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蘇文慧(Wen-Hui Su)

Appointment:Associate Professor

LabCancer Systems Biology Laboratory


University/NationNational Defense Medical Center, Taiwan

Tel: (03)2118800 ext.3564


Research website

Research interests:

 As a genetic disease, cancer occupied various specific genetic changes in chromosome that can affect subsequent gene expression and finally leads to the process of tumourigenesis. Genetic changes in cancer cell can be found in two different cells-- germline cells and somatic cells. Genetic changes in germline cells like single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) are relate to the susceptibility of diseases. We can use genome-wide association studies (GWAS) to discover the relationship between those genetic variations and disease status then use it to discover cancer susceptible genes. On the other hand, genetic changes in somatic cells like chromosome aberration and alteration of genetic expression can be found in tumor tissues which can be studied by integration of various biological information using bioinformatic and comparative genomic strategies. In our lab, we tried to use integrate systems biology and genetic statistics to discover susceptible markers and signature genes in nasopharyngeal carcinoma and hepatocellular carcinoma.


  1. Xiao-Yu Zuo, Qi-Sheng Feng, Jian Sun, Pan-Pan Wei, Yoon-Ming Chin, Yun-Miao Guo, Yun-Fei Xia, Bo Li, Xiao-Jun Xia, Wei-Hua Jia, Jian-Jun Liu, Alan Soo-Beng Khoo, Taisei Mushiroda, Ching-Ching Ng*, Wen-Hui Su, Yi-Xin Zeng, and Jin-Xin Bei (2019) X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma. Biology of Sex Differences 10:13 (equal contributed corresponding author)
  2. Wen-Hui Su*, Yuh-Shan Jou, Jia-Hao Zhang, Chun-Ming Ho, Dar-In Tai (2018) Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. Journal of Cancer 9(15): 2678-2686 (*Corresponding author)
  3. The Telomeres Mendelian Randomization Collaboration (2017) Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study. JAMA Oncology 3(5):636-651
  4. Jin-Xin Bei, Wen-Hui Su, Ching-Ching Ng, Kai Yu, Yoon-Ming Chin, Pei-Jen Lou, Wan-Lun Hsu, James D. McKay, Chien-Jen Chen, Yu-Sun Chang, Jian-Jun Liu, Yi-Xin Zeng, and Allan Hildesheim for the International Nasopharyngeal Carcinoma Genetics Working Group (2016) A GWAS meta-analysis and replication study identifies a novel locus within CLPTM1L/TERT associated with nasopharyngeal carcinoma in individuals of Chinese ancestry. Cancer Epidemiology Biomarkers & Prevention 25(1):188-92 (equal contributed first author)
  5. Wen-Hui Su*, Chi-Cking Chiu, Yin Yao Shugart (2015) Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese population. BMC Cancer 15:598. (*Corresponding author)
  6. Su-Wei Chang, Cathy Shen-Jang Fann, Wen-Hui Su, Yu Chen Wang, Chia Chan Weng, Chia-Jung Yu, Chia-Lin Hsu, Ai-Ru Hsieh, Rong-Nan Chien, Chia-Ming Chu, Dar-In Tai (2014) A Genome-Wide Association Study on Chronic HBV Infection and Its Clinical Progression in Male Han-Taiwanese. PLoS One 9(6):e99724.
  7. Wen-Hui Su*, Yin Yao Shugart, Kai-Ping Chang, Ngan-Ming Tsang, Ka-Po Tse, and Yu-Sun Chang (2013) How Genome-Wide SNP-SNP Interactions Relate to Nasopharyngeal Carcinoma Susceptibility. PLoS One 8(12):e83034. (*Corresponding author)
