ: Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle. International Journal of Nanomedicine. 7:5137-5149, 2012

Ma YH*, Chen SY, Tu SJ, Yang HW, Liu HL: Manipulation of magnetic nanoparticle retention and hemodynamic consequence in microcirculation: assessment by laser speckle imaging. International Journal of Nanomedicine. 7: 2817-2827, 2012

Liu HL, Chen PY, Yang HW, Wu JS, Tseng IC, Ma YJ, Huang CY, Tsai HC, Chen SM, Lu YJ, Huang CY, Hua MY, Ma YH, Yen TC and Wei KC: In vivo MR quantification of superparamagnetic iron oxide nanoparticle leakage during low-frequency-ultrasound–induced blood–brain barrier opening in swine. Journal of Magnetic Resonance Imaging. 34:1313–1324, 2011

Liang CJ, Tseng CP, Yang CM and Ma YH*: 20-HETE inhibits ATP-induced cyclooxygenase 2 expression via peroxisome proliferator activator receptor in vascular smooth muscle cells. British Journal of Pharmacology. 163:815-825, 2011

Chen JP, Yang PC, Ma YH, and Wu T: Characterization of chitosan magnetic nanoparticles for in situ delivery of tissue plasminogen activator. Carbohydrate Polymers. 84:364-372, 2011

Chen JP, Yang PC, Ma YH and Lu YJ: Superparamagnetic iron oxide nanoparticles for delivery of tissue plasminogen activator. Journal of Nanoscience and Nanotechnology. 11(12):11089-11094, 2011

Chen PY, Liu HL, Hua MY, Yang HW, Huang CY, Chu PC, Lyu LA, Tsai HC, Chen SM, Lu YJ, Wang JJ, Yen TC, Ma YH, Wu T, Chen JP, Chuang JI, Shin JW, Hsueh C, and Wei KC: Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment.  Neuro-Oncology. 12(10): 1050-1060, 2010

Yen CH, Ma YH, Yu HP, Lau YT*: Reduction of superior mesenteric hemodynamic responsiveness to [Sar1,Thr8]-angiotensin II and bradykinin, but not sodium nitroprusside, in the presence of homocysteine infusion. Chinese Journal of Physiology. 53(1): 45-51, 2010

Honors and Awards

National Science Council Award for Excellence (2011)

Faculty Counseling Award, Chang Gung University (2011)

Faculty Teaching Award, Chang Gung University (2005)

Research Evaluation and Allocation Award, University of California, San Francisco (1997)

Molecular / Cellular Training Grant, NIH Institutional National Research Service Award (1992-96)

American Heart Association (Wisconsin Affiliate) Postdoctoral Award (1991)

International Affairs

Antioxidative magnetic nanoparticles based on natural antioxidants: Nanoparticle-cell interactions (MOST 105-2923-B-182-001-MY3; NMRPD1F0031~33)


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