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Guo-Jen Huang (黃國正)

Appointment:Associate Professor

Lab:Functional Neuroscience


University/Nation:University of Cambridge, UK

Tel:(03)2118800 ext.3802


Research website:

Research interests

For more than 100 years, neuroscientists assumed that there was no generation of new neurons in the adult brain. However, in 1965, scientists claimed new neurons are formed in the adult brain. Subsequently, the 1990s sparked a period of intensive work by researchers who strived to unveil factors controlling hippocampal neurogenesis and investigate the functions of newly-formed neurons. Unfortunately, there is still no consensus on what functions these new neurons perform.

The hippocampus is considered a key anatomical structure for learning and emotion. Thus, scientists have assumed that the functions of newly form neurons in the adult hippocampus were also linked to learning and emotion. Over the next several years, I am going to use genetically modified mice to answer what is the function of adult neurogenesis.

Publications:  (*corresponding author)       

Chang S, Bok P, Sun C-P, Edwards A, Huang G-J*. Neuropsin inactivation has protective effects against depressive-like behaviours and memory impairment induced by chronic stress. PLoS Genetics 2016; 12(10): e1006356

Lin YT, Liu TY, Yang CY, Yu YL, Chen TC, Day YJ, Chang CC, Huang GJ, Chen JC. Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation. Psychoneuroendocrinology 2016 May 18;71:73-85. 

Tarn WY, Kuo HC, Yu HI, Liu SW, Tseng CT, Dhananjaya D, Hung KY, Tu CC, Chang SH, Huang GJ, Chiu IM. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Molecular Biology of the Cell 2016 May 15;27(10):1676-83.

Cai N, Li Y, Chang S, Liang J, Lin C, Zhang X, Liang L, Hu J, Chan W, Kendler KS, Malinauskas T, Huang GJ, Li Q, Mott R, Flint J. Genetic control over mtDNA and Its relationship to major depressive disorder. Current Biology 2015 Dec 21;25(24):3170-77.

Tsai CY, Tsai CY, Arnold S, Huang GJ*. Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle. Nature Communications 2015 Sep 29;6:8373. doi: 10.1038/ncomms9373.

Lee KC, Yu JF, Lee YS, Huang GJ, Chan HL, Lin IT, Chen JH. In vivo sodium MRI for mouse model of ischemic stroke at 7 T: Preliminary results. Journal of Medical and Biological Engineering 2015 Sep 30;35;643-650

Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G,  Jiang G, Jiang T,Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H,Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J,Marchini J, Chen Y, Xu Q, Xu X, Mott R, Huang GJ, Kendler K, Flint J. Molecular signatures of major depression. Current Biology 2015 May 4;25(9):1146-56. (co-senior author)

Huang GJ*, Edwards A, Tsai CY, Lee YS, Peng L, Era T, Hirabayashi Y, Tsai CY. Nishikawa S, Iwakura Y, Chen SJ, Flint J. Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice. PLoS ONE 2014 Feb; 9(2): e86471

Groves JO, Leslie I, Huang GJ, McHugh SB, Taylor A, Mott R, Munafò M, Bannerman DM, Flint J. Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model. PLoS Genetics 2013;9(9):e1003718

Huang GJ*, Ben-David E, Tort Piella A, Edwards A, Flint J, Shifman S*. Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice. PLoS ONE 2012 Apr 25; 7(4): e35901

Edwards A, Treiber CD, Breuss M, Pidsley R, Huang GJ, Cleak J, Oliver PL, Flint J. Keays DA. Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse. Neuroscience 2011 Nov 10; 195:191-200

Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Parent JM, Johnsen A,Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T-cells and cellular proliferation in the adult hippocampus. PLoS Biology 2010 Dec 14; 8(12):e1000561

Keays DA, Cleak J, Huang GJ, Edwards A, Braun A, Treiber C, Pidlsey R, Flint J. The role of Tuba1a in adult hippocampal neurogenesis and the formation of the dentate gyrus. Developmental Neuroscience 2010 Oct; 32(4):268-77

Huang GJ, Shifman S, Johannesson M, Yalcin B, Valdar W, Taylor J, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research 2009 Jun; 19(6):1133-40

Arnold S#, Huang GJ#( equal contribution), Cheung A, Era T, Nishikawa SI, Bikoff E, Molnar E, Robertson E, Groszer M. The T-box transcription factor Tbr2/Eomes regulates neurogenesis in the cortical subventricular zone. Genes & Development 2008 Sep 15; 22(18):2479-84

Huang GJ*, Bannerman D, Flint J. Chronic fluoxetine treatment alters behaviour, but not adult hippocampal neurogenesis, in BALB/cJ mice. Molecular Psychiatry 2008 Feb; 13, 119-121. 

Keays DA, Tian G, Poirier K, Huang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnár Z,Piñon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, FlintJ. Mutations in α-tubulin cause hippocampal defects in mice and lissencephaly in humans. Cell 2007 Jan 12; 128(1):45-57

Huang GJ, Herbert J. Stimulation of neurogenesis in the dentate gyrus of the adult rat by fluoxetine requires rhythmic change in corticosterone. Biological Psychiatry 2006 Apr 1; 59(7):619-24

Huang GJ*,  Herbert J. The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoids. Neuroscience 2005 Aug 135(3):803-13

Huang GJ, Herbert J. Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat. Neuropsychopharmacology 2005 Feb 30:231-241.


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