Ling-Yu Wang

Appointment : Assistant Professor

Lab：Epigenetic oncology

Education : Ph.D.

University/Nation：University of California, Davis/ USA

Tel:

E-mail : lywang@mail.cgu.edu.tw

Research website :

Research interests:

We are interested in studying histone modification and lncRNA- mediated mechanisms involved in tumorigenesis, aiming to identify potential therapeutic strategies and to evaluate small molecule agents for cancer treatment. We are also interested in understanding the interaction between mesenchymal stem cells (MSC) and cancer cells in tumor microenvironment. By characterizing the potencies of MSC and MSC-derived extracellular vesicles, we hope to define the therapeutic potentials of MSC in regenerative medicine.

Publications:

Wang HJ*, Pochampalli M*, Wang LY*, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, and Kung HJ. 2019. Oncogene. Jan;38(1):17-32

Shih JW, Chiang WF, Wu Alexander TH, Wu MH, Wang LY, Yu YL, Hung YW, Wang WC, Chu CY, Hung CL, Changou C, Yen Y, Kung HJ. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression. 2017. Nature Communication. Jun 22;8:15874  

Wang J, Wang H, Wang LY, Cai D, Duan Z, Zhang Y, Chen P, Zou JX, Xu J, Chen X, Kung HJ, Chen H. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. 2016. Cell Death and Differentiation. 23(11):1886-1896.

Wang LY, Hung CL, Yang J, Chen YR, Izumiya Y, Chen H, Wang WC, Ann D, Kung HJKDM4A coactivates E2F1 to regulate PDK-dependent metabolic switch between mitochondrial oxidation and glycolysis. 2016. Cell Reports. 16: 3016-3027

Shih JW*, Wang LY*, Hung CL, Kung HJ, Hsieh CL. Non-coding RNAs in castration-resistant prostate cancer: regulation of androgen receptor signaling and cancer metabolism. 2015. Int J Mol Sci. 16(12): 28943–28978.  

Hung CL*, Wang LY*, Yu YL, Chen H, Srivastava S, Petrovics G, Kung HJ. A novel long non-coding RNA connects c-Myc to tumor metabolism. 2014. Proc Natl Acad Sci USA. 111(52):18697-702.

Chu CH*, Wang LY*, Hsu KC*, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. 2014. J Med Chem.(14):5975-85

Ghosh P, Qui Y, Wang LY, Kung HJ. Tyrosine kinome profiling: oncogenic mutations and therapeutic targeting in cancer. Molecular Oncology: Causes of Cancer and Targets for Treatment. ISBN: 9780521876629. Editors: Gelmann

E, Sawyers C, and Rauscher III F. Cambridge University Press. 2014.