Mei-Ling Cheng

Mei-Ling Cheng




University/NationNational Taiwan University, Taiwan

Tel886-3-211-8800 ext.3811、3650

Research website

Research interests

1. Oxidative stress and cell metabolism

2. Study the role of oxidative stress on degenerative diseases

3. LC/MS-based Metabolomic approach for degenerative disease study

Publications :

  1. Hsu SC, Chen CL, Cheng ML, Chu CY, Changou CA, Yu YL, Yeh SD, Kuo TC, Kuo CC, Chuu CP, Li CF, Wang LH, Chen HW, Yen Y, Ann DK, Wang HJ, Kung HJ. (2021) Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes. Theranostics 11(15): 7527-7545.
  2. Ma H, Zhang F, Zhou L, Cao T, Sun D, Wen S, Zhu J, Xiong Z, Tsau MT, Cheng ML, Hung LM, Zhou Y, Li Q. (2021) c-Src facilitates tumorigenesis by phosphorylating and activating G6PD. Oncogene 40(14): 2567-2580.
  3. Huang YC, Cheng ML, Tang HY, Huang CY, Chen KM, Wang JS. (2021) Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis. Antioxidants 10(2): 285.
  4. Tsai HI, Lo CJ, Lee CW, Lin JR, Lee WC, Ho HY, Tsai CY, Cheng ML*, Yu HP. (2021) A panel of biomarkers in the prediction for early allograft dysfunction and mortality after living donor liver transplantation. American Journal of Translational Research 13(1): 372-382. (*Correspondent Author)
  5. Cheng CW, Liu MH, Tang HY, Cheng ML, Wang CH. (2021) Factors associated with elevated plasma phenylalanine in patients with heart failure. Amino Acids 53(2): 149-157.
  6. Lo CJ, Ko YS, Chang SW, Tang HY, Huang CY, Huang YC, Ho HY, Lin CM, Cheng ML. (2020) Metabolic signatures of muscle mass loss in an elderly Taiwanese population. Aging 13(1):944-956.
  7. Tang HY, Wang CH, Ho HY, Lin JF, Lo CJ, Huang CY, Cheng ML. (2020) Characteristic of Metabolic Status in Heart Failure and Its Impact in Outcome Perspective. Metabolites 10(11): E437.
  8. Chen WS, Liu MH, Cheng ML, Wang CH. (2020) Decreases in Circulating Concentrations of Short-Chain Acylcarnitines are Associated with Systolic Function Improvement After Decompensated Heart Failure. International Heart Journal 61(5):1014-1021.
  9. Huang JP, Cheng ML, Wang CH, Huang SS, Hsieh PS, Chang CC, Kuo CY, Chen KH, Hung LM. (2020) Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat. Pharmacological Research 160: 105201.
  10.  Chang-Chien J, Huang HY, Tsai HJ, Lo CJ, Lin WC, Tseng YL, Wang SL, Ho HY, Cheng ML*, Yao TC. (2020) Metabolomic differences of exhaled breath condensate among children with and without asthma. Pediatric Allergy and Immunology. (*Correspondent Author)
  11. Liang KH, Cheng ML#, Lo CJ, Lin YH, Lai MW, Lin WR, Yeh CT. (2020) Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study. Scientific Reports 10(1):10926. (# Co-first author paper)
  12. Chiu CY, Cheng ML, Chiang MH, Wang CJ, Tsai MH, Lin G. (2020) Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma. Journal of Clinical Medicine 9(3): E887.
  13. Ma H, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM, Cheng ML*, Li Q. (2020) c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3. Cell Reports 30(12): 4235-4249. (*Correspondent Author)
  14. Cheng ML, Chien KY, Lai CH, Li GJ, Lin JF, Ho HY. (2020) Metabolic Reprogramming of Host Cells in Response to Enteroviral Infection. Cells 9(2): E473.
  15. Weng WC, Huang WY, Tang HY, Cheng ML, Chen KH. (2019) The Differences of Serum Metabolites Between Patients With Early-Stage Alzheimer's Disease and Mild Cognitive Impairment. Frontiers in Neurology 10: 1223.
  16. Cheng SC, Chen K, Chiu CY, Lu KY, Lu HY, Chiang MH, Tsai CK, Lo CJ, Cheng ML, Chang TC, Lin G. (2019) Metabolomic biomarkers in cervicovaginal fluid for detecting endometrial cancer through nuclear magnetic resonance spectroscopy. Metabolomics 15(11): 146.
  17. Lin HT, Cheng ML#, Lo CJ, Lin G, Lin SF, Yeh JT, Ho HY, Lin JR, Liu FC. (2019) 1H Nuclear Magnetic Resonance (NMR)-Based Cerebrospinal Fluid and Plasma Metabolomic Analysis in Type 2 Diabetic Patients and Risk Prediction for Diabetic Microangiopathy. Journal of Clinical Medicine 8(6): E874. (# Co-first author paper)
