Horng-Heng Juang

莊宏亨 (Horng-Heng Juang)

Appointment：Professor

Lab：Molecular Endocrinology and Cellular Metabolism Laboratory

Education：Ph.D.

University/Nation：University of Maryland / USA

Tel：5071

E-mail：hhj143@mail.cgu.edu.tw

Research website：

Research interests：

Publications：

  1. Juang HH, Musah AI, Schwabe C, Anderson LL. 1989. Effect of relaxin and antirelaxin serum on porcine sperm motility. Animal Reproduction Science 20:21-29.
  2. Juang HH, Musah AI, Schwabe C, Anderson LL. 1990. Immunoactive relaxin in boar seminal plasma and its correlation with sperm motility. Animal Reproduction Science 22:47-53.
  3. Juang HH, Musah AI, Anderson LL. 1990. Ethylendiamine-tetracacetic acid (EDTA) and caffeine are antagonistic to anti-relaxin serum inhibition of porcine sperm motiligy. Animal Reproduction Science 22:253-260.
  4. Kapcala LP, Juang HH, Weng CF. 1990. Corticotropin-releasing hormone and dexamethasone do not alter secretion of immunoreactive-beta-endorphin from dissociated fetal hypothalamic cell culture. Brain Research 532:76-81.
  5. Kapcala LP, Weng CF, Juang HH. 1992. Protein kinase C activation stimulates beta-endorphin secretion from hypothalamic cells. Brain Research Bulletin 29:553-557.
  6. Juang HH, Costello L, Franklin R. 1995. Androgen modulation of multiple start sites of the mitochondrial aspartate amino-transferase gene in rat prostate. Journal of Biology Chemistry 270:12629-12634.
  7. Franklin R, Juang HH, Zou J, Costello L. 1995. Regulation of citrate metabolism by androgen in LNCaP human prostate carcinoma cell line. Endocrine 3:603-607.
  8. Juang HH, Musah AI, Schwabe C, Ford, JJ, Anderson, LL. 1996. Relaxin in peripherial plasma of boars during development, couplation, after administration of human chorionic gonadotropin and after castration. Journal of reproduction and Fertility 107:1-6.
  9. Juang HH. 2004. Modulatin of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells. Molecular Genetics and Metabolism 81:244-252.
  10. Juang HH. 2004. Cyclic Adenosine 3’,5’- Monosphosphate mediate prolactin regulation of mitochondrial aconitase in human prostate carcinoma cells. Molecular and Cellular Endocrinology 219:141-149.
  11. Juang HH. 2004. Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3’,5’- monosphosphate signal transduction pathway in human prostate carcinoma cells. Prostate 61:92-102.
  12. Juang HH. 2004. Modulation of iron on mitochondrial aconitase expression in human prostatic carcinoma cells. Molecular and Cellular Biochemistry 265:185-194.
  13. Juang HH, Hsieh ML, Tsui KH. 2004. Testosterone modulates mitochondrial aconitase in the full-length human androgen receptor-transfected PC-3 prostatic carcinoma cells. Journal of Molecular Endocrinology 33:121-132.
  14. Tsui KH, Chang PL, Lin HT, Juang HH.* 2004. Down-regulation of prostate specific antigen promoter by p53 in human prostate cancer cells. Journal of Urology 172:2035-2039.
  15. Tsui KH, Wu LL, Chang PL, Hsieh ML, Juang HH.* 2004. Identifying the combination of the transcriptional regulatory sequences on prostate-specific antigen and human glandular kallikrein genes. Journal of Urology 172:2029-2034.
  16. Feng TH, Tsui KH, Juang HH.* 2005. Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells. Chinese Journal of Physiology 48:93-100.
  17. Hsieh ML, Juang HH.* 2005. Cell growth effects of triiodothyronine and expression of thyroid hormone receptor in prostate carcinoma cells. Journal of Andrology 26: 422-428.
  18. Tsui KH, Chang PL, Juang HH.* 2006. Zinc blocks gene expression of mitochondrial aconitase in human prostatic carcinoma cells. International Journal of Cancer 118:609-615.
  19. Tsui KH, Chang PL, Juang HH. 2006. Maganese antagonizes iron blocking the mitochondrial aconitase expression in human prostate carcinoma cells. Asian Journal of Andrology 8:307-315.
