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Hsi-Hsien Lin


Hsi-Hsien Lin

Appointment: Professor

LabMolecular Immunology

Education: Ph.D.

University/NationUniversity of Tennessee/U.S.A.

Tel: 3321

E-mail: hhlin@mail.cgu.edu.tw

Research website:  

Laboratory personnel: Master student:1 ; Res. Assistant:4

Research interests:

The research of my laboratory focuses principally on the functions and regulation of adhesion GPCRs. Specific interest includes:

1. The identification and characterization of, and the structural-functional study of the EGF-TM7 receptors, including EMR2, CD97 and F4/80.

2. The signaling pathways of EMR2 and CD97 receptors.

3. The role of adhesion-GPCRs in osteoclast differentiation and function.

4. Molecular and functional characterization of BFPP-associated GPR56 mutations.

5. The identification of the cellular ligand(s) of GPR56.

6. The role of GPR56 in tumor biology.

7. The expression and functional characterization of GPR56 in immune system.

We are well experienced in various biological assays of macrophage and neutrophil functions as well as tumor biology. Most modern technologies in molecular biology, cell biology, immunology, proteomics and biochemistry are well established in the laboratory.


*: corresponding author; &: co-first author

  1. Tai-Ying Chu&, Celine Zheng-Gerard&, Kuan-Yeh Huang, Yu-Chi Chang, Ying-Wen Chen, Kuan-Yu I, Yu-Ling Lo, Nien-Yi Chiang, Chien-Hao Huang, Hsin-Yi Chen, Martin Stacey, Siamon Gordon, Wen-Yi Tseng, Chiao-Yin Sun, Yen-Mu Wu, Yi-Shin Pan, Chien-Hao Huang, Chun-Yen Lin, Tse-Ching Chen, Kamel El Omari, Marilina Antonelou, Scott R Henderson, Alan Salama, Elena Seiradake*, and Hsi-Hsien Lin* 2022 GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Nature Communications 13(1):6385 (doi.org/10.1038/s41467-022-34083-1) (SCI, IF=17.694) (co-corresponding author)
  2. Hsi-Hsien Lin*, Kwai-Fong Ng, Tse-Ching Chen, Wen-Yi Tseng* 2022 Ligands and Beyond: Mechanosensitive Adhesion GPCRs. Pharmaceuticals 15(2), 219 (doi.org/10.3390/ph15020219) (SCI, IF=5.215) (co-corresponding author).
  3. Yi-Shu Huang, Wen-Yi Tseng, Joy Ogbechi, Louise M. Topping, Felix Clanchy, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhongtian Xue, Leif G. Salford, Hans-Olov Sjögren, Trevor W. Stone, Hsi-Hsien Lin, Shue-Fen Luo* and Richard O. Williams* 2021 Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proc Natl Acad Sci USA May 11, 118 (19) e2100939118; (doi:10.1073/pnas2100939118) (SCI, IF=12.779)
  4. Kuan-Yu I&, Wen-Yi Tseng&, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng and Hsi-Hsien Lin* 2021 Stimulation of vibratory urticaria-associated adhesion-GPCR, EMR2/ADGRE2, triggers the NLRP3 inflammasome activation signal in human monocytes. Frontiers in Immunology 11: 602016 (doi: 10.3389/fimmu.2020.602016) (SCI, IF=8.786) (corresponding author)
  5. Kwai-Fong Ng&, Tse-Ching Chen&, Martin Stacey, and Hsi-Hsien Lin* 2021 Role of ADGRG1/GPR56 in tumor progression. Cells 10, 3352 (doi.org/10.3390/cells10123352) (SCI, IF=7.666) (corresponding author).
  6. Abhishek Kumar Singh and Hsi-Hsien Lin* 2021 The role of GPR56/ADGRG1 in health and disease. Biomedical Journal 44(5):534-547 (doi:10.1016/j.bj.2021.04.012) (SCI, IF=7.892) (corresponding author)
  7. Hsi-Hsien Lin*, Yu-Ling Lo, Wen-Chih Wang, Kuan-Yeh Huang, Kuan-Yu I, and Gin-Wen Chang 2020  Overexpression of FAM46A, a non-canonical poly(A) polymerase, promotes hemin-induced hemoglobinization in K562 cells. Frontiers in Cell and Developmental Biology 8: 414 (doi: 10.3389/fcell.2020.00414 )(SCI, IF=6.081) (corresponding author)
