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郭敏玲

郭敏玲(Ming-Ling Kuo)

Appointment: Professor

Lab<span lang="EN-US" style="color: black; mso-themecolor: text1Molecular Immunology Laboratory

EducationPh.D.

University/NationState University of New Jersey, USA

Tel: (03)2118800 ext.3319/3320

E-mailmingling@mail.cgu.edu.tw

Research website

Research interests:

 

  • Pubication

*: Correspondence author  : Co-correspondence author  #: equal contribution

2021

●  Chen J-C, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L, Chen S-C, Chui C-H. 2021 (March 01). Fetal macrophages exposed to Salmonella antigens elicit protective immunity against overwhelming Salmonella challenge in a murine model. Biomedicines. 9(3): 245-260. (DOI: 10.3390/biomedicines9030245)

2020

●  Chen Y-W, Huang M-Z, Vhen C-L, Kuo C-Y, Yang C-Y, Ni-Chiang C, Chen Y-Y, Hsieh C-M, Wu H-Y, Kuo M-L, Chiu C-H, Lai C-H*. 2020 (Aug 4). PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. 2020. Part. Fibre Toxicol. 2020. 17:37-51. (DOI: 10.1186/s12989-020-00362-2.)

●  Khan M, Huang Y-A, Kuo C-Y, Lin T, Lu C-H, Chen L-C, Kuo M-L*. 2020. (July 30). Blocking pannexin1 reduces airway inflammation in a murine model of asthma. Am. J. Transl. Res. 2020. 12(7): 4074–4083. (PMCID: PMC7407700)

●  Ma Janson, Chan C-C, Huang W-C, Kuo M-L*. 2020 (June 08). Berberine inhibits pro-inflammatory cytokine-induced IL-6 and CCL11 production via modulation of STAT6 pathway in human bronchial epithelial cells. Int. J. Med. Sci. 2020.17(10): 1464- 1473. (DOI: 10.7150/ijms.45400)

●  Chen J-C, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L. 2020 (June 18). Fetal exposure to oncoantigen elicited antigen-specific adaptive immunity against tumorigenesis. J. Immunother. Cancer. 2020. 8(1): e000137. (DOI: 10.1136/jitc-2019-000137)

●  Lu C-H, Chen C-M, Ma J,Wu C-J, Chen L-I, Kuo M-L*. 2020 (Apr 27). DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation. Int. Immunopharmacol. 2020. 84:106542. (DOI:10.1016/j.intimp.2020.106542)

●  Lin S-J *, Hsu C-Y, Kuo M-L, Lee P-T, Hsiao H-S, Chen J-Y*. 2020 (Apr 3). Phenotypic and functional characterization of natural killer cells in rheumatoid arthritis-regulation with interleukin-15. Sci. Rep. 2020. 10:5858-5866. (DOI: 10.1038/s41598-020-62654-z)

●  Chang Y-L, Lo H-Y, Cheng S-P, Chang K-T, Lin X-F, Lee S-P, Ma Janson, Kuo M-L, Hsieh M-F*, Chin C-K*. 2020 (Feb).Therapeutic efficacy of subcutaneous and intraperitoneal injections of a single dose of human umbilical mesenchymal stem cells in acute and chronic colitis in a mouse model. J. Med. Biol. Eng. 2020. 40:82-90. (DOI: 100.1007/s40846-019-00494-7)

2019

●  Wu C-J, Cho S, Huang H-Y, Lu C-H, Russ J, Cruz L-O, Cunha da Cunha F-F, Chen M-C, Lin L-L, Warner L-M,Liao H-K, Utzschneider D-T, Quon S, Berner J, Camara N-O-S, Zehn D, Belmonte J-C-I, Chen L-C, Huang S-, Kuo M-L, Lu L-F*. 2019 (Dec 11). MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation. Sci. Adv. 2020. 5(12):eaaw1715. (DOI: 10.1126/sciadv.aaw1715)

●  Ting N-C, Hung W-C, Chen L-C, Yang S-H*, Kuo M-L*. 2019 (Nov 15). Descurainia sophia water extract ameliorates eosinophil infiltration and airway hyperresponsiveness by reducing Th2 cytokine production in asthmatic mice. Am. J. Chin. Med. 2019. 47(7):1507-1522. (DOI: 10.1142/S0192415X19500770.)