  20. Tsui KH, Feng TH, Chang PL, Juang HH.* 2007. Callium deregulate mitochondrial aconitase gene in the human prostate carcinoma cells. Andrology Update 1:304-312.
  21. Tsui KH, Chen SM, Wang TM, Juang HH, Cheng CL, Sun GH, Chang PL. 2007. Comparisoms of vided urine cytology, nuclear matrix protein-22 and bladder tumor associated antigen tests for bladder cancer of geriatric male patients in Taiwan. Asian Journal of Andrology 9:711-715.
  22. Tsiu KH, Juang HH, Lee TH, Chang PL, Che CL, Yuang B Y-M. 2008. Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples. Acta Pharmacologica Sinica 29:364-370.
  23. Tsui KH, Hsieh WC, Lin MH, Chang PL, Juang HH.* 2008. Triiodothyronine Modulates cell proliferation of human prostatic carcinoma cells by downregulation of the b-cell translocation gene 2. Prostate 68: 610-619.
  24. Tsui KH, Feng TH, Chung LC, Chao CH, Chang PL, Juang HH.* 2008. Prostate specific antigen gene expression in androgen insensitive prostate carcinoma subculture cell line. AntiCancer Research 28:1969-1976.
  25. Tsui KH, Chang PL, Feng TH, Chung LC, Shu SY, Juang HH.* 2008. Down-regulation of matriptase by overexpression of bikunin attenuates cell invasion in prostate carcinoma cells. AntiCancer Research 28:1977-1984.
  26. Tsui KH, Chang PL, Feng TH, Chung LC, Sung HC, Juang HH.* 2008. Evaluating the function of matriptase and N-acetylglucosaminyltransferase V in prostate cancer metastasis. Anticancer Research 28: 1993-2000.
  27. Tsui KH, Feng TH, Hsieh WC, Chang PL, Juang HH.* 2008. Expression of interleukin-6 is downregulated by 17-(allylamino)-17-demethoxygeldanamycin in human prostatic carcinoma cells. Acta Pharmacologica Sinica 29:1334-1341.
  28. Tsui KH, Feng TH, Lin CM, Chang PL, Juang HH.* 2008. Curcumin blocks the activating of androgen and interlukin-6 on prostate specific antigen expression in human prostatic carcinoma cells. Journal of Andrology 29: 661-668.
  29. Pang ST, Hsieh WC, Chuang CK, Chao CH, Weng WH, Juang HH.* 2009. Thioredoxin-interacting protein: an oxidative-stress related gene is upregulated by glucose in human prostate carcinoma cells. Journal of Molecular Endocrinology 42:205-214.
  30. Juang HH, Lin YF, Chang PL, Tsui KH. 2010. Cardiac glycosides reduce prostate specific antigen expression by downregulation of prostate-derived Ets factor. Journal of Urology 84: 2158-2164.
  31. Tsui KH, Feng TH, Lin YF, Chang PL, Juang HH.* 2011. p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells. Prostate 71:62-70.
  32. Tsui KH, Lin YF, ChenYH, Chang PL, Juang HH.* 2011. Mechanisms by which interleukin-6 regulates prostate specific antigen gene expression in prostate LNCaP carcinoma cells. Journal of Andrology 32:383-393.
  33. Chung LC, Tsui KH, Feng TH, Lee SL, Chang PL, Juang HH.* 2011. Curcumin provides potential protection against the activation of hypoxia and prolyl 4-hydroxylase inhibitors on prostate-specific antigen expression in human prostate carcinoma cells. Molecular Nutrition and Food Research 55:1666-1676.
  34. Chiang KC, Yeh CN, Chen HY, Lee JM, Juang HH, Chen MF, Takano M, Kittaka A, and Chen TC. 2011. 19-Nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (MART-10) is a potent cell growth regulator with enhanced chemotherapeutic potency in liver cancer cells. Steroids 76:1513-1519.
  35. Chung LC, Tsui KH, Feng TH, Lee SL, Chang PL, Juang HH.* 2012. L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N- myc downstream regulated gene 1 in prostate carcinoma cells American Journal of Physiology Cell Physiology 302:C676-C685.
  36. Tsui KH, Chung LC, Feng TH, Chang PL, Juang HH.* 2012. Upregulation of prostate-derived ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. International Journal of Cancer 130: 2812-2823.
