鄭邑荃

鄭邑荃 (Yi-Chuan Cheng)

神經退化與再生研究室  

個人學經歷：

長庚大學 ─ 教授
長庚醫院 ─ 神經科學研究中心 研究員

英國國家醫學研究院 ─ 博士後研究員
英國諾丁漢大學 ─ 基因與發育學博士
英國倫敦大學帝國學院 ─ 人類分子遺傳學碩士
中山醫學大學 ─ 醫事技術系學士

研究室現有：

博士班研究生5人

碩士班研究生5人

專任研究助理2人

大學部專題生4人

電子郵件帳號：yccheng@mail.cgu.edu.tw

電話：032118800轉3396

 

 

研究方向及研究室特色：

主要研究計畫：

  1. 運動障礙疾病 (帕金森氏症、漸凍人)

我們實驗室透過與長庚醫療體系與國外研究機構合作，以遺傳分析和高通量研究發現許多新的基因與帕金森氏症及肌萎縮側索硬化症等運動障礙疾病有關。然而，這些基因在運動障礙中的病理作用和基本機制大多不清楚。我們採用神經毒劑、基因突變、誘導性轉殖基因等方法，建立了帕金森氏症和肌萎縮側索硬化症的動物模式，剖析候選基因的生理、病理功能及其調控途徑，並找出可作為治療用途的化學物質和分子以及營養補充品。

  1. 脊髓損傷與再生

我們也試圖找出在脊髓損傷後，參與在脊髓再生中的新的分子調控路徑和細胞。在哺乳動物中，脊髓損傷會導致神經細胞損失，並造成永久性的殘疾。相比之下，斑馬魚有能力再生其受傷的脊髓，並恢復活動能力，因此提供了一個有效的動物模式來開發潛在的治療策略。我們已經確定了幾個參與改善斑馬魚脊髓再生的分子，這對於非再生脊椎動物的成人神經再生來說開啟了一個新的治療策略，因此，在未來也可能應用於脊髓損傷的細胞和分子治療。

  1. 神經發育與腦腫瘤

神經母细胞具有自我新生和多樣分化的能力，能夠分化為神經元、星形膠質細胞、寡樹突膠細胞等多種神經细胞。在許多神經退行性疾病和腦腫瘤中，其存活、增殖、分化和遷移的調控路徑經常被破壞或改變。因此，了解神經發育過程中的基因調控和訊息傳遞路徑可以提供與神經退化和腦腫瘤發生的相關知識，並發現新的治療方法和策略。我們正在研究不正常的發育過程是如何導致退化和腫瘤的，特别著重在Notch訊息傳遞路徑在調節神經發育、神經退化和腦腫瘤發生中的作用，從而發展這些疾病的治療方法。

其他合作計畫

遺傳性腎臟疾病

台灣洗腎人數高居世界第一。我們長期與長庚醫院腎臟科醫師合作，建立了罹患遺傳性腎臟疾病的斑馬魚模式，並使用腎臟螢光斑馬魚品系，以利用斑馬魚胚胎體透明可直接觀察腎臟病變之優勢，研究遺傳性腎臟疾病中之分子調控機制及篩選治療藥物。

