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Chia-Jung Yu

Appointment: Professor

LabFunctional Proteomics Laboratory

Education: Ph.D.

University/NationNational Taiwan University/ Taiwan

Tel: +886-3-211-8800 ext.3424

E-mail : yucj1124@mail.cgu.edu.tw

Research website :http://d000003200.wixsite.com/yu-cj

Research interests:

1.  Development of biomarkers for lung adenocarcinoma by proteomic approaches.

2.  Mechanistic study of biomarkers in lung cancer.

3.  Characterization of human Arl1 protein complexes functioning in vesicle trafficking.

Publications: (*, Corresponding author)

  1. Hsiao TF, Wang CL, Wu YC, Feng HP, Chiu YC, Lin HY, Liu KJ, Chang GC, Chien KY, Yu JS, Yu CJ.* Integrative omics analysis reveals soluble cadherin-3 as a survival predictor and an early monitoring marker of EGFR tyrosine kinase inhibitor therapy in lung cancer. Clin Cancer Res. 2020 Jul 1;26(13):3220-3229. doi: 10.1158/1078-0432.CCR-19-3972. Epub 2020 Mar 10.
  2. Chen KJ, Chiang TC, Yu CJ, Lee FJ*. Arl4A and Pak1 cooperative recruitment to plasma membrane contributes to    sustained Pak1 activation for cell migration. J. Cell Sci. 2020 Feb 4;133(3). pii: jcs233361. doi: 10.1242/jcs.233361.
  3. Chang JW, Shih CL, Wang CL, Luo JD, Wang CW, Hsieh JJ, Yu CJ, Chiou CC*. Transcriptomic analysis in liquid biopsy identifies circulating PCTAIRE-1 mRNA as a biomarker in NSCLC. Cancer Genom. Proteom. 2020 Jan-Feb;17(1):91-100.
  4. Huang JX, Wu YC, Cheng YY, Wang CL, Yu CJ*. IRF1 Negatively regulates oncogenic KPNA2 expression under growth stimulation and hypoxia in lung cancer cells. Oncotargets Ther. 2019 Dec; 2019(12): 11475-11486.
  5. Ho ML, Kuo WK, Chu LJ, Yeh IH, Fan CW, Chang HI, Yuan CL, Chou TY, Chen HY, Yang SW, Chang LC, Luo M, Wu TH, Chang YI, Yu CJ, Hua CC*, Ng WV*. N-acetylgalactosamine-6-sulfatase (GALNS), Similar to Glycodelin, Is a Potential General Biomarker for Multiple Malignancies. Anticancer Res. 2019 Nov;39(11):6317-6324. 
  6. Chen YC, Jiang PH, Chen HM, Chen CH, Wang YT, Chen YJ, Yu CJ, Teng SC*. Glucose intake hampers PKA-regulated HSP90 chaperone activity. Elife. 2018 Dec 5;7. pii: e39925. doi: 10.7554/eLife.39925. 
  7. Lin YH, Wu MH, Huang YH, Yeh CT, Chi HC, Tsai CY, Chuang WY, Yu CJ, Chung IH, Chen CY, Lin KH. Thyroid hormone negatively regulates tumorigenesis through suppression of BC200. Endocr. Relat. Cancer. 2018 Dec 1;25(12):967-979. doi:10.1530/ERC-18-0176. 
  8. Hsu RM, Zhong CY, Wang CL, Liao WC, Yang C, Lin SY, Lin JW, Cheng HY, Li PY, Yu CJ*. Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness by modulating NF-κB activity. Cell Commun Signal. 2018 Apr 27;16(1):19. doi: 10.1186/s12964-018-0230-5.
  9. Wang CI, Yu CJ, Huang Y, Yi JS, Cheng HW, Kao HK, Lao WW, Chang KP*. Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer. Head Neck. 2018 Mar 15. doi: 10.1002/hed.25145.  (equal to first author) 
  10. Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC*. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Nucleic Acids Res. 2017 Oct 13;45(18):10492-10503. doi: 10.1093/nar/gkx683. 
  11. Yang CW, Tseng SF, Yu CJ, Chung CY, Chang CY, Pobiega S, Teng SC*. Telomere shortening triggers a feedback loop to enhance end protection. Nucleic Acids Res. 2017 Aug 21;45(14):8314-8328. doi: 10.1093/nar/gkx503.
  12. Yu CJ, Lee FJ*. Multiple activities of Arl1 GTPase in the trans-Golgi network. J. Cell Sci. 2017 May 15;130(10):1691-1699.
  13. Tsai CH, Chen YJ, Yu CJ, Tzeng SR, Wu IC, Kuo WH, Lin MC, Chan NL, Wu KJ, Teng SC*. SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and  Cancer Proliferation. Cancer Res. 2016 Oct 15;76(20):6043-6053. 
  14. Hsu CH, Hsu CW, Hsueh C, Wang CL, Wu YC, Wu CC, Liu CC, Yu JS, Chang YS, Yu CJ*. Identification and characterization of potential biomarkers by quantitative tissue proteomics of primary lung adenocarcinoma. Mol. Cell. Proteomics 2016 Jul;15(7):2396-410 .
  15. Wang CI, ChenYY, Wang CL, Yu JS, Chang YS, Yu CJ*. mTOR regulates proteasomal degradation and Dp1/E2F1-mediated transcription of KPNA2 in lung cancer cells. Oncotarget 2016 May 3;7(18):25432-42. 
  16. Hsu JW, Tang PH, Wang IH, Liu CL, Chen WH, Tsai PC, Chen KY, Chen KJ, Yu CJ, Lee FJ*. Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p. Proc.      Natl. Acad. Sci. U S A., 2016 Mar 22;113(12):E1683-90. 
  17. Shih CL, Chong KY, Hsu SC, Chien HJ, Ma CT, Chang JW, Yu CJ*, Chiou CC*. Development of a magnetic bead-based method for the collection of circulating extracellular vesicles. N. Biotechnol. 2016 Jan 25;33(1):116-22. 


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