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鄭邑荃

邑荃 (Yi-Chuan Cheng)

神經發育與腫瘤研究室  

個人學經歷:

長庚大學 副教授

林口長庚醫院神經科學研究中心 副研究員
英國國家醫學研究院 博士後研究員
英國諾丁漢大學 基因與發育學博士
英國倫敦大學帝國學院 人類分子遺傳學碩士
中山醫學大學 醫事技術系學士

研究室現有:

博士後研究員 1

博士班研究生3

碩士班研究生4

專任研究助理1

大學部專題生5

電子郵件帳號:yccheng@mail.cgu.edu.tw

電話:0321188003396

 

 

研究方向及研究室特色:

 

1. 主要研究計畫:

神經系統發育、神經退化疾病、神經腫瘤形成之分子調控機制

 神經系統乃由多樣不同功能之神經細胞所構成,這些細胞皆源自於神經幹細胞,經由增生、分化、移行、及死亡等過程而發育成熟,組成具完整生理功能的神經系統。這些發育過程皆需要精準的分子調控,而異常的分子調控可影響神經細胞成長,導致疾病或腫瘤形成。因此,我們研究在胚胎時期神經系統發育之分子調控機制,並研究這些調控機制的異常如何造成神經退化疾病以及神經腫瘤的形成,以開發新的治療方法。

 關於神經退化疾病方面,我們著重於神經發育缺損如何造成失智症漸凍人 及肌張力不全症,及其治療方法。

 關於神經腫瘤方面,我們研究神經膠質瘤(glioma)以及髓母細胞瘤(medulloblastoma)的形成與治療。

 我們以斑馬魚胚胎、人類神經幹細胞、與神經腫瘤細胞為研究工具。重點為研究NotchRGS訊息傳遞及其調控因子於神經發育、神經退化疾病、及神經腫瘤中之功能。並利用研究成果開發新治療藥物。

  

2. 其他計畫

    血液幹細胞的發育與成長機制

 血液幹細胞可分化成為各種血球以及淋巴球。血液細胞成長不良可造成貧血、免疫缺乏、血液凝結障礙等疾病;而異常的血球細胞增生可造成多種血癌。我們研究在胚胎時期血液幹細胞成長及分化的分子調控機制,以期了解遺傳性血液細胞成長不良以及血癌形成的原因。此研究成果並有助我們發展以血液幹細胞作為治療多種疾病的方法。

    以斑馬魚為工具研究遺傳性腎臟疾病

 台灣洗腎人數高居世界第一。我們長期與長庚醫院腎臟科醫師合作,建立了罹患遺傳性腎臟疾病的斑馬魚模式,並使用腎臟螢光斑馬魚品系,以利用斑馬魚胚胎體透明可直接觀察腎臟病變之優勢,研究遺傳性腎臟疾病中之分子調控機制及篩選治療藥物。

Research interests

 The neural progenitors exhibit self-renewing and multipotency and are capable to differentiate into diverse collection of neural cells such as neurons, astrocytes, and oligodendrocytes. The pathways regulating their survival, proliferation, differentiation, and migration are frequently disrupted or altered in many neurodegenerative disorders and brain tumors. Therefore, understanding the gene regulatory and signaling processes in neural development may provide directly knowledge relevant to neural degeneration and brain tumorigenesis and lead to novel therapies and strategies that will advance the treatment of these diseases. We are investigating how aberrant developmental processes contribute to degeneration and tumors with a particular focus on the role of Notch and RGS signaling pathways in regulating neural development, neural degeneration, and brain tumorigenesis. We are using zebrafish, neural stem cells, and brain tumor cells as models.

 近年發表論文:

1.           Chiang MC, Nicol CJ, Cheng YC, Lin KH, Yen CH, Lin CH (2016, Apr). Rosiglitazone activation of PPARγ-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced mitochondrial dysfunction and oxidative stress. Neurobiology of aging, 40:181-90. (SCI, NEUROSCIENCES 42/252).

2.           Hung FC, Shih HY, Cheng YC, Chao CC. (2015, Dec). Growth-Arrest-Specific 7 Gene Regulates Neural Crest Formation and Craniofacial Development in Zebrafish. Stem Cells and Development, 015 Dec 15;24(24):2943-51. (SCI).

3.           Yi-Chuan Cheng*, Yin-Cheng Huang, Tu-Hsueh Yeh, Hung-Yu Shih, Ching-Yu Lin, Sheng-Jia Lin, Ching-Chi Chiu, Ching-Wen Huang and Yun-Jin Jiang (2015, Dec). Deltex1 is inhibited by the Notch–Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Development, (2015) 10:28 (published online ahead of print). (SCI).