近年論文與著作：

  1. Wu YM, Lee CH, Cheng YC, Lu JJ, Wang SH. (2020 Oct). Association between CAI microsatellite, multilocus sequence typing, and clinical significance within Candida albicans isolates. Medical Mycology. myaa090 [Epub ahead of print].
  2. Chiang MC, Nicol CJB, Cheng YC, Yen C, Lin CH, Chen SJ, Huang RN. (2020 May). Nanogold Neuroprotection in Human Neural Stem Cells Against Amyloid-beta-induced Mitochondrial Dysfunction. Neuroscience. 21;435:44-57.
  3. Wang SH, Chen CC, Lee CH, Chen XA, Chang TY, Cheng YC, Young JJ, Lu JJ. (2020 Jan [Epub 2019 Nov 15]). Fungicidal and anti-biofilm activities of trimethylchitosan-stabilized silver nanoparticles against Candida species in zebrafish embryos. International Journal of Biological Macromolecules, 143:724-731.
  4. Lin CH, Nicol CJB, Cheng YC, Yen C, Wang YS, Chiang MC. (2020 Jan (Epub 2019 Oct 3)). Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffold. Brain Res. 1726:146492.
  5. Wang HL, Lu CS, Yeh TH, Shen YM, Weng YH, Huang YZ, Chen RS, Liu YC, Cheng YC, Chang HC, Chen YL, Chen YJ, Lin YW, Hsu CC, Lin HL, Chiu CH, Chiu CC. (2019 Oct) Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease. J Clin Neurol. 15(4):488-495.
  6. Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL. (2019 Sep). Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Front Cell Neurosci. 13:399.
  7. Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL. (2019 June). PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Mol Neurobiol. 56(6), 3835-3853.
  8. Chang MC, Cheng YC. (2019). ‘Zebrafish Model for Leptospirosis Kidney Disease’, in Yang CW, Pan MJ, Yang HY (eds.), Leptospirosis and the Kidney, Translational Research in Biomedicine, KARGER AG, Basel, Vol. 7, 76-81 - 2019
  9. Ku YC, Lai MH, Lo CC, Cheng YC, Qiu JT, Tarn WY, Lai MC. (2018 Dec). DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries. Mol Cell Biol. 11;39(1). pii: e00285-18.
  10. Hsieh YC, Chiang MC, Huang TC, Yeh TH, Shih HY, Liu HF, Chen HY, Wang CP, Cheng YC* (2018 Dec). Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system. Developmental Dynamics, 247(12):1264-1275.
  11. Lin CH, Nicol CJB, Cheng YC, Chen SJ, Yen CH, Huang RN, Chiang MC. (2018 Sep [Epub 2018 Jun]). Rosiglitazone rescues human neural stem cells from amyloid-beta induced ER stress via PPARγ dependent signaling. Exp Cell Res. 370(2):312-321.
  12. Yeh TH, Liu HF, Li YW, Lu CS, Shih HY, Chiu CC, Lin SJ, Huang YC, Cheng YC*. (2018, Jun [Epub 2019 Mar]). C9orf72 is Essential for Neurodevelopment and Motility Mediated by Cyclin G1. Experimental Neurology, 304:114-124.
  13. Wu YH, Lee YH, Shih HY, Chen SH, Cheng YC*, Chiu D. (2018, Jan). Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis. Cell Death and Disease, 9(1):10.
  14. Chiang MC, Nicol CJ, Cheng YC. (2018, May (online 2017, Oct)). Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress. Neurochemistry International, Volume 115, , Pages 1-10
  15. Lin CH, Cheng YC, Nicol CJ, Lin KH, Yen CH, Chiang MC. (2017, Oct (online 2017, Aug)). Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells. Experimental Cell Research, 15;359(2):367-373.
  16. Chiang MC, Cheng YC, Nicol CJ, Lin CH. (2017, Nov (online 2017, Sep)). The neuroprotective role of rosiglitazone in advanced glycation end product treated human neural stem cells is PPARgamma-dependent. International Journal of Biochemistry and Cell Biology, 92:121-133.
  17. Chiu CC, Yeh TH, Lu CS, Huang YC, Cheng YC, Huang YZ, Weng YH, Liu YC, Lai SC, Chen YL, Chen YJ, Chen CL, Chen HY, Lin YW, Wang HL. (2017 Sep). PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway. Oncotarget. 8(45):79046-79060.
  18. Huang YC, Lin SJ, Shih HY, Chou CH, Chu HH, Chiu CC, Yuh CH, Yeh TH, Cheng YC*. (2017, Jun (2017, Sep). Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation. Oncotarget. 8(38): 63110–63120.
  19. Chang MY, Ma TL, Hung CC, Tian YC, Chen YC, Yang CW, Cheng YC*. (2017, Aug). Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency. Scientific Reports, 7(1):7161.
  20. Chung MM, Nicol CJ, Cheng YC, Lin KH, Chen YL, Pei D, Lin CH, Shih YN, Yen CH, Chen SJ, Huang RN, Chiang MC. (2017, Mar (online 2017, Feb)). Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs. Experimental Cell Research, 352(1):75-83.
