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許勝傑

 

Sheng-Chieh Hsu  (許勝傑)

Appointment: Assistant Professor

Lab：Molecular Cell and Cancer Laboratory

Education: Ph.D.

University/Nation：Yang-Ming University/ Taiwan

Tel: 886-3-211-8800 #3690

E-mail: schsu@mail.cgu.edu.tw

Research website:

Laboratory personnel:

Postdoctoral fellow: 0 ; Ph.D. student: 1 ; Master student: 0 ; Res. Assistant: 0 ; Undergraduate: 0

Research interests:：

1. To study the roles of cell membrane proteins in tumorigenesis and chemotherapeutic resistance

Cell membrane proteins can trigger intracellular signal transduction and regulate cell proliferation, differentiation and survival. Abnormal membrane protein expression and activation often lead to various types of tumors, including breast cancer, ovarian cancer, lung cancer and head and neck cancer, and are quite related to the resistance to chemotherapy. This laboratory is interested in the molecular mechanisms of different cell membrane proteins involved in tumorigenesis. The membrane proteins studied include epidermal growth factor receptor (EGFR), E-cadherin and ATP-binding cassette transporters (ABC transporters). This basic research has led to the development of novel nano-drugs and related cancer treatment methods

2. To establish a screening platform for nucleic acid aptamers

Aptamer is a short-chain nucleic acids that can identify a variety of different molecules. It is an emerging technology that is expected to replace antibody and become the next development trend in detection reagents and drug development. We establish a screening platform for nucleic acid aptamers through the screening aptamer for C-peptide of pre-proinsulin. It can further provide customized services for the development of diagnosis reagents.

Publications (2016-):

  1. Huang JP, Hsu SC, Meir YJ, Hsieh PS, ChangCC, Chen KH, Chen JK, Hung LM. 2018. Role of dysfunctional adipocytes in cholesterol-induced nonobese metabolic syndrome. J. Mol. Endocrinol.60(4):307-321 (2020 JCR, IF 5.098, 35/145 ENDOCRINOLOGY & METABOLISM)
  2. Lin PY, Hsu SC, Chen HC, Len WB, Hsiao FC, Liu MC, Pan PL, Lin TC, Lee YH, Meir YJ. 2018. Optimization of reprogramming culture condition for the generation of induced pluripotent stem cells from Col1a1 4F2A-Oct4-GFP mice with high efficiency. FEBS J. 285(9):1667-1683 (2020 JCR, IF 5.542, 72/297 BIOCHEMISTRY & MOLECULAR BIOLOGY)
  3. Huang JP ‡, Hsu SC ‡, Li DE, Chen KH, Kuo CY, Hung LM. (‡, equally contributed) 2018. Resveratrol mitigates high-fat diet-induced vascular dysfunction by activating the Akt/eNOS/NO and Sirt1/ER pathway. J Cardiovasc Phamacol. 72(5):231-241. (2020 JCR, IF 3.105, 71/141 CARDIAC & CARDIOVASCULAR SYSTEMS)
  4. Hsiao SH, Lusvarghi S, Huang YH, Ambudkar SV, Hsu SC＊, Wu CP＊. 2019 The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents. Cancer Lett. 445:34-44. (2020 JCR, IF 8.679, 34/242 ONCOLOGY)

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