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楊雅晴(Ya-Chin Yang)

AppointmentAssociate Professor

LabNeurobiology Laboratory


University/NationNational Taiwan University, Taiwan

Tel: (03)2118800 ext. 3394


Research website http://ls.cgu.edu.tw/files/11-1038-1559.php

Research interests:

 Information processing by neural circuits in the mammalian brain 



Published papers (First and/or Corresponding Author):

Y.-C. Yang*, Hu C-C and Lai Y-C (2015) Non-additive modulation of synaptic transmission by serotonin, adenosine,and cholinergic modulators in the sensory thalamus. Frontiers in Cellular Neuroscience9:60. (*Corresponding Author)

Y.-C. Yang*, C.-C. Hu, C.-S. Huang, and P.-Y. Chou (2014) Thalamic synaptic transmission of sensory information modulated by synergistic interaction of adenosine and serotonin. Journal of Neurochemistry 128:852-863(*Corresponding Author)

Y.-C. Yang, C.-H. Tai, M.-K. Pan, C.-C. Kuo (2014) The T-type calcium channel as a new therapeutic target for Parkinson’s disease. (Invited Review) Pflügers Archiv466(4):747-755 

C.-H. Tai, M.-K. Pan, J. J. Lin, C.-S. Huang, Y.-C. Yang* and C.-C. Kuo* (2012) Subthalamic discharges as a causal determinant of parkinsonian motor deficits. Annals of Neurology 72(3):464-76. (*Corresponding Author)

C.-H. Tai#, Y.-C. Yang#(co-first author), M.-K. Pan, C.-S. Huang, and C.-C. Kuo (2011) Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease. #equal contribution. Journal of Clinical Investigation 121(8):3289-3305.

Y.-C. Yang, S. Lin, P.-C. Chang, H.-C. Lin, and C.-C. Kuo (2011) Functional extension of amino acid triads from the fourth transmembrane segment (S4) into its external linker in Shaker K+ Channels. Journal of Biological Chemistry 286: 37503-37514
Y.-C. Yang, C.-S. Huang, and C.-C. Kuo (2010) Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels. Anesthesiology 113(1):160-174
Y.-C. Yang#, C.-H. Lee#, and C.-C. Kuo (2010) Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+ block of NMDA receptors. #equal contribution. Journal of Physiology (London) 588(4):633-650
Y.-C. Yang, J.-Y. Hsieh, and C.-C. Kuo (2009) The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channel. Journal of General Physiology 134: 95-113
Y.-C. Yang, C.-J. Own, and C.-C. Kuo (2007) A hydrophobic element secures S4 voltage sensor in position in the resting Shaker K+ channel. Journal of Physiology (London) 582(3):1059-1072
Y.-C. Yang and C.-C. Kuo (2005) An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+. Journal of General Physiology 125:465-481.
Y.-C. Yang and C.-C. Kuo (2003) The position of the fourth segment of domain 4 determines status of the inactivation gate in Na+ channels.Journal of Neuroscience 23:4922-4930.

Y.-C. Yang and C.-C. Kuo (2002) Inhibition of Na+ current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker. Molecular Pharmacology 62:1228-1237.



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