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Hsi-Hsien Lin

Appointment: Associate Professor

LabMolecular Immunology

Education: Ph.D.

University/NationUniversity of Tennessee/U.S.A.

Tel: 3321

E-mail: hhlin@mail.cgu.edu.tw

Research website: https://sites.google.com/site/hhlinlab/

Laboratory personnel: Master student:1 ; Res. Assistant:5

Research interests:

The research of my laboratory focuses principally on the functions and regulation of adhesion GPCRs. Specific interest includes:

1. The identification and characterization of, and the structural-functional study of the EGF-TM7 receptors, including EMR2, CD97 and F4/80.

2. The signaling pathways of EMR2 and CD97 receptors.

3. The role of adhesion-GPCRs in osteoclast differentiation and function.

4. Molecular and functional characterization of BFPP-associated GPR56 mutations.

5. The identification of the cellular ligand(s) of GPR56.

6. The role of GPR56 in tumor biology.

7. The expression and functional characterization of GPR56 in immune system.

We are well experienced in various biological assays of macrophage and neutrophil functions as well as tumor biology. Most modern technologies in molecular biology, cell biology, immunology, proteomics and biochemistry are well established in the laboratory.


*: corresponding author; &: co-first author

  1. C.-J. Wu, C.-H. Lu, L.-C. Chen, D. T. Nguyen, Y.-S. Huang, H.-H. Lin, C.-Y.Lin, M.-L. Kuo 2016 CD4 down regulation and raft dissociation by the non-depleting YTS177 antibody hinder murine T helper cell activities. Biochemical and Biophysical Research Communications 473:973-979 (SCI, IF=3.575).
  2. N.-Y. Chiang, G.-W. Chang, Y.-S. Huang, Y.-M. Peng, C.-C. Hsiao, M.-L. Kuo, H.-H. Lin* 2016 Heparin interacts with adhesion-GPCR GPR56/ADGRG1, reduces receptor shedding, and promotes cell adhesion and motility. J. Cell Science 129:2156-2169 (SCI, IF=5.285) (corresponding author)
  3. G.-W. Chang&, C.-C. Hsiao&, Y.-M. Peng, F.A. Vieira Braga, N.A.M. Kragten, E.B.M. Remmerswaal, M.D.B. van de Garde, R. Straussberg, G. M. König, E. Kostenis, V. Knäuper, L. Meyaard, René A.W. van Lier, K.P. van Gisbergen, H.-H. Lin*, J. Hamann* 2016 The adhesion G protein-coupled receptor GPR56/ADGRG1 is an inhibitory receptor on human NK cells. Cell Reports 15:1757-1770 (SCI, IF=9.423) (co-corresponding author) http://f1000.com/prime/726360335?subscriptioncode=6eddd323-c280-496f-bca2- 5659f844a6c6
  4. H.-H. Lin*, M. Stacey* 2016 G protein-coupled receptors in myeloid cells. Microbiology Spectrum Aug. 2016, 4(4) doi:10.1128/microbiolspec. MCHD-0028-2016 (co-corresponding author)
  5. Matthias Nieberler, Robert J. Kittel, Alexander G. Petrenko, Hsi-Hsien Lin*, Tobias Langenhan* 2016 Control of Adhesion GPCR function through proteolytic processing. (invited chapter) Handbook of Experimental Pharmacology 234:83-109 (co-corresponding author)
  6. Jörg Hamann*, Cheng-Chih Hsiao, Chang-Sup Lee, Kodi Ravichandran, and Hsi-Hsien Lin* 2016 Adhesion GPCRs as modulators of immune cell function. (invited chapter) Handbook of Experimental Pharmacology 234: 329-350 (co-corresponding author)
  7. Chien-Hao  Huang, Wen-Juei  Jeng, Yu-Pin  Ho, Wei Teng, Yi-Chung  Hsieh,Wei-Ting  Chen, Yi-Cheng Chen, Hsi-Hsien  Lin, I-Shyan  Sheen, and Chun-Yen Lin 2016 Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients. Sci. Rep. 6: 38250; doi:10.1038/srep38250 (SCI, IF=4.379)
  8. Nien-Yi Chiang&, Yen-Ming Peng&, Horng-Heng Juang, Tse-Ching Chen, Hsiao-Lin Pan, Gin-Wen Chang, Hsi-Hsien Lin* 2017 GPR56/ADGRG1 activation promotes melanoma cell migration via NTF dissociation and CTF-mediated Gα12/13/RhoA signaling. J. Inv. Dermatol. 137:727-736 (SCI, IF=8.551) (corresponding author)
  9. Kuan-Yu I, Yi-Shu Huang, Ching-Hsun Hu, Wen-Yi Tseng, Chia-Hsin Cheng, Martin Stacey, Siamon Gordon, Gin-Wen Chang, Hsi-Hsien Lin* 2017 Activation of EMR2/ADGRE2 induces macrophage differentiation and inflammatory responses via Ga16/Akt/MAPK/NF-kB signaling pathways. Frontiers in Immunology  8:373   (doi:10.3389/fimmu.2017.00373) (SCI, IF=7.561) (corresponding author)
