Ya-Chin Yang

 

楊雅晴(Ya-Chin Yang)

Appointment：Professor

Lab：Neurobiology Laboratory

Education：Ph.D.

University/Nation：National Taiwan University, Taiwan

Tel: (03)2118800 ext. 3394

E-mail：ycyang@mail.cgu.edu.tw

Research website： http://ls.cgu.edu.tw/files/11-1038-1559.php

Research interests: 

 Information processing by neural circuits in the mammalian brain

Publications:  

Selected Recent Publications:

  1. C.-S. Huang, G.-H. Wang, H.-H. Chuang, A.-Y. Chuang, J.-Y. Yeh, Y.-C. Lai, Y.-C. Yang. Conveyance of cortical pacing for parkinsonian tremor-like hyperkinetic behavior by subthalamic dysrhythmia. Cell Reports (2021) 35:109007 (Corresponding Author)
  2. Y.-C. Lin, Y.-C. Lai, P. Chou, S.-W. Hsueh, T.-H. Lin, C.-S. Huang, R.-W. Wang, Y.-C. Yang, C.-C. Kuo. How can a Na+ channel inhibitor ameliorate seizures in Lennox-Gastaut syndrome? Annals of Neurology (2021) 89(6): 1099-1113 (Corresponding Author)
  3. Y.-C. Yang, G.‐H. Wang, A.‐Y. Chuang, S.‐W. Hsueh. Perampanel reduces paroxysmal depolarizing shift and inhibitory synaptic input in excitatory neurons to inhibit epileptic network oscillations. British Journal of Pharmacology (2020) 177(22):5177-5194 (Corresponding Author)
  4. G.-H. Wang, P. Chou, S.-W. Hsueh, Y.-C. Yang, C.-C. Kuo. Glutamate transmission rather than cellular pacemaking propels excitatory-inhibitory resonance for ictogenesis in amygdala. Neurobiology of Disease (2020)148:105188 (Corresponding Author)
  5. P. Chou, G.-H. Wang, S.-W. Hsueh, Y.-C. Yang, C.-C. Kuo. Delta-frequency augmentation and synchronization in seizure discharges and telencephalic transmission. iScience (2020) 23(11):101666  (Corresponding Author)
  6. Y.-S. Chen, Y.-C. Tu, Y.-C. Lai, Erin Liu, Y.-C. Yang, C.-C. Kuo. Desensitization of NMDA channels requires ligand binding to both GluN1 and GluN2 subunits to constrict the pore beside the activation gate. Journal of Neurochemistry (2019) 153:549–566 (Corresponding Author)
  7. C.-S. Huang, G.-H. Wang, C.-H. Tai, C.-C. Hu, Y.-C. Yang. Antiarrhythmics cure brain arrhythmia: the imperativeness of subthalamic ERG K+ channels in parkinsonian discharges. Science Advances (2017) 3:e1602272 (Corresponding Author)
  8. Y.-C. Yang, Hu C-C and Lai Y-C. Non-additive modulation of synaptic transmission by serotonin, adenosine,and cholinergic modulators in the sensory thalamus. Frontiers in Cellular Neuroscience (2015) 9:60. (Corresponding Author)
  9. Y.-C. Yang*, C.-C. Hu, C.-S. Huang, and P.-Y. Chou. Thalamic synaptic transmission of sensory information modulated by synergistic interaction of adenosine and serotonin. Journal of Neurochemistry (2014) 128:852-863 (Corresponding Author)
  10. Y.-C. Yang, C.-H. Tai, M.-K. Pan, C.-C. Kuo. The T-type calcium channel as a new therapeutic target for Parkinson’s disease. (Invited Review) Pflügers Archiv (2014) 466(4):747-755 
  11. C.-H. Tai, M.-K. Pan, J. J. Lin, C.-S. Huang, Y.-C. Yang and C.-C. Kuo (2012) Subthalamic discharges as a causal determinant of parkinsonian motor deficits. Annals of Neurology 72(3):464-76. (Corresponding Author)
  12. C.-H. Tai#, Y.-C. Yang#(co-first author), M.-K. Pan, C.-S. Huang, and C.-C. Kuo Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease. #equal contribution. Journal of Clinical Investigation (2011) 121(8):3289-3305.
  13. Y.-C. Yang, S. Lin, P.-C. Chang, H.-C. Lin, and C.-C. Kuo Functional extension of amino acid triads from the fourth transmembrane segment (S4) into its external linker in Shaker K+ Channels. Journal of Biological Chemistry (2011) 286: 37503-37514
  14. Y.-C. Yang, C.-S. Huang, and C.-C. Kuo (2010) Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels. Anesthesiology (2010) 113(1):160-174