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Sen-Yung Hsieh

Sen-Yung Hsieh (謝森永)

Appointments：Professor of Medicine

Lab：Gastroenterology and Hepatology

Education：MD, PhD

School/Nation：University of Pennsylvania, PA, U.S.A.

Tel: 03 3281200 ext 7938

E-mail: siming@cgmh.org.tw

Research website:

研究室現有： 博士後研究員 2 人

博士班研究生  0  人

碩士班研究生 0 人

專任研究助理  5  人

大學部專題生  0  人

Research outline：(1-3 pages)

The goals of this lab are 1) to elucidate of the molecular basis of liver diseases, including tumor development, progression, invasion and metastasis, and the roles of gut microbiota in the modulation of host metabolic and immune responses to liver diseases and potentially clinical applications, 2) to improve current therapies to liver cancer and diseases, 3) to prevent the occurrence of liver cancers in patients of chronic hepatitis, such as viral hepatitis, alcoholic liver disease, and metabolic associated liver diseases. The platforms applying to these studies include genomics, proteomics, metabolomics, molecular and cellular biology, immunology, and animal models.

Selected publications: (*correspondents)

  1. Jei-Ming Peng, Sheng-Hsuan Lin, Ming-Chin Yu, Sen-Yung Hsieh*. CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis. J Clin Invest. 2021 Jan 4;131(1):e133525. doi: 10.1172/JCI133525.
  2. Jei-Ming Peng, Ruo-Han Tseng, Tsung-Chieh Shih, Sen-Yung Hsieh*. CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling. Cancer Letters. 497 (2021) 66–76. 2020 Oct 14;S0304-3835(20)30540-1.
  3. Tsai CL, Chang JR, Yu MC, Lee CH, Chen TC, Chuang WY, Kuo T, Lin CC, Lin SM, Hsieh SY*. Functional genomics identifies hepatitis-induced STAT3-TYRO3-STAT3 signaling as a potential therapeutic target of hepatoma. Clin Cancer Res. 2020 Mar 1;26(5):1185-1197.
  4. Sung CM, Chen KF, Lin YF, Ke HM, Huang HY, Gong YN, Tsai WS, You JF, Lu MJ, Cheng HT, Lin CY, Kuo CJ, Tsai IJ*, Hsieh SY*. Predicting Clinical Outcomes of Cirrhosis Patients With Hepatic Encephalopathy From the Fecal Microbiome. Cell Mol Gastroenterol Hepatol. 2019;8:301-318.
  5. Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H, Hung MC, Hsieh SY*. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology. 2018 Jun;67(6):2226-2243.         
  6. Ng AWT, Poon SL, Huang MN, Lim JQ, Boot A, Yu W, Suzuki Y, Thangaraju S, Ng CCY, Tan P, Pang ST, Huang HY, Yu MC, Lee PH, Hsieh SY*, Chang AY*, Teh BT*, Rozen SG*. Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. Science Transl Med. 2017 Oct 18;9(412). pii: eaan6446. doi: 10.1126/scitranslmed.aan6446.
  7. Tsai SC, Lin CC, Shih TC, Tseng RJ, Yu MC, Lin YJ, Hsieh SY*. The miR-200b-ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma. Mol Carcinog. 2017 Sep;56(9):2035-2047.
  8. Bera R, Chiou CY, Yu MC, Peng JM, He CR, Hsu CY, Huang HL, Ho UY, Lin SM, Lin YJ, Hsieh SY*. Functional Genomics Identified a Novel Protein Tyrosine Phosphatase Receptor Type F-Mediated Growth Inhibition in Hepatocarcinogenesis. Hepatology. 2014Jun;59(6):2238-2250.
  9. Lo SL, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang SF, Chang CJ, Lin YJ, Yung BY, Hsieh SY*. A novel interaction of nucleophosmin with BCL2-Associated X protein regulating death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013 May;57(5):1893-905.
  10. Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, Lee YS, Yen TC, Hsieh SY*. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatology, 2012 Sept 57(3):584-91.
  11. Hsieh SY*, He JR, Hsu CY, Chen WJ, Bera R, Lin KY, Shih TC, Yu MC, Lin YJ, Chang CJ, Weng WH, Huang SF. Neuregulin/erythroblastic leukemia viral oncogene homolog 3 autocrine loop contributes to invasion and early recurrence of human hepatoma. Hepatology. 2011 Feb;53(2):504-16.
  12. Hsieh SY*, Meng XJ, Wu YH, Liu ST, Tam AW, Lin DY and Liaw YF. Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J. Clin. Microbiol. 1999. 37:3828-3834. (Hsieh SY*為唯一指導作者)
  13. Eller C, Heydmann L, Colpitts C, .., Hsieh SY, et al. A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. Nat Commun. 2020 Jun 1;11(1):2707. doi: 10.1038/s41467-020-16517-w.)  
  1. Lee CH, Chang CJ, Lin YJ, Yen CL, Shen CH, Cheng YT, Lin CC, Hsieh SY*. Nomogram predicting extrahepatic metastasis of hepatocellular carcinoma based on commonly available clinical data. JGH Open. (An official journal of the Asia Pacific Association for the Study of the Liver) 2018 Nov 1;3(1):38-45. doi: 10.1002/jgh3.12102. eCollection 2019 Feb.
  2. Jusakul A, Cutcutache I, .., Hsieh SY, Yu MC, .., Teh BT, Tan P. Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. Cancer Discovery. 2017 Jun 30. pii: CD-17-0368. doi: 10.1158/2159-8290 [Epub ahead of print]