  8. Wen-Hui Su*, Allan Hildesheim, and Yu-Sun Chang (2013) Human Leukocyte Antigens and Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: Old Associations Offer New Clues into the Role of Immunity in Infection-Associated Cancers. Frontiers in Oncology 3(299):1-9. (Invited Review) (*Corresponding author)
  9. Wan-Lun Hsu, Ka-Po Tse, Sharon Liang, Yin-Chu Chien, Wen-Hui Su, Kelly Yu, Yu-Juen Cheng, Ngan-Ming Tsang, Mow-Ming Hsu, Kai-Ping Chang, I-How Chen, Tzu-I Chen, Czau-Siung Yang, Alisa Goldstein, Chien-Jen Chen, Allan Hildesheim, and Yu-Sun Chang (2012) Evaluation of Human Leukocyte Antigen-A (HLA-A), Other non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal Carcinoma. PLoS One 7(8): e42767.
  10. Lin KT, Wang YW, Chen CT, Ho CM, Su WH, and Jou YS. (2012) HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clinical Cancer Research 18(17): 4691-4701.
  11. C-Y Chang, S-C Lin, W-H Su, C-M Ho, and Y-S Jou. (2012) Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma. Oncogene 31(21):2640-52.
  12. Sen Kao, Cheng-Kai Shiau, De-Leung Gu, Chun-Ming Ho, Wen-Hui Su, Chian-Feng Chen, Chi-Hung Lin, Yuh-Shan Jou. (2012) IGDB.NSCLC: Integrated Genomic Database of Non-Small Cell Lung Cancer. Nucleic Acids Research 40(Database issue): D972-7.
  13. Ka-Po Tse, Wen-Hui Su, Min-lee Yang, Hsiao-Yun Cheng, Ngan-Ming Tsang, Kai-Ping Chang, Sheng-Po Hao, Yin Yao Shugart, and Yu-Sun Chang. (2011) A gender-specific association of CNV at 6p21.3 with NPC susceptibility. Human Molecular Genetics 20(14):2889-2896. (SCI: Impact factor: 5.340, 23/166 GENETICS & HEREDITY) (equal contributed first author)
  14. Chih-Ching Wu, Chia-Wei Hsu, Chi-De Chen, Chia-Jung Yu, Kai-Ping Chang, Dar-In Tai, Hao-Ping Liu, Wen-Hui Su, Yu-Sun Chang, and Jau-Song Yu (2010) Candidate Serological Biomarkers for Cancer Identified from the Secretomes of 23 Cancer Cell Lines and the Human Protein Atlas. Molecular and Cellular Proteomics 9(6):1100-17.
  15. Ka-Po Tse, Wen-Hui Su, Kai-Ping Chang, Ngan-Ming Tsang, Chia-Jung Yu, Petrus Tang, Lee-Chu See, Chuen Hsueh, Min-Lee Yang , Sheng-Po Hao, Hong-Yi Li, Ming-Hsi Wang, Li-Ping Liao, Lih-Chyang Chen, Sheue-Rong Lin, Yu-Sun Chang, and Yin Yao Shugart. (2009) Genome-wide association study reveals multiple nasopharyngeal Carcinoma-associated loci within the HLA region at chromosome 6p21.3. American Journal of Human Genetics 85(2):194-203  (equal contributed first author) (NSC 99-3112-B-182-006)
  16. Wen-Hui Su, Chuan-Chuan Chao, Shiou-Hwei Yeh, Ding-Shinn Chen, Pei-Jer Chen, and Yuh-Shan Jou. (2007) OncoDB.HCC: An integrated genomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci. Nucleic Acids Research, 35:D727-D731.
  17. Ya-Hui Chang, Wen-Hui Su, Tso-Ching Lee, Hsiao-Fang Sunny Sun, Chia-Hsaing Chen, Wen-Harn Pan, Shih-Feng Tsai and Yuh-Shan Jou2005TPMD: A Database and Resources of Microsatellite Marker Genotyped in Taiwanese Populations. Nucleic Acids Research 33:D174-D177. (SCI: Impact factor: 10.162, 14/286 BIOCHEMISTRY & MOLECULAR BIOLOGY) (equal contributed first author)



























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