陳鈴津 (Alice L. Yu, M.D., Ph.D.)

職稱：特聘講座教授暨副所長

研究室名稱：林口長庚紀念醫院 幹細胞與轉譯癌症研究所

最高學歷：M.D. / Ph.D. 微生物與免疫

學校/國家：台大醫科/美國芝加哥大學

分機號碼：03-3281200#5218

電子郵件帳號： aliceyu@cgmh.org.tw

個人網頁網址：http://www1.cgmh.org.tw/intr/intr2/c33a0/cgmh/homepage/e_stemcell_4.html

研究室現有： 博士後研究員   12人

博士班研究生    8人

碩士班研究生    0人

專任研究助理    5人

大學部專題生    0人

研究興趣：腫瘤免疫學與癌症免疫治療、腫瘤幹細胞生物學、轉譯醫學、臨床癌症學

研究方向：

陳鈴津教授長久以來對於轉譯醫學一直抱有熱忱，致力於聯繫基礎研究與臨床醫學間橋樑的工作。她尤其熱衷於以癌症特定分子之變化為標靶，發展小分子到生物製劑的新療法。陳教授已經在美國領導數個國際合作團隊之臨床試驗；身為GD2免疫標靶癌症治療之先驅，她所研究的抗GD2單株抗體歷經新藥申請、臨床試驗第一、二、三期的測試，最終結果證實此抗體在高風險神經母細胞瘤的治療成效上有顯著的改善。此結果也獲得美國食品與藥物管理署(FDA)於2015年3月10日核准此抗GD2單株抗體(學名dinutuximab)之上市。陳教授目前正積極研發可用於治療神經母細胞瘤、小細胞肺癌以及黑色素瘤等的類GD2抗體(anti-idiotype)，以及可用於治療高表現GloboH或Gb5的上皮細胞癌，如乳癌、肺癌、卵巢癌、胰臟癌等的GloboH疫苗。陳教授近年來的研究主要專注於醣質免疫學，尤其著重於探討醣脂質在腫瘤微環境之角色，以及探究新穎的乳癌幹細胞分子標誌，以協助癌症之早期診斷與發展嶄新療法。此外，陳教授亦致力於改善臨床試驗方案在設計與執行面之架構。

最近五年所發表論文：

Selected Recent Relevant Publications (Selected from 149 publications):

1.  Chang WW, Lee CH, Lee P… Wong CH*, Yu AL*. (2008) Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis. PNAS USA, 105(33): 11667-11672.

2.  Gilman AL, Ozkaynak MF, Matthay KK, Krailo M, Yu AL*, et al. (2009) Phase I study of ch14.18 with GM-CSF and IL-2 in Children with neuroblastoma following autologous bone marrow transplant or stem cell rescue: a report from the Children’s Oncology Group. J. Clin. Oncol., 27(1): 85-91.

3.  Yu AL*, Gilman AL, Ozkaynak MF, et al for the Children’s Oncology Group (COG). (2010) Anti-GD2 Antibody with GM-CSF, IL2 and Isotretinoin for Neuroblastoma. New Engl. J. Med., 363(14): 1324-1334.

4.  Sorkin LS*, Otto M, Baldwin III WM,… Yu AL*. (2010) Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain, 149(1): 135-142.

5.  Lin RJ, Lin YC, Yu AL*. (2010) miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells. Mol. Carcinogenesis, 49(8): 719-727.

6.  Lin RJ, Lin YC, Chen J,… Yu AL*. (2010) microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Ca. Res., 70(20): 7841-50.

7.  Wu TN, Lin KH, Chang YJ,… Yu AL*, Wong CH*. (2011) Avidity of CD1d-ligand-receptor ternary complex contributes to Th1 polarization and anticancer efficacy. PNAS USA, 108(42):17275-80.

8.  Lin HH, Li YC, Chang CH,… Yu AL*, Chen CH*. (2012) Single nuclei raman spectroscopy for drug evaluation. Anal. Chem., 84(1): 113-20.

9.  Matthay KK, Rani EG, Yu AL*. (2012) Promising therapeutic targets in neuroblastoma. Clin. Ca. Res., 18(10): 2740-53.

10. Chan YT, Lin YC, Lin RJ,… Yu AL*. (2013) Concordant and discordant regulation of target genes by miR-31 and its isoforms. PLoS ONE, 8(3): e58169.

11. Chang WW, Lin RJ, Yu J,… Yu AL*. (2013) The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors. Breast Ca. Res., 12;15(3):R39.

12. Chang BM, Lin HH, Su LJ… Yu AL*, Chang HC*. (2013)Highly fluorescent nanodiamonds protein-functionalized for cell labeling and targeting. Advanced Functional Materials, 23(46): 5737-45.

13. Tsai YC, Huang JR, Cheng JY,… Yu AL*. (2013) A prevalent cancer associated glycan, Globo H ceramide, induces immune-suppression by reducing Notch1 signaling. J. Ca. Sci. & Ther., 5: 264-270.

14. Terme M, Dorvillius M, Cochonneau D,… Yu AL, et al. (2013) Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects than therapeutic ch14.18 antibody to GD2 without induced allodynia. PLoS ONE, 9(2): e87210.

15. Barnhill LM, Williams RT, Cohen O, …, Yu AL*, Diccianni MB*. (2014) High Expression of CAI2, a 9p21-Embedded Long Noncoding RNA, Contributes to Advanced-Stage Neuroblastoma. Cancer Res., 74(14): 3753-3763.

16. Huang JR, Tsai YC,… Yu AL*. (2014) α-GalCer but not phenyl-glycolipids induced NKT cell anergy and IL-33 mediated MDSC accumulation via upregulation of egr2/3. J. Immunol., 192(4): 1972-81.

17. Lin JJ, Huang CS, Yu J,… Yu AL*. (2014) Malignant phyllodes tumors display mesenchymal stem cell features and ALDH/GD2 identify their tumor stem cells. Breast Ca. Res., 16: R29.

18. Lin JW, Chang YJ, Yang WB, Yu AL*, Wong CH*. (2014) The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes. PLoS ONE, 9(4): e94040.

19. Fu CH, Lin RJ, Yu J,… Yu AL*. (2014) SHIP2 plays an oncogenic role in breast cancer stem cells through JNK/vimentin activation and its phosphatase activity. Stem Cells, 32: 2048-60.

20. Hung JT, Tsai YC, Lin WD, … Wong CH*, Yu AL*. (2014) Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus. Antiviral Res., 107: 110-118.

21. Kelner MJ, Diccianni MB, Yu AL, Rutherford MR, Estes LA, Morgenstern R. (2014) Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue. Free Radic. Biol. Med., 69: 167-171.

22. Chang CH, Fan TC, Yu JC, … Yu AL*. (2014) The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer. J. Translational Medicine, 12: 257.

23. Cheng JY, Wang SH, Lin JW, … Yu AL*. (2014) Globo-H ceramide shed from cancer cells triggers translin-associated factor X-dependent angiogenesis. Cancer Res., 74: 6856-66.