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Li-Man Hung

Li-Man Hung, PhD

Appointment : Professor

LabCardiovascular Laboratory

Education : Ph.D.

University/NationChang Gung University

259 Wen-Hwa 1st Road, Kwei-San, Tao-Yuan, Taiwan

Tel: 03-2118800 ext 3338

E-mail : lisahung@mail.cgu.edu.tw

Research website :

Research interests:

Cardiac & Cardiovascular Systems

Pharmacology & Pharmacy



  1. Ma H, Zhang F, Zhou L, Cao T, Sun D, Wen S, Zhu J, Xiong Z, Tsau MT, Cheng ML, Hung LM, Zhou Y, Li Q. c-Src facilitates tumorigenesis by phosphorylating and activating G6PD. Oncogene. 2021 Mar 8. 
  2. Yu-Hao Liu , Chien-Chang Chen , Yi-Jen Hsueh , Hung LMDavid Hui-Kang MaHung-Chi ChenWen-Bin LenYaa-Jyuhn J Meir. Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming through Modulating STAT3 and Erk1/2 Activity. Cells. 31;10(2):284. 2021
  3. Chu WK, Hung LM, Hou CW, Chen JK. PKC Regulates YAP Expression through Alternative Splicing of YAP 3'UTR Pre-mRNA by hnRNP F.  Int J Mol Sci. 12;22(2):E694. 2021
  4. Huang JP, Cheng ML, Wang CH, Huang SS, Hsieh PS, Chang CC, Kuo CY, Chen KH, Hung LM* (correspondence). Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat. Pharmacol Res. 2020 Oct;160:105201
  5. Chang CC, Chang CY, Lin PC, Huang JP, Chen KH, Yen TH, Hung LM* (correspondence), Administration of low-dose resveratrol attenuated hepatic inflammation and lipid accumulation in high cholesterol-fructose diet-induced rat model of nonalcoholic fatty liver disease. Chin J Physiol. 63(4):149-155, 2020.
  6. Ma H, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM* (correspondence), Cheng ML, Li Q. c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3. Cell Rep. 24;30(12)4235-4249, 2020.
  7. Chan YH, Chang GJ, Lai YJ, Chen WJ, Chang SH, Hung LM, Kuo CT, Yeh YH. Atrial fibrillation and its arrhythmogenesis associated with insulin resistance. Cardiovasc Diabetol.  26;18(1):125, 2019.
  8. Huang JP, Hsu SC, Li DE, Chen KH, Kuo CY, Hung LM* (correspondence). Resveratrol Mitigates High-Fat Diet-Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway. Journal of Cardiovascular Pharmacology. 72(5):231-241, 2018.
  9. Chu WK, Hung LM, Hou CW, Chen JK. Heterogeneous ribonucleoprotein F regulates YAP expression via a G-tract in 3'UTR. Biochim Biophys Acta Gene Regul Mech. S1874-9399 (18)30174-3, 2018.
  10. Chung YH, Lu KY, Chiu SC, Lo CJ, Hung LM, Huang JP, Cheng ML, Wang CH, Tsai CK, Lin YC, Chang SH, Lin G. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media Mol Imaging.  Jul 12;2018
  11. Huang JP, Hsu SC, Meir YJ, Hsieh PS, Chang CC, Chen KH, Chen JK, Hung LM* (correspondence). Role of dysfunctional adipocytes in cholesterol-induced nonobese metabolic syndrome. J Mol Endocrinol. 60(4)307-321, 2018.
  12. Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung LM, Ruan J, Mak TW, Li Q, Han J. 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell Rep. 30;19(9)1846-1857, 2017.
  13. Jiang B, Zhang J, Xia J, Zhao W, Wu Y, Shi M, Luo L, Zhou H, Chen A, Ma H, Zhao Q, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, He Y, Li X, Hung LM, Mak TW, Li Q. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. Cell Rep. 11;19(2)389-400, 2017.
  14. Huang JP, Cheng ML, Hung CY, Wang CH, Hsieh PS, Shiao MS, Chen JK, Li DE, Hung LM*(correspondence). Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets. Journal of Diabetes.  9(10)936-946, 2017.
  15. Jiung-Pang Huang, Mei-Ling Cheng, Chao-HungWang, Ming-Shi Shiao, Jan-Kan Chen & Hung LM*(correspondence). High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy. International Journal of Cardiology. 215 (2016): 6576, 2016.
  16. Chih-Chun Chang, Keng-Yang Lin, Kang-Yu Peng, Yuan-Ji Day & Hung LM* (correspondence). Resveratrol exerts anti-obesity in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells. Endocrine Journal. 63 (2): 169-78, 2016

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