楊光華

楊光華(Guang-Huar Young)

職稱

助理教授

楊光華老師

最高學歷

國立台灣大學微生物與生化學研究所 博士

E-mail

D000019047@cgu.edu.tw;

r6623612@ms24.hinet.net

電話：

+886-3-211-8800 ext.3812

傳真

+886-3-211-8700

實驗室

專長

生物化學、腎臟學

研究方向及研究室特色

台灣邁入超高齡化社會後，國人在腎臟疾病的醫療支出始終高居不下，腎臟疾病防治成為我國主要的公共衛生挑戰之一。

腎元是腎臟結構的基本單位，由腎小體與腎小管共同組成，負責調節血液物質的再吸收及尿液排除。成年後的腎元缺乏再生及分化的能力，因而年齡增長將伴隨著腎臟過濾功能逐年下降，而腎臟若發生損傷，會加速慢性腎病的進程而難以挽回。

本實驗室致力於腎臟損傷後的轉譯醫學，整合從基礎到臨床的研究，開發有效的早期預測及治療手段，希望能提升國人的健康福祉。

現階段主要的研究方向如下：

1. 腎臟損傷後的早期預測及藥物治療。

2. 調節嘌呤補救途徑延緩糖尿病腎病變。

論文與著作
  1. Jui-Yung Yang , Cha-Chun Chen, Shun-Cheng Chang, Jiun-Ting Yeh, Hui-Fu Huang, Hwang-Chi Lin, Shang-Hsi Lin, Yu-Hsien Lin, Lin-Gwei Wei, Tom J Liu, Shih-Yuan Hung, Hui-Mei Yang, Hui-Hsiu Chang, Chih-Hsin Wang, Yuan-Sheng Tzeng, Chieh-Huei Huang, Chang-Yi Chou, Ying-Sheng Lin, Shih-Yi Yang, Han-Min Chen, Jiun-Tsai Lin, Yi-Fang Cheng, Guang-Huar Young, Chun-Fang Huang, Ya-Chun Kuo, Niann-Tzyy Dai. EClinicalMedicine. 2022 Jul 10;51:101497. ENERGI-F703 gel, as a new topical treatment for diabetic foot and leg ulcers: A multicenter, randomized, double-blind, phase II trial. (SCI)
  2. Guang-Huar Young, Jiun-Tsai Lin, Yi-Fang Cheng, Chia-Fang Ho, Qian-Yu Kuok, Ru-Chun Hsu, Wan-Rou Liao, Chin-Chen Chen, and Han-Min Chen. FASEB J.  2021 Mar; 35(3): e21296. Modulation of adenine phosphoribosyltransferase-mediated salvage pathway to accelerate diabetic wound healing. (SCI)
  3. Huang-Ming Chang, Kang-Yung Peng, Chieh-Kai Chan , Chiao-Yin Sun , Ying-Ying Chen , Han-Mei Chang, Chun-Lin Huang , Pei-Chun Liu , Peng-Ying Chen , Kuo-Chuan Wang, Wei-Jie Wang , Chen-Chi Wu, Yu-Feng Lin, Tai-Shuan Lai , Tao-Min Huang , Guang-Huar Young, Shuei-Liong Lin, Marlies Ostermann, Tzong-Shinn Chu, Jeff S Chueh , Vin-Cent Wu. Cell Death & Disease. 2021 Apr 17;12(5):409. FGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling. (SCI)
  4. Guang-Huar Young, Sung-Chun Tang, Vin-Cent Wu, Kuo-Chuan Wang, Jing-Yi Nong, Po-Yuan Huang, Chaur-Jong Hu, Hung-Yi Chiou, Jiann-Shing Jeng, Chung Y Hsu. The functional role of hemojuvelin in acute ischemic stroke. J Cereb Blood Flow Metab.  2020 Jun; 40(6):1316-1327.  (SCI)
  5. Tzong-Ta Wu, Chin-Chen Chen, Jiun-Tsai Lin, Guang-Huar Young, Hsin-Chieh Wang, Han-Min Chen. The anti-inflammatory function of adenine occurs through AMPK activation and its downstream transcriptional regulation in THP-1 cells. Biosci Biotechnol Biochem. 2019 Dec; 83(12):2220-2229. (SCI)
