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Shiang-Fu Huang

職稱Associate professor

研究室名稱Molecular epidemiology Lab.

最高學歷M.D., Ph.D.

學校/國家Chang Gung University, Taiwan




研究室現有:Post-doctor:  1

博士班研究生 0 

碩士班研究生 1 

專任研究助理 2 

大學部專題生 0 


Clinically, my field is focusing on head and neck surgery managing oral cavity cancer, oropharyngeal and laryngeal cancers. Special interest is on the salivary gland surgery.

Researches in our lab are mainly on the molecular epidemiology of oral cavity cancer. We also investigated SNPs, genetic mutations, copy number alterations and proteins over-expression in the tumorigenesis and prognosis in oral cavity cancer. We have collaborated with Chang Gung Memorial Hospital and collected thousands of specimens and blood samples that are ready for molecular epidemiology research.


  1. Chen HH, Wang HM, Fan KH, Lin CY, Yen TC, Liao CT, Chen IH, Kang CJ, Huang SF*. Pre-treatment levels of C-reactive protein and squamous cell carcinoma antigen for predicting the aggressiveness of pharyngolaryngeal carcinoma. PLoS ONE. 2013; 8(1): e55327.
  2. Tsan DL, Lin CY, Kang CJ, Huang SF, Fan KH, Liao CT, Chen IH, Lee LY, Wang HM, Chang JT. The comparison between weekly and three-weekly cisplatin delivered concurrently with radiotherapy for patients with postoperative high-risk squamous cell carcinoma of the oral cavity. Radiat Oncol. 2012 Dec 18;7:215.
  3. Hung TM, Wang HM, Kang CJ, Huang SF, Liao CT, Chan SC, Ng SH, Chen IH, Lin CY, Fan KH, Chang JT. Pretreatment (18)F-FDG PET standardized uptake value of primary tumor and neck lymph nodes as a predictor of distant metastasis for patients with nasopharyngeal carcinoma. Oral Oncol. 2013; 49(2):169-74.
  4. Liao CT, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Ng SH, Lin CH, Tsao CK, Chen IH, Chang KP, Huang SF, Kang CJ, Fang KH, Wang YC, Chang YL, Huang YC, Tsai CY, Yen TC. Comparative outcomes in oral cavity cancer with resected pT4a and pT4b. Oral Oncol. 2013; 49(3):230-6. 
  5. Fang HY, Huang XY, Chien HT, Chang JTC, Liao CT, Huang JJ, Wei FC, Wang HM, Chen IH, Kang CJ, Huang SF*. Refining the role of pre-operative C-reactive protein (CRP) by neutrophil/lymphocyte ratio (NLR) in oral cavity squamous cell carcinoma. Laryngoscope 2013; Nov, 123(11):2690–2699.
  6. Lai CH, Huang SF, Liao CT, Chen IH, Wang HM, Hsieh LL. Clinical significance in oral cavity squamous cell carcinoma of pathogenic somatic mitochondrial mutations. PLoS ONE. 2013, 8(6): e65578. doi:10.1371/journal.pone.0065578.
  7. Ng SH, Lin CY, Chan SC, Yen TC, Liao CT, Chang JTC, Ko SF, Wang HM, Huang SF, Lin YC, Wang JJ. Dynamic Contrast-Enhanced MR Imaging Predicts Local Control in Oropharyngeal or Hypopharyngeal Squamous Cell Carcinoma Treated with Chemoradiotherapy. PLoS ONE. 2013, 8(8): e72230. doi:10.1371/journal.pone. 0072230.
  8. Hsu CL, Chan SC, Chang KP, Lin TL, Lin CY, Hsieh CH, Huang SF, Tsang NM, Lee LY, Ng SH, Wang HM. Clinical scenario of EBV DNA follow-up in patients of treated localized nasopharyngeal carcinoma. Oral oncology 2013; 49(6):620-625.
  9. Hung TM, Chen CC, Lin CY, Ng SH, Kang CJ, Huang SF, Liao CT, Fan KH, Wang HM, Chang JT. Prognostic value of prepontine cistern invasion in nasopharyngeal carcinoma treated by intensity-modulated radiotherapy. Oral oncology 2014; 50(3):228-233.
  10. Lee LA, Huang CG, Tsao KC, Liao CT, Kang CJ, Chang KP, Huang SF, Chen IH, Fang TJ, Li HY, Yang SL, Lee LY, Hsueh C, Chen TC, Lin CY, Fan KH, Wang HM, Ng SH, Chang YL, Lai CH, Shih SR, Yen TC. Increasing rates of low-risk human papillomavirus infections in patients with oral cavity squamous cell carcinoma: association with clinical outcomes. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2013; Aug 57(4):331-337.
  11. Liao CT, Wallace CG, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Ng SH, Lin CH, Tsao CK, Chen IH, Huang SF, Kang CJ, Yen TC. Clinical evidence of field cancerization in patients with oral cavity cancer in a betel quid chewing area. Oral oncology 2014; Aug; 50(8):721-31.
  12. Fan KH, Lin CY, Kang CJ, Lee LY, Huang SF, Liao CT, Chen IH, Ng SH, Wang HM, Chang JT. Postoperative concomitant chemoradiotherapy improved treatment outcomes of patients with oral cavity cancer with multiple-node metastases but no other major risk factors. PLoS One 2014; Feb 24; 9(2):e86922.
