王錫五

職稱：教授

研究室名稱：內分泌實驗室

最高學歷：Ph.D.

學校/國家：美國北卡羅來納州立大學

分機號碼：5253

電子郵件帳號： swwang@mail.cgu.edu.tw

個人網頁網址：

研究室現有： 博士後研究員  人

博士班研究生   人

碩士班研究生 4 人

專任研究助理  1  人

大學部專題生  1   人

研究方向及研究室特色： 
內分泌實驗室位於醫學大樓八樓醫學生物共同研究室的一角，共同研究室係由六位不同研究領域的老師組成，包括藥理、生化、解剖及生理方面。本實驗室除在開放的空間擁有三個實驗檯外，尚有細胞培養室、放射線操作室及共用之儀器室，並與解剖科莊宏亨老師實驗室互動，進行分生方面的研究；亦與醫院皮膚科及醫美主治醫師胡倩婷合作。本實驗室主要的研究主題為： 
食物中的營養成分對於人體內分泌及免疫細胞功能之作用機制 
此類營養成分有來自蕃茄的茄紅素，茶葉的兒茶素，辣椒中的蕃椒辣素等小分子，觀察這些營養物對：
(1) 人血中免疫細胞(如：淋巴球、單核球)分泌細胞素(Cytokines)的影響。
(2) 內分泌系統(大鼠卵巢、睪丸、腎上腺)荷爾蒙分泌之影響。 
(3) 腎癌細胞RCC分泌細胞素及生長之影響。

(4) 皮膚癌(melanoma)細胞生長之影響。

中藥及藥物對免疫或內分泌之作用 
以市面上常見之中藥，如「甘草素」、「黃蓮」、「雷公藤」、或救心的成分「毛地黃」為主，觀察其對內分泌腺體分泌荷爾蒙、腎癌細胞RCC、皮膚癌(melanoma)細胞、及免疫細胞分泌細胞素之影響。

最近五年所發表論文：2013-2017

1. Wang KL, Hsia SM, Yeh JY, Cheng SC, Wang PS*, and Wang SW*.  Anti-Proliferative Effects of Evodiamine on Human Breast Cancer Cells. PLoS ONE 2013. 8(6): e67297.

     (I.F.2.806     Rank:15/64=23.438%    Field: Multidisciplinary Sciences)

2. Tsui KH, Wang SW, Chung LC, Feng TH, Lee TY, Chang PL, and Juang HH*. Mechanisms by Which Interleukin-6 Attenuates Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells. BioMed Research International. (Journal of Biomedicine and Biotechnology)  2013 Article ID 791212,

      (I.F.:2.476, Rank:67/160=41.875%  Field: BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

      (I.F.:2.476, Rank:65/128=50.781%    Field: MEDICINE, RESEARCH & EXPERIMENTAL)

3. Tsui KH, Chung LC, Wang SW, Feng TH, Chang PL, and Juang HH*. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells. J Mol Endocrinol. 2013; 51, 131–141.

      (I.F.:3.577, Rank:53/138=38.406%, Field: ENDOCRINOLOGY & METABOLISM)

4. Hwang GS, Hu S, Lin YH, Chen ST, Tang TK Wang PS, Wang. SW*. Arecoline inhibits interleukin-2 secretion in Jurkat cells by decreasing the expression of alpha7-nicotinic acetylcholine receptors and prostaglandin E₂. J Physiol Pharmacol. 2013; 64(10), 535-543.

          (I.F.:2.883     Rank:29/84=34.523%    Field: Physiology)

5. Lieu FK, Lin CY, Wang PS, Jian CY, Yeh YH, Chen YA, Wang KL, Lin YC, Chang LL, Wang GJ, Wang SW*. Effect of swimming on the production of aldosterone in rats. PLOS ONE 2014, Oct, 9:e87080.

    (I.F.2.806     Rank:15/64=23.438%    Field: MULTIDISCIPLINARY SCIENCES)

6. Chang YJ, Hwu CM, Yeh CC, Wang PS*, Wang SW*. Effects of subacute hypothyroidism on metabolism and growth-related molecules. Molecules 2014. 19(8):11178-11195.