  37. Tsui KH, Chang YL, Feng TH, Chang PL, Juang HH.* 2012. Glycoprotein transmembrane nmb: an androgen-downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells. Prostate 72:1431-1442.
  38. Tsui KH, Chang YL, Feng TH, Chung LC, Lee TY, Chang PL, Juang HH.* 2012. Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells. Journal of Molecular Endocrinology 49:153-163.
  39. Chiang KC, Yeh CN, Chen SC, Shen SC, Hsu JT, Yeh TS, Pang JH, Su LJ, Takano M, Kittaka A, Juang HH*, Chen TC*. 2012. MART-10, a new generation of vitamin D analog, is more potent than 1α,25-dihydroxyvitamin D(3) in inhibiting cell proliferation and inducing apoptosis in ER+ MCF-7 breast cancer cells. Evidence Based Complement Alternative Medicine 2012:e310872.
  40. Chiang KC, Yeh CN, Hsu JT, Yeh TS, Jan YY, Wu CT, Chen HY, Jwo SC, Takano M, Kittaka A, Juang HH,* Chen TC.* 2013. Evaluation of the potential therapeutic role of a new generation of vitamin D analog, MART-10, in human pancreatic cancer cells in vitro and in vivo Cell Cycle 12:1316-1325.
  41. Tsui KH, Wang SW, Chung LC, Feng TH, Chen YH, Chang PL, Juang HH.* 2013. Mechanisms by which interleukin-6 attenuates cell invasion and tumorigenesis in human bladder carcinoma cells. BioMed Research International 2013:e791212
  42. Yeh CN, Chiang KC, Juang HH, Pang JH S, Yu CS, Lin KJ, Yeh TS*, Jan YYi.* 2013. Reappraisal of the therapeutic role of celecoxib in cholangiocarcinoma. PLoS one 8:e69928.
  43. Tsui KH, Chung LC, Wang SW, Feng TH, Chang PL, Juang HH.* 2013. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells. Journal of Molecular Endocrinology 51:131-141
  44. Juang HH, Chung LC, Feng TH, Lee YH, Chang PL, Tsui KH. 2013. Metallothionein 3: an androgen-upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells. Prostate 73:1495-1506.
  45. Chiang KC, Yeh CN , Hsu JT , Chen LW , Kuo SF , Sun CC , Huang CC , Pang JHS , Flanagan JN , Takano M, Kittaka A, Juang HH, Yang SW*, Chen TC* . 2013. MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase. Journal of Steroid Biochemistry and Molecular Biology. 138:427-434.
  46. Lee WC, Lin YH, Hou CP, Chang PL, Chen CL, Juang HH, Tsui KH. 2013. Prostatectomy using different lasers for the treatment of benign prostate hyperplasia in aging males. Clinical Interventions in Aging 8: 1483–1488
  47. Chiang KC, Chen SC, Yeh C-N, Pang S JH , Shen SC, Hsu JT, Liu YY, Chen LW, Kuo SF, Takano M, Kittaka A, Sun CC, Juang HH*, Chen TC*. 2014. MART-10, a less calcemic vitamin D analog, is more potent than 1α,25-dihydroxyvitamin D3 in inhibiting the metastatic potential of MCF-7 breast cancer cells in vitro. Journal of Steroid Biochemistry and Molecular Biology. 139:54-60.
  48. Chiang KC, Tsui KH, Chung LC, Yeh CN, Chang PL, Chen WT, Juang HH.* 2014. Topoisomerase inhibitors modulate gene expression of B-cell translocation gene 2 and prostate specific antigen in prostate carcinoma cells. PLoS One 9:e89117.
  49. Chiang KC, Tsui KH, Chung LC, Yeh CN, Chen WT, Chang PL, Juang HH*. 2014. Celastrol blocks interleukin-6 gene expression via downregulation of NF-κB in prostate carcinoma cells. PLoS One 9:e93151
  50. Chiang KC, Yeh CN, Lin KJ, Su LJ, Yen TC, Pang JHS, Kittaka A, Sun CC, Chen MF, Jan YY, Chen TA, Juang HH*, Yeh TS*. 2014. Chemopreventive and Chemotherapeutic Effect of dietary supplementation of vitamin D on cholangiocarcinoma in a chemical-induced animal model. Oncotarget 5:3849-3861.
  51. Chiang KC, Tsui KH, Chung LC, Yeh CN, Feng TH, Chen WT, Chang PL, Chiang HY, Juang HH*. 2014. Cisplatin modulates B-cell translocation gene 2 to attenuate cell proliferation of prostate carcinoma cells in both p53-dependent and p53-independent pathways. Scientific Report 4:5512.