  3. Hsieh SY*, Lee CH, Lin CC. Platelet: A friend of foe of the patients with hepatoma? Liver Int. 2016; 36: 615.
  4. Lee CH, Lin YJ, Lin CC, Yen CL, Shen CH, Chang CJ, Hsieh SY*. Pretreatment platelet count early predicts extrahepatic metastasis of human hepatoma. Liver International. 2015 Oct;35(10):2327-36.
  5. Hsieh SY*, He JR, Yu MC, Lee WC, Chen TC, Lo SJ, Bera R, Sung CM, Chiu CT. Secreted ERBB3 Isoforms are Serum Markers for Early Hepatoma in Patients with Chronic Hepatitis and Cirrhosis. J Proteome Res. 2011 Aug 31. 10:4715-24.
  6. Hsieh SY*, Huang SF, Yu MC, Yeh TS, Chen TC, Lin YJ, Chang CJ, Sung CM, Lee YL, Hsu CY. Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinogenesis, 2010, 49(5):476-87.
  7. Hsieh SY*, Hsu CY, He JR, Liu CL, Lo SJ, Chen YC, Huang HY. Identifying Apoptosis-Evasion Proteins/Pathways in Human Hepatoma Cells via Induction of Cellular Hormesis by UV Irradiation. J Proteome Res. 2009 Aug;8(8):3977-86.
  8. Lee CH, Chang CJ, Lin YJ, Yeh CN, Chen MF, Hsieh SY*. Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma. Br J Cancer. 2009 May 26;100(11):1765-70.
  9.  Hsieh SY*, Zhang FH, Wu YT, Chen JK, Lee YL. Profiling the proteome dynamics during the cell cycle of human hepatoma cells. Proteomics 2008 Jul;8(14):2872-84.
  10. Hsieh SY*, Tseng CL, Lee YS, Kuo AJ, Sun CF, Lin YH, Chen JK. Highly efficient classification and identification of human pathogenic bacteria by MALDI-TOF MS. Mol Cell Proteomics. 2008 Feb;7(2):448-456.
  11. Pan YS, Lee YS, Lee YL. Lee WC, Hsieh SY*. Differentially profiling the low-expression transcriptomes of human hepatoma using a novel SSH/microarray approach. BMC Genomics. 2006 May 31;7(1):131: 1-11.
  12. Hsieh SY*, Chen RK, Pan YH, Lee HL.  Systematical evaluation of the effects of sample collection procedures on low-molecular-weight serum/plasma proteome profiling. Proteomics. 2006; May 6(10):3189-98.
  13. Hsieh SY*, Shih TC, Chen YM, Chien KY, Chou YY, Lee YS. Comparative proteomic studies on the pathogenesis of human ulcerative colitis. Proteomics 2006 Oct;6(19):5322-31.
  14. Hsieh SY*, Chen WC, Shih TC, Yeh CY, Jeng ZT. Dys-regulation of clusterin in human hepatoma is not associated with tumorigenesis but is secondary to cell response to external stresses. Mol Carcinogenesis 2005; 43: 100-107
  15. Hsieh SY*, Chen WY, Yeh TS, Sheen IS, Huang SF. High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma. Oncogene 2005; 24(43):6584-9.
  1. Hsieh SY*, Chen WC, Shih TC, Yeh CY, Jeng ZT. Dys-regulation of clusterin in human hepatoma is not associated with tumorigenesis but is secondary to cell response to external stresses. Mol Carcinogenesis 2005; 43: 100-107.
  2. Hsieh SY*, Hsieh PS, Chiu CT, Chen WY. Dickkopf-3/REIC functions as a suppressor gene of tumor growth. Oncogene 2004; 23 :9183-9189.
  3. Hsieh SY*, Liaw SF, Lee SN, Hsieh PS, Chu CM, Liaw YF. Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells. Br J Cancer 2003; 88:210-216.
  4. Lin CH, Hsieh SY*, Sheen IS, WC Lee, TC Chen, YF Liaw. Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Research 2001; 61:4238-4243.
  5. Hsieh SY*, Wu YH, Lin DY, Chu CM, Liaw YF. Correlation of mutational analysis to clinical features in Taiwanese patients with Gilbert’s syndrome. Am J Gastroenterol 2001; 96:1188-1193.
  6. Hsieh SY*, Wu YH, Ho YP, Tsao KC, Yeh CT and Liaw YF. High prevalence of TT virus infection in healthy children and adults and in patients with liver disease in Taiwan. J. Clin. Microbiol. 1999; 37:1829-1831.
  7. Hsieh SY*, Yang PY, Ho YP, Chu CM and Liaw YF. Identification of a novel strain of hepatitis E virus Responsible for sporadic acute hepatitis in Taiwan. J Med Virol. 1998. 55:300-304.
  8. Hsieh SY*, et al. Identification of a novel strain of hepatitis E virus responsible for sporadic acute hepatitis in Taiwan. J Med Virol. 1998 Aug;55(4):300-4.
  9. Hsieh SY*, Yang PY, Chen HC and Liaw YF. Cloning and characterization of the extreme 5' -terminal sequences of the RNA genomes of GB virus C/hepatitis G virus. Proc. Natl. Acad. Sci. USA 1997; 94:3206-10.
  10. Hsieh SY*, Yang PY, Chiu CM and Liaw YF. Role of the ribozyme of hepatitis delta virus in the transcription after the polyadenylation.  Biochem. Biophy. Res. Comm. 1994; 205:864-871.
  11. Hsieh SY*, Yang PY, Chu CM and Liaw YF. Polyadenylation mRNA of hepatitis delta virus is dependent on the structure of the nascent RNA and regulated by either the small or large delta antigen. Nucl. Acids Res. 1994; 22:391-396.

 

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