●  Lin S-J, Kuo M-L, Hsiao H-S, Lee P-T, Lee W-I, Chen J-Y*, Huang J-L*. 2019 (Mar 31).Cytotoxic Function and Cytokine Production of Natural Killer Cells and Natural Killer T-like Cells in Systemic Lupus Erythematosis-Regulation with Interleukin-15. Mediat. Inflamm. 2019. Article ID 4236562, 12 pages. (DOI:10.1155/2019/4236562)

●  Hua M-C, Su H-M, Kuo M-L, Chen C-C, Yao T-, Tsai M-H,Liao S-L, Lai S-H, Chiu C-, Su K-W, Chen L-C, Yeh K-W, Huang J-L*. 2019 (Mar). Association of maternal allergy with human milk soluble CD14 and fatty acids, and early childhood atopic dermatitis. Pediatr. Allergy Immunol. 2019. 30(2):204-213. (DOI: 10.1111/pai.13011.)

2018

●  Lin T-C*, Kuo C-C*, Wu C-Y, Yeh K-W, Kuo M-L, Huang J-L. 2018 (Dec 19). The Role of 5-Methoxytryptophan in Pediatric-Onset Lupus Nephritis A Retrospective Cohort Study. J. Microbiol. Immunol. Infect. 2020 (Oct.) 53(5): 797-802. (DOI: 10.1016/j.jmii.2018.12.003)

●  Wu C-J, Tseng P-H, Chan C-C, Sara Quon, Chen L-C, Kuo M-L*. 2018 (Oct. 8) OK-432 acts as adjuvant to modulate T helper 2 inflammatory responses in a murine model of asthma. J Immunol Res. 2018. (2):1-9. Article ID 1697276, 9 pages. (DOI: 10.1155/2018/1697276)

●  Chen J-C*, Ou L-S, Chan C-C, Kuo M-L, Tseng L-Y, Chang H-L. 2018 (Mar 2). In utero exposure to exosomal and B-cell alloantigens lessens alloreactivity of recipients’ lymphocytes rather than confers Allograft tolerance. Front. Immunol. 2018. 9:418-426.
(DOI: 10.3389/fimmu.2018.00418)

●  Chen L-C, Tseng H-M, Kuo M-L, Chiu C-Y, Liao S-L, Su K-W, Tsai M-H, Hua M-C, Lai S-H, Yao T-C, Yeh K-W, Wu A-H, Huang J-L*, Huang S-K*. 2018 (Mar). A composite of exhaled LTB4, LXA4, FeNO and FEV1 as an “asthma classification ratio” characterizes childhood asthma. Allergy. 2018. 73(3):627-634. (DOI: 10.1111/all.13318)

●  Lin T-C, Wu J-Y, Kuo M-L, Ou L-S, Yeh K-W, Huang J-L*.  2018 (Feb). Correlation between disease activity of pediatric-onset systemic lupus erythematosus and level of vitamin D in Taiwan: A case-cohort study. J. Microbiol. Immunol. Infect. 2018. 51(1) 110-114. (DOI:10.1016/j.jmii.2015.12.005)

●  Lee M-H, Chang T-C, Liao C-T, Chen Y-S, Kuo M-L, Shen C-R*. 2018 (Feb 9). Interleukin 17 and peripheral IL-17-expressing T cells are negatively correlated with the overall survival of head and neck cancer patients. Oncotarget. 2018. 9(11):9825-9837. (DOI:10.18632/oncotarget.23934)

2017

●  Kuo C-Y, Huang W-C, Liou C-J, Chen L-C,Shen J-J*, Kuo M-L*. 2017 (Nov 21). Tomatidine attenuates airway hyperresponsiveness and inflammation by suppressing Th2 cytokines in a mouse model of asthma. Mediat. Inflamm. 2017. 4:5261803. (DOI 10.1155/2017/5261803)

●  Lin S-J, Kuo M-L, Hsiao H-S, Lee P-T, Chen J-Y*, Huang J-L*. 2017 (Oct 12). Activating and inhibitory receptors on natural killer cells in patients with systemic lupus erythematosis-regulation with interleukin-15. PLoS One. 2017.12(10): e0186223. (DOI 10.1371/journal.pone.0186223)

●  Hua M-C, Su H-M, Yao T-C, Kuo M-L, Lai M-W, Tsai M-H, Huang J-L*. 2017 (July 31) Alternation of plasma fatty acids composition and desaturase activities in children with liver steatosis. PLoS One. 2017. 12(7):e0182277. (DOI 10.1371/journal.pone.0182277)

2016

●  Lu C-H, Wu C-J, Chan C-C, Nguyen D-T,Lin K-R, Lin S-J, Chen L-C, Yen J-Y, Kuo M-L*. 2016 (Nov 8). DNA methyltransferase inhibitor promotes human CD4+CD25hFOXP3+ regulatory T lymphocyte induction under suboptimal TCR stimulation. Front. Immunol. 2016. 7: 488-499. (DOI 10.3389/fimmu.2016.00488.)

