is interested in understanding the molecular mechanisms and functionalities
of membrane proteins involved in cancer development. Specifically, my main
research focuses on the epidermal growth factor receptor (EGFR), a receptor
tyrosine kinase (RTK). Overexpression or activation of EGFR is often found in
tumors with epithelial origin that is also associated with poor prognosis,
metastasis and chemoresistance. Interestingly, this
cell membrane receptor, which has been extensively studied, not only
transduces signals from the cell membrane, but also can translocate into the
nucleus and play a role in gene regulation. We are currently using molecular
biology, bioinformatics and pharmacological methods to explore the mechanisms
and functions of membrane proteins nuclear translocation in attempt to
identify new cancer biomarkers and develop treatment strategies.
- Wu JC, Hsu SC,
Wang SY, Huang YH, Sheen IJ, Shih HH, Syu WJ.
"Defective" mutations of hepatitis D viruses in chronic
hepatitis D patients. World J Gastroenterol.
- Lo HW, Hsu SC,
Ali-Seyed M., Gunduz
M, Xia W, Wei Y, Bartholomeusz G., Shih JY,
Hung MC. Nuclear interaction of EGFR and STAT3 in the activation of iNOS/NO pathway. Cancer Cell 7(6):575-89, 2005.
- Chuang CH, Chiu HJ, Hsu
SC, Ho JY, Syu WJ. Comparison of Tir from enterohemorrahgic
and enteropathogenic Escherichia coli
strains: two homologues with distinct intracellular properties. J.
Biomed. Sci. 1:73-87, 2006. (SCI)
- Lo HW, Hsu SC,
Hung MC. EGFR signaling pathway in breast cancers: from traditional
signal transduction to direct nuclear translocalization.
Breast Cancer Res. Treat. 95(3):211-8, 2006. Review (SCI)
- Lo HW, Ali-Seyed M, Wu Y, Bartholomeusz
G, Hsu SC, Hung MC. Nuclear-cytoplasmic transport of EGFR
involves receptor endocytosis, importin beta1
and CRM1. J. Cell. Biochem. 98(6):1570-83,
- Hsu SC and Hung MC.
Characterization of a novel tripartite nuclear localization sequence in
the EGFR family. J Biol. Chem. 282(14):10432-40, 2007. (SCI)
- Lo WH, Hsu SC,
Xia W, Cao X, Shih JY, Abbruzzese JL, Hortobagyi GN, Hung MC. Epidermal growth factor
receptor cooperates with signal transducer and activator 3 to induce
epithelial-mesenchymal transition in cancer
cells via up-regulation of TWIST gene expression. Cancer Res.
67(19): 9066-76, 2007. (SCI)
- Hsu SC, Miller SA, Wang Y,
Hung MC. Nuclear EGFR is required for cisplatin
resistance and DNA repair. Am. J. Transl. Res. 1(3):249-58, 2009.
- Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y,
Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, Hung MC. RNA helicase
A is a DNA-binding partner for EGFR-mediated transcriptional activation
in the nucleus. Proc. Natl. Acad. Sci. 107(37):16125-30, 2010. (SCI)