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Chia-Jung Yu


Chia-Jung Yu

Appointment: Professor

LabFunctional Proteomics Laboratory

Education: Ph.D.

University/NationNational Taiwan University/ Taiwan

Tel: +886-3-211-8800 ext.3424

E-mail : yucj1124@mail.cgu.edu.tw

Research website :http://d000003200.wixsite.com/yu-cj

Research interests:

1.  Development of biomarkers for lung adenocarcinoma by proteomic approaches.

2.  Mechanistic study of biomarkers in lung cancer.

3.  Characterization of human Arl1 protein complexes functioning in vesicle trafficking.

Publications: (*, Corresponding author)

  1. Lin MC, Yu CJ, Lee FJ*. Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane. Proc. Natl. Acad. Sci. U S A. 2022 Jul 26;119(30):e2207414119. doi: 10.1073/pnas.2207414119. Epub 2022 Jul 20.
  2. Wang YH, Chiu WY, Chen YT, Cai PJ, Wu YC, Wu JL, Chen BH, Liu YW, Yu CJ, Lee FJ*. Golgin Imh1 and GARP complex cooperate to restore the impaired SNARE recycling transport induced by ER stress. Cell Rep. 2022 Mar 22;38(12):110488. doi: 10.1016/j.celrep.2022.110488.
  3. Liao WC, Lin TJ, Liu YC, Wei YS, Chen GY, Feng HP, Chang YF, Chang HT, Wang CL, Chi HC, Wang CI, Lin KH, Ou Yang WT, Yu CJ*. Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma. Cancer Sci. 2022 Jan;113(1):205-220. doi: 10.1111/cas.15197. Epub 2021 Nov 25.
  4. Feng HP, Cheng HY, TF Hsiao, Lin TW, Hsu JW, Huang LH, Yu CJ*. ArfGAP1 acts as a GTPase-activating protein for human ADP-ribosylation factor-like 1 protein. FASEB J. 2021 Apr;35(4):e21337. doi: 10.1096/fj.202000818RR.
  5. Hsiao TF, Wang CL, Wu YC, Feng HP, Chiu YC, Lin HY, Liu KJ, Chang GC, Chien KY, Yu JS, Yu CJ.* Integrative omics analysis reveals soluble cadherin-3 as a survival predictor and an early monitoring marker of EGFR tyrosine kinase inhibitor therapy in lung cancer. Clin Cancer Res. 2020 Jul 1;26(13):3220-3229. doi: 10.1158/1078-0432.CCR-19-3972. Epub 2020 Mar 10.
  6. Chen KJ, Chiang TC, Yu CJ, Lee FJ*. Arl4A and Pak1 cooperative recruitment to plasma membrane contributes to    sustained Pak1 activation for cell migration. J. Cell Sci. 2020 Feb 4;133(3). pii: jcs233361. doi: 10.1242/jcs.233361.
  7. Chang JW, Shih CL, Wang CL, Luo JD, Wang CW, Hsieh JJ, Yu CJ, Chiou CC*. Transcriptomic analysis in liquid biopsy identifies circulating PCTAIRE-1 mRNA as a biomarker in NSCLC. Cancer Genom. Proteom. 2020 Jan-Feb;17(1):91-100.
  8. Huang JX, Wu YC, Cheng YY, Wang CL, Yu CJ*. IRF1 Negatively regulates oncogenic KPNA2 expression under growth stimulation and hypoxia in lung cancer cells. Oncotargets Ther. 2019 Dec; 2019(12): 11475-11486.
  9. Ho ML, Kuo WK, Chu LJ, Yeh IH, Fan CW, Chang HI, Yuan CL, Chou TY, Chen HY, Yang SW, Chang LC, Luo M, Wu TH, Chang YI, Yu CJ, Hua CC*, Ng WV*. N-acetylgalactosamine-6-sulfatase (GALNS), Similar to Glycodelin, Is a Potential General Biomarker for Multiple Malignancies. Anticancer Res. 2019 Nov;39(11):6317-6324. 
  10. Chen YC, Jiang PH, Chen HM, Chen CH, Wang YT, Chen YJ, Yu CJ, Teng SC*. Glucose intake hampers PKA-regulated HSP90 chaperone activity. Elife. 2018 Dec 5;7. pii: e39925. doi: 10.7554/eLife.39925. 
  11. Lin YH, Wu MH, Huang YH, Yeh CT, Chi HC, Tsai CY, Chuang WY, Yu CJ, Chung IH, Chen CY, Lin KH. Thyroid hormone negatively regulates tumorigenesis through suppression of BC200. Endocr. Relat. Cancer. 2018 Dec 1;25(12):967-979. doi:10.1530/ERC-18-0176. 
  12. Hsu RM, Zhong CY, Wang CL, Liao WC, Yang C, Lin SY, Lin JW, Cheng HY, Li PY, Yu CJ*. Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness by modulating NF-κB activity. Cell Commun Signal. 2018 Apr 27;16(1):19. doi: 10.1186/s12964-018-0230-5.
  13. Wang CI, Yu CJ, Huang Y, Yi JS, Cheng HW, Kao HK, Lao WW, Chang KP*. Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer. Head Neck. 2018 Mar 15. doi: 10.1002/hed.25145.  (equal to first author) 


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