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Chuan Chiang-Ni

AppointmentsAssociate Professor

Lab:Bacterial pathogenesis Lab


School/NationNational Cheng Kung University (Taiwan, ROC.)

Tel: 886-3-2118800 ext. 3712

E-mail: entchuan@gap.cgu.edu.tw

Research website: https://sites.google.com/a/gap.cgu.edu.tw/bac_pathog/

Research outline(1-3 pages)

  Streptococcus pyogenes (group A Streptococcus, GAS) is the major human pathogen causes various diseases including pharyngitis, cellulitis, scarlet fever, necrotizing fasciitis, and toxic shock syndrome. Although this pathogen is sensitive to antibiotics treatment, it still causes more than 500,000 deaths per year in the global scale. In addition, no vaccine is available for preventing GAS infections. My research focuses on studying the mechanism of GAS virulence genes regulation under stress conditions, and the biological significance of GAS phenotypic heterogeneity and instability.

Publications: https://orcid.org/0000-0002-0753-035X

Selected publications (2016-2019)

Chen MF, Chang CH, Chiang-Ni C, Hsieh PH, Shih HN, Ueng SWN, Chang Y*. 2019. Rapid analysis of bacterial composition in periprosthetic joint infection by 16S rRNA metagenomic sequencing. Bone Joint Res. Accepted.

Hou TY, Chiang-Ni C, Teng SH*. 2019. Current status of MALDI-TOF mass spectrometry in clinical microbiology. J Food Drug Anal. 27:404-414. https://doi.org/10.1016/j.jfda.2019.01.001

Chiang-Ni C*, Kao CY#, Hsu CY#, Chiu CH. 2018. Phosphorylation at the D53 but not T65 residue of CovR determines the repression of rgg and speB transcription in emm1- and emm49-type group A streptococci. J Bacteriol. 201:e00681-18. https://doi.org/10.1128/JB.00681-18

Chiang-Ni C*, Shi YA, Lai CH, Chiu CH. 2018. Cytotoxicity and survival fitness of invasive covS mutant of group A Streptococcus in phagocytic cells. Front Microbiol. 9:2592. https://doi.org/10.3389/fmicb.2018.02592

Hsieh CL, Huang HM, Hsieh SY, Zheng PX, Lin YS, Chiang-Ni C, Tsai PJ, Wang SY, Liu CC, Wu JJ*. 2018. NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells. Front in Microbiol 9:1733. https://doi.org/10.3389/fmicb.2018.01733

Chiang-Ni C*, Tseng HC, Hung CH, Chiu CH. 2017. Acidic stress enhances CovR/S-dependent gene repression through activation of the covR/S promoter in emm1-type group A Streptococcus. Int J Med Microbiol 307:329-339. https://doi.org/10.1016/j.ijmm.2017.06.002

Zheng PX, Chan YC, Chiou CS, Hsieh CL, Chiang-Ni C, Wu JJ*. 2017. Highly prevalent emmSTG840.0 and emmSTC839.0 types of erythromycin non-susceptible group G Streptococcus isolated from bacteremia in southern Taiwan. J Microbiol Immunol Infect 50:831-838. https://doi.org/10.1016/j.jmii.2016.12.010

Hou JN, Chen TH, Chiang YH, Peng JY, Yang TH, Cheng CC, Sofiyatun E, Chiu CH, Chiang-Ni C*, Chen WJ*. 2017. PERK signal-modulated protein translation promotes the survivability of Dengue 2 virus-infected mosquito cells and extends viral replication. Viruses 9. https://doi.org/10.3390/v9090262

Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH*. 2017. Cytolethal distending toxin enhances radiosensitivity in prostate cancer cells by regulating autophagy. Front Cell Infect Microbiol 7:223. https://doi.org/10.3389/fcimb.2017.00223

Chiang-Ni C*, Chu TP, Wu JJ, Chiu CH. 2016. Repression of Rgg but not upregulation of LacD.1 in emm1-type covS mutant mediates the SpeB repression in group A Streptococcus. Front Microbiol 7:1935. https://doi.org/10.3389/fmicb.2016.01935

Chiang-Ni C, Zheng PX, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2016. Epidemiology analysis of Streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system. J Clin Microbiol 54:157-162. https://doi.org/10.1128/JCM.02089-15

Chiang-Ni C*, Nian SY, Wu JJ, Chen CJ. 2016. Oxygen-dependent phenotypic variation in group A Streptococcus. J Microbiol Immunol Infect 49:837-842. https://doi.org/10.1016/j.jmii.2014.11.010

Lai CH*, Huang JC, Chiang-Ni C, Li JP, Wu LT, Wu HS, Sun YC, Lin ML, Lee JF, Lin HJ. 2016. Mixed infections of Helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan. Gastroenterol Res Pract 2016:7521913. https://doi.org/10.1155/2016/7521913

Lai CK, Chen YA, Lin CJ, Lin HJ, Kao MC, Huang MZ, Lin YH, Chiang-Ni C, Chen CJ, Lo UG, Lin LC, Lin H, Hsieh JT, Lai CH*. 2016. Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin. Front Cell Infect Microbiol 6:9. https://doi.org/10.3389/fcimb.2016.00009


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