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Chuan Chiang-Ni

Chuan Chiang-Ni


Lab:Bacterial pathogenesis Lab


School/NationNational Cheng Kung University (Taiwan, ROC.)

Tel: 886-3-2118800 ext. 3712

E-mail: entchuan@gap.cgu.edu.tw

Lab members

Postdoctoral researcher: 0

Ph.D. student: 1

Master student: 3

Research assistant: 1

Undergraduate student: 2

Research website:  

Research outline

Streptococcus pyogenes (group A Streptococcus, GAS) is an important human pathogen which causes various diseases including pharyngitis, cellulitis, scarlet fever, necrotizing fasciitis, and toxic shock syndrome. Although this pathogen is sensitive to antibiotics treatment, it still causes more than 500,000 deaths per year on the global scale. In addition, no vaccine is available for preventing GAS infections. My research focuses on studying the mechanism of GAS virulence genes regulation under stress conditions by combining bacterial genetics manipulations with different in vitro and in vivo experiment models. In addition, in order to extend the observations of clinical surveillance, the biological significance of GAS phenotypic heterogeneity and instability are studied.

Publications : 2020-2016 (*: Corresponding author)

  • Hsieh CL, Hsieh SY, Huang HM, Lu SL, Omori H, Zheng PX, Ho YN, Cheng YL, Lin YS, Chiang-Ni C, Tsai PJ, Wang SY, Liu CC, Noda T, Wu JJ*. 2020. Nicotinamide increases intracellular NAD(+) Content to enhance autophagy-mediated group A streptococcal clearance in endothelial cells. Front Microbiol 11:117. https://doi.org/10.3389/fmicb.2020.00117
  • Chiang-Ni C*, Chiou HJ, Tseng HC, Hsu CY, Chiu CH. 2020. RocA regulates phosphatase activity of virulence sensor CovS of group A Streptococcus in growth phase- and pH-dependent manners. mSphere 5:e00361-00320. https://doi.org/10.1128/msphere.00361-20
  • Chen YW, Huang MZ, Chen CL, Kuo CY, Yang CY, Chiang-Ni C, Chen YM, Hsieh CM, Wu HY, Kuo ML, Chiu CH, Lai CH*. 2020. PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Part Fibre Toxicol 17:37. https://doi.org/10.1186/s12989-020-00362-2
  • Hou TY, Chiang-Ni C, Teng SH*. 2019. Current status of MALDI-TOF mass spectrometry in clinical microbiology. J Food Drug Anal 27:404-414. https://doi.org/10.1016/j.jfda.2019.01.001
  • Chiang-Ni C*, Tseng HC, Shi YA, Chiu CH. 2019. Effect of phosphatase activity of the control of virulence sensor (CovS) on clindamycin-mediated streptolysin O production in group A Streptococcus. Infect Immun 87:e00583-00519. https://doi.org/10.1128/IAI.00583-19
  • Chiang-Ni C*, Kao CY, Hsu CY, Chiu CH. 2019. Phosphorylation at the D53 but not T65 residue of CovR determines the repression of rgg and speB transcription in emm1- and emm49-type group A streptococci. J Bacteriol 201:e00681-00618. https://doi.org/10.1128/JB.00681-18
  • Chen MF, Chang CH, Chiang-Ni C, Hsieh PH, Shih HN, Ueng SWN, Chang Y*. 2019. Rapid analysis of bacterial composition in prosthetic joint infection by 16S rRNA metagenomic sequencing. Bone Joint Res 8:367-377. https://doi.org/10.1302/2046-3758.88.BJR-2019-0003.R2
  • Hsieh CL, Huang HM, Hsieh SY, Zheng PX, Lin YS, Chiang-Ni C, Tsai PJ, Wang SY, Liu CC, Wu JJ*. 2018. NAD-glycohydrolase depletes intracellular NAD(+) and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells. Front Microbiol 9:1733. https://doi.org/10.3389/fmicb.2018.01733
  • Chiang-Ni C*, Shi YA, Lai CH, Chiu CH. 2018. Cytotoxicity and survival fitness of Invasive covS mutant of group A Streptococcus in phagocytic cells. Front Microbiol 9:2592. https://doi.org/10.3389/fmicb.2018.02592
  • Zheng PX, Chan YC, Chiou CS, Hsieh CL, Chiang-Ni C, Wu JJ*. 2017. Highly prevalent emmSTG840.0 and emmSTC839.0 types of erythromycin non-susceptible group G Streptococcus isolated from bacteremia in southern Taiwan. J Microbiol Immunol Infect 50:831-838. https://doi.org/10.1016/j.jmii.2016.12.010
  • Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH*. 2017. Cytolethal distending toxin enhances radiosensitivity in prostate cancer cells by regulating autophagy. Front Cell Infect Microbiol 7:223. https://doi.org/10.3389/fcimb.2017.00223
  • Hou JN, Chen TH, Chiang YH, Peng JY, Yang TH, Cheng CC, Sofiyatun E, Chiu CH, Chiang-Ni C, Chen WJ. 2017. PERK signal-modulated protein translation promotes the survivability of Dengue 2 virus-infected mosquito cells and extends viral replication. Viruses 9. https://doi.org/10.3390/v9090262
  • Chiang-Ni C*, Tseng HC, Hung CH, Chiu CH. 2017. Acidic stress enhances CovR/S-dependent gene repression through activation of the covR/S promoter in emm1-type group A Streptococcus. Int J Med Microbiol 307:329-339. https://doi.org/10.1016/j.ijmm.2017.06.002
  • Lai CK, Chen YA, Lin CJ, Lin HJ, Kao MC, Huang MZ, Lin YH, Chiang-Ni C, Chen CJ, Lo UG, Lin LC, Lin H, Hsieh JT, Lai CH*. 2016. Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin. Front Cell Infect Microbiol 6:9. https://doi.org/10.3389/fcimb.2016.00009
  • Lai CH*, Huang JC, Chiang-Ni C, Li JP, Wu LT, Wu HS, Sun YC, Lin ML, Lee JF, Lin HJ. 2016. Mixed infections of Helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan. Gastroenterol Res Pract 2016:7521913. https://doi.org/10.1155/2016/7521913
  • Chiang-Ni C, Zheng PX, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2016. Epidemiology analysis of Streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system. J Clin Microbiol 54:157-162. https://doi.org/10.1128/JCM.02089-15
  • Chiang-Ni C*, Nian SY, Wu JJ, Chen CJ. 2016. Oxygen-dependent phenotypic variation in group A streptococcus. J Microbiol Immunol Infect 49:837-842. https://doi.org/10.1016/j.jmii.2014.11.010
  • Chiang-Ni C*, Chu TP, Wu JJ, Chiu CH. 2016. Repression of Rgg but not upregulation of LacD.1 in emm1-type covS mutant mediates the SpeB repression in group A Streptococcus. Front Microbiol 7:1935. https://doi.org/10.3389/fmicb.2016.01935


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