  6. Wen-Ching Shen, Chan-Jung Liang, Tao-Ming Huang, Chen-Wei Liu, Shu-Huei Wang, Guang-Huar Young, Jaw-Shiun Tsai, Ying-Chin Tseng, Yu-Sen Peng, Vin-Cent Wu, Yuh-Lien Chen. Archives of Toxicology.  2016 (90) 2779–2792. Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway. (SCI)
  7. Guang-Huar Young, Jiun-Tsai Lin, Yi-Fang Cheng, Chun-Fang Huang, Cheng-Yu Chao, Jing-Yi Nong, Po-Ku Chen and Han-Min Chen, Journal of Proteomics 2015 Apr 29;120:204-14. Identification of Adenine modulating AMPK activation in NIH/3T3 cells by Proteomic Approach. (SCI)
  8. Yi-Fang Cheng*, Guang-Huar Young*, Jiun-Tsai Lin, Hyun-Hwa Jang, Chin-Chen Chen, Jing-Yi Nong, Po-Ku Chen, Cheng-Yi Kuo, Shao-Hsuan Kao, Yao-Jen Liang, Han-Min Chen.  PLoS One.  2015 Nov 6;10(11):e0142283. Activation of AMP-activated protein kinase by adenine alleviates TNF-alpha-induced inflammation in human umbilical vein endothelial cells. (SCI)
  9. Yi-Fang Cheng, Guang-Huar Young, Tsu-Man Chiu, Jiun-Tsai Lin, Pei-Ru Huang, Cheng-Yi Kuo, Yao-Jen Liang, Po-Ku Chen, Sung-Fang Chen, Ching-Yi Cheng, Han-Min Chen. Experimental Dermatology. 2016 Feb; 25(2):162-4. doi: 10.1111/exd.12881. Adenine supplement delays senescence in cultured human follicle dermal papilla cells.  (SCI)
  10. Guang-Huar Young, Tao-Min Huang, Che-Hsiung Wu ,Chun-Fu Lai, Chun-Cheng Hou, Kang-Yung Peng, Chan-Jung Liang, Shuei-Liong Lin, Shih-Chung Chang, Pi-Ru Tsai, Kwan-Dun Wu, Vin-Cent Wu*, Wen-Je Ko*, the NSARF group. Antioxidants & Redox Signaling.2014 Mar 10;20 (8):1181-94. Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor. (SCI).
  11. Chiao-Yin Sun, Guang-Huar Young, Yu-Ting Hsieh, Yau-Hung Chen, Mai-Szu Wu, Jia-Hung Lee, Chin-Chan Lee. Journal of the American Society of Nephrology. 2015 Feb;26(2):281-90. Protein-bound uremic toxins induce tissue remodeling by targeting epidermal growth factor receptor. (SCI)
  12. Chun-Fu Lai, Shuei-Liong Lin, Wen-Chih Chiang, Yung-Ming Chen, Vin-Cent Wu, Guang-Huar Young, Wen-Je Ko, Min-Liang Kuo, Tun-Jun Tsai, and Kwan-Dun Wu. The American Journal of Physiology-Renal Physiology.  2014 Jun 11. pii: ajprenal.00670.2013. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. (SCI)
  13. Chan-Jung Liang, Wen-Ching Shen, Fu-Bing Chang, Vin-Cent Wu, Shu-Huei Wang, Guang-Huar Young, Jaw-Shiun Tsai, Ying-Chin Tseng, Yu-Sen Peng, Yuh-Lien Chen. Cell Transplantation. 2015;24(7):1363-77. Endothelial progenitor cells derived from Wharton's jelly of human umbilical cord attenuate ischemic acute kidney injury by increasing vascularization and decreasing apoptosis, inflammation, and fibrosis.  (SCI)
