歐陽品 (Pin Ouyang)

Appointment：Professor

Lab：Transgenic Mice Core Laboratory

Education：Ph.D.

University/Nation：Harvard University, USA

Tel: (03)2118800 ext.5267

E-mail：ouyang@mail.cgu.edu.tw

Research website： memo.cgu.edu.tw/pin

Research interests:

Publications:

1. Hsu S.Y., Y.J. Chen and P. Ouyang* 2011. Pnn and SR family proteins are differentially expressed in mouse central nervous system. Histochem. Cell Biol. 135:361-373. (SCI)

2. Chang Y. C., C.H. Wu, T.C. Yen and P. Ouyang* 2012. Centrosomal protein 55 (Cep55) stability is negatively regulated by p53 protein through polo-like kinase 1 (PLK1). J. Biol. Chem. 287:4376-4385. (SCI)

3. Leu S., Y. M. Lin, C. H. Wu and P. Ouyang* 2012. Loss of pnn expression   results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD. J. Cell Sci. 125:3164-3172. (SCI) Targeted article selected by GlobalMedical Discovery (http//:globalmedicaldiscovery.com)

4. Hsu S.Y., Yi-Chuan Cheng, Hung-Yu Shih and P. Ouyang* 2012. Dissection of the role of   Pinin in the development of zebrafish posterior pharyngeal cartilages. Histochem. Cell Biol. 138:127-140. (SCI)

5. Wu Hsu-Pin, Shu-Yuan Hsu, Wen-Ai Wu, Ji-Wei Hu and P. Ouyang* 2014. Transgenic mice expressing mutant Pinin exhibit muscular dystrophy, nebulin deficiency and elevated expression of slow-type muscle fiber genes. Biochem. Biophys. Res. Com.443: 313-320.

6. Pan T. L., Shu-Yuan Hsu, Pei-Wen Wang, Ya-Ting Cheng, Yu-Cheng Chang, Sudipta Saha, Jiwei Hu and P. Ouyang* 2015. FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosome stability via enhancing expression of endoplasmic reticulum stress chaperones. Cell Cycle 14(8): 1174-87.

7. Lin Y.M., C. C. Wu, Y. C. Chang., C.H. Wu, H.L. Ho, J. W. Hu, R. C. Chang, C.T. Wang and P. Ouyang* 2016. Targeted disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. Biochem. Biophys. Res. Com. 469:903-910.

8. Lin Y.M., Pao-Hsien Chu, Yun-Zhu Li, and P. Ouyang* 2017.Ribosomal protein pNO40 mediates nuceleolar sequestration of SR family splicing factors and its overexpression impairs mRNA metabolism. Cellular Signalling 32;12-23.

9. Shih Hung-Yu, Shu-Hsu Hsu, Pin Ouyang, Sheng-Jia Lin, Ting-Yun Chou, Ming-Chang Chiang, and Yi-Chuan Cheng 2017. Bmp5 regulates neural cell survival and proliferation via tow different signaling pathways. Stem Cells 35:1003-1014.

10. Tam BT, Yu AP, Tam EW, Monks DA, Wang XP, Pei XM, Koh SP, Sin TK, Law        HK, Ugwu FN, Supriya R, Yung BY, Yip SP, Wong SC, Chan LW, Lai CW, Ouyang P, and Siu PM. 2018. Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury. Scientific Reports 207:8(1)3689.  

11. Lin Y.M., Pao-Hsien Chu, and P. Ouyang* 2018. Tsg101 interacts with androgen receptor and attenuates its expression through the endosome/lysosome pathway. Biochem. Biophys. Res. Com. 503:157-164.

12. Lin Y.M., Pao-Hsien Chu, and P. Ouyang* 2019. Ectopically expressed pNO40 suppresses ribosomal RNA synthesis by inhibiting UBF-dependent transcription activation. Biochem. Biophys. Res. Com. 516:381-387.

13. Lin Y.M., Pao-Hsien Chu, and P. Ouyang* 2021. Depletion of UXT, a novel TSG101 interaction proteins, leads to enhanced Cep55 attenuation through lysosome degradation. Biochem. Biophys. Res. Com. 542:59-64.