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吳明道(Ming-Dao Wu)

Appointment: Professor

LabCarbohydrate Immunochemistry Laboratory,CGU

Education : Ph.D.

University/NationNew York Medical College,USA

Tel: (03)2118800 ext.5175

E-mail : amwu@mail.cgu.edu.tw

Research website:

Research interests:



1.      Singh T, Wu JH, Peumans WJ, Rouge P, Van Damme EJ, Wu AM*, Recognition profile of Morus nigra agglutinin  expressed by monomeric ligands, simple clusters and mammalian polyvalent glycotopes. (Morniga G) Mol. Immunol. 44(4):451-462, 2007. (Morniga G)

2.      Wu AM*, Singh T, Liu JH, Krzeminski M, Russwurm R, Siebert HC, Bonvin AM, Andre S, Gabius HJ, Activity-structure correlations in divergent lectin evolution: fine specificity of chicken galectin CG-14 and computational analysis of flexible ligand docking for CG-14 and the closely related CG-16. Glycobiology. 17(2):165-184, 2007. (CG-14)

3.      Wu AM*, Wu JH, Tsai MS, Yang Z, Sharon N, Herp A, Differential affinities of Erythrina cristagalli lectin (ECL) toward monosaccharides and polyvalent mammalian structural units. Glycoconjugate J. 24(9):591-604, 2007. (ECL)

4.      Wu AM*, Khoo KH, Yu SY, Yang Z, Kannagi R, Watkins WM, Glycomic mapping of pseudomucinous human ovarian cyst glycoproteins: identification of Lewis and sialyl Lewis glycotopes. Proteomics. 7(20): 3699-3717, 2007. (HOC350)

5.      Wang D, Wu AM*, Carbohydrate microarrays for lectin characterization and glyco-epitope identification. Lectin: Analytical Technologies, Ed. CL Nilsson, Elsevier, NL, 167-192, 2007.

6.      Garbius HJ, Wu AM, Galectins as regulators of tumor growth and invasion by targeting distinct cell surface glycans and implications for drug design. Galectins, John Wiley & Sons, Inc., Hoboken, New Jersey, Anatole A. Kiyosov, Zbigniew J. Witczak, David Platt (ED), 71-86, 2008 .

7.      Yang Z, Tsai MS, Wu JH, Herp A, Wu AM*, Defining the carbohydrate specificities of Erythrina corallodendron lectin (ECorL) as polyvalent Galβ1-4GlcNAc (II) > monomeric II > monomeric Gal and GalNAc. Chang Gung Med. J. 31:26-43, 2008. (ECorL)

8.      Yu SY, Khoo KH, Yang Z, Herp A, Wu AM*, Glycomic mapping of O- and N-linked glycans from major rat sublingual mucin. Glycoconjugate J. 25:199212, 2008. (RSL)

9.      Wu AM*, Wu JH, Yang Z., Singh T, Goldstein IJ, Sharon N., Differential contributions of recognition factors of two plant lectinsAmaranthus caudatus lectin and Arachis hypogea agglutinin, reacting with Thomsen-Friedenreich disaccharide (Gal1-3GalNAc1-Ser/Thr), Biochimie. 90:1769-1780, 2008. (ACL&PNA)

10.      Wu AM*, Lisowska E, Duk M, Yang Z, Lectins as tools in glycoconjugate research. glycoconjugate J. 26:899-913, 2009.

11.      Yang Z, Wu AM*, Kuo HW, Wu JH, Kannagi R, Expression of sialyl Lex, sialyl Lea, Lex and Ley glycotopes in secreted human ovarian cyst glycoproteins, Biochimie. 91: 423-433, 2009. (Lewis)

12.      Wu AM*, Wu JH, Singh T, Singha B, Sudakevitz D, Gilboa-Garber N, Multivalent human blood group ABH and Lewis glycotopes are key recognition factors for a LFuc >Man binding lectin from phytopathogenic Ralstonia solanacearum, Biochim. Biophys. Acta. 1790: 249-259, 2009. (RSL)

13.      Yu SY, Yang Z, Khoo KH, Wu AM*, Identification of blood group A/ A-Leb/y and B/ B-Leb/y active glycotopes co-expressed on the O-glycans isolated from two distinct human ovarian cyst fluids, Proteomics. 9: 3445–3462, 2009. (AB)