  21. Lin SJ, Chiang MC, Shih HY, Chiang KC, Cheng YC* (2017, Jun (online 2017, Feb)). Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Development Genes and Evolution, doi: 10.1007/s00427-017-0575-6.
  22. Lin SJ, Chiang MC, Shih HY, Hsu LS, Yeh TH, Huang YC, Lin CY, Cheng YC*. (2017, Mar (online 2016, Dec)). Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade. Biochimica et Biophysica Acta Molecular Cell Research, 1864 (3): 463–474.
  23. Shih HY, Hsu SY, Ouyang P, Lin SJ, Chou TY, Chiang MC, Cheng YC*. (2017, Apr (online 2016, Oct)). Bmp5 Regulates Neural Crest Cell Survival and Proliferation Via Two Different Signaling Pathways. Stem Cells, 35(4):1003-1014.
  24. Chiang MC, Cheng YC, Chen SJ, Yen CH, Huang RN. (2016, Oct). Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction. Experimental Cell Research, 347(2):322-31.
  25. Chiang KC, Hsu SY, Lin SJ, Yeh CN, Pang JH, Wang SY, Hsu JT, Yeh TS, Chen LW, Kuo SF, Cheng YC*, Juang HH. (2016, Aug). PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model. Anticancer Research, 36(8):3997-4005.
  26. Chiu CC, Yeh TH, Lai SC, Weng YH, Huang YC, Cheng YC, Chen RS, Huang YZ, Hung J, Chen CC, Lin WY, Chang HC, Chen YJ, Chen CL, Chen HY, Lin YW, Wu-Chou YH, Wang HL, Lu CS. (2016, Aug). Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson’s disease. Oncotarget, 7(34):54215-54227.
  27. Chang MY, Cheng YC, Hsu SH, Ma TL, Chou LF, Hsu HH, Tian YC, Chen YC, Sun YJ, Hung CC, Pan RL, Yang CW. (2016, Jun). Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae. Scientific Reports, 6:27838.
  28. Chiang MC, Nicol CJ, Cheng YC, Lin KH, Yen CH, Lin CH. (2016, Apr). Rosiglitazone activation of PPARγ-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced mitochondrial dysfunction and oxidative stress. Neurobiology of Aging, 40:181-90.
  29. Hung FC, Shih HY, Cheng YC, Chao CC. (2015, Dec). Growth-Arrest-Specific 7 Gene Regulates Neural Crest Formation and Craniofacial Development in Zebrafish. Stem Cells and Development, 15;24(24):2943-51.
  30. Cheng YC*, Huang YC, Yeh TH, Shih HY, Lin CY, Lin SJ, Chiu CC, Huang CW, Jiang YJ. (2015, Dec). Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glialdifferentiation. Neural Development, 30;10:28.
  31. Chung MM, Chen YL, Pei D, Cheng YC, Sun B, Nicol CJ, Yen CH, Chen HM, Liang YJ, Chiang MC. (2015, May). The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent. Biochimica et Biophysica Acta Molecular Basis of Disease, 1852(5):720-31.
  32. Huang YC, Shih HY, Lin SJ, Chiu CC, Ma TL, Yeh TH, Cheng YC*. (2015, May). The Epigenetic Factor Kmt2a/Mll1 Regulates Neural Progenitor Proliferation and Neuronal and Glial Differentiation. Developmental neurobiology, 75(5):452-62.
  33. Chiang MC, Cheng YC, Nicol CJ, Lin KH, Yen CH, Chen SJ, Huang RN. Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells. Experimental Cell Research, 2015 Nov 1;338(2):183-93.
  34. Cheng YC*, Chiang MC, Shih HY, Ma TL, Yeh TH, Huang YC, Lin CY, Lin SJ. (2015, Jan). The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulatesneurogenesis and gliogenesis. Developmental Biology, 397(1):116-28.
  35. Chiang MC, Cheng YC, Chen HM, Liang YJ, Yen CH. (2014, Jan). Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway. Mitochondrion, 14(1):7-17.
  36. Yeh CW, Kao SH, Cheng YC, Hsu LS. (2013, Sep). Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival viamodulation of raf1a gene expression. The Journal of Biological Chemistry, 27;288(39):27927-39.
  37. Chen SY, Shih HY, Lin SJ, Hsiao CD, Li ZC, Cheng YC*. (2013, Sep). Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science, 126, 5626–5634
  38. Hsieh FY, Ma TL, Shih HY, Lin SJ, Huang CW, Wang HY, Cheng YC* (2013, Mar). Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish. Developmental Biology, 375(1), 1-12.
  39. Lin YL, Tsai YJ, Liu YF, Cheng YC, Hung CM, Lee YJ, Pan HC, Li C (2013, Mar). The critical role of protein arginine methyltransferase prmt8 in Zebrafish embryonic and neural development is non-redundant with its paralogue prmt1. PLoS ONE, 8(3):e55221.
  40. Cheng YC*, Hsieh FY, Chiang MC, Scotting PJ, Shih HY, Lin SJ, Wu HL, Lee HT (2013, Jan). Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with Notch signaling. PLoS ONE, 8(1):e54262.