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蘇文慧

蘇文慧(Wen-Hui Su)

職稱:助理教授

研究室名稱:癌症系統生物學研究室

最高學歷:Ph.D.

學校/國家:國防醫學院

分機號碼:3564

電子郵件帳號whsu@mail.cgu.edu.tw

個人網頁網址:

研究室現有: 博士後研究員

博士班研究生

碩士班研究生

專任研究助理

大學部專題生

 

研究方向研究室特色
 癌症做為一種遺傳的疾病,許多關於癌症的變化,常是先在染色體中發生,進而影響基因的表現,而導致癌症發生,或形成癌症特殊的標誌。我們在染色體上找到與癌症相關的變化,可以分為兩大類。一類為在生殖細胞(germline cells)就有的變異,例如單一核苷酸變異(SNP)或是複製數變異(copy number variation),讓帶有這些變異或基因型的人較其他人更容易得病,我們可以利用全基因體關聯性分析(genome-wide association study) 的方法,來研究有哪些變異會造成對疾病的感受性的差異。進而去找到造成這種感受性差異的癌症基因。另一類,則是在體細胞(somatic cells)中成形的癌組織內,常會見到的是染色體畸變(chromosome aberration)和基因表現改變的現象,我們也可以利用生物資訊和比較基因體學的方法,將目前已有的這些資訊整合起來,試著找出與癌症的標誌基因。在我們實驗室裏,就是試著以系統生物學和遺傳統計的方法,將這些訊息進行整合,試著找出與鼻咽癌(nasopharyngeal carcinoma)和肝癌(hepatocellular carcinoma)相關的感受性標誌及標誌基因。

最近五年所發表論文:

1. Jin-Xin Bei, Wen-Hui Su, Ching-Ching Ng, Kai Yu, Yoon-Ming Chin, Pei-Jen Lou, Wan-Lun Hsu, James D. McKay, Chien-Jen Chen, Yu-Sun Chang, Jian-Jun Liu, Yi-Xin Zeng, and Allan Hildesheim for the   International Nasopharyngeal Carcinoma Genetics Working Group (2016) A GWAS meta-analysis and replication study identifies  anovel locus within CLPTM1L/TERT associated with nasopharyngeal carcinoma in individuals of Chinese ancestry.   Cancer Epidemiology Biomarkers & Prevention 25(1):188-92 (SCI: Impact factor: 3.622, 25/172165 PUBLIC,  ENVIRONMENTAL & OCCUPATIONAL HEALTH)  (equal contributed first author)

2. Wen-Hui Su*, Chi-Cking Chiu, Yin Yao Shugart (2015) Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese population. BMC Cancer 15:598. (SCI: Impact factor: 3.265, 85/213 ONCOLOGY) (*Corresponding author) (NSC 101-2314-B-182-MYC, MOST 104-2314-B-182-033-MY3, CMRPD1A0383, CMRPD3D0121)

3. Su-Wei Chang, Cathy Shen-Jang Fann, Wen-Hui Su, Yu Chen Wang, Chia Chan Weng, Chia-Jung Yu, Chia-Lin Hsu, Ai-Ru Hsieh, Rong-Nan Chien, Chia-Ming Chu, Dar-In Tai (2014) A Genome-Wide Association Study on Chronic HBV Infection and Its Clinical Progression in Male Han-Taiwanese. PLoS One 9(6):e99724. (SCI: Impact factor: 3.057, 11/63 MULTIDISCIPLINARY SCIENCES)

4.  Wen-Hui Su*, Yin Yao Shugart, Kai-Ping Chang, Ngan-Ming Tsang, Ka-Po Tse, and Yu-Sun Chang (2013) How Genome-Wide SNP-SNP Interactions Relate to Nasopharyngeal Carcinoma Susceptibility. PLoS One 8(12):e83034. (SCI: Impact factor: 3.057, 11/63 MULTIDISCIPLINARY SCIENCES) (*Corresponding author) (NSC 101-2314-B-182-051-MY3; CMRPD1A0381)

5. Wen-Hui Su*, Allan Hildesheim, and Yu-Sun Chang (2013) Human Leukocyte Antigens and Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: Old Associations Offer New Clues into the Role of I mmunity in Infection-Associated Cancers. Frontiers in Oncology 3(299):1-9. (Invited Review) (*Corresponding author)

6. Wan-Lun Hsu, Ka-Po Tse, Sharon Liang, Yin-Chu Chien, Wen-Hui Su, Kelly Yu, Yu-Juen Cheng, Ngan-Ming Tsang, Mow-Ming Hsu, Kai-Ping Chang, I-How Chen, Tzu-I Chen, Czau-Siung Yang, Alisa Goldstein, Chien-Jen Chen, Allan Hildesheim, and Yu-Sun Chang (2012) Evaluation of Human Leukocyte Antigen-A (HLA-A), Other non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal  Carcinoma. PLoS One 7(8): e42767. (SCI: Impact factor: 3.057, 11/63 MULTIDISCIPLINARY SCIENCES)

7. Lin KT, Wang YW, Chen CT, Ho CM, Su WH, and Jou YS. (2012) HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clinical Cancer Research 18(17): 4691-4701. (SCI: Impact factor: 8.738, 12/213 ONCOLOGY)

8. C-Y Chang, S-C Lin, W-H Su, C-M Ho, and Y-S Jou. (2012) Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma. Oncogene 31(21):2640-52. (SCI: Impact factor: 7.932, 72/213 ONCOLOGY)

 

 

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