  14. Vin-Cent Wu, Cho-Kai Wu, Yi-Cheng Chang, Guang-Huar Young, Shann-Ching Chen, Wei-Shiung Yang, Chien-Yuan Chen, Wei-Jie Wang, Chien-Yu Lin, Yen-Hung Lin, Shuei-Liong Lin, Shih-Chieh Chueh, Kwan-Dun Wu,TAIPAI study group. Journal of Hypertension 2013 July 31(7):1396-1405. Association of the variations in the HSD3[beta] gene with primary aldosteronism. (SCI)
  15. Vin-Cent Wu*, Guang-Huar Young*, Po-Hsun Huang, Shyh-Chyi Lo, Kuo-Chuan Wang, Chiao-Yin Sun, Chan-Jung Liang, Tao-Ming Huang, Jou-Han Chen, Fan-Chi Chang, Yuh-Lien Chen, Yih-Shing Kuo, Jin-Bor Chen, Jaw-Wen Chen, Yung-Ming Chen, Wen-Jo Ko, Kwan-Dun Wu. Angiogenesis, 2013 Jul;16(3):609-24. In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin. (SCI)
  16. Wen-Ching Shen, Chan-Jung Liang, Vin-Cent Wu, Shu-Huei Wang, Guang-Huar Young, I-Rue Lai, Chung-Liang Chien, Seu-Mei Wang, Kwan-Dun Wu, and Yuh-Lien Chen. Stem Cells and Development. 2013 May 1;22(9):1408-18. Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression. (SCI)
  17. Chih-Chung Shiao, Wen-Je Ko, Vin-Cent Wu, Tao-Min Huang, Chun-Fu Lai, Yu-Feng Lin, Chia-Ter Chao, Tzong-Shinn Chu, Hung-Bin Tsai, Pei-Chen Wu, Guang-Huar Young, Tze-Wah Kao, Jenq-Wen Huang, Yung-Ming Chen, Shuei-Liong Lin, Ming-Shou Wu, Pi-Ru Tsai, Kwan-Dun Wu, Ming-Jiuh Wang. PLoS One 2012, Aug 7(8):e42952. U-Curve Association between Timing of Renal Replacement Therapy Initiation and In-Hospital Mortality in Postoperative Acute Kidney Injury. (SCI)
  18. Guang-Huar Young and Vin-Cent Wu (2012, Apr). Kidney International 2012 Apr;81(7):611-2. KLOTHO methylation is linked to uremic toxins and chronic kidney disease. (SCI)
  19. Yi-Chen Lin, Han-Min Chen, I-Min Chou, An-Na Chen, Chia-Pei Chen, Guang-Huar Young, Chi-Tsai Lin, Chiung-Hsiang Cheng, Shih-Chung Chang, Rong-Huay Juang (2012, Apr). PLoS One 2012, 7:e35336. Plastidial Starch Phosphorylase in Sweet Potato Roots Is Proteolytically Modified by Protein-Protein Interaction with the 20S Proteasome. (SCI)
  20. Vin-Cent Wu, Chun-Fu Lai, Chih-Chung Shiao, Yu-Feng Lin, Pei-Chen Wu, Chia-Ter Chao, Fu- Chang Hu, Tao-Min Huang, Yu-Chang Yeh, I-Jung Tsai, Tze-Wah Kao, Yin-Yi Han, Wen-Chung Wu,Chun-Cheng Hou, Guang-Huar Young, Wen-Je Ko, Tun-Jun Tsai, Kwan-Dun Wu. PLoS One 2012 Mar 7:e30836. Effect of Diuretic Use on 30-Day Postdialysis Mortality in Critically Ill Patients Receiving Acute Dialysis. (SCI)