  10. Kuo-An Wu#, Chih-Ching Wu#, Chi-De Chen, Chi-Ming Chu, Li-Jane Shih, Yu-Ching Liu, Chia-Jung Yu, Hsi-Hsien Lin*, Chia-Yu Yang* 2017 Proteome profiling reveals novel biomarkers to identify parapneumonic effusions. Sci. Rep. 7 (1): 4026 (doi:10.1038/s41598-017-04189-4)(SCI, IF=4.379) (co-corresponding author)
  11. Hsi-Hsien Lin*, Cheng-Chih Hsiao, Caroline Pabst, Josée Hébert, Torsten Schöneberg and Jörg Hamann* 2017 Adhesion GPCRs in regulating immune responses and inflammation. Advances in Immunology 136:163-201 (co-corresponding author) (SCI, IF=3.543)
  12. Wen-Yi Tseng, I-Shu Huang, Hsi-Hsien Lin, Shue-Fen Luo, Kay McNamee, Felix Clanchy, Richard Williams 2018 TNFR1 and TNFR2 signalling and its clinical implications. Cytokine 101:19-25 (http://dx.doi.org/10.1016/j.cyto.2016.08.027) (SCI, IF=3.861)
  13. Yi-Shu Huang, Nien-Yi Chiang, Gin-Wen Chang, Hsi-Hsien Lin* 2018 Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation. Sci. Rep. 8: 4532 (doi:10.1038/s41598-018-22849-x) (SCI, IF=4.379) (corresponding author)
  14. Kuan-Yeh Huang and Hsi-Hsien Lin* 2018 The activation and signaling mechanisms of GPR56/ADGRG1 in melanoma cell. Frontiers in Oncology 8: 304 (doi:10.3389/fonc.2018.00304) (SCI, IF=6.244) (corresponding author)
  15. Wen-Yi Tseng, Yeong-Jian Jan Wu, Tai-Yun Yang, Nien-Yi Chiang, Wen-Pin Tsai, Siamon Gordon, Gin-Wen Chang, Chang-Fu Kuo, Shue-Fen Luo*, Hsi-Hsien Lin* 2018 High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis. Journal of Microbiology, Immunology and Infection 51(4):485-491 (co-corresponding author) (SCI, IF=4.399) (http://dx.doi.org/10.1016/j.jmii.2016.11.010)
  16. Cheng-Chih Hsiao#, Tai-Ying Chu#, Chia-Jung Wu, Maartje van den Biggelaar, Caroline Pabst, Josée Hébert, Taco W. Kuijpers, Brendon P. Scicluna, Kuan-Yu I, Tse-Ching Chen, Ines Liebscher, Jörg Hamann*, and Hsi-Hsien Lin* 2018 The adhesion G protein-coupled receptor GPR97/ADGRG3 is expressed in human granulocytes and triggers antimicrobial effector functions. Frontiers in Immunology 9: 2830  (doi:10.3389/fimmu.2018.02830) (SCI, IF=7.561) (co-corresponding author)
  17. Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The RGD motif is involved in CD97/ADGRE5-promoted cell adhesion and viability of HT1080 cells. Sci. Rep. 9:1517 (doi:10.1038/s41598-018-38045-w)(SCI, IF=4.379) (corresponding author)
  18. Wen-Ye Tjong and Hsi-Hsien Lin* 2019 The role of the RGD-motif in CD97/ADGRE5- and EMR2/ADGRE2-modulated tumor angiogenesis. Biochemical and Biophysical Research Communications 520:243-249 (doi:10.1016/j.bbrc.2019.09.113)(SCI, IF=3.575) (corresponding author)
  19. Po-Hsiang Chen, Yi-Tung Chen, Tai-Ying Chu, Tian-Hsiang Ma, Mei-Hsuan Wu, Hsi-Hsien Lin, Yu-Sun Chang*, Bertrand Chin-Ming Tan* and Szecheng J. Lo* 2020 Nucleolar size control by a non-apoptotic p53-caspases-deubiquitylase axis confers bacterial resistance. The FASEB Journal 2020; 34(1):1107-1121. (doi.org/10.1096/fj.201901959R)(SCI, IF=5.191)
  20. Hsi-Hsien Lin*, Yu-Ling Lo, Wen-Chih Wang, Kuan-Yeh Huang, Kuan-Yu I, and Gin-Wen Chang  2020  Overexpression of FAM46A, a non-canonical poly(A) polymerase, promotes hemin-induced hemoglobinization in K562 cells. Frontiers in Cell and Developmental Biology 8: 414 (doi: 10.3389/fcell.2020.00414 )(SCI, IF=6.684) (first and corresponding author)
  21. Kuan-Yu I&, Wen-Yi Tseng&, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng and Hsi-Hsien Lin* 2021 Stimulation of vibratory urticaria-associated adhesion-GPCR, EMR2/ADGRE2, triggers the NLRP3 inflammasome activation signal in human monocytes. Frontiers in Immunology 11: 602016 (doi: 10.3389/fimmu.2020.602016) (SCI, IF=7.561) (corresponding author)
  22. Yi-Shu Huang, Wen-Yi Tseng, Joy Ogbechi, Louise M. Topping, Felix Clanchy, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhongtian Xue, Leif G. Salford, Hans-Olov Sjögren, Trevor W. Stone, Hsi-Hsien Lin, Shue-Fen Luo* and Richard O. Williams* 2021 Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proc Natl Acad Sci USA May 11, 118 (19) e2100939118; (doi:10.1073/pnas2100939118) (SCI, IF=11.205)
  23. Abhishek Kumar Singh and Hsi-Hsien Lin* 2021 The Role of GPR56/ADGRG1 in Health and Disease. Biomedical Journal (in press)(doi:10.1016/j.bj.2021.04.012)(SCI, IF=4.91)








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