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賴志河

賴志河 (Chih-Ho Lai)

職稱：教授

研究室名稱：感染免疫研究室

最高學歷：Ph.D.

學校/國家：清華大學/台灣

分機號碼：(lab) 3895/ (office) 5116

電子郵件帳號：chlai@mail.cgu.edu.tw

個人網頁網址：https://sites.google.com/a/gap.cgu.edu.tw/infection-and-immunity/  

研究室現有： 博士後研究員 0 人

博士班研究生  2  人

碩士班研究生 3 人

專任研究助理  2  人

大學部專題生  6  人

研究方向及研究室特色：

我們實驗室主要的研究方向是探討微生物致病機轉與宿主免疫反應，並開發有效之治療藥物。研究之微生物主題包含：幽門螺旋桿菌(Helicobacter pylori)、空腸彎曲桿菌(Campylobacter jejuni)、鏈球菌(Streptococcus pneumoniae)及嗜血桿菌(Haemophilus influenzae)等常見致病菌與免疫細胞之相互作用及導致感染疾病。此外，我們也嘗試開發細菌毒素應用於治療癌幹細胞(cancer stem cells)、探討微生物相(microbiota)與轉譯醫學等臨床議題，希望能將研究成果應用於臨床治療。我們非常歡迎對感染免疫學領域有興趣的大學部專題生、碩、博班研究生一起參與實驗室的研究。