4.           Chiang MC, Cheng YC, Nicol CJ, Lin KH, Yen CH, Chen SJ, Huang RN. (2015, Nov). Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells. Experimental Cell Research, 2015 Nov 1;338(2):183-93. (SCI, 86/211, ONCOLOGY).

5.           Chung MM, Chen YL, Pei D, Cheng YC, Sun B, Nicol CJ, Yen CH, Chen HM, Liang YJ, Chiang MC (2015, May). The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPKdependent. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1852(5), 720-31. (SCI, Biochimstry and Molecular Biology (54/291)).

6.           Cheng YC*, Chiang MC, Shih HY, Ma TL, Yeh TH, Huang YC, Lin CY, Lin SJ. (2015, Jan). The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis. Developmental Biology, 397(1), 116-28. (SCI, Developmental Biology (9/41)). CMRPD170511-170513

7.           Huang YC, Shih HY, Lin SJ, Chiu CC, Ma TL, Yeh TH, Cheng YC*. (2015, May). The epigenetic factor Kmt2a/Mll1 regulates neural progenitor proliferation and neuronal and glial differentiation. Developmental Neurobiology, 75(5):452-62. (SCI, Developmental Biology (7/41)).

8.           Chiang MC, Cheng YC, Chen HM, Liang YJ, Yen CH. (2014, Jan). Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway. Mitochondrion, 14(1):7-17. (SCI, 42/161, Genetics & Heredity).

9.           Chen SY, Shih HY, Lin SJ, Hsiao CD, Li ZC, Cheng YC*. (2013, Dec). Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science, 126:5626-34. (SCI, 38/185, Cell Biology).

10.         Yeh CW, Kao SH, Cheng YC, Hsu LS. (2013, Sep). Knockdown of cyclin dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression. Journal of Biological Chemistry, 288(39):27927-39. (SCI, 62/290, Biochemistry & Molecular Biology).

11.         Hsieh FY, Ma TL, Shih HY, Lin SJ, Huang CW, Wang HY, Cheng YC* (2013, Mar). Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish. Developmental Biology, 375(1), 1-12. (SCI, 7/40, Developmental Biology).

12.         YL Lin, YJ Tsai, YF Liu, YC Cheng, CM Hung, YJ Lee, HC Pan, C Li (2013, Mar). The critical role of protein arginine methyltransferase prmt8 in zebrafish embryonic and neural development is non-redundant with its paralogue prmt1. PLoS ONE, 8(3), e55221. (SCI, 12/85, Biology).

13.         Cheng YC*, Hsieh FY, Chiang MC, Scotting PJ, Shih HY, Lin SJ, Wu HL, Lee HT (2013, Jan). Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with Notch signaling. PLoS ONE, 8(1):e54262. (SCI, 12/85, Biology).

14.         Chiang MC, Cheng YC, Lin KH, Yen CH (2013, Jan). PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha. Neuroscience, 229, 118–129. (SCI, 94/224, Neurosciences).

15.         Hung FC, Cheng YC, Sun NK, Chao CC (2013, Jan). Identification and functional characterization of zebrafish Gas7 gene in early development. Journal of Neuroscience Research, 91(1), 51-61. (SCI, 123/244, Neurosciences).

16.         Cheng YC*, Scotting PJ, Hsu LS, Lin SJ, Shih HY, Hsieh FY, Wu HL, Tsao CL, Shen CJ. (2012, Oct). Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling. Cellular and Molecular Life Sciences, 70(5), 935-950. (SCI, 33/181, Cell Biology).

17.         Hsu SY, Cheng YC, Shih HY, Ouyang P (2012, Jul). Dissection of the role of Pinin in the development of zebrafish posterior pharyngeal cartilages. Histochemistry and Cell Biology, 138(1), p127-40. (SCI, 2/10, Microscopy).

18.         Chiang MC, Lin H, Cheng YC, Yen CH, Huang RN, Lin KH (2012, Jun). Betaadrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system. Journal of Neuroscience Methods, 207(2), p130-6. (SCI, 175/244, Neurosciences).

19.         Chang MY, Lu JK, Tian YC, Chen YC, Hung CC, Huang YH, Chen YH, Wu MS, Yang CW, Cheng YC* (2011, Sep). Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD. Journal of the American Society of Nephrology, 22(9), 1696-1706. (SCI, 1/73, Urology and Nephrology).

20.         Chung PC, Lin WS, Scotting PJ, Hsieh FY, Wu HL, Cheng YC* (2011, Apr). Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis. PLoS One, 6(4), e19394. (SCI, 12/85, Biology).

 

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