●  Lin S-J, Kuo M-L, Hsiao H-S, Lee P-T. 2016 (Nov). Azithromycin modulates immune response of monocyte-derived dendritic cells and CD4+ T cells. Immunopharmacol. 2016. 40:318-326. (DOI dx.doi.org/10.1016/j.intimp.2016.09.012)

●  Lin S-J, Chen J-Y, Kuo M-L, Hsiao H-S, Lee P-T, Huang J-L*. 2016 (Oct). Effect of interleukin-15 on CD11b, CD54, and CD62l expression on natural killer cell and natural killer T-like cells in systemic lupus erythematosis. Mediat. Inflamm. 2016:9675861. (DOI 10.1155/2016/9675861)

●  Chan C-K, Lin T-C, Huang Y-A, Chen Y-S, Wu C-L, Lo H-Y, Kuo M-L, Wu K-H*, Huang J-L*. 2016 (Oct) The modulation of Th2 immune pathway in the immunosuppressive effect of human umbilical cord mesenchymal stem cells in a murine asthmatic model. Inflamm. Res. 2016. 65(10):795-801. (DOI 10.1007/s00011-016-0961-y)

●  Chen J-C, Chan C-C, Wu C-J, Ou L-S, Yu H-Y, Chang H-L, Tseng L-Y, Kuo M-L*. 2016 (Oct 15). Fetal phagocytes take up allergens to initiate Th2 immunity and facilitate allergic airway responses. Am. J. Respir. Crit. Care Med. 2016. 194(8):934-947. (DOI: 10.1164/rccm.201508-1703OC)

●  Chan C-C, Lai C-W, Wu C-J, Chen L-C, Tao M-H, Kuo M-L*. 2016 (Aug 1). Liver-specific allergen gene transfer by adeno-associated virus suppresses allergic airway inflammation in mice. Hu. Gene Ther. 2016. 27(8):631-642. (DOI: 10.1089/hum.2015.161)

●  Chiang N-Y, Chang G-W, Huang Y-S, Peng Y-M, Hsiao C-C, Kuo M-L, Lin H-H*. 2016 (June 1). Heparin interacts with adhesion-GPCR GPR56/ADGRG1, reduces receptor shedding, and promotes cell adhesion and motility. J. Cell Sci. 2016. 129 (11): 2156-2169. (DOI:10.1242/jcs.174458)

●  Wu C-J, Lu C-H, Chen L-C, Nguyen DT, Huang Y-S, Lin H-H, Lin C-Y, Kuo M-L*. 2016 (May 13).CD4 down regulation and raft dissociation by the non-depleting YTS177 antibody hinder murine T helper cell activities. Biochem. Biophy. Res. Co. 2016. 473 (4): 973-979. (DOI:10.1016/j.bbrc.2016.04.001)

●  Cho S, Wu C-J, Yasuda T, Cruz L, Khan A, Lin L-L, Nguyen D, Miller M, Lee H-M, Kuo M-L, Broide DH, Rajewsky K, Rudensky A, and Lu L-F*. 2016 (Feb 8). MiR-23~27~24 clusters control effector T cell differentiation and function. J. Exp. Med. 2016. 213 (2): 235-249. (DOI: 10.1084/jem.20150990)

2015

●  Lin S-J, Huang Y-C, Cheng P-J, Lee P-T, Hsiao H-S, Kuo M-L*. 2015 (Dec). Interleukin-15 enhances the expansion and function of natural killer T cells from adult peripheral and umbilical cord blood. Cytokine  2015. 76(2):348-355. (DOI:10.1016/j.cyto.2015.09.015)

●  Shen C-R, Juang H-H, Chen H-S, Yang C-J, Wu C-J, Lee M-H, Hwang Y-S, Kuo M-L, Chen Y-S, Chen J-K, Liu C-L*. 2015 (Nov). The correlation between chitin and acidic mammalian chitinase in animal models of allergic asthma. Int. J. Mol. Sci. 2015. 16 (11):27371–27377. (DOI:10.3390/ijms161126033)

●  Chen J-C, Ou L-S, Yu H-Y, Kuo M-L, Chang P-Y, Chang H-L. 2015 (May). Postnatal donor lymphocytes enhance prenatally-created chimerism at the risk of graft-versus-host disease. Am. J. Transl. Res. 17(5): 941-949. (DOI: 10.1155/2014/531092)

●  Yang T-Y, Chiang N-Y, Tseng W-Y, Pan H-L, Peng Y-M, Shen J-J, Wu K-A, Kuo M-L, Chang G-W, Lin H-H*.2015(May). Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA. Protein Expr. Purif. 2015.109: 85- 92. (DOI: 10.1016/j.pep.2014.11.013)

2014

●  Liou C-J, Cheng P-Y, Huang W-C, Chan C-C, Chen M-C, Kuo M-L, Shen J-J*. 2014 (Nov). Oral lovastatin attenuates airway Inflammation and mucus secretion in ovalbumin-induced asthmatic mice. Allergy Asthma Immunol. Res. 2014. 6(6):548-557. (DOI: 10.4168/aair.2014.6.6.548)

●  Lin S-J, Lu C-H, Yan D-C, Lee P-T, Hsiao H-S, Kuo M-L*. 2014 (Oct) Expansion of regulatory T cells from umbilical cord blood and adult peripheral blood CD4+CD25+ T cells. Immunol. Res. 2014. 60 (1):105-111. (DOI: 10.1007/s12026-014-8488-1)

●  Chen J-C, Ou L-S, Yu H-Y, Kuo M-L, Chang P-Y, Chang H-L. 2014 (Jul). Recipients with in utero induction of tolerance upregulated MHC class I in the engrafted donor skin. Dis Markers. 2014:531092. (DOI: 10.1155/2014/531092)

●  Huang W-C #, Chan C-C #, Wu S-J, Chen L-C, Shen J-J, Kuo M-L, Chen M-C, Liou C-J. 2014 (Jan). Matrine attenuates allergic airway inflammation and eosinophil infiltration by suppressing eotaxin and Th2 cytokines production in asthmatic mice. J. Ethnopharmacol. 2014. 151 (1): 470-477. (DOI:10.1016/j.jep.2013.10.065)

  • Review articles:
  1. Lin S-J, Yan D-C, Lee Y-C, Hsiao H-S, Lee P-T, and Kuo M-L*. 2012 (Feb). Umbilical cord blood immunology - revelance to stem cell transplantation. Clin. Rev. Allergy Immunol. 42 (1): 45-57.
    (DOI: 10.1007/s12016-011-8289-4, Dec 2011)
  2. Lin S-J and Kuo M-L. 2011 (Nov). Cytotoxic function of umbilical cord blood natural killer cells: relevance to adoptive immunotherapy. Pediatr. Hematol. Oncol. 28 (8): 640-646.
    (DOI
    i:10.3109/08880018.2011.613092, Oct 4, 2011)
  3. Lin S-J, Yan D-C, Lee Y-C, and Kuo M-L*. 2008 (Nov). Role of interleukin-15 in umbilical cord blood transplantation. Int. Rev. Immunol. 27 (6): 518-531.
    (DOI: 10.1080/08830180802317940).
  • Book chapters:
  1. Lin S-J, Lee P-T, Kuo M-L. Cytokine activation of natural killer cells. Ch19. pp  in Cancer Vaccines: Methods and Protocols, Methods in Molecular Biology, Vol 1139. Springer Science+Business Media, New York, NY, USA. DOI:10.1007/978-1-4939-0345-0_19.
  2. Lin S-J, Lee Y-C, Yan D-C, Kuo M-L. Natural killer cells in allergy. Ch38, pp 511-517, in Lotze M and Thomson A, eds. Natural Killer Cells, Basic Science and Clinical Application, Elsevier, San Diego, CA, USA. 2009.
  • Perspectives or comments:
  1. Lin H-H, Kuo M-L. 2012 (Mar). The 2011 Nobel Prize in Physiology or Medicine. Chang Gung Med. J. 35 (2): 93-95.
  2. Kuo M-L*. 2009. Attempts to bridge the gap between scientific mechanism-based medicine and Chinese herbal extract treatment for asthma. in press, Pediatr. Neonatol. 49 (4): 101-102. (editorial comments, not SCI)

2021/05/05更新

 

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