  18. Wang CH, Cheng ML, Liu MH, Fu TC. (2019) Amino Acid-Based Metabolic Profile Provides Functional Assessment and Prognostic Value for Heart Failure Outpatients. Disease Markers 2019: 8632726.
  19. Lee TH, Cheng ML, Shiao MS, Lin CN. (2019) Metabolomics study in severe extracranial carotid artery stenosis. BMC Neurology 19(1): 138.
  20. Chiu CY, Cheng ML, Chiang MH, Kuo YL, Tsai MH, Chiu CC, Lin G. (2019) Gut microbial-derived butyrate is inversely associated with IgE responses to allergens in childhood asthma. Pediatric Allergy and Immunology 30(7): 689-697.
  21. Huang SS, Lin JY, Chen WS, Liu MH, Cheng CW, Cheng ML, Wang CH. (2019) Phenylalanine and leucine-defined metabolic types identify high mortality risk in patients with severe infection. International Journal of Infectious Diseases 85: 143-149.
  22. Hung CY, Yeh TS, Tsai CK, Wu RC, Lai YC, Chiang MH, Lu KY, Lin CN, Cheng ML, Lin G. (2019) Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis. World Journal of Gastrointestinal Oncology 11(3):181-194.
  23. Yang CH, Liang CT, Jiang ST, Chen KH, Yang CC, Cheng ML, Ho HY. (2019) A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor Is Highly Susceptible to Oral Infection with Clinical Isolates of Enterovirus 71. Journal of Virology 93(11):e00183-19.
  24. Chiu CY, Cheng ML, Wong KS, Lai SH, Chiang MH, Tsai MH, Lin G. (2019) Metabolomics Reveals Anaerobic Bacterial Fermentation and Hypoxanthine Accumulation for Fibrinous Pleural Effusions in Children with Pneumonia. Journal of proteome research 18(3):1248-1254.
  25. Cheng ML, Lin JF, Huang CY, Li GJ, Shih LM, Chiu DT, Ho HY. (2019) Sedoheptulose-1,7-bisphospate Accumulation and Metabolic Anomalies in Hepatoma Cells Exposed to Oxidative Stress. Oxidative Medicine and Cellular Longevity 2019:5913635.
  26. Chen IC, Chang CN, Chen WL, Lin TH, Chao CY, Lin CH, Lin HY, Cheng ML, Chiang MC, Lin JY, Wu YR, Lee-Chen GJ, Chen CM. (2019) Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3. The American Journal of Chinese Medicine 47(1): 63-95.
  27. Lynn KS, Cheng ML, Yang HC, Liang YJ, Kang MJ, Chen FL, Shiao MS, Pan WH. (2019) Vegetable signatures derived from human urinary metabolomic data in controlled feeding studies. Journal of proteome research 18(1): 159-168.
  28. Tsai HI, Lo CJ, Zheng CW, Lee CW, Lee WC, Lin JR, Shiao MS, Cheng ML*, Yu HP. (2018) A Lipidomics Study Reveals Lipid Signatures Associated with Early Allograft Dysfunction in Living Donor Liver Transplantation. Journal of clinical medicine 8(1):E30. (*Correspondent Author)
  29. Lo CJ, Tang HY, Huang CY, Lin CM, Ho HY, Shiao MS, Cheng ML. (2018) Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese. Journal of clinical medicine 8(1):E13.
  30. Wang CH, Cheng ML, Liu MH. (2018) Amino Acid-Based Metabolic Panel Provides Robust Prognostic Value Additive to B-Natriuretic Peptide and Traditional Risk Factors in Heart Failure. Disease Markers 2018:3784589.
  31. Shih LM, Tang HY, Lynn KS, Huang CY, Ho HY, Cheng ML. (2018) Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity. Molecules 23(11):E2862.
  32. Wang CH, Cheng ML, Liu MH. (2018) Simplified plasma essential amino acid-based profiling provides metabolic information and prognostic value additive to traditional risk factors in heart failure. Amino Acids 50(12):1739-1748.
  33. Tsai CK, Yeh TS, Wu RC, Lai YC, Chiang MH, Lu KY, Hung CY, Ho HY, Cheng ML, Lin G. (2018) Metabolomic alterations and chromosomal instability status in gastric cancer. World Journal of Gastroenterology 24(33):3760-3769.
  34. Lin WC, Chakraborty A, Huang SC, Wang PY, Hsieh YJ, Chien KY, Lee YH, Chang CC, Tang HY, Lin YT, Tung CS, Luo JD, Chen TW, Lin TY, Cheng ML, Chen YT, Yeh CT, Liu JL, Sung LY, Shiao MS, Yu JS, Chang YS, Pai LM. (2018) Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase. Cell Reports 24(10):2733-2745.
  35. Chung YH, Lu KY, Chiu SC, Lo CJ, Hung LM, Huang JP, Cheng ML, Wang CH, Tsai CK, Lin YC, Chang SH, Lin G. (2018) Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging 2018:8751267.
  36. Chen KH, Chen YL, Tang HY, Hung CC, Yen TH, Cheng ML, Shiao MS, Chen JK. (2018) Dietary Leucine Supplement Ameliorates Hepatic Steatosis and Diabetic Nephropathy in db/db Mice. International Journal of Molecular Sciences 19(7):E1921.
  37. Chang KH, Cheng ML, Chiang MC, Chen CM. (2018) Lipophilic antioxidants in neurodegenerative diseases. Clinica Chimica Acta 485:79-87.
  38. Chiu CY, Lin G, Cheng ML, Chiang MH, Tsai MH, Su KW, Hua MC, Liao SL, Lai SH, Yao TC, Yeh KW, Huang JL. (2018) Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood. Pediatric Allergy and Immunology 29(5): 496-503.
  39. Chang SW, Cheng ML, Shiao MS, Yeh CT, Wang CH, Fan CM, Chiu CT, Chang ML. (2018) Recovery of lipid metabolic alterations in hepatitis C patients after viral clearance: Incomplete restoration with accelerated ω-oxidation. Journal of Clinical Lipidology 12(3):756-766.
  40. Chang KH, Cheng ML#, Tang HY, Huang CY, Wu YR, Chen CM. (2018) Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson’s Disease. Molecular Neurobiology 55(8):6319-6328. (# Co-first author paper)
  41. Tang HY, Wang CH, Ho HY, Wu PT, Hung CL, Huang CY, Wu PR, Yeh YH, Cheng ML. (2018) Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. Redox Biology 14:499-508.
  42. Sun CY, Cheng ML, Pan HC, Lee JH, Lee CC. (2017) Protein-bound uremic toxins impaired mitochondrial dynamics and functions. Oncotarget 8(44):77722-77733.
  43. Cheng WH, Huang KY, Huang PJ, Lee CC, Yeh YM, Ku FM, Lin R, Cheng ML, Chiu CH, Tang P. (2017) γ-Carboxymuconolactone decarboxylase: a novel cell cycle-related basal body protein in the early branching eukaryote Trichomonas vaginalis. Parasites & Vectors 10(1):443.
  44. Chen SG, Leu YL, Cheng ML, Ting SC, Liu CC, Wang SD, Yang CH, Hung CY, Sakurai H, Chen KH, Ho HY. (2017) Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Scientific Reports 7(1):12264.
  45. Tang HY, Chiu DT, Lin JF, Huang CY, Chang KH, Lyu RK, Ro LS, Kuo HC, Cheng ML*, Chen CM. (2017) Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome. Scientific Reports 7(1):8140. ( *Correspondent Author)
  46. Lin YH, Wu MH, Huang YH, Yeh CT, Cheng ML, Chi HC, Tsai CY, Chung IH, Chen CY, Lin KH. (2017) Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma. Hepatology 67(1): 188-203.
  47. Wu HQ, Cheng ML#, Lai JM, Wu HH, Chen MC, Liu WH, Wu WH, Chang PM, Huang CF, Tsou AP, Shiao MS, Wang FS. (2017) Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a. PLOS Computational Biology 13(7):e1005618. (# Co-first author paper)
  48. Ho HY, Lin YT, Lin G, Wu PR,Cheng ML. (2017) Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation. Redox Biology 12:916-928.
  49. Tang HY, Ho HY, Chiu DT, Huang CY, Cheng ML*, Chen CM. (2017) Alterations of plasma concentrations of lipophilic antioxidants are associated with Guillain-Barre syndrome. Clinica Chimica Acta 470:75-80. (*Correspondent Author)
  50. Chen SG, Cheng ML, Chen KH, Horng JT, Liu CC, Wang SM, Sakurai H, Leu YL, Wang SD, Ho HY. (2017) Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Scientific Reports 7(1):935.
  51. Wang CH, Cheng ML, Liu MH, Kuo LT, Shiao MS. (2017) Metabolic profile provides prognostic value better than galectin-3 in patients with heart failure. Journal of Cardiology 70(1):92-98.
  52. Chen TL, Yang HC, Hung CY, Ou MH, Pan YY, Cheng ML, Stern A, Lo SJ, Chiu DT. (2017) Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Cell Death and Disease 8(1):e2545.
  53. Huang JP, Cheng ML, Hung CY, Wang CH, Hsieh PS, Shiao MS, Chen JK, Li DE, Hung LM. (2017) Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets. Journal of Diabetes 9(10):936-946.