張煥宗(Huan-Tsung Chang)

職稱

教授

最高學歷

愛荷華州立大學博士

E-mail 

changht@mail.cgu.edu.tw

電話：

+886-3-211-8800 ext.3020

傳真

+886-3-211-8700

實驗室

奈米醫藥、感測器和催化劑實驗https://www.ch.ntu.edu.tw/~htchang/

專長

分析化學和奈米科學

研究方向及研究室特色

我們團隊致力於綠色合成奈米材料，並將其應用於感測器、細胞影像、藥物、奈米酵素、奈米催化劑及新能源等。研究重點如下：

(I)    金、銀、銅及碳奈米點光學探針的開發

(II)   奈米藥物的合成與其在抗菌、抗凝血和抗癌的應用

(III)  奈米微結構的組裝和應用

(IV)  奈米材料於燃料電池、超級電容及二氧化碳還原的應用

論文與著作

Publications:

代表著作:

1.     Anand, A.; Jian, H.-J.; Huang, H.-H.; Hean, L.E.; Li, Y.-J.; Lai*, J.-Y.; Chou, H.-D.; Kang, E.Y.-C.; Wu, W.-C.; Lai, C.-C.; Huang, C.-C.; H.-T. Chang* “Anti-angiogenic Carbon Nanovesicles Loaded with Bevacizumab for the Treatment of Age-related Macular Degeneration” Carbon 2023, 2023, 201, 362-370.

2.     Lin, Y.-F.; Lin, Y.-S.; Huang, T.-Y.; Wei, S.-C.; Wu, R.-S.; Huang, C.-C.; Huang, Y-F.*; Chang, H.-T.* “Photoswitchable Carbon-dot Liposomes Mediate Catalytic Cascade Reactions for Amplified Dynamic Treatment of Tumor Cells” Journal of Colloid and Interface Sci. 2022, 628, 717–725.

3.     Wu, R.-S.; Lin, Y.-S.; Nain, A.; Unnikrishnan, B.; Lin, Y.-F.; Yang, C.-R.; Chen, T.-H.; Huang, Y.-F.*; Huang, C.-C.; Chang, H.-T.* “Evaluation of Chemotherapeutic Response in Living Cells Using Subcellular Organelle‒Selective Amphipathic Carbon Dots” Biosens. Bioelectron. 2022, 211, 114362.

4.     Sangili, A.; Unnikrishnan, B.; Nain, A.; Hsu, Y.-J.; Wu, R.-S.; Huang, C.-C. *; Chang, H.-T.* “Stable Carbon Encapsulated Titanium Carbide MXene Aqueous lnk for Fabricating High-performance Supercapacitors” Energy Storage Mater. 2022, 53, 51−61.

5.    Lin, W.-J.; Lin, Y.-S.; Chang, H.-T.*; Unnikrishnan, B.; Huang, C.-C.* “Electrocatalytic CuBr@CuO Nanoparticles Based Salivary Glucose Probes” Biosens. Bioelectron. 2021, 194, 113610.

6.     Wu, C.-W.; Unnikrishnan, B.; Chen, I.-W. P.; Harroun, S. G.; Chang, H.-T.*; Hung, C.-C.* “Excellent Oxidation Resistive MXene Aqueous Ink for Micro-Supercapacitor Application” Energy Storage Mater. 2020, 25, 563−571.

7.    Xu, D.; Lin, Q.*; Chang, H.-T.* “Recent Advances and Sensing Applications of Carbon Dots” Small Methods 2019, 4, 1900387.

8.     Chen, T.-H.; Chang, H.-T.* “Stable and Photoswitchable Carbon-Dot Liposome” ACS Appl. Mater. Inter. 2017, 9, 44259–44263.

9.     Chen, P.-C.; Periasamy, A. P.; Harroun, S. G.; Wu, W.-P.; Chang, H.-T.* “Photoluminescence Sensing Systems Based on Copper, Gold and Silver Nanomaterials” Coord. Chem. Rev. 2016, 320, 129–138.

10.   Chen, W.-Y.; Chang, H.-Y.; Lu, J.-K.; Huang, Y.-C.; Harroun, S. G.; Tseng, Y.-T.; Li, Y.-J.; Huang, C.-C.; Chang, H.-T.* “Self-Assembly of Antimicrobial Peptides on Gold Nanodots: Against Multidrug-Resistant Bacteria and Wound Healing Application” Adv. Funct. Mater. 2015, 25, 7189–7199.

11.   Shih, C.-C.; Chen, P.-C.; Lin, G.-L.; Wang, C.-W.; Chang, H.-T.* “Optical and Electrochemical Applications of Silicon–Carbon Dots/Silicon Dioxide Nanocomposites” ACS Nano 2015, 9, 312–319.

12.   Hsu, P.-C.; Chang, H.-T.* “Synthesis of High-Quality Carbon Nanodots from Hydrophilic Compounds: Role of Functional Groups” Chem. Commun. 2012, 3984–3986

13.   Shiang, Y.-C.; Hsu, C.-L.; Huang, C.-C.*; Chang, H.-T.* “Gold Nanoparticles Presenting Hybridized Self-Assembled Aptamers That Exhibit Enhanced Inhibition of Thrombin” Angew. Chem. Int. Ed. 2011, 50, 7660–7665.

14.   Yang, Z.; Chen, C.-Y.; Liu, C.-W.; Li, C.-L.; Chang, H.-T.* “Quantum Dot-Sensitized Solar Cells Featuring CuS/CoS Electrodes Provide 4.1% Efficiency” Adv. Energy Mater. 2011, 1, 259–264.

15.  Chiang, C.-K.; Chen, W.-T.; Chang, H.-T.* “Nanoparticle-Based Mass Spectrometry for the Analysis of Biomolecules” Chem. Soc. Rev. 2011, 40, 1269–1281.

16.  Lan, G.-Y.; Huang, C.-C.; Chang, H.-T.* “Silver Nanoclusters as Fluorescent Probes for Selective and Sensitive Detection of Copper Ions” Chem. Commun. 2010, 46, 1257–1259.

17.  Yang, Z.; Chen, C.-Y.; Liu, C.-W.; Chang, H.-T.* “Electrocatalytic Sulfur Electrodes for CdS/CdSe Quantum Dot–Sensitized Solar Cells” Chem. Commun. 2010, 46, 5485–5487.

18.   Huang, C.-C.; Yang, Z.; Lee, K.-H.; Chang, H.-T.* “Synthesis of Highly Fluorescent Gold Nanoparticles for Sensing Mercury(II)” Angew. Chem. Int. Ed. 2007, 46, 6824-6828.

19.  Lin, Y.-W.; Tseng, W.-L.*; Chang, H.-T.* “Using a Layer-by-Layer Assembly Technique to Fabricate Multicolored-Light-Emitting Films of CdSe@CdS and CdTe Quantum Dots” Adv. Mater. 2006, 18, 1381-1386.

20.  Huang, C.-C.; Chang, H.-T.* “Selective Gold Nanoparticle-Based “Turn-On” Fluorescent Sensors for Detection of Mercury(II) in Aqueous Solution” Anal. Chem. 2006, 78, 8332–8338.