Mei Chao

Mei Chao

  (Mei Chao)


LabMolecular Virology Laboratory


University/NationUniversity of Pennsylvania, USA

Tel: (03)2118800 ext 5134

Research website

Research interests:


Publications:(*corresponding author)

1.     Chao, M.*, H. N. Wang, Y. J. Lu, Y. S. Chang, and J. S. Yu. 2015. The V-val subtype Epstein-Barr virus nuclear antigen 1 promotes cell survival after serum withdrawal. Oncol. Rep. 33(2):958-966.

2.     Fang, Y. K., K. Y. Huang, P. J. Huang, R. Lin, M. Chao*, and P. Tang*. 2015. Gene-expression analysis of cold-stress response in the sexually transmitted protist Trichomonas vaginalis. J. Microbiol. Immunol. Infect. 48(6):662-675.

3.     Hsu, C. W., M. Chao*, Y. C. Chen, M. L. Chang, S. F. Huang, and C. T. Yeh*. 2015. Detection of hepatitis D virus RNA carrying large fragment deletions in patients with severe hepatitis B/D receiving oral antiviral therapy. J. Med. Virol. 87(4):634-641.

4.     Lin, C. C., Z. W. Yang, S. B. Iang, and M. Chao*. 2015. Reduced genetic distance and high replication levels increase the RNA recombination rate of hepatitis delta virus. Virus Res. 195:79-85.

5.     Chao, M.*, C. C. Lin, F. M. Lin, H. P. Li, and S. B. Iang. 2015. Whole-genome analysis of genetic recombination of hepatitis delta virus: molecular domain in delta antigen determining trans-activating efficiency. J. Gen. Virol. 96(12):3460-3469.

6.    Chao, M.*, T. C. Wang, C. C. Lin, R. Yung-Liang Wang, W. B. Lin, S. E. Lee, Y. Y. Cheng, C. T. Yeh, and S. B. Iang. 2017. Analyses of a whole-genome inter-clade recombination map of hepatitis delta virus suggest a host polymerase-driven and viral RNA structure-promoted template-switching mechanism for viral RNA recombination. Oncotarget 8(37):60841-60859.

7.     Lin, C. C., C. C. Lee, S. H. Lin, P. J. Huang, H. P. Li, Y. S. Chang, P. Tang, and M. Chao*. 2017. RNA recombination in hepatitis delta virus: Identification of a novel naturally occurring recombinant. J. Microbiol. Immunol. Infect. 50(6):771-780.

8.     Chiang, K. C., S. W. Yang, K. P. Chang, T. H. Feng, K. S. Chang, K. H. Tsui, Y. S. Shin, C. C. Chen, M. Chao*, and H. H. Juang*. 2018. Caffeic acid phenethyl ester induces N-myc downstream regulated gene 1 to inhibit cell proliferation and invasion of human nasopharyngeal cancer cells. Int. J. Mol. Sci. 19(5): 1397.

9.     Chung, A. K., C. N. OuYang, H. Liu, M. Chao, J. D. Luo, C. Y. Lee, Y. J. Lu, I. C. Chung, L. C. Chen, S. M. Wu, N. M. Tsang, K. P. Chang, C. L. Hsu, H. P. Li, and Y. S. Chang. 2019. Targeted sequencing of cancer-related genes in nasopharyngeal carcinoma identifies mutations in the TGF-beta pathway. Cancer Med. 8(11):5116-5127.

10.   Huang, P. H., C. C. Hu, C. H. Chien, L. W. Chen, R. N. Chien, Y. S. Lin, M. Chao, C. L. Lin, and C. T. Yeh. 2019. The defective allele of aldehyde dehydrogenase 2 gene is associated with favorable postoperative prognosis in hepatocellular carcinoma. J. Cancer 10(23):5735-5743.

11.   Hsu, C. W., H. H. Juang, C. Y. Kuo, H. P. Li, S. B. Iang, S. H. Lin, C. T. Yeh, and M. Chao*. 2019. Structural pattern differences in unbranched rod-like RNA of hepatitis delta virus affect RNA editing. Viruses 11(10):934.

12.   Lee, K. C., C. L. Lin, C. W. Hsu, M. L. Chang, Y. C. Chen, W. R. Lin, M. W. Lai, K. H. Lin, M. Chao, R. N. Chien, and C. T. Yeh. 2020. Decreasing seroprevalence of anti-hepatitis D virus antibodies in the antiviral era with inverse association with hepatitis B virus DNA, Taiwan, 2006 to 2019. J. Med. Virol. 92(1):124-127.

13.  Chiang, K. C., K. S. Chang, S. Y. Hsu, H. C. Sung, T. H. Feng, M. Chao*, and H. H. Juang*. 2020. Human heme oxygenase-1 induced by interleukin-6 via JAK/STAT3 athways is a tumor suppressor gene in hepatoma cells. Antioxidants. 9 (3):251.


  1. Li, H. P., M. Chao, S. J. Chen, and Y.S. Chang. 2009. Chapter 5. Epstein-Barr Virus and Its Oncogenesis. In Human Oncogenic Viruses. Edited by Ou, J. H. J. and T. S. B. Yen. World Scientific Publishing Co. (ISBN 978-981-283-346-4)

  1. Chao, M., Y. Y. Lin, and P. J. Chen. 2019. Chapter 7. Recombination Between Hepatitis D Viruses. In Hepatitis D Virology, Management and Methodology. Edited by Rizzetto, M. and A. Smedile. (ISBN 978-88-490-0646-9)