Hui-Yi Hsiao

Position

Assistant Professor

Education

PhD., Department of Biology, New York University, USA

Email

ivyhsiao@mail.cgu.edu.tw

Office Tel

Lab Tel

Fax

Laboratory

Tissue Engineering & Regenerative Medicine Lab

Specialty

Tissue Engineering, Regenerative Medicine, Stem Cell Research, Lymphedema Research

Lab & Research Interest

In my lab, we focus on two distinct research topics.

1. Tissue engineering in bone, cartilage, adipose and hair Regeneration

Tissue engineering is one of the strategies using in regenerative medicine. Many tissue engineered studies combine cells, biomaterials and growth factors to generate engineered tissue to repair or replace the damaged one. The design of engineered tissues is to reach promotion of angiogenesis and cell differentiation for neo-tissue regeneration. Our lab incorporates adult stem cells and biomaterials to design 3D customized tissue constructs for different tissue regeneration (Fig. 1). Our goal in tissue regeneration spans from the regeneration of hard tissues such as bone and cartilage, to soft tissues like adipose, lymphatic tissue, and hair.

2. The mechanism and treatment of lymphedema disease

Lymphedema is the abnormal accumulation of excess lymph remained as tissue fluid in the interstitial space resulting from the obstruction of lymph drainage. Lymphedema can be categorized as primary and secondary lymphedema. Primary lymphedema is the abnormal development of lymph system, mostly is congenital. Secondary lymphedema is the damage of the lymph system resulting from infection, cancer or radiation. After lymph nodes removal and radiation treatments on breast cancer or gynecological cancer patients, roughly up to 40% of breast cancer patients and 20-49 % gynecological cancer patients have complications on failure of lymph drainage causing the development of lymphedema. There is very little information regarding how the lymphedema symptoms have been induced during the development of lymphedema. Furthermore, how to treat or prevent the development of lymphedema is also important for future clinical application. In our lab, we study the mechanism of the lymphedema and find the feasible approaches for lymphedema treatment (Fig.2).

Publications

(Selected Publications)

1. Hsiao HY, J.W. Liu, M. Pappalardo, M.H. Cheng, The Impacts of Lymph on the Adipogenesis of Adipose-Derived Stem Cells, Plast Reconstr Surg  (2023).

2. Hsiao HY, W.C. Hsieh, F.C. Chang, J.W. Liu, W.L. Kuo, D.C. Cheong, J.J. Huang, The Effect of Negative Pressure on Wound Healing and Regeneration in Closed Incisions under High Tension: Evidence from Animal Studies and Clinical Experience, 2022 J Clin Med 12(1)

3. Sakarya AH, Huang CW, Yang CY, Hsiao HY, Chang FC, Huang JJ. Vascularized lymph node transplantation successfully reverses lymphedema and maintains immunity in a rat lymphedema model. Bioeng Transl Med. 2022 Feb;7:e10301

4. Hsiao HY, Nien CY, Hong HH, Cheng MH, Yen TH. Application of dental stem cells in three-dimensional tissue regeneration. World J Stem Cells 2021Nov;13:1610-24

5.     Huang CW, Chang YC, Hsiao HY, Liu JW, Chang FC, Huang JJ. Creation of a rat lymphedema model using extensive lymph node dissection and circumferential soft tissue resection: Is this a reliable model? Microsurgery 2021Nov;41:762-71.

6.     Hsiao HY, Lai CY, Liu JW, Yu YY, Chang FC, Huang JJ. Fate of Fat Grafting In Vivo and In Vitro: Does the Suction-Assisted Lipectomy Device Matter? Aesthet Surg J 2021 Sep ;41:NP1323-NP36.

7.     Hsiao HY, Cheng CM, Kao SW, et al. The effect of bone inhibitors on periosteum-guided cartilage regeneration. Sci Rep 2020 May;10:8372.

8.     Hsiao HY, Chung CW, Santos JH, Villaflores OB, Lu TT. Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue engineering. Dalton Trans 2019 Apr;48:9431-53.

9.     Hsiao HY, Yang CY, Liu JW, Brey EM, Cheng MH. Periosteal Osteogenic Capacity Depends on Tissue Source. Tissue Eng Part A 2018 Dec;24:1733-41.

10.  Yang CY, Ho OA, Cheng MH, Hsiao HY*. Critical Ischemia Time, Perfusion, and Drainage Function of Vascularized Lymph Nodes. Plast Reconstr Surg 2018 Sep;142:688-97.

11.   Ng CY, Yen H, Hsiao HY*, Su SC. Phytochemicals in Skin Cancer Prevention and Treatment: An Updated Review. Int J Mol Sci 2018 March;19(4):941

12. Hsiao HY, Yang SR, Brey EM, Chu IM, Cheng MH. Hydrogel Delivery of Mesenchymal Stem Cell-Expressing Bone Morphogenetic Protein-2 Enhances Bone Defect Repair. Plast Reconstr Surg Glob Open 2016 Aug;4:e838.

13.   Hsiao HY, Liu JW, Brey EM, Cheng MH. The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model. PLoS One 2016 Apr;11:e0154328.

14.   Hsiao HY, Jukam D, Johnston R, Desplan C. The neuronal transcription factor erect wing regulates specification and maintenance of Drosophila R8 photoreceptor subtypes. Dev Biol 2013 Sep;381:482-90.

15.   Hsiao HY, Johnston RJ, Jr., Jukam D, Vasiliauskas D, Desplan C, Rister J. Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas. J Vis Exp 2012 Nov:4347.

16.   Hsiao HY, He Q, Van Waasbergen LG, Grossman AR. Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways. J Bacteriol 2004 Jun;186:3882-8.