  8. Po-Hsiang Chen, Yi-Tung Chen, Tai-Ying Chu, Tian-Hsiang Ma, Mei-Hsuan Wu, Hsi-Hsien Lin, Yu-Sun Chang*, Bertrand Chin-Ming Tan* and Szecheng J. Lo* 2020 Nucleolar size control by a non-apoptotic p53-caspases-deubiquitylase axis confers bacterial resistance. The FASEB Journal 2020; 34(1):1107-1121. (doi.org/10.1096/fj.201901959R)(SCI, IF=5.834)
  9. Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The role of the RGD-motif in CD97/ADGRE5- and EMR2/ADGRE2-modulated tumor angiogenesis. Biochemical and Biophysical Research Communications 520:243-249 (doi:10.1016/j.bbrc.2019.09.113)(SCI, IF=3.322) (corresponding author)
  10. Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells. Sci. Rep. 9:1517 (doi:10.1038/s41598-018-38045-w)(SCI, IF=4.996) (corresponding author)
  11. Cheng-Chih Hsiao#, Tai-Ying Chu#, Chia-Jung Wu, Maartje van den Biggelaar, Caroline Pabst, Josée Hébert, Taco W. Kuijpers, Brendon P. Scicluna, Kuan-Yu I, Tse-Ching Chen, Ines Liebscher, Jörg Hamann*, and Hsi-Hsien Lin* 2018 The adhesion G protein-coupled receptor GPR97/ADGRG3 is expressed in human granulocytes and triggers antimicrobial effector functions. Frontiers in Immunology 9: 2830  (doi:10.3389/fimmu.2018.02830) (SCI, IF=8.786) (co-corresponding author)
  12. Wen-Yi Tseng, Yeong-Jian Jan Wu, Tai-Yun Yang, Nien-Yi Chiang, Wen-Pin Tsai, Siamon Gordon, Gin-Wen Chang, Chang-Fu Kuo, Shue-Fen Luo*, Hsi-Hsien Lin* 2018 High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis. Journal of Microbiology, Immunology and Infection 51(4):485-491 (SCI, IF=10.273) (co-corresponding author) (http://dx.doi.org/10.1016/j.jmii.2016.11.010)
  13. Kuan-Yeh Huang and Hsi-Hsien Lin* 2018 The activation and signaling mechanisms of GPR56/ADGRG1 in melanoma cell. Frontiers in Oncology 8: 304 (doi:10.3389/fonc.2018.00304) (SCI, IF=7.783) (corresponding author)
  14. Yi-Shu Huang, Nien-Yi Chiang, Gin-Wen Chang, Hsi-Hsien Lin* 2018 Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation. Sci. Rep. 8: 4532 (doi:10.1038/s41598-018-22849-x) (SCI, IF=4.996) (corresponding author)
  15. Wen-Yi Tseng, I-Shu Huang, Hsi-Hsien Lin, Shue-Fen Luo, Kay McNamee, Felix Clanchy, Richard Williams 2018 TNFR1 and TNFR2 signalling and its clinical implications. Cytokine 101:19-25 (http://dx.doi.org/10.1016/j.cyto.2016.08.027) (SCI, IF=3.926)
  16. Hsi-Hsien Lin*, Cheng-Chih Hsiao, Caroline Pabst, Josée Hébert, Torsten Schöneberg and Jörg Hamann* 2017 Adhesion GPCRs in regulating immune responses and inflammation. Advances in Immunology 136:163-201 (co-corresponding author) (SCI, IF=5.325)
  17. Kuo-An Wu#, Chih-Ching Wu#, Chi-De Chen, Chi-Ming Chu, Li-Jane Shih, Yu-Ching Liu, Chia-Jung Yu, Hsi-Hsien Lin*, Chia-Yu Yang* 2017 Proteome profiling reveals novel biomarkers to identify parapneumonic effusions. Sci. Rep. 7 (1): 4026 (doi:10.1038/s41598-017-04189-4) (SCI, IF=4.996) (co-corresponding author)
  18. Kuan-Yu I, Yi-Shu Huang, Ching-Hsun Hu, Wen-Yi Tseng, Chia-Hsin Cheng, Martin Stacey, Siamon Gordon, Gin-Wen Chang, Hsi-Hsien Lin* 2017 Activation of EMR2/ADGRE2 induces macrophage differentiation and inflammatory responses via Ga16/Akt/MAPK/NF-kB signaling pathways. Frontiers in Immunology  8:373 (doi:10.3389/fimmu.2017.00373) (SCI, IF=8.786) (corresponding author)
  19. Nien-Yi Chiang&, Yen-Ming Peng&, Horng-Heng Juang, Tse-Ching Chen, Hsiao-Lin Pan, Gin-Wen Chang, Hsi-Hsien Lin* 2017 GPR56/ADGRG1 activation promotes melanoma cell migration via NTF dissociation and CTF-mediated Gα12/13/RhoA signaling. J. Inv. Dermatol. 137:727-736 (SCI, IF=7.590) (corresponding author)







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