14.      Wu AM*, Wu JH, Liu JH, Chen YY, Singha B, Chow LP, Lin JY, Roles of mammalian structural units, ligand cluster and polyvalency in the Abrus precatorius agglutinin and glycoprotein recognition process, Mol. Immunol., 46:3427-3437, 2009.  (APA)

15.      Wu JH, Wu AM*, Yang Z, Chen YY, Singha B, Chow LP, Lin JY, Recognition intensities of submolecular structures, mammalian glyco-structural units, ligand cluster and polyvalency in abrin-a-carbohydrate interactions. Biochimie, 92: 147-156, 2010 (Abrin-a)

16.      Wu AM*, Gong YP, Li CC, Gilboa-Garber N, Duality of the carbohydrate-recognition system of Pseudomonas aeruginosa-II lectin (PA-IIL). FEBS Lett., 584: 2371-2375, 2010. (PA-II)

17.      Wu AM*, Liu JH, Gong YP, Li CC, Chang ET, Multiple recognition systems adopting four different glycotopes at the same domain for the Agaricus bisporus agglutinin–glycan interactions. FEBS Lett., 584: 3561-3566, 2010. (ABA)

18.      Yen MH, Wu AM*, Yang Z, Gong YP, Chang ET, Recognition Roles of the Carbohydrate Glycotopes of Human and Bovine Lactoferrins in LectinN-glycan Interactions. Biochim. Biophys. Acta., 1810: 139-149, 2011. (Lactoferrin)

19.      Krzeminski M, Singh T, Andre S, Lensch M, Wu AM*, Bonvin AMJJ and Gabius HJ, Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region. Biochim. Biophys. Acta. 1810: 150-161, 2011. (Human galectin-3)

20.      Wu AM*, Human blood group ABH/Ii, Lea, b, x, y and sialyl Lea, x glycotopes, internal structures and immunochemical roles of human ovarian cyst glycoproteins. Adv. Exp. Med. Biol., 70533-51, 2011. (HOC)

21.      Wu AM*, Liu JH, Singh T, Yang Z. Recognition Roles of mammalian structural units and polyvalency in lectin-glycan interactions. Adv. Exp. Med. Biol., 70599-116, 2011. (polyvalent, lectin)

22.      Wu AM*, Singh T, Liu JH, Andre S, Lensch M, Siebert HC, Krzeminski M, Bonvin AMJJ, Kaltner H, Wu JH, and Gabius HJ, Adhesion/growth-regulatory galectins: insights into their ligand selectivity using natural glycoproteins and glycotopes. Adv. Exp. Med. Biol., 705117-141, 2011. (Chicken galectins)

23.      Rouge P*, Peumans WJ, Van Damme EJM, Barre A, Singh T, Wu JH, Wu AM, Glycotope structures and intramolecular affinity factors of plant lectins for Tn/T antigens. Adv. Exp. Med. Biol., 705143-154, 2011. (VVLB4, Morniga G, WBAI, jacalin, MPA, PNA)

24.      Gilboa-Garber N*, Zinger-Yosovich KD, Sudakevitz D, Lerrer B, Imberty A, Wimmerova M, Wu AM, and Garber NC, The five bacterial lectins (PA-IL, PA-IIL, RSL, RS-IIL and CV-IIL) – interactions with diverse animal cells and glycoproteins. Adv. Exp. Med. Biol., 705 155-211, 2011. (PA-IL, PA-IIL, RSL, RS-IIL and CV-IIL)

25.      Wu AM (ed) The Molecular Immunology of Complex Carbohydrates-3(單一編輯), Adv. Exp. Med. Biol., 705: 1-809, Springer/Plenum Publishers, New York and London, 2011.(Book)

26.      Wu AM*, Jia-Hua Liua, Anthony Herpa, Dvora Sudakevitzb and Nechama Gilboa-Garberb, Relative Intensities of recognition factors at two combining sites of Ralstonia solanacearum lectin (RSL) for accommodating LFucα1, DManα1 and Gal13/4GlcNAc glycotopes FEBS Lett. 586:1294-1299, 2012 (RSL)

27.      Wu AM*, Lectin, Encyclopedia of Biophysics Springer. New York/London, 2012.(百科全書)



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