  13. Wang HM, Hsu CL, Hsieh CH, Fan KH, Lin CY, Chang JTC, Huang SF, Chen IH, Liao CT, Ng SK. Concurrent chemoradiotherapy using cisplatin, tegafur, and leucovorin for advanced squamous cell carcinoma of the hypopharynx and oropharynx. Biomed J 2014; May-June 37 (3): 133-140.
  14. Chen IH, Liao CT, Wang HM, Huang JJ, Kang CJ, Huang SF*. Using SCC antigen and CRP levels as prognostic biomarkers in recurrent oral cavity squamous cell carcinoma. PLoS ONE 2014 Jul 25;9(7):e103265. doi: 10.1371/journal.pone.0103265.
  15. Huang CG, Lee LA, Tsao KC, Liao CT, Yang LY, Kang CJ, Chang KP, Huang SF, Chen IH, Yang SL, Lee LY, Hsueh C, Chen TC, Lin CY, Fan KH, Chang TC, Wang HM, Ng SH, Yen TC. Human papillomavirus 16/18 E7 viral loads predict distant metastasis in oral cavity squamous cell carcinoma. J Clin Virol. 2014 Oct;61(2):230-6. doi: 10.1016/j.jcv.2014.07.007. Epub 2014 Jul 22.
  16. Lu YC, Chang JT, Liao CT, Kang CJ, Huang SF, Chen IH, Huang CC, Huang YC, Chen WH, Tsai CY, Wang HM, Yen TC, You GR, Chiang CH, Cheng AJ. OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway. Mol Cancer. 2014 Sep 19;13:218. doi: 10.1186/1476-4598-13-218.
  17. Young CK, Wu JH, Liao CT, Chen IH, Kang CJ, Wang YC, Huang SF*. The use of squamous cell carcinoma antigen in predicting distant metastasis in oral-cavity squamous cell carcinoma. J Taiwan Otolaryngol Head Neck Surg. 2014 Sep; 49(3): 155-163.
  18. Kang CJ, Lin CY, Yang LY, Ho TY, Lee LY, Fan KH, Wang HM, Huang SF, Chang KP, Fang KH, Ng SH, Liao CT, Yen TC.Positive clinical impact of an additional PET/CT scan before adjuvant radiotherapy or concurrent chemoradiotherapy in patients with advanced oral cavity squamous cell carcinoma. J Nucl Med. 2015 Jan;56(1):22-30. doi: 10.2967/jnumed.114.145300. Epub 2014 Dec 18.
  19. Huang SF*, Chang JTC, Liao CT, Kang CJ, Lin CY, Fan KH, Wang HM, Chen IH. The role of elective neck dissection in early stage buccal cancer. Laryngoscope 2015 Jan; 125(1):128–133.
  20. Hsieh CHC, Chen YDC, Huang SFC, Wang HM, Wu MH. The effect of primary cancer cell culture models on the results of drug chemosensitivity assays: the application of perfusion microbioreactor system as cell culture vessel. Biomed Res Int. 2015:470283. doi: 10.1155/2015/470283. Epub 2015 Jan 14.
  21. Hsu YPC, Hsieh CHC, Chien HT, Lai CH, Tsao CK, Liao CT, Kang CJ, Wang HM, Chang JTC, Huang SF*. Serum Markers of CYFRA 21-1 and C-Reactive Proteins in Oral Squamous Cell Carcinoma. World J Surg Oncol 2015:Aug 21;13(1):253. (SCI)
  22. Zelken JA, Kang CJ, Huang SF, Liao CT, Tsao CK. Refinements in flap design and inset for pharyngoesophageal reconstruction with free thigh flaps. Microsurgery. 2015 Jun 10. doi: 10.1002/micr.22432. [Epub ahead of print]
  23. Liao CT, Fan KH, Kang CJ, Lin CY, Chang JT, Tsang NM, Huang BS, Chao YK, Lee LY, Hsueh C, Wang HM, Liau CT, Hsu CL, Hsieh CH, Ng SH, Lin CH, Tsao CK, Fang TJ, Huang SF, Chang KP, Yen TC. Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. PLoS One. 2015 Sep 3;10(9):e0136918.
  24. Lee LA, Huang CG, Tsao KC, Liao CT, Kang CJ, Chang KP, Huang SF, Chen IH, Fang TJ, Li HY, Yang SL, Lee LY, Hsueh C, Lin CY, Fan KH, Chang TC, Wang HM, Ng SH, Yen TC. Human Papillomavirus Infections are Common and Predict Mortality in a Retrospective Cohort Study of Taiwanese Patients with Oral Cavity Cancer. Medicine (Baltimore). 2015 Nov;94(47):e2069. doi: 10.1097/MD.0000000000002069.
  25. Chin SC, Lin CY, Huang BS, Tsang NM, Fan KH, Ku YK, Hsu CL, Chan SC, Huang SF, Li CH, Tseng HJ, Liao CT, Liu HL, Sung K. Pretreatment Dynamic Contrast-Enhanced MRI Improves Prediction of Early Distant Metastases in Patients With Nasopharyngeal Carcinoma. Medicine (Baltimore). 2016 Feb;95(6):e2567. doi: 10.1097/MD.0000000000002567.
  26. Adel M, Tsao CK, Wei FC, Chien HT, Lai CH, Liao CT, Wang HM, Fan KH, Kang CJ, Chang JTC, Huang SF*. Preoperative SCC antigen, CRP serum levels, and lymph node density in oral squamous cell carcinoma. Medicine 2016 Apr; 95 (14): e3149. doi: 10.1097/MD.0000000000003149.


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