最近五年所發表論文：

  1. Kuo CJ, Ke JN, Kuo T, Lin CY, Hsieh SY, Chiu YF, Wu HY, Bui NN, Chiu CH, Chiu CT, Lai CH*. Multiple amino acid substitutions in penicillin-binding protein-1A confer amoxicillin resistance in refractory Helicobacter pylori infection. J Microbiol Immunol Infect. 2022; S1684-1182 (22)00104-9.
  2. Chou LF, Chen TW, Yang HY, Tian YC, Chang MY, Hung CC, Lai CH, Hsu SH, Tsai CY, Ko YC, Lian JH, Yang CW*. Implication of the IL-10-expression signature in the pathogenicity of Leptospira- infected macrophages. Microbiol Spectr. 2022;10(3):e0259521.
  3. Lien HM, Wang YY, Huang MZ, Wu HY, Chen CC, Hung SW, Chiu CH, Lai CH*. Gastroprotective effect of Anisomeles indica on aspirin-induced gastric ulcer in mice. Antioxidants 2022; 11(12):1-13.
  4. Lai CH*, Lin TL, Huang MZ, Li SW, Wu HY, Chiu YF, Yang CY, Chiu CH, Lai HC*. Gut commensal Parabacteroides goldsteinii MTS01 Alters gut microbiota composition and reduces cholesterol to mitigate Helicobacter pylori-induced pathogenesis. Front Immunol. 2022;13(916848):1-13.
  5. Lo UG, Chen YA, Cen J, Deng S, Luo J, Zhau H, Ho L, Lai CH, Mu P, Chung LWK, Hsieh JT*. The driver role of JAK- STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy- and castration-resistant prostate cancer. Clin Transl Med. 2022;12(8):e978.
  6. Chiang MH, Ho SM, Wu HY, Lin YC, Tsai WH, Wu T, Lai CH*, Wu CL*. Drosophila model for studying gut microbiota in behaviors and neurodegenerative diseases. Biomedicines. 2022;10(3):596.
  7. Lee CF, Chen YA, Hernandez E, Pong RC, Ma S, Hofstad M, Kapur P, Zhau H, Chung LW, Lai CH, Lin H, Lee MS, Raj GV, Hsieh JT*. The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC. Clin Transl Med. 2022;12(2):e695.
  8. Hsu CY, Yeh JY, Chen CY, Wu HY, Chiang MH, Wu CL, Lin HJ, Chiu CH, Lai CH*. Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells. Virulence. 2021;12(1):2341-2351. 
  9. Lin TY, Lan WH, Chiu YF, Feng CL, Chiu CH, Kuo CJ, Lai CH*. Statins' regulation of the virulence factors of Helicobacter pylori and the production of ROS may inhibit the development of gastric cancer. Antioxidants. 2021;10(8):1-14.
  10. Lai YR, Chang YF, Ma J, Chiu CH, Kuo ML, Lai CH*. From DNA damage to cancer progression: potential effects of cytolethal distending toxin. Front Immunol. 2021;12(760451):1-8.
  11. Kuo CJ, Lee CH, Chang ML, Lin CY, Lin WR, Su MY, Chiu CH, Tseng CN, Wu YS, Chiu CT, Lai CH*. Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection. J Microbiol Immunol Infect. 2021;54(6):1184-1187.
  12. Gagliardi MC, Iwabuchi K, Lai CH*. Editorial: Role of lipid rafts in anti-microbial immune response. Front Immunol. 2021;12(654776):1-2.
  13. Chen YA, Lai YR, Wu HY, Lo YJ, Chang YF, Hung CL, Lin CJ, Lo UG, Lin H, Hsieh JT, Chiu CH, Lin YH, Lai CH*. Bacterial genotoxin-coated nanoparticles for radiotherapy sensitization in prostate cancer. Biomedicines. 2021;9(2):1-15.
  14. Yeh JY, Lin HJ, Kuo CJ, Feng CL, Chou CH, Lin CD, Wu HY, Li CY, Chiu CH, Lai CH*. Campylobacter jejuni cytolethal distending toxin C exploits lipid rafts to mitigate Helicobacter pylori-induced pathogenesis. Front Cell Dev Biol. 2021;8:1-10.
  15. Chen YW, Huang MZ, Chen CL, Yang CY, Chiang-Ni C, Chen YY, Wu HY, Kuo ML, Chiu CH, Lai CH*. PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Particle and Fibre Toxicology. 2020;17(1):1-14.
  16. Chen YW, Li SW, Lin CD, Huang MZ, Lin HJ, Chin CY, Lai YR, Chiu CH, Yang CY, Lai CH*. Fine particulate matter exposure alters pulmonary microbiota composition and aggravates pneumococcus-induced lung pathogenesis. Frontiers in Cell and Developmental Biology. 2020;8:1-13.
  17. Liu YK, Kuo HC, Lai CH, Chou CC*. Single amino acid utilization for bacterial categorization. Scientific Reports. 2020;10(1):1-12.
  18. Sit WY, Chen YA, Chen YL, Lai CH*, Wang WC*. Cellular evasion strategies of Helicobacter pylori in regulating its intracellular fate. Seminars in Cell & Developmental Biology. 2020;101:59-67.
  19. Chou CH, Lai YR, Chi CY, Ho MW, Liao WC, Ho CM, Chen YA, Chen CY, Lin YT, Lin CD, Lai CH*. Long-term surveillance of antibiotic prescriptions and the prevalence of antimicrobial resistance in non-fermenting Gram-negative bacilli. Microorganisms. 2020;8(3):1-11.
