Chia-Yu Yang

楊佳郁 (Chia-Yu Yang)

Appointments： Associate  Professor

Lab：Clinical Immunomics

Education：Ph.D.

School/Nation：National Defense Medical Center/Taiwan

Tel: 3527/3469

E-mail: chiayu-yang@mail.cgu.edu.tw

Research website:

  Research outline：

  1. Oral cavity squamous cell carcinomas (OSCC), the fourth most prevalent among males in Taiwan, is an aggressive tumor and is the most common malignancy in the oral cavity, representing up to 90% of all malignant neoplasms of the oral cavity. The highly recurrence rate and metastasis is still major problem for OSCC treatment. We previously identified and published the specific genetic signatures in OSCC patients from Taiwan using whole exome sequencing. Furthermore, we performed the RNA-seq analysis, quantitative reverse transcription polymerase chain reaction (RT-qPCR) assays, and immunohistochemistry (IHC) staining of tumor tissues and adjacent non-tumor tissues from OSCC patients for characterization and validation of the potential dysregulated genes and proteins in oral cancer. Thus, development of target therapy with precision medicine for OSCC are urgent need. Also, no useful genetic biomarkers are reliable for OSCC patient selection. Patient-derived oral cancer xenografts (PDX) maintain the molecular, genetic and histological features of origin patients’ tumor through serial passaging in mice. The PDX models can provide a more-relevant system to test clinically directed questions. Our lab established and characterized the histopathological features and genomics signatures in paired primary tumor and xenografts. We intend to clarify the useful biomarkers for predicating drug response and mechanisms in oral cancer.
  2. Parapneumonic effusion (PPE), which occurs approximately in 40% of pneumonia patients, is an accumulation of exudative pleural fluid associated with the pulmonary infection. The morbidity and mortality of pneumonia increase when the patient presents with the PPE, because this stage correlates with more-advanced pneumonia. Based on fluid characteristics, PPEs are classified as uncomplicated parapneumonic effusions (UPPE), complicated parapneumonic effusions (CPPE), or empyema. The pneumonia patients with empyema have a 50% mortality rate. A number of potential immune-related proteins have been evaluated in our lab. We aim to identify potential biosignatures to aid in distinguishing different stages and predicating outcomes of PPE.
  3. The high-throughput sequencing technology is becoming a dominant platform for the study of microbial population genomics. With this culture-free and cost-effective technique, researchers can combine multiple samples in a single sequencing run, studying taxonomic composition of samples from environments, complex microbiomes or clinical specimen. The variable regions of bacteria 16S rRNA are frequently used in phylogenetic classifications to identify genera or species. High-throughput 16S rRNA sequencing technology provides more comprehensive bacteria profiling for revealing hundreds of bacteria in clinical samples, which can facilitate the discovery of bacteria biomarkers. Our lab established the microbiome sequencing platform and bioinformatics tools for identifying the microbiome community in various clinical samples such as saliva, sputum, and stool. We aim to identify the correlation of microbiome and disease progression.

Publications:

  1. Yang CY*, Chiu LL*, Tan TH. (2016) TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cellular Signalling, 28, 145-151. (*These authors contributed equally to this study) (IF=4.191, 65/184 in CELL BIOLOGY)
  2. Wu KA, Wu CC, Chen CD, Chu CM, Shih LJ, Liu YC, Wang CL, Lin HH#, Yang CY#. (2017) Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions. Scientific Reports 7(4026):1-10. (IF=4.259, 10/64 in MULTIDISCIPLINARY SCIENCES)
  3. Chen TW, Lee CC, Liu H, Wu CS, Pickering CR, Huang PJ, Wang J, Chang YF, Yeh YM, Chen CD, Li HP, Luo JD, Tan BC, Chan EH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW, See LC, Tang P, Yu JS, Liao WC, Chiang KW, Rodriguez H, Myers JN, Chang KP, Chang YS. (2017) APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. Nature Communications 8(1):465. (IF=12.124, 3/64 in MULTIDISCIPLINARY SCIENCES)
  4. Wu SM, Liu H, Huang PJ, Chang IY, Lee CC, Yang CY, Tsai WS, Tan BC. (2018) circlncRNAnet: an integrated web-based resource for mapping functional networks of long or circular forms of noncoding RNAs. GigaScience. 7(1):1-10. (IF=6.871, 6/64 in MULTIDISCIPLINARY SCIENCES)
  5. Yang CY, Yeh YM, Yu HF, Chin CY, Hsu CW, Liu H, Huang PJ, Hu SN, Liao CT, Chang KP, Chang YL. (2018). Oral microbiota community dynamics associated with Oral Squamous Cell Carcinoma staging. Frontiers in Microbiology, 9:1-15. (IF=4.076, 26/125 in Microbiology).
  6. Huang PJ, Lee CC, Chiu LY, Huang KY, YM Yeh, Yang CY, Chiu CH, Tang P. (2018). VAReporter: variant reporter for cancer research of massive parallel sequencing. BMC Genomics, 19(suppl2):86. (IF=3.729, 35/160 in Biotechnology & Applied Microbiology).
  7. Yang CY*, Chiu LL*, Chang CC*, Chuang HC, Tan TH. (2018) Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation. THE FASEB Journal, 32(12) 6760-6770. (*These authors contributed equally to this study) (IF= 5.391, 46/299 in Biochemistry & Molecular Biology)
  8. Lin HJ, Jiang ZP, Lo HR, Feng CL, Chen CJ, Yang CY, Huang MZ, Wu HY, Chen YA, Chen Y, Chiu CH, Lai CH. (2019) Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation. Frontiers in Immunology. 10: 109 (IF= 5.085, 38/158 in Immunology)
  9. Wang LJ, Yang CY, Chou WJ, Lee MJ, Chou MC, Kuo HC, Yeh YM, Lee SY, Huang LH, Li SC. (2019) Gut microbiota and dietary patterns in children with attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry, 29(3):287-297. (IF= 3.941, 8/128 in Psychiatry)
  10. Wu KA, Wu CC, Liu YC, Hsueh PC, Chin CY, Wan CL, Chu CM, Shih LJ, Yang CY#. (2019) Combined serum biomarkers in the noninvasive diagnosis of complicated parapneumonic effusions and empyema. BMC Pulmonary Medicine, 19(1):108 (IF= 2.813, 27/64 in Respiratory system)
  11. Wu SM, Tsai WS, Chiang SF, Lai YH, Ma CP, Wang JH, Lin J, Lu PS, Yang CY, Tan CM, Liu H. (2020) Comprehensive transcriptome profiling of Taiwanese colorectal cancer implicates an ethnic basis for pathogenesis. Scientific Reports, 10(1):4526 (IF=3.998, 17/71 in Multidisciplinary sciences)
  12. Yang CY, Liu CR, Chang YF, OuYang CN, Hsieh CH, Huang YL, Wang CI, Jan FW, Wang WL, Tsai TL, Liu H, Tseng CP, Chang YS, Wu CC, Chang KP. (2020) Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts. Cancers, 12(7):1726 (IF= 6.126, 37/244 in Oncology)
  13. Chen YW, Huang MZ, Chen CL, Kuo CY, Yang CY, Chuan NC, Chen YY, Hsieh CM, Wu HY, Kuo ML, Chiu CH, Lai CH. (2020) PM 2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Particle and Fibre Toxicology, 17(1):37 (IF= 7.546, 3/92 in Toxicology)
  14. Yang CY*, Chuang HC*, Tsai CY, Xiao YZ, Yang JY, Huang RH, Shih YC, Tan TH. (2020) DUSP11 Attenuates Lipopolysaccharide-Induced Macrophage Activation by Targeting TAK1. The Journal of Immunology, 205(6): 1644–1652 (*These authors contributed equally to this study) (IF= 4.886, 44/158 in Immunology)
  15. Hsueh PC, Wu KA, Yang CY, Hsu CW, Wang CL, Hung CM, Chen YT, Yu JS, Wu CC. (2020) Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Analytica Chimica Acta. 1128: 238-250 (IF= 5.977, 10/86 in Chemistry, Analytical)
  16. Lin CY, Lin CY, Yeh YM, Yang LY, Lee YS, Chao A, Chin CY, Chao AS* & Yang CY*. (2020) Severe preeclampsia is associated with a higher relative abundance of Prevotella bivia in the vaginal microbiota. Scientific Reports. 18249 (*corresponding author) (IF=3.998, 17/71 in Multidisciplinary sciences)
  17. Chen YW, Li SW, Lin CD, Huang MZ, Lin HJ, Chin CY, Lai YR, Chiu CH, Yang CY* and Lai CH*. (2020) Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis. Frontiers in cell and developmental biology. 8:570484 (*corresponding author) (IF=5.186, 54/195 in Cell Biology)
  18. Yang CY, Kuo YH, Chen M, Wang CL, Shih LJ, Liu YC, Hsueh PC, Lai YH, Chu CM, Wu CC, Wu KA. (2021) Pleural cytokines MIF and MIP-3α as novel biomarkers for complicated parapneumonic effusions and empyema. Scientific Reports, doi: 10.1038/s41598-021-81053-6. (IF=3.998, 17/71 in Multidisciplinary sciences)
  19. Tseng MH, Fan WJ, Liu H, Yang CY, Ding JJ, Lee HJ, Huang SM, Lin SH, Huang JL. (2021) Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis. Frontiers in Medicine, 7:621609. DOI: 10.3389/fmed.2020.621609. (IF=3.900, 29/165 in Medicine, general & internal)
  20. Yang CY, Li SW, Chih CY, CW Hsu, Lee CC, Yeh YM, Wu KA. (2021) Association of exacerbation phenotype with the sputum microbiome in chronic obstructive pulmonary disease patients during the clinically stable state. Journal of Translational Medicine, 19:121 (IF=4.124, 45/139 in Medicine, research & experimental)