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Yi-Ting Chen

陳怡婷 (Yi-Ting Chen)

Appointment : Professor

Lab：Proteomics and Metabolomics Laboratory for Translational Research

Education : Ph.D.

University/Nation：National Tsing Hua University/Taiwan

Tel: +88632118800 ext.3558

E-mail : ytchen@mail.cgu.edu.tw

Research website : https://sites.google.com/site/cguytc/home

Research interests:

Our group’s research is dedicated to the development of targeted and untargeted proteomic and metabolomic platforms for disease diagnosis / prognosis. We have established several workflows for the identification of novel biosignature candidate molecules, including proteins and metabolites, for human disease. The methods are primarily based on analytical chemistry, mass spectrometry and bioinformatics to study the real world and clinical unmet needs. We have established Omics approaches to investigate the alteration of biological molecules in various biomedical specimens including blood, tissue, cell lysates and secretome, urine, saliva, and amniotic fluids, etc. The current research focus is the development of a systems biology approach to the identification and quantification of proteins/peptides and metabolites associated with the bladder cancer, oral cancer, renal diseases, and energy-metabolism during disease progression. We have established the standard workflow for targeted and precise quantification of more than two hundred of biomolecules in a LC-MS run using multiple reaction monitoring MS (MRM-MS), which has been called the gold standard of MS-based quantitation methods. The laboratory is interested in research directed toward disease biomarker discovery using clinical human tissues, body fluids and associated cell models. The laboratory is also involved in various collaborations with chemical and biomedical researchers as well as clinical physicians (oncologists, urologists, pediatrician, and obstetrician) at the and international levels.

ORCID: https://orcid.org/0000-0002-0063-4965

Website: https://sites.google.com/site/cguytc/home

Publications:

  1. Jau-Song Yu, Yi-Ting Chen, Wei-Fang Chiang, Yung-Chin Hsiao, Lichieh Julie Chu, Lai-Chu See, Chi-Sheng Wu, Hui-Tzu Tu, Hsiao-Wei Chen, Chia-Chun Chen, Wei-Chao Liao, Ya-Ting Chang, Chih-Ching Wu, Che-Yi Lin, Shyun-Yeu Liu, Shu-Ti Chiou, Shu-Li Cha, Kai-Ping Chang, Chih-Yen Chien, Chee-Jen Chang, John D. Young, Chia C. Pao, Yu-Sun Chang*, Leland H. Hartwell*, Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan, PNAS, 2016, 113, 11549–11554. (Co-first author).
  2. Yi-Ting Chen*, Hsiao-Wei Chen, Chun-Feng Wu, Lichieh Julie Chu, Wei-Fang Chiang, Chih-Ching Wu, Jau-Song Yu, Cheng-Han Tsai, Kung-Hao Liang, Yu-Sun Chang, Maureen Wu, Wei-Ting Ou Yang, Development of a multiplexed LC-MRM/MS method for evaluation of salivary proteins as oral cancer biomarkers. Mol. Cell Proteomics. 16, 799-811. 2017.
  3. Chi-hung Shao, Chien-Lun Chen, Chao-Jung Chen, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang, Jau-Song Yu, Chiun-Gung Juo*, Kun-Pin Wu*, Metabolite marker discovery for the detection of bladder cancer by comparative metabolomics. Oncotarget, 2017 Jun 13;8(24):38802-38810. 2017.
  4. Yung-Chin Hsiao, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Szu-Fan Chen, Yao-Ning Chuang, Shih-Yu Lin, Chia-Chun Wu, Ya-Ting Chang, Lichieh Julie Chu, Yi-Ting Chen, Shu-Li Chia, Chih-Yen Chien, Kai-Ping Chang,Yu-Sun Chang, and Jau-Song Yu, Development of a multiplexed assay for oral cancer candidate biomarkers using peptide immunoaffinity enrichment and targeted mass spectrometry. Mol. Cell Proteomics. 2017 Oct;16(10):1829-1849.
  5. Cheng-Han Tsai, Yi-Ting Chen*, Clinical proteomics of genitourinary cancer for the development of biomarkers. Clinics in Oncology, 2017, 2, 1326-1327. 
  6. Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang* & Yu-Sun Chang*. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. NATURE COMMUNICATIONS. 2017, 8: 465.
  7. Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, and Jau-Song Yu. Variability assessment of 90 salivary proteins in intra-day and inter-day samples from healthy donors by multiple reaction monitoring-mass spectrometry. Proteomics Clinical Applications, 2018 Mar;12(2). doi: 10.1002/prca.201700039. Epub 2018 Feb 7.
  8. Cheng-Han Tsai1, Yi-Ting Chen*, Ying-Hsu Chang, Chuen Hsueh, Chung-Yi Liu, Yu-Sun Chang, Chien-Lun Chen*, Jau-Song Yu*. Systematic Verification of Bladder Cancer-Associated Tissue Protein Biomarker Candidates in Clinical Urine Specimens. Oncotarget, 2018, 9:30731-30747. (Co-first author and co-corresponding author).
  9. Cheng-Chia Lee, Chih-Hsiang Chang, Shao-Wei Chen*, Pei-Chun Fan, SuWei Chang, Yi-Ting Chen, Yu-Yun Nan, Pyng-Jing Lin, Feng-Chun Tsai. Preoperative Risk Assessment Improves Biomarker Detection for Predicting Acute Kidney Injury After Cardiac Surgery, PLOS ONE, 2018, 13 (9), e0203447.
  10. Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, and Li-Mei Pai*. Histidine-dependent protein methylation is required for compartmentalization of CTP Synthase, Cell Reports, 2018, 24, 2733–2745.
  11. Cheng-Chia Lee, Ya-Ju Hsieh, Shao-Wei Chen, Shu-Hsuan Fu, Chia-Wei Hsu, Chih-Ching Wu, Wei Han, Yunong Li, Huan Tao, Yu-Sun Chang, Jau-Song Yu, Liang Li, Chih-Hsiang Chang, Yi-Ting Chen*, Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patient. Scientific Reports, 2018, 8, Article number: 17774.
  12. Yi-Ting Chen*, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu Chang*. Development of Biomarkers of Genitourinary Cancer using Mass Spectrometry-Based Clinical Proteomics, Journal of Food and Drug Analysis, 2019, 27, 2: 387-403.
  13. Yi-Ting Chen*, Hsin-Chien Huang, Ya-Ju Hsieh, Shu-Hsuan Fu, Liang Li, Chien-Lun Chen, Lichieh Julie Chu, Jau-Song Yu. Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers. Journal of Food and Drug Analysis, 2019, 27(2), 460-474.
  14. Chia-Wei Hsu, Yi-Ting Chen, Ya-Ju Hsieh, Kai-Ping Chang, Pei-Chun Hsueh, Ting-Wen Chen, Jau-Song Yu, Yu-Sun Chang, Liang Li*, Chih-Ching Wu*. Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma. Analytica Chimica Acta. 2019, 1050, 113-122. (Co-first author)
  15. Jia-Jin Chen, Pei-Chun Fan, George Kou, Su-Wei Chang, Yi-Ting Chen, Cheng-Chia Lee, Chih-Hsiang Chang*, Meta-analysis: urinary calprotectin for discrimination of intrinsic and prerenal acute kidney injury, J. Clin. Med., 2019, 8(1), E74.
  16. Pei-Chun Fan, Jason Chih-Hsiang Changa, Chia-Ni Lin,Cheng-Chia Leea, Yi-Ting Chen, Pao-Hsien Chu, George Koua, Yueh-An Lu, Chih-Wei Yang, Yung-Chang Chen*. Serum Indoxyl Sulfate Predicts Adverse Cardiovascular Events in Patients with Chronic Kidney Disease. Journal of the Formosan Medical Association, 2019, 118, 1099-1106.
  17. Hao-Wei Chu, Kai-Ping Chang, Chia-Wei Hsu, Ian Yi-Feng Chang, Hao-Ping Liu, Yi-Ting Chen, and Chih-Ching Wu, Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches. Molecular & Cellular Proteomics. 2019, 18(9), 1796-1806.
  18. Yi-Ting Chen*, Wei-Ting Ou Yang, Horng-Heng Juang, Chien-Lun Chen*, Hsiao-Wei Chen, Ke-Hung Tsui, Ying-Hsu Chang, Cheng-Han Tsai, Chuen Hsueh, Wei-Chao Liao, Proteomic characterization of arsenic and cadmium exposure in bladder cells", Rapid Commun Mass Spectrom. 2020;34(S1):e8578.
  19. Cheng-Chia Lee, Chih-Hsiang Chang, Ya-Lien Cheng, George Kuo, Shao-Wei Chen, Yi-Jung Li, Yi-Ting Chen, Ya-Chung Tian * , Diagnostic performance of Cyclophilin A in cardiac surgery-associated acute kidney injury. J. Clin. Med. 2020, 9, 108; doi:10.3390/jcm9010108.
  20. Pei-Chun Hsueh; Kuo-An Wu; Chia-Yu Yang; Chia-Wei Hsu; Chih-Liang Wang; Chu-Mi Hung; Yi-Ting Chen; Jau-Song Yu; Chih-Ching Wu*. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Analytica Chimica Acta. 2020, 1128, 238-250.
  21. Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash & Jau-Song Yu*. Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses. Sci. Rep. 11, 9583 (2021).
  22. Jia‑You Lin, Bao‑Rong Juo, Yu‑Hsuan Yeh, Shu‑Hsuan Fu, Yi‑Ting Chen, Chien‑Lun Chen* and Kun‑Pin Wu*. Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics, BMC Bioinformatics. 2021, 22, 305.

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