  21. Vin-Cent Wu, Tao-Min Huang, Pei-Chen Wu, Wei-Jie Wang, Chia-Ter Chao, Shao-Yu Yang, Chih- Chung Shiao, Fu-Chang Hu, Chun-Fu Lai, Yu-Feng Lin, Yin-Yi Han, Yih-Sharng Chen, Ron-Bin Hsu, Guang-Huar Young, Shoei-Shen Wang, Pi-Ru Tsai, Yung-Ming Chen, Ting-Ting Chao, Wen-Je Ko, Kwan-Dun Wu, the NSARF Group. PLoS One 2012 Jan 7:e27687. Preoperative Proteinuria Is Associated with Long-Term Progression to Chronic Dialysis and Mortality after Coronary Artery Bypass Grafting Surgery. (SCI)
  22. Vin-Cent Wu, Tao-Min Huang, Chun-Fu Lai, Chih-Chung Shiao, Yu-Feng Lin, Tzong-Shinn Chu,Pei-Chen Wu, Chia-Ter Chao, Jann-Yuan Wang, Tze-Wah Kao, Guang-Huar Young, Pi-Ru Tsai,Hung-Bin Tsai, Chieh-Li Wang, Ming-Shou Wu, Wen-Chih Chiang, I-Jung Tsai, Fu-Chang Hu, Shuei-Liong Lin, Yung-Ming Chen, Tun-Jun Tsai, Wen-Je Ko and Kwan-Dun Wu, on behalf of the NSARF Group  Kidney International 2011 Aug 7:e27687. Acute-on-chronic kidney injury at hospital discharge is associated with long-term dialysis and mortality. (SCI)
  23. Yu-Hsiang Chou, Tao-Min Huang, Vin-Cent Wu, Cheng-Yi Wang, Chih-Chung Shiao, Chun-Fu Lai, Hung-Bin Tsai, Chia-Ter Chao, Guang-Huar Young, Wei-Jei Wang, Tze-Wah Kao, Shuei-Liong Lin, Yin-Yi Han, Anne Chou, Tzu-Hsin Lin, Ya-Wen Yang, Yung-Ming Chen, Pi-Ru Tsai, Yu-Feng Lin, Jenq-Wen Huang, Wen-Chih Chiang, Nai-Kuan Chou, Wen-Je Ko, Kwan-Dun Wu, Tun-Jun Tsai1 and the NSARF Study Group. Critical Care 2011 Jun 15: R134. Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury. (SCI)
  24. Tao-Min Huang*, Vin-Cent Wu*, Guang-Huar Young, Yu-Feng Lin, Chih-Chung Shiao, Pei-Chen Wu, Wen-Yi Li, Hsi-Yu Yu, Fu-Chang Hu, Jou-Wei Lin, Yih-Sharng Chen, Yen-Hung Lin, Shoei-Shen Wang, Ron-Bin Hsu, Fan-Chi Chang, Nai-Kuan Chou, Tzong-Shinn Chu, Yu-Chang Yeh, Pi-Ru Tsai, Jenq-Wen Huang, Shuei-Liong Lin, Yung-Ming Chen, Wen-Je Ko and Kwan-Dun Wu. Journal of the American Society of Nephrology 2010 Nov 22(1):156-63. Preoperative Proteinuria Predicts Adverse Renal Outcomes after Coronary Artery Bypass Grafting. (SCI)
  25. Chih-Chung Shiao, Vin-Cent Wu, Wen-Yi Li, Yu-Feng Lin, Fu-Chang Hu, Guang-Huar Young. Chin-Chi Kuo, Tze-Wah Kao, Down-Ming Huang, Yung-Ming Chen, Pi-Ru Tsai, Shuei-Liong Lin, Nai-Kuan Chou, Tzu-Hsin Lin, Yu-Chang Yeh, Chih-Hsien Wang, Anne Chou, Wen-Je Ko, Kwan-Dun Wu. Critical Care 2009 Oct 13(5): R171. Late initiation of renal replacement therapy is associated with worse outcomes in acute kidney injury after major abdominal surgery. (SCI)
  26. Guang-Huar Young, Han-Min Chen, Chi-Tsai Lin, Kuang-Ching Tseng, Jiann-Shing Wu, Rong-Huay Juang. Planta 2006 Feb 223:468-478. Site-specific phosphorylation of L-form starch phosphorylase by the protein kinase activity from sweet potato roots. (SCI).