葉儀君

職稱：助理教授

研究室名稱：腎臟生理暨病理研究室

最高學歷：Ph.D.

學校/國家：成功大學基礎醫學研究所

分機號碼：03-2118800 ext.5253

電子郵件帳號：yichunyeh0201@gmail.com

個人網頁網址：

研究室現有： 博士後研究員   人

博士班研究生    人

碩士班研究生  人

專任研究助理    人

大學部專題生     人

研究方向及實驗室特色：

慢性腎臟疾病是一個全球性的健康問題，也是高齡化社會公共衛生支出的巨大負擔與隱憂。在台灣因腎臟衰竭須接受洗腎的人口居高不下，所耗費的醫療資源更佔健保支出之冠。

慢性腎衰的重要特徵之一是腎小管間質纖維化，病理表現是間質中產生過量的細胞外基質，及腎小管上皮細胞的萎縮，進而導致腎臟功能逐漸喪失。對於間質纖維化的詳盡機制、細胞外基質物理化學性質的變化、及基質變化如何影響細胞特性的改變、又或是細胞在疾病發展過程中，如何應對不同種細胞間交互的改變等，一直是腎臟纖維化過程中尚未釐清的課題。而其中最根本的問題是：纖維化本身是否可逆? 什麼程度可逆、可清除、又或是可被停止? 而什麼情況下，則會導致不可逆、又或是造成更全面性的影響? 我們藉由細胞及動物實驗模式的建立，希望能更全面了解慢性腎臟疾病發展的過程與機制。希望隊學術知識奠定更多基礎，更宏觀的視野外，也期待對藥物的發展，台灣社會經濟有長遠的建樹。

實驗室位置：第一醫學大樓8樓A區生物醫學共同研究室

產學合作：昱星生物科技股份有限公司

發表論文、著作及專利

1. Cheng YS, Chen HY, Lin YC, Lin YS, Yeh YC, Yeh YH, Cheng YH, Lin YM, Weng HY, Lin TY, Lin SC. The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia. Andrology, 2023 Feb 13.
2. Dulloo I, Atakpa-Adaju P, Yeh YC, Levet C, Muliyil S, Lu F, Taylor CW, Freeman M. iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat. Commun., 2022 Mar 13(1):1257.
3. Grieve AG, Yeh YC, Zarcone L, Breuning J, Johnson N, Strisovsky K, Brown MH, Parekh AB, Freeman M. Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Mol Cell., 2021 Dec; 81, 4784-4798.
4. Yeh YC, Lin YP, Kramer H and Parekh AB. Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression. Hum Mol Genet., 2019 Jul; 21;29(11): 1808-1823, 2019.
5. Yeh YC, Lin HH, and Tang MJ. Dichotomy of DDR1 functions in epithelial cells. Biochem Biophys Acta Mol Cell Res., 2019 Nov; 1886(11): 118473.

-Review paper.

6. Yeh YC, and Parekh AB. Calcium Entry Channels in Non-Excitable Cells. Chapter of CRAC channels and Ca²⁺-dependent gene expression. Editors: Kozak JA and Putney JW. CRC Press/Taylor & Francis, 2018. -Contribute to a Book chapter.
7. Yeh YC, Ling JY, Chen WC, Lin HH, and Tang MJ. Mechanotransduction of matrix stiffness in the regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and b1 integrin. Sci Rep., 2017 Nov; 8;7(1): 15008.

-Introduced by Extracellular Matrix News 8.44 November 9, 2017.

-Top 100 read cell biology papers from Scientific Reports in 2017.

8. Chen HR^*, Yeh YC^*, Tang MJ, and Wang YK. DDR1 promotes E-cadherin stability via inhibition of Src activation-mediated E-cadherin endocytosis. Sci Rep., 8;6:36336, 2016. (^*Co-first author).
9. Yeh YC, and Parekh AB. Distinct structural domains of caveolin-1 independently regulate CRAC channels and Ca²⁺ microdomain-dependent gene expression. Mol Cell Biol., 35:1341-1349, 2015.

-Marked on the spotlight section.

10. Yeh YC, and Tang MJ. Functions of DDR1 in epithelial cell differentiation. Chapter of Discoidin domain receptors in health and disease. Editors: Fridman R and Huang P. Springer Publisher, 2015.

     -Contribute to a Book chapter.

11. Yeh YC, Tang MJ, and Parekh AB. Caveolin-1 alters the pattern of cytoplasmic Ca²⁺ oscillation and Ca²⁺-dependent gene expression by enhancing leukotriene receptor desensitization. J Biol Chem., 289: 17843-17853, 2014.

-Recommended by Faculty 1000 of Cell Biology.

12. Yeh YC, Lin HH, and Tang MJ. A tale of two collagen receptors, integrin β1 and DDR1, in epithelial cell differentiation. Am J Physiol Cell Physiol., 303: C1207-1217, 2012.

-Review paper.

13. Yeh YC, Wu CC, Wang YK, and Tang MJ. DDR1 triggers epithelial cell differentiation by promoting cell adhesion through the stabilization of E-cadherin. Mol Biol Cell., 22: 940-953, 2011.
14. Lin SC, Chien CW, Lee JC, Yeh YC, Hsu KF, Lai YY, Lin SC, and Tsai SJ. Repression of dual specificity phosphatase-2 by hypoxia increases chemoresistance and cancer malignancy. J Clin Invest., 121: 1905-1916, 2011.
15. Yeh YC, Wei WC, Sung JM, Lin SC, Chang WT, Tang MJ. TGF-β1 induces Smad3-dependent β1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol., 177: 1743-1754, 2010.
16. Wang CZ, Yeh YC, Tang MJ. DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading. Am J Physiol Cell Physiol 297(2): C419-429, 2009.
17. Yeh YC, Wang CZ, Tang MJ. Discoidin domain receptor 1 activation suppresses alpha2beta1 integrin-dependent cell spreading through inhibition of Cdc42 activity. J Cell Physiol., 218(1): 146-156, 2009.