     (I.F.2.861     Rank:17/59=28.814%    Field: CHEMISTRY, ORGANIC)

7. Wang ZH, Hsu HW, Chou JC, Yu CH, Bau DT, Wang GJ, Huang CY, Wang PS*, and Wang SW*. Cytotoxic Effect of S-Petasin and Iso-S-Petasin on the Proliferation of Human Prostate Cancer Cells. Anticancer Res. 2015, Jan, 35: 191-200.

      (I.F.=1.937     Rank:161/217=74.194%    Field: Oncology)

8. Sindy Hu, Wen-Chyuan Chen, Guey-Shyang Hwang, Szu-Tah Chen, Song-Bor Kuo, Yifen Chen, Galina Idova, Shyi-Wu Wang*. Changes in plasma steroids and cytokines levels in betel chewing patients in Taiwan. Steroids 2016, July,111:134-138.

(I.F.=2.282     Rank: 186/290 = 64.138 %    Field:Biochemistry )

(I.F.=2.282,  Rank: 95/138 = 68.84 %    Field:Endocrinology/Metabolism)

9. Chen CW, Jian CY, Lin PH, Chen CC, Lieu FK, Soong C, Hsieh CC, Wan CY, Idova G, Hu S, Wang SW*, and Wang PS*. Role of testosterone in regulating induction of TNF-a in rat spleen via ERK signaling pathway. Steroid, 2016, July, 111: 148-154.

(I.F.=2.282     Rank: 186/290 = 64.138 %    Field:Biochemistry )

(I.F.=2.282, Rank: 95/138 = 68.84 %    Field:Endocrinology/Metabolism)

10. Wang KL, Huang WC, Chou JC, Ting-Chun Weng TC, Sindy Hu S, Fu-Kong Lieu FK, Wei-Ho Lai WH, Idova G, Wang PS*, Wang SW*. Effects of acrolein on aldosterone release from zona glomerulosa cells in male rats. Steroids, 2016, July,111:89-94.

(I.F.=2.282     Rank: 186/290 = 64.138 %    Field:Biochemistry )

(I.F.=2.282, Rank: 95/138 = 68.84 %     Field:Endocrinology/Metabolism)

11. Yeh YH, Chou JC, Weng TC, Lieu FK, Lin JY, Yeh CC, Hu S, Wang PS*, Idova G, and Wang SW*. Effects of acrolein on the production of corticosterone in male rats. Steroids 2016, July,111:139-147.

(I.F.=2.282     Rank: 186/290 = 64.138 %   Field:Biochemistry )

(I.F.=2.282, Rank: 95/138 = 68.84 %    Field:Endocrinology/Metabolism)

12. Lin PH, Jian CY, Chou JC, Chen CW, Chen CC, Soong C, Hu S, Lieu FK*, Wang PS*, and Wang SW*. Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats. Sci. Reports 2016, Aug., 6:32085

(I.F.=4.259     Rank: 10/64 = 15.625 %    Field: Multidisciplinary Sci )

13. Chen CW, Chen CC, Jian CY, Lin PH, Chou JC, Teng HS, Hu S, Lieu FK*, Wang PS*, and Wang SW*. Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes. J Appl Physiol. 2016, Oct., 121: 870–877.

(I.F.=3.351     Rank: 8/81 = 9.877 %    Field: Sport Science)

14. Chen CC, Chen CW, Lin PH, Chou JC, Weng TC, Jian CY, Hu S, Lai WH, Lieu FK*, Wang SW*,  and Wang PS*. Interactive Effect of Corticosterone and Lactate on Regulation of Testosterone Production in Rat Leydig Cells. Journal of Cellular Physiology 2017, Aug, 232: 2135–2144

(I.F.=4.080     Rank: 16/84 = 19.05 %    Field: physiology)

(I.F.=4.080     Rank: 68/190 = 35.79 %    Field: cell biology)

15. Hwang GS, Chen CC, Chou JC, Chang LL, Kan SF, Lai WH, Lieu FK, Hu S, Wang PS, Wang SW*. Stimulatory effect of intermittent hypoxia on the production of corticosterone by zona fasciculata-reticularis cells in rats. Sci Reports, 2017 Aug, 7:9035.

 (I.F.=4.259     Rank: 10/64 = 15.625 %    Field:Multidisciplinary Sci )