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徐錦源

徐

徐錦源(Chin-Yuan Hsu

AppointmentAssociate Professor

LabAnti-aging Laboratory

EducationPh.D.

University/NationNational Tsing-Hua University, Taiwan

Tel: (03)2118800 ext.3402

E-mailhsu@mail.cgu.edu.tw

Research website

Research interests:

1. The mechanisms of aging and lifespan extension in honeybees.

2. The mechanism of lifespan extension at ambient temperature reduction.

3. Anti-aging drugs screen.

Publications:

  1. Lu CY, Weng YT, Tan B, Hsu CY* (2021) The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles. GeroScience.
  2. Hsu CY*, Weng YT (2021) Long-term inhibition of ferritin2 synthesis in trophocytes and oenocytes by ferritin2 double-stranded RNA ingestion to investigate the mechanisms of magnetoreception in honey bees (Apis mellifera). PLoS ONE 16(8):e0256341.
  3. Hsu CY*, Lo HF, Mutti N.S et al. (2019) Ferritin RNA interference inhibits the formation of iron granules in the trophocytes of worker honey bees (Apis mellifera). Sci Rep 9, 10098.
  4. Lu CY, Qiu JT, Hsu CY* (2018) Cellular energy metabolism is maintained during aging in long-living queen bees. Arch. Insect Biochem. Physiol.Doi:10.1002/arch.21468.
  5. Lu CY, Chuang YL, Hsu CY* (2017) Aging results in a decline in cellular energy metabolism in the trophocytes and oenocytes of worker honeybees (Apis mellifera). Apidologie 48:761-775.
  6. Hsu CY*, Qiu JT, Chan YP, (2016) Cellular degradation activity is maintained during aging in long-living queen bees. Biogerontology 17:829-840.
  7. Lu CY, Hsu CY* (2015) Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii). Age doi:10.1007/s11357-015-9775-z.
  8. Hsu CY*, Lu CY (2015) Mitochondrial energy utilization maintains young status in the trophocytes and fat cells of old queen honeybees. Apidologie doi:10.1007/s13592-015-0348-z.
  9. Hsu CY*, Hu TH (2014) Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees. Biogerontology 15:389-400.
  10. Hsu CY*, Chuang YL (2014) Changes in energy-regulated molecules in the trophocytes and fat cells of young and old worker honeybees. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 69:955-964.
  11. Hsu CY*, Hsieh YS (2014) Oxidative stress decreases in the trophocytes and fat cells of worker honeybees during aging. Biogerontology 15:129-137.
  12. Hsu CY*, Chuang YL, Chan YP (2014) Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera) Exp. Gerontol. 50:128-136.
  13. Hsieh YS, Hsu CY* (2013) Oxidative stress and anti-oxidant enzyme activities in the trophocytes and fat cells of queen honeybees (Apis mellifera). Rejuv. Res. 16:295-303.
  14. Chuang YL, Hsu CY* (2013) Changes in mitochondrial energy utilization in young and old worker honeybees. Age 35:1867-1879.
  15. Hsu CY*, Chan YP (2013) The use of honeybees reared in a thermostatic chamber for aging studies. Age 35:149-158.
  16. Hsieh YS, Hsu CY* (2011) The changes of age-related molecules in the trophocytes and fat cells of queen honeybees (Apis mellifera). Apidologie 42:728-739.
  17. Hsu CY*, Chan Y.P. (2011) Identification and localization of proteins associated with biomineralization in the iron deposition vesicles of honeybees (Apis mellifera). PLoS ONE 6(4):e19088. doi:10.1371/journal.pone.0019088
  18. Hsieh YS, Hsu CY* (2011) Honeybee trophocytes and fat cells as target cells for cellular senescence studies. Exp. Gerontol. 46:233-240.
  19. Hsu CY*, Chiu YC (2009) Ambient temperature influences aging in an annual fish (Nothobranchius rachovii). Aging Cell 8:726-737.
  20. Hsu CY*, Chiu YC, Hsu WL, Chan YP (2008) Age-related markers assayed at different developmental stages of the annual fish Nothobranchius rachovii. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 63A:1267-1276.
  21. Hsu CY*) (2008) Antioxidant activity of extracts from Pyrrosia petiolosa. Fitoterapia 79:64-66.
  22. Hsu CY*, Ko FY, Li CW, Fann K, Lue JT (2007) Magnetoreception system in honeybees (Apis mellifera). PLoS ONE 2(4): e395. doi:10.1371/journal.pone.0000395.
  23. Hsu CY* (2004) The processes of iron deposition in the common hornet (Vespa affinis). Biol. Cell 96:529-537.
  24. Liou ML, Hsu CY* (1998) Japanese encephalitis virus transports across the cerebral blood vessels by endocytosis in mouse brain. Cell & Tissue Res. 293:389-394.
  25. Hsu CY, Li CW (1994) Magnetoreception in honeybees (Apis mellifera). Science 265:95-97.

   26. Hsu CY, Li CW (1993) The ultrastructure and formation of iron granules in the honey bee (Apis mellifera).            J. Exp. Biol. 180:1-13.

 

 

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