洪錦堂 (Jim-Tong Horng)

Appointment：Professor

Lab：Cell Biology Laboratory

Education：Ph.D.

University/Nation：University of Cambridge, UK

Tel: (03)2118800 ext.5156

E-mail：jimtong@mail.cgu.edu.tw

Research website： http://memo.cgu.edu.tw/jim-tong/index.htm

Research interests:

Publications: *corresponding author

1. Tang, W.F., Yang, S.Y., Wu, B.W., Jheng, J.R., Chen, Y.L., Shih, C.H., Lin, K.H., Lai, H.C., Tang, P., Horng*, J.T., 2007. Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. The Journal of biological chemistry 282, 5888-5898.

2. Wu, B.W., Pan, T.L., Leu, Y.L., Chang, Y.K., Tai, P.J., Lin, K.H., Horng*, J.T., 2007. Antiviral effects of Salvia miltiorrhiza (Danshen) against enterovirus 71. The American journal of Chinese medicine 35, 153-168.

3. Lin, T.Y., Liu, Y.C., Jheng, J.R., Tsai, H.P., Jan, J.T., Wong, W.R., Horng*, J.T., 2009. Anti-enterovirus 71 activity screening of chinese herbs with anti-infection and inflammation activities. The American journal of Chinese medicine 37, 143-158.

4. Jheng, J.R., Lau, K.S., Tang, W.F., Wu, M.S., Horng*, J.T., 2010. Endoplasmic reticulum stress is induced and modulated by enterovirus 71. Cellular microbiology 12, 796-813.

5. Shih#, S.R., Horng#, J.T., Poon, L.L., Chen, T.C., Yeh, J.Y., Hsieh, H.P., Tseng, S.N., Chiang, C., Li, W.L., Chao, Y.S., Hsu, J.T., 2010. BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses. The Journal of antimicrobial chemotherapy 65, 63-71.

6. Yeh#, J.Y., Coumar#, M.S., Horng#, J.T., Shiao, H.Y., Kuo, F.M., Lee, H.L., Chen, I.C., Chang, C.W., Tang, W.F., Tseng, S.N., Chen, C.J., Shih, S.R., Hsu, J.T., Liao, C.C., Chao, Y.S., Hsieh, H.P., 2010. Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives. Journal of medicinal chemistry 53, 1519-1533.

7. Shih, S.R., Chu, T.Y., Reddy, G.R., Tseng, S.N., Chen, H.L., Tang, W.F., Wu, M.S., Yeh, J.Y., Chao, Y.S., Hsu, J.T., Hsieh, H.P., Horng*, J.T., 2010. Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity. Journal of biomedical science 17, 13.

8. Wu, M.S., Yen, H.R., Chang, C.W., Peng, T.Y., Hsieh, C.F., Chen, C.J., Lin, T.Y., Horng*, J.T., 2011. Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export. Journal of ethnopharmacology 134, 614-623.

9. Hsu, J.T., Yeh, J.Y., Lin, T.J., Li, M.L., Wu, M.S., Hsieh, C.F., Chou, Y.C., Tang, W.F., Lau, K.S., Hung, H.C., Fang, M.Y., Ko, S., Hsieh, H.P., Horng*, J.T., 2012. Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus. Antimicrob Agents Chemother 56, 647-657.

10. Chang, C.W., Leu, Y.L., Horng*, J.T., 2012. Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. Viruses 4, 539-556.

11. Hsieh, C.F., Lo, C.W., Liu, C.H., Lin, S., Yen, H.R., Lin, T.Y., Horng*, J.T., 2012. Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus. Journal of ethnopharmacology 143, 57-67.

12. Jheng, J.R., Lin, C.Y., Horng*, J.T., Lau, K.S., 2012. Inhibition of enterovirus 71 entry by transcription factor XBP1. Biochemical and biophysical research communications 420, 882-887.

13. Yeh, J.Y., Coumar, M.S., Shiao, H.Y., Lin, T.J., Lee, Y.C., Hung, H.C., Ko, S., Kuo, F.M., Fang, M.Y., Huang, Y.L., Hsu, J.T., Yeh, T.K., Shih, S.R., Chao, Y.S., Horng*, J.T., Hsieh, H.P., 2012. Anti-influenza Drug Discovery: Identification of an Orally Bioavailable Quinoline Derivative through Activity- and Property-Guided Lead Optimization. ChemMedChem 7, 1546-1550.

14. Hsieh, C.F., Yen, H.R., Liu, C.H., Lin, S., Horng*, J.T., 2012. Ching-fang-pai-tu-san inhibits the release of influenza virus. Journal of ethnopharmacology. In press