Jump to the main content block

Kuo-Chu Lai

               Kuo-Chu Lai

AppointmentsAssistant Professor

LabCell Cytotoxicity Laboratory

EducationPh.D.

School/NationNational Yang-Ming University/Taiwan

Tel: #3035

E-mail: kuochu@mail.cgu.edu.tw

Research website: https://tcue504.weebly.com/

研究室現有: 博士後研究員 

博士班研究生   

碩士班研究生 2

專任研究助理   1

大學部專題生   

Research outline(1-3 pages)

My major research interests are exploring the underlying mechanism of cancer cachexia and developing effective therapeutic agents against cancer growth and progression. Our studies will provide new insight into the cancer cachexia and potential strategies for cancer treatment.

  1. Investigation of the molecular mechanism of cancer cachexia.

Head and neck cancer (HNC) is the sixth most common cancer in the world. There are 600,000 new cases of HNC are diagnosed worldwide each year each year. Epidemiological studies over last 20 years reveal that the overall incidence of young patients under 45 who encounter HNC, especially oral squamous cell carcinoma (OSCC), is growing steadily. Therefore, understanding the molecular mechanism of HNC progression is the basis for developing therapeutic strategies. Our preliminary results have demonstrated that interferon induced protein with tetratricopeptide repeats 2 (IFIT2) depletion could enhance epithelial-mesenchymal transition (EMT), migration, invasion, angiogenesis, and metastasis, suggesting that IFIT2 may act as a metastasis suppressor. More currently, we found that mice bearing HNC cells expressing sh-IFIT2 exhibited cachexia syndrome. Cachexia syndrome is one of the most lethal effects in cancer patients. The frequency of cancer-related cachexia is considerably high (60-80%) in HNC. However, the detail mechanisms responsible for cancer cachexia are poorly understood. Therefore, we aim to investigate the role of IFIT2 in HNC cachexia.

II. Discovery and development of anticancer agents from natural products or novel synthetic chemicals.

In the past, we have made efforts to examine the anti-tumor effects of natural products, such as oroxylin A, Antrodia cinnamomea (AC) and novel synthetic quinazolinone derivatives. To mimic the chronic use of natural products, we established an in vitro long-term treatment    

model and demonstrated that oroxylin A inhibition of migration following long-term treatment may be due to its suppression of CCL2 in OSCC cells. Moreover, we explored the antitumor effect of novel Antrodia cinnamomea extract (AC009) on colorectal cancer cells. We are currently focusing on the anti-tumor effects of novel DNA bifunctional alkylating agents and quinazoline derivations. In the future, more natural products or novel synthetic chemicals will be tested.

Publications:

  1. K.C. Lai, Y.T. Chia, L.H. Yih, Y.L. Lu, S.T. Chang, Z.X. Hong, T.L. Chen, M.J. Ho, Antitumor Effects of the Novel Quinazolinone Holu-12: Induction of Mitotic Arrest and Apoptosis in Human Oral Squamous Cell Carcinoma CAL27 Cells, Anticancer Research, 2020, Submitted. (First author)
  2. P. Regmi, K.C. Lai, C.J. Liu and T.C. Lee, SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells, Cancers, 2020, 12, 3527, 1-22
  3. A.S. Patel, V. Jain, V.N. Rao, Y.W. Lin, A. Shah, K.C. Lai, T.L. Su, T.C. Lee, Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo [1,2-b]isoquinoline derivatives, European Journal of Medicinal Chemistry, 2020, 202:112516.
  4. T.J. Lin, K.C. Lai, A.S. Lee, C.H. Chang, C.L. Liu, C.H. Chung, Novel antrodia cinnamomea extract reduced cancer stem-Like phenotype changes and resensitized KRAS mutant colorectal cancer via a microRNA-27a pathway, Cancers, 2019; 11:1657, 1-15
  5. W.T. Ku, J.J. Tung, T.J.F. Lee, K.C. Lai, Long-term exposure to oroxylin A inhibits metastasis by suppressing CCL2 in oral squamous cell carcinoma cells, Cancers, 2019, 11:353, 1-19 (*corresponding author)
  6. C.H. Chu, S.C. Chang, H.H. Wang, S.H. Yang, K.C. Lai, T.C. Lee, Prognostic values of EPDR1 hypermethylation and its inhibitory function on tumor invasion in colorectal cancer, Cancers, 2018, 10:393, 1-19 (*corresponding author)
  7. K.C. Lai, C.J. Liu, T.J. Lin, A.C. Mar, H.H. Wang, C.W. Chen, Z.X. Hong , T.C. Lee,  Blocking TNF-α inhibits angiogenesis and growth of IFIT2-depleted metastatic oral squamous cell carcinoma cells. Cancer Letters, 2016, 370:207-215 (*corresponding author)

Click Num: