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簡昆 (Kun-Yi Chien)

AppointmentAssociate Professor

LabProteomics Core Laboratory


University/NationNational Tsing-Hua University, Taiwan

Tel: (03)2118800 ext.5971


Research website

Research interests:



  1. Chen, T.-S., Chung, F.-Y., Tjong, S.-C., Goh, K.-S., Huang, W.-N., Chien, K. -Y., Wu, P.-L., Lin, H.-C., Chen, C.-J. and Wu, W.-G. Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins. Biochemistry 2005, 44(20):7414-7426.
  2. Wu, C.-C., Chien, K. -Y., Tsang, N.-M., Chang K,-P., Hao, S.-P., Tsao, C.-H., Chang, Y.-S. and Yu, J.-S. Cancer cell-secreted proteomes as a basis for searching potential tumor markers - nasopharyngeal carcinoma as a model. Proteomics 2005, 5(12):3173-3182.
  3. Cheng, A.-J., Chen, L.-C., Chien, K.-Y., Chen, Y.-J., Chang, J.-T., Wang, H.-M., Liao, C.-T. and Chen, I.-H. Oral Cancer Plasma Tumor Marker Identified with Bead-Based Affinity Fractionated Proteomic Technology. Clin. Chem. 2005, 51(12):2236-2244.
  4. Hwang, T. -L., Liang, -Y., Chien, K. -Y. and Yu, J. -S. Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma. Proteomics 2006, 6(7):2259-2272.
  5. Chien, K. –Y., Chang, Y. -S, Yu, J. -S, Fan, L. -W., Lee, C. -W. and Chi, L. -M. Identification of a new in vivo phosphorylation site in the cytoplasmic carboxyl terminus of EBV-LMP1 by tandem mass spectrometry. Biochem. Biophys. Res. Commun. 2006, 348(1):47-55.
  6. Chen, C. -T., Chen, W. -Y., Tsai, P. -J., Chien, K. –Y., Yu, J. -S. and Chen, Y. -C.* Rapid enrichment of phosphopeptides and phosphoproteins from complex samples using magnetic particles coated with alumina as the concentrating probes for MALDI MS analysis. J. Proteome Res. 2007, 6(1):316-325.
  7. Chen, C. -D., Wang, C. -S., Huang, Y. -H., Chien, K. -Y., Liang, Y., Chen, W. -J. and Lin, K. -H.* Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance. Proteomics 2007, 7(1):155-167.
  8. Lin, J. -Y., Li, M. -L., Huang, P. -N., Chien, K. –Y., Horng, J. -T. and Shih, S. -R.* Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication. J. Gen. Virol. 2008, 89(10):2540-2549.
  9. Huang, K. -Y., Chien, K. –Y., Lin, Y. -C., Hsu, W. -M., Fong, I. -K., Huang, P. -J., Yueh, Y. -M., Gan, R. -R. and Tang, P.* A proteome reference map of Trichomonas vaginalis. Parasitol Res. 2009, 104(4):927-933.
  10. Chi, L. -M., Lee, C. -W., Chang, K. -P., Hao, S. -P., Lee, H. -M., Liang, Y., Hsueh, C., Yu, C. -J., Lee, I. -N., Chang, Y. -J., Lee, S. -Y., Yeh, Y. -M., Chang, Y. -S., Chien, K. -Y.* and Yu, J. -S.* Enhanced interferon signaling pathway in oral cancer revealed by quantitative proteome analysis of microdissected specimens using 16O/18O labeling and integrated 2DLC-ESI-MALDI tandem MS. Mol. Cell. Proteomics 2009, 8(7):1453-1474.



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