  20. Kuo CJ, Chen CY, Lo HR, Feng CL, Wu HY, Huang MZ, Liao TN, Chen YA, Lai CH*. Helicobacter pylori induces IL-33 production and recruits ST-2 to lipid rafts to exacerbate inflammation. Cells. 2019;8:1-13.
  21. Huang J, Lo UG, Wu S, Wang B, Pong RC, Lai CH, Lin H, He D, Hsieh JT, Wu K*. The roles and mechanism of IFIT5 in bladder cancer epithelial-mesenchymal transition and progression. Cell Death Dis. 2019;10(6):1-12. 
  22. Lin HJ, Jiang ZP, Lo HR, Feng CL, Chen CJ, Yang CY, Huang MZ, Wu HY, Chen YA, Chiu CH, Lai CH*. Coalescence of RAGE in lipid rafts in response to cytolethal distending toxin-induced inflammation. Front Immunol. 2019;10:1-10.
  23. Lien HM, Wu HY, Hung CL, Chen CJ, Wu CL, Chen CC, Lin HJ, Lai CH*. Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori. Sci Rep. 2019;9:1-7.
  24. Chen YH, Tsai WH, Wu HY, Chen CY, Yeh WL, Chen YH, Hsu HY, Chen WW, Chen YW, Lin TL, Lai HC, Lin YH, Lai CH*. Probiotic Lactobacillus spp. act against Helicobacter pylori-induced inflammation. J Clin Med. 2019;8:1-16.
  25. Yun EJ, Lin CJ, Dang A, Hernandez E, Guo J, Chen WM, Kim N, Kapur P, Brugarolas J, Wu K, He D, Lai CH, Lin H, Saha D, Baek ST, Chen BPC, Hsieh JT*. Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation. Clin Cancer Res. 2019;25(14):4542-4551.
  26. Hu PJ, Chen MY, Wu MS, Lin YC, Shih PH, Lai CH*, Lin HJ*. Clinical evaluation of CA72-4 for screening gastric cancer in a healthy population: a multicenter retrospective study. Cancers. 2019;11(5):1-8. 
  27. Chen YA, Shih HW, Lin YC, Hsu HY, Wu TF, Tsai CH, Wu CL, Wu HY, Hsieh JT, Tang CH, Lai CH*. Simvastatin sensitizes radioresistant prostate cancer cells by compromising DNA double-strand break repair. Front Pharmacol. 2018;13(600):1-9.
  28. Lai CH*, Huang JC, Cheng HH, Wu MC, Huang MZ, Hsu HY, Chen YA, Hsu CY, Pan YJ, Chu YT, Chen TJ, Wu YF, Chiu YF, Wang HJ, Wang WC*. Helicobacter pylori cholesterol glucosylation modulates autophagy for increasing intracellular survival in macrophages. Cell Microbiol. 2018;27:e12947:1-11.
  29. Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH*. Antrocin sensitizes prostate cancer cells to radiotherapy through inhibiting PI3K/AKT and MAPK signaling pathways. Cancers. 2018;11:1-18.
  30. Chen YA, Lin YJ, Lin CL, Lin HJ, Wu HS, Hsu HY, Sun YC, Wu HY, Lai CH*, Kao CH*. Simvastatin therapy for drug repositioning to reduce the risk of prostate cancer mortality in patients with hyperlipidemia. Front Pharmacol. 2018;22(225):1-7.
  31. Chen YA, Lien HM, Kao MC, Lo UG, Lin LC, Lin CJ, Chang SJ, Chen CC, Hsieh JT, Lin H, Tang CH, Lai CH*. Sensitization of radioresistant prostate cancer cells by resveratrol isolated from Arachis hypogaea stems. PLoS One. 2017;12(1):1-16.
  32. Lin LC, Gao AC, Lai CH*, Hsieh JT*, Lin H*. Induction of neuroendocrine differentiation in castration resistant prostate cancer cells by adipocyte differentiation-related protein (ADRP) delivered by exosomes. Cancer Lett. 2017;391:74-82.
  33. Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH*. Cytolethal distending toxin enhances radiosensitivity in prostate cancer cells by regulating autophagy. Front Cell Infect Microbiol. 2017; 7(223):1-8.
  34. Peng YH, Chen CK, Su CH, Liao WC, Muo CH, Hsia TC, Sung FC, Lai CH*, Kao CH*. Increased risk of chronic obstructive pulmonary disease among patients with Helicobacter pylori infection: a population-based cohort study. Clin Respir J. 2017;11:558-565.
  35. Liao WC, Huang MZ, Wang ML, Lin CJ, Lu TL, Lo HR, Pan YJ, Sun YC, Kao MC, Lin HJ, Lai CH*. Statin decreases Helicobacter pylori burden in macrophages by promoting autophagy. Front Cell Infect Microbiol. 2017;6(203):1-11.
  36. Lin CJ, Liao WC, Chen YA, Lin HJ, Feng CL, Lin CL, Lin YJ, Kao MC, Huang MZ, Lai CH*, Kao CH*. Statin therapy is associated with reduced risk of peptic ulcer disease in the Taiwanese population. Front Pharmacol. 2017; 8(210):1-8.
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