邱亞芳
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職稱：副教授 研究室名稱：病毒學實驗室 學校/國家：長庚大學/台灣 電子郵件帳號： yfchiu@mail.cgu.edu.tw |
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研究室現有： 博士後研究員 0 人 博士班研究生 0 人 碩士班研究生 2 人 大學部專題生 1 人 |
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研究方向及研究室特色 Understanding how oncogenic viruses establish themselves in cells to cause cancers using live-cell imaging for uncovering the potential therapeutic targets to eliminate viral genomes and thereby eradicate its oncogenic gene products from infected cells. Understanding the pathogenesis of influenza virus and Enterovirus with live-cells imaging
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Publications ： 1. Ting-Yu Lin, Wen-Hsi Lan, Ya-Fang Chiu (Co-first), Chun-Lung Feng, Cheng-Hsun Chiu, Chia-Jung Kuo *, Chih-Ho Lai *. Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer. Antioxidants 2021, 10, 1293. doi: 10.3390/antiox10081293 2. Chien-Hui Hung, Ya-Fang Chiu, Wen-Hung Wang, Lee-Wen Chen, Pey-Jium Chang, Tsung-Yu Huang, Ying-Ju Lin, Wan-Ju Tsai, Chia-Ching Yang. Interaction between BGLF2 and BBLF1 is required for the efficient production of infectious Epstein-Barr virus particles. Frontiers in Microbiology 2019 (SCI, IF 4.259, 32/133, Microbiology) 3. Chih-Ho Lai, Ju-Chun Huang, Hsin-Hung Cheng, Meng-Chen Wu, Mei-Zi Huang, Hui-Ying Hsu, YuAn Chen, Chung-Yao Hsu, Yi-Jiun Pan, Yen-Ting Chu, Tsan-Jan Chen, Yu-Fang Wu, Wei Yang Sit, Jai-Shin Liu, Ya-Fang Chiu, Hung-Jung Wang, Wen-Ching Wang. Helicobacter pylori cholesterol glucosylation modulates autophagy for increasing intracellular survival in macrophages 2018 Cellular Microbiology DOI: 10.1111/cmi.12947 (SCI: 4.410) 4. Ya-Fang Chiu and Bill Sugden. Plasmid-Partitioning by Human Tumor Viruses 2018 Journal of Virology doi: 10.1128/JVI.02170-17 (SCI: 4.663) 5. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Kaposi's Sarcomaassociated Herpesvirus (KSHV) stably clusters its genomes across generations to maintain itself extrachromosomally. Journal of Cell Biology 2017; 216 doi: 10.1083/jcb.201702013 (SCI: 7.955) 6. Ya-Fang Chiu and Bill Sugden. Epstein-Barr Virus' Path from Latent to Productive Infection. Annual Review of Virology 2016; 3:359-72 (SCI: 4.143) doi: 10.1146/annurev-virology-110615-042358 7. Reza Djavadian, Ya-Fang Chiu, and Eric Johannsen. An Epstein-Barr Virus-Encoded Protein Complex Requires an Origin of Lytic Replication in cis to Mediate Late Gene Transcription. PLOS Pathogens 2016; 12 (6): e1005718. doi:10.1371/journal.ppat.1005718 (SCI: 6.608) 8. Denis Lee, Kathryn Norby, Mitchell Hayes, Ya-Fang Chiu, Bill Sugden, Paul F. Lambert. Using Organotypic Epithelial Tissue Culture to Study the Human Papillomavirus Life Cycle. Current Protocols in Microbiology 2016; 41: 14B.8.1-14B.8.19. doi: 10.1002/cpmc.4. 9. Kathleen R. Makielski, Denis Lee, Laurel D. Lorenz, Dhananjay M. Nawandar, Ya-Fang Chiu, Shannon C. Kenney, Paul F. Lambert. Human Papillomavirus Promotes Epstein-barr Virus Maintenance and Lytic Reactivation in Oral Keratinocytes. Virology 2016; 495: 52-62. doi: 10.1016/j.virol.2016.05.005 (SCI: 3.353) 10. Chien-Hui Hung, Lee-Wen Chen, Wen-Hung Wang, Pey-Jium Chang, Ya-Fang Chiu, Chen-Chia Hung, Ying-Ju Lin, Jieh-Yuan Liou, Wen-Ju Tsai, and Shih-Tung Liu. Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via ERK-kinase Pathway. Journal of Virology 2014; 88:12133-45. doi: 10.1128/JVI.02033-14. (SCI: 4.439) 11. David T. Vereide, Eri Seto, Ya-Fang Chiu, Mitchell Hayes, Takanobu Tagawa, Adam Grundhoff, Wolfgang Hammerschmidt, and Bill Sugden. Epstein-Barr Virus Maintains Lymphomas Via Its miRNAs. Oncogene 2014; 33:1258-64. doi: 10.1038/onc.2013.71. (SCI: 8.459) 12. Ya-Fang Chiu, Arthur U. Sugden, and Bill Sugden. Epstein-Barr Viral Productive Amplification Reprograms Nuclear Architecture, DNA Replication and Histone Deposition. Cell Host & Microbes 2013; 14:607-18. doi: 10.1016/j.chom.2013.11.009. (SCI: 12.194) 13. Malika Kuzembayeva, Ya-Fang Chiu, and Bill Sugden. Comparing Proteomics and RISC Immunoprecipitations to Identify Targets of Epstein-Barr Viral miRNAs. PLoS One 2012; 7:e47409. doi: 10.1371/journal.pone.0047409. (SCI: 3.730) 14. Kathryn Norby, Ya-Fang Chiu, and Bill Sugden. Monitoring Plasmid Replication in Live Mammalian Cells over Multiple Generations by Fluorescence Microscopy. Journal of Visualized Experiments 2012; (70): e4305. doi: 10.3791/4305. (SCI: 1.325) 15. Ya-Fang Chiu, Bill Sugden, Pey-Jium Chang, Lee-Wen Chen, Ying-Ju Lin, Yu-Ching Lan, Chih-Ho Lai, Jieh-Yuan Liou, Shih-Tung Liu, and Chien-Hui Hung. Characterization and Intracellular Trafficking of Epstein-Barr Virus BBLF1, A Protein Involved in Virion Maturation. Journal of Virology 2012; 86:9647- 55. doi: 10.1128/JVI.01126-12. (SCI: 5.076) 16. Ching-Yi Yiu, Shih-Ying Chen, Li-Kwan Chang, Ya-Fang Chiu, and Tsuey-Pin Lin. Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle. Molecules 2010; 15:7115-24. doi: 10.3390/molecules15107115. (SCI: 1.988) 17. Yu-Hsiu Lee, Ya-Fang Chiu, Wen-Hung Wang, Li-Kwan Chang, and Shih-Tung Liu. 2008. Activation of the ERK Signal Transduction Pathway by Epstein-Barr Virus Immediate-early Protein Rta. Journal of General Virology 2008; 89(Pt 10):2437-46. doi: 10.1099/vir.0.2008/003897-0. (SCI: 3.092) 18. Ya-Fang Chiu, Chao-Ping Tung, Yu-Hsiu Lee, Wen-Hung Wang, Ching Li, Jia-Yan Hung, Chen-Yu Wang, Yasushi Kawaguchi, and Shih-Tung Liu. A Comprehensive Library of Mutations of Epstein Barr Virus. Journal of General Virology 2007; 88(Pt 9):2463-72. (SCI: 3.120 Molecules) 19. Li-Kwan Chang, Ta-Tung Wei, Ya-Fang Chiu, Chao-Ping Tung, Jian-Ying Chuang, Shang-Kai Hung, Ching Li, and Shih-Tung Liu. Inhibition of Epstein-Barr Virus Lytic Cycle by (–)-Epigallocatechin Gallate. Biochemical and Biophysical Research Communications 2003; 301:1062-8. (SCI: 2.836) Conference Presentations Invited speaker: 1. Invited speaker, The 41st International Herpesvirus Workshop, 2016 Oral presentation 1. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Kaposi’s Sarcomaassociated Herpesvirus Stably Clusters its Genomes Across Generations to Maintain Itself Extrachromosomally. Biomedical Research Symposium of National Health Research Institutes, 2019 2. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Identifying An Unprecedented Partitioning Mechanism for KSHV Genomes. The 41st International Herpesvirus Workshop, 2016 3. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Identifying An Unprecedented Partitioning Mechanism for KSHV Genomes. 18th International Workshop on KSHV and Related Agents, 2015 4. Ya-Fang Chiu, Arthur U. Sugden, and Bill Sugden. Epstein-Barr Viral Productive Amplification Reprograms Nuclear Architecture, DNA Replication and Histone Deposition. The 39th International Herpesvirus Workshop, 2014. Poster 1. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Kaposi’s Sarcomaassociated Herpesvirus Stably Clusters its Genomes Across Generations to Maintain Itself Extrachromosomally. Biomedical Research Symposium of National Health Research Institutes, 2019 2. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Kaposi’s Sarcomaassociated Herpesvirus Stably Clusters its Genomes Across Generations to Maintain Itself Extrachromosomally. Biomedical Research Symposium of National Health Research Institutes, 2018 3. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Kaposi’s sarcomaassociated herpesvirus stably clusters its genomes across generations to maintain itself extrachromosomally. “Nasopharyngeal Carcinoma” Gordon Research Conference, 2018 4. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. KSHV Stably Clusters its Genomes Across Generations to Maintain Itself Extrachromosomally. The 4th ASM Conference on Viral Manipulation of Nuclear Processes, 2017 5. Ya-Fang Chiu, Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden. Identifying An Unprecedented Partitioning Mechanism for KSHV Genomes. The 41st International Herpesvirus Workshop, 2016 6. Ya-Fang Chiu, Arthur U. Sugden, and Bill Sugden. Epstein-Barr Viral Productive Amplification Reprograms Nuclear Architecture, DNA Replication and Histone Deposition. The 39th International Herpesvirus Workshop, 2014 7. David T. Vereide, Eri Seto, Ya-Fang Chiu, Mitchell Hayes, Adam Grundhoff, Wolfgang Hammerschmidt, and Bill Sugden Epstein-Barr Virus Inhibits Caspase 3 via its miRNAs to Maintain Type I Burkitt’s Lymphomas The 15th International Symposium on EBV and associated diseases, 2012 8. Ya-Fang Chiu, Chien-Hui Hung, and Shih-Tung Liu. The Role of BBLF1 protein in Epstein-Barr virus maturation, Host-Microbes Interactions symposium, The Taiwan Society Biochemistry and Molecular Biology, 2007 9. Ya-Fang Chiu, Chao-Tung Tung, and Shih-Tung Liu. Epstein-Barr Virus Mutants Generated with Tn5. The 5th NHRI Conference on Tumor Associated Herpesviruses, 2004 10. Li-Kwan Chang, Ya-Fang Chiu, and Shih-Tung Liu. Activation of the Immediate-Early Genes and Lytic Cycle of Epstein-Barr virus by Heat Shock. The 4th NHRI Conference on Tumor Associated Herpesviruses, National health Research Institutes, 2002 11. Li-Kwan Chang, Ya-Fang Chiu, and Shih-Tung Liu. Activation of the Immediate-Early Genes and Lytic Cycle of Epstein-Barr virus by Heat Shock, American Society for Microbiology, 2002 Research Support: The Ministry of Science and Technology (MOST109-2320-B-182-028-MY3); PI NTD$4,170,000 2020-2023 The Ministry of Science and Technology (MOST106-2320-B-182-036-MY3); PI NTD$4,766,000 2017-2020 National Health Research Institute (NHRI-EX107-10623BI); PI NTD$5,340,000 2017-2019 Chang Gung Medical Research Program (CMRPD1K0321); PI NTD$1,002,060 2020-2021 Chang Gung Medical Research Program (CMRPD1G0511); PI NTD$3,300,510 2017-2019 The Ministry of Science and Technology (MOST104-2320-B-182-034-MY2); CoPI NTD1,370,000 2016-2017 The Ministry of Science and Technology (MOST-105-2320-B-182-033); PI NTD$1,100,000 2016-2017 Chang Gung Memorial Hospital Foundation (BMRPF